1.AIM2介导的泛凋亡在干眼中的分子机制及虾青素靶向干预研究-国家自然科学基金（面上）（2026.01-2029.12）主持.在研

2.基于流固耦合模拟和机器学习的角膜区域性生物力学模型构建与验证-国家自然科学基金（面上）（2022.01-2025.12）主持.在研

3.基于超声压痕和剪切波层析成像的角膜生物力学特性检测技术研究-北京市自然科学基金（面上）（2024.01-2026.12）主持.在研

4.基于微型 RLC 传感器的无线眼睑压力与剪切力测量接触镜系统的开发与应用-首都医学科学创新中心有组织科研专项（2025.07-2028.07）主持.在研

5.多极射频干眼治疗仪的开发及其有效性、安全性验证-首都卫生发展科研专项(2024.01-2026.12)主持.在研

6.新型鼻、耳、泪道系统药物缓释可降解支架的研制及临床应用研究-国家重点研发计划（2023.05-2026.04）项目骨干.在研

7.基于Scheimpflug高速摄像技术的在体角膜生物力学测量方法的建立与应用研究-国家自然科学基金（青年）（2017.01-2019.12）主持.已结题

8.基于高频超声印压技术的在体角膜生物力学测量方法的建立与应用研究-北京市自然科学基金（青年）（2017.01-2018.12）主持.已结题

9.基于氮化镓LED的个性化紫外交联仪器的开发及验证-北京市科技新星交叉项目(2023.10-2025.10)主持.已结题

10.在体角膜生物力学测量方法的建立-北京市科技新星计划（2018.01-2020.12）主持.已结题

11.基于微力测量系统的眼睑压力与眼表微创伤疾病关系的研究-北京同仁医院（2018.01-2021.12）主持.已结题

12.基于Scheimpflug高速摄像技术的在体角膜生物力学测量方法的建立与应用研究-北航-首医大数据精准医疗高精尖创新中心（2020.01-2021.12）主持.已结题

13. 眼科显微手术机器人系统集成与临床试验研究-国家重点研发计划（2017.12-2020.11）参与.已结题

一、近五年以第一/通讯作者发表的重要科研论文：

1.Bao J, Wen Y, Tian L*, Jie Y*. Decoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological Mechanisms. Clin Rev Allergy Immunol. 2025 Aug 29;68(1):85.

2.Tian L#, Guo Y#, Wang S, Li Z, Wang N, Jie Y. Efficacy of far infrared functional glasses in the treatment of meibomian gland dysfunction-related dry eye. MedComm (2020). 2024 Mar 22;5(4):e507.

3.Wang YH, Li SY, Feng J, Wen Y, Sun XL, Tian L*, Jie Y*. Efficacy and safety of minor salivary gland transplantation for the treatment of severe dry eye disease: a single-arm meta-analysis. Int J Surg. 2025 Aug 1;111(8):5466-5474.

4.Tian L, Gao Z, Zhu L, Shi X, Zhao S, Gu H, Xu G, Wang L, Dai H, Zhang H, Jin X, Ma K, Xu Y, Ma L, Pei C, Ke B, Krösser S, Zhang Y, Jie Y. Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients: A Randomized Clinical Trial. JAMA Ophthalmol. 2023 Apr 1;141(4):385-392.

5.Cao K#, Tian L#, Ma DL, Zhao SQ, Li A, Jin ZB, Jie Y. Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia: A Randomized Clinical Trial. JAMA Ophthalmol. 2024 Jun 1;142(6):560-567.

5.Li Y#, Tian L#, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y. Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome. Free Radic Biol Med. 2024 Sep;222:106-121.

6.Tian L#, Jin X#, Wang J, Xu Y, Lu C, Zhao S, Zhu Q, Dai H, Gu H, Zhang M, Wang L, Lu X, Ma L, Zhu L, Zeng Q, Zhang H, Fu Y, Li S, Tao L, Ren Q, Ding F, Zhang S, Zhu S, Li Z, Jie Y. Varenicline solution nasal spray for dry eye disease in Chinese patients: a randomized phase 3 trial. Lancet Reg Health West Pac. 2024 Feb 27;45:101032. 

