个人信息
Personal Information
联系方式
Contact Information
关于我
Personal Profile
一、教育经历
2008.09–2013.07, 北京大学, 分子医学, 博士
2004.09–2008.06, 中国农业大学, 生命科学, 学士
二、科研与学术工作经历
2019.11-至今, 首都医科大学附属北京安贞医院心肺血管疾病研究所，副研究员
2016.08-2019.10, 首都医科大学附属北京安贞医院心肺血管疾病研究所，助理研究员
2013.07-2016.07, 北京大学分子医学研究所，博士后
三、主持课题
1. 国家自然科学基金面上项目，新致病基因C10orf71在扩张型心肌病发生中的作用机制研究，2022/01-2025/12
2. 国家自然科学基金青年项目，冠心病新易感基因RGS5在动脉粥样硬化中的作用机制研究，2019/01-2021/12
四、近5年代表性论文
1. Yang Li, Li Song, Wei Rong, Yuanwei Zhang, Xiaoming Yao, Xiaodong Fang, Yulin Li* and Jie Du*; Exome risk score for predicting susceptibility to and severity of isolated thoracic aortic aneurysm, Human Molecular Genetics, 2022, ddac099. Online ahead of print.
2. Yang Li#; Shijuan Gao#; Yingchun Han#; Li Song; Yu Kong; Yao Jiao; Shan Huang; Jie Du*; Yulin Li*; Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm, Circulation Research, 2021, 128(1): 8-23.
3. Yang Li#; Han Yan#; Jian Guo; Yingchun Han; Cuifang Zhang; Xiuying Liu; Jie Du; Xiao-Li Tian*; Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease, Cardiovascular Research, 2021, 117(1): 240-255.
4. Yang Li; Yu Kong; Weixun Duan; Shiqiang Yu; Xinmin Zhou; Yerong Hu; Jing-Song Ou; Dinghua Yi; Jinsheng Xie; Junming Zhu; Lizhong Sun; Yulin Li*; and Jie Du*; Evaluating the monogenic contribution and genotype-phenotype correlation in patients with isolated thoracic aortic aneurysm, European Journal of Human Genetics, 2021 Jul;29(7):1129-1138.
5. Yang Li#; Dao Wen Wang#; Yundai Chen#; Can Chen#; Jian Guo; Shu Zhang; Zhijun Sun; Hu Ding; Yan Yao; Lei Zhou; Ke Xu; Chun Song; Fan Yang; Bin Zhao; Han Yan; Wen-Jing Wang; Chong Wu; Xiangfeng Lu; Xueli Yang; Jie Dong; Guyan Zheng; Shuhan Tian; Yanjun Cui; Lijuan Jin; Gangqiong Liu; Hanbin Cui; Shenghuang Wang; Feng Jiang; Changhua Wang; Jeanette Erdmann; Linyao Zeng; Shian Huang; Jianfeng Zhong; Yuehua Ma; Wenjiang Chen; Jianli Sun; Wei Lei; Shenghan Chen; Shaoqi Rao; Dongfeng Gu; Heribert Schunkert; Xiao-Li Tian*; Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, 38(4): 964-975.
主持课题
1. 国家自然科学基金面上项目，新致病基因C10orf71在扩张型心肌病发生中的作用机制研究，2022/01-2025/12
2. 国家自然科学基金青年项目，冠心病新易感基因RGS5在动脉粥样硬化中的作用机制研究，2019/01-2021/12
目前的在研项目包括：
1，鉴定胸主动脉瘤的新致病基因并揭示致病机制。
2，鉴定扩张型心肌病的新致病基因并揭示致病机制。
3，基于基因组学的急性冠脉综合征管理体系研发和临床转化
我的研究集中在心血管疾病的遗传病因学，即从遗传的角度解释疾病为什么会发生。关注的疾病既有复杂多基因疾病也包括单基因疾病，鉴定了多个冠心病的易感基因和胸主动脉瘤的致病基因。
近5年代表性论文
1. Yang Li, Li Song, Wei Rong, Yuanwei Zhang, Xiaoming Yao, Xiaodong Fang, Yulin Li* and Jie Du*; Exome risk score for predicting susceptibility to and severity of isolated thoracic aortic aneurysm, Human Molecular Genetics, 2022, ddac099. Online ahead of print.
2. Yang Li#; Shijuan Gao#; Yingchun Han#; Li Song; Yu Kong; Yao Jiao; Shan Huang; Jie Du*; Yulin Li*; Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm, Circulation Research, 2021, 128(1): 8-23.
3. Yang Li#; Han Yan#; Jian Guo; Yingchun Han; Cuifang Zhang; Xiuying Liu; Jie Du; Xiao-Li Tian*; Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease, Cardiovascular Research, 2021, 117(1): 240-255.
4. Yang Li; Yu Kong; Weixun Duan; Shiqiang Yu; Xinmin Zhou; Yerong Hu; Jing-Song Ou; Dinghua Yi; Jinsheng Xie; Junming Zhu; Lizhong Sun; Yulin Li*; and Jie Du*; Evaluating the monogenic contribution and genotype-phenotype correlation in patients with isolated thoracic aortic aneurysm, European Journal of Human Genetics, 2021 Jul;29(7):1129-1138.
5. Yang Li#; Dao Wen Wang#; Yundai Chen#; Can Chen#; Jian Guo; Shu Zhang; Zhijun Sun; Hu Ding; Yan Yao; Lei Zhou; Ke Xu; Chun Song; Fan Yang; Bin Zhao; Han Yan; Wen-Jing Wang; Chong Wu; Xiangfeng Lu; Xueli Yang; Jie Dong; Guyan Zheng; Shuhan Tian; Yanjun Cui; Lijuan Jin; Gangqiong Liu; Hanbin Cui; Shenghuang Wang; Feng Jiang; Changhua Wang; Jeanette Erdmann; Linyao Zeng; Shian Huang; Jianfeng Zhong; Yuehua Ma; Wenjiang Chen; Jianli Sun; Wei Lei; Shenghan Chen; Shaoqi Rao; Dongfeng Gu; Heribert Schunkert; Xiao-Li Tian*; Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, 38(4): 964-975.
文件上传中...
