课题组目前有肿瘤学博导1人，硕导1人，博士生2名，硕士生5名。团队长期致力于具有重要转化前景的原始创新性肿瘤基础研究。

国自然面上项目（82172913）

国自然青年项目（81502384）

发表SCI文章（近五年）

1.       Jian Liu; Chunxiao Li; JinsongWang; Dongkui Xu; Haijuan Wang; Ting Wang; Lina Li; Hui Li; Peng Nan; Jingyao Zhang; Yang Wang; Changzhi Huang; Dong Chen; Yi Zhang; Tao Wen; Qimin Zhan; Fei Ma; Haili Qian. Chromatin modifier MTA1regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing. Nature Communications, 2020,11(1), 4455. 

2.       Lina Li #, Jian Liu #,* (通讯 & 并一), Hongsheng Xue, ChunxiaoLi, Qun Liu, Yantong Zhou, Ting Wang, Haijuan Wang, Haili Qian, Tao Wen. ATGF-β-MTA1-SOX4-EZH2 signaling axis drives epithelial-mesenchymal transition intumor metastasis. Oncogene, 2020.39(10): 2125-2139.   

3.       Liu Q, Liu H, Huang X, Fan X, Xiao Z, Yan R,Yao J, An G, Ge Y, Miao J, Liu J*.A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer. Cancer Gene Therapy, 2023, 30(1):192-208  

4.       Qun Liu, Heshu Liu, Lina Li , Xiaomei Dong,Xiaoli Ru, Xiana Fan, Tao Wen, JianLiu*. ATAD2predicts poor outcomes in patients with ovarian cancer and is a marker ofproliferation. Int J Oncol.2020;56(1):219-231.

5.       Liu J; Li C.; Xue H; Li L; Liu Q; Wang H; Wen T;Qian H. Cancer metastasis-associated protein 1 localizes to the nucleolus andregulates pre-rRNA synthesis in cancer cells. J Cell Biochem. 2021;122(2):180-188. 

6.       Liu J, Liu Z, LiuQ, Li L, Fan X, Wen T, An G. CLEC3B is downregulated and inhibits proliferationin clear cell renal cell carcinoma. Oncol Rep. 2018;40:2023-2035.   

7.       Liu J, Liu Q, WangH, Li C, Wen T, An G, Qian H. NuRD subunit MTA1 interacts with the DNAnon-homologous end joining Ku complex in cancer cells. RSC Advances 2018;8:35218-35225. 

8.       Liu J,Xue H, Li C, Chen X, Yao J, Xu D, Qian Hai. MTA1 localizes to the mitoticspindle apparatus and interacts with TPR in spindle assembly checkpointregulation. BBRC, 2023, 675, 106-112

9.       Zheng L, Liu Q, Li R, Chen S, Tan J, Li L,Dong X, Huang C, Wen T, Liu J*.Targeting MDK Abrogates IFN-γ-Elicited Metastasis in Cancers of VariousOrigins. Frontiers in oncology, 2022,12:885656.

10.    Zhe Liu# , Jian Liu# , Xichen Dong, Xin Hu, Yuliang Jiang, Lina Li ,Tan Du, Lei Yang, Tao Wen* , Guangyu An*, Guosheng Feng*. Tn antigen promoteshuman colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymaltransition activation. JCMM.2019;23(3):2083-2092.   

授权发明专利：

《MDK抑制剂在制备用于抑制干扰素-γ治疗引起的肿瘤转移的药物中的应用》，刘健 温韬 郑路雨 姚健楠，发明专利，2022，授权号：CN 114404601 B