7.Wang Y, Hu X, Yang K, Zhang Y, Deng S, Wang Z, Li S, Tian L*, Jie Y*. Clinical outcomes of modified simple limbal epithelial transplantation for limbal stem cell deficiency in Chinese population: a retrospective case series. Stem Cell Res Ther. 2021 May 1;12(1):259. 

8.Ren ZK#, Feng J#, Tian L#*, Wang KN, Wang JY, Shu YC, Hao YR, Jie Y, Zhou GQ. A topological-aware automatic grading model corneal epithelial damage evaluation from full Corneal Fluorescence Staining images. Comput Biol Med. 2025 Jan;184:109451. 

9.Tian L, Wen Y, Li S, Zhang P, Wang Y, Wang J, Cao K, Du L, Wang N, Jie Y. Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease. Front Nutr. 2022 Jan 13;8:796951. 

10.Tian L, Zhang H, Guo LL, Qin X, Zhang D, Li L, Wu Y, Jie Y, Zhang H. Corrigendum: Distribution of corneal geometric landmarks and relationship between their distances and biomechanical parameters in the development of keratoconus. Front Bioeng Biotechnol. 2023 Jan 10;10:1104956.

11.Tian L, Qin X, Zhang H, Zhang D, Guo LL, Zhang HX, Wu Y, Jie Y, Li L. Corrigendum: A potential screening index of corneal biomechanics in healthy subjects, forme fruste keratoconus patients and clinical keratoconus patients. Front Bioeng Biotechnol. 2022 Aug 30;10:1011816. 

12.Qin X#, Tian L#, Zhang H, Zhang D, Jie Y, Zhang HX, Li L. Determine Corneal Biomechanical Parameters by Finite Element Simulation and Parametric Analysis Based on ORA Measurements. Front Bioeng Biotechnol. 2022 Apr 13;10:862947. 

13.Zhang D#, Tian L#, Zhang H, Zheng Y, Fu C, Zhai C, Jie Y, Li L. Differences of Corneal Biomechanics Among Thin Normal Cornea, Forme-Fruste Keratoconus, and Cornea After SMILE. Front Bioeng Biotechnol. 2022 May 13;10:861924. 

14.Zhang P#, Tian L#, Bao J, Li S, Li A, Wen Y, Wang J, Jie Y. Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway. Invest Ophthalmol Vis Sci. 2022 Mar 2;63(3):29. 

15.Deng X#, Tian L#, Zhang Y, Li A, Cai S, Zhou Y, Jie Y. Is histogram manipulation always beneficial when trying to improve model performance across devices? Experiments using a Meibomian gland segmentation model. Front Cell Dev Biol. 2022 Dec 5;10:1067914.

16.Yang K, Wen Y, Zhu L, Bao JY, Li S, Wang YH, Feng J, Tian L*, Jie Y*. The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum. Biomed Environ Sci. 2023 Nov 20;36(11):1005-1014. 

17.Tian L#, Cao K#, Fan WY, Ohno-Matsui K, Ma DL, Duan AL, Jie Y. Non-invasive low-level red-light therapy for axial length control in pediatric extreme myopia. iScience. 2025 Aug 26;28(10):113459.

18.Bao J#, Tian L#, Meng Y, Wu B, Wang J, He J, Shao Q, Wang C, Jie Y, Zhang L. Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis. Clin Transl Allergy. 2022 Mar;12(3):e12139. 

19.Guo Y, Guo LL, Yang W, Tian L*, Jie Y*. Age-related analysis of corneal biomechanical parameters in healthy Chinese individuals. Sci Rep. 2024 Sep 17;14(1):21713. 

20.Wang Y, Yuan J, Wen Y, Li S, Tian L*, Jie Y*. Clinical observation of esculin and digitalisglycosides eye drops with 0.3% sodium hyaluronate eye drops for dry eye disease: a randomized controlled trial. Sci Rep. 2025 Feb 17;15(1):5747.

二、学术著作

1.《干眼病》主译 科学技术文献出版社2023

2.《同仁干眼实用诊疗》主编 人民卫生出版社 2023

3.《巩膜炎》副主译 科学技术文献出版社 2020

4.《眼健康大百科》副主编 科学技术文献出版社 2019

三、重要奖项

 眼表疾病中西医结合理论基础及创新诊疗策略研究 中国中西医结合学会科学技术奖 一等奖 

 眼表疾病关键诊疗技术创新及推广应用 北京市科学技术奖 一等奖