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近5年在主要研究方向上发表SCI10余篇，主持的省部级科研项目5项，获得多项专利，在中华医学会呼吸病学分会、中国医师协会体外循环专业委员会、中国医师协会呼吸分会-呼吸危重症委员会、中国心胸血管麻醉学会体外生命支持分会、中国病理生理学会危重症专业委员会等多个学会担任重要职务，并任国家药品监督管理局医疗器械技术审评专家，多次受邀参加国内学术会议并作报告。通过数据积累，首次描述报道了由中国学者命名并报道的55型腺病毒感染所致的重症肺炎合并极重度呼吸衰竭患者的临床特点和预后（Critical Care）；在规范的ECMO实施与管理的基础上，团队开展了一系列相关临床研究和技术改进，初步探索了ECMO低剂量抗凝策略的可行性、ECMO相关院内感染的防控以及ECMO支持过程中极危重急性呼吸窘迫综合征（ARDS）患者的呼吸机调节策略等。其中ARDS患者呼吸机调节的策略，先后获得首都特色临床应用研究与成果推广以及首发专项重点攻关项目的支持。该研究提出结合跨肺压指导呼气末正压（PEEP）调节的新肺休息策略，能更有效地进行肺保护、肺休息，降低肺损伤风险，甚至有可能改善患者的预后。研究结果已经在Critical Care Medicine发表，并获得体外生命支持组织（ELSO）的认可和推荐，通过会议专题发言、课程培训等形式加以推广。
2025年4月30日，北京朝阳医院呼吸与危重症救治团队荣获第29届“中国青年五四奖章集体”。
2025.1-2027.12 低目标全身抗凝联合膜肺局部抗凝新策略在体外膜式氧合的应用研究（Ggyfz202507）
2024.1-2026.12 早期非侵入膈神经电刺激对重症社区获得性肺炎有创机械通气中老年患者撤机的影响（首发2024-2-1064）
2022.4-2025.4 高层次公共卫生技术人才建设项目（学科带头人-01-19）
2021-2023 早期俯卧位通气在体外膜式氧合治疗危重急性呼吸窘迫综合征中的应用研究（XMLX202105）
2020-2024 体外二氧化碳清除技术（ECCO2R）治疗慢性阻塞性肺疾病急性加重合并高碳酸血症患者的前瞻性随机对照研究（Z201100005520030）
2020.3-2020.5 早期糖皮质激素治疗新型冠状病毒肺炎的前瞻性多中心随机对照研究（COVID-19-BHA03）
学术论文
1、Tang, Xiao et al. “Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Anonymized, Randomized Controlled Trial.” Chest vol. 168,1 (2025): 119-130. doi:10.1016/j.chest.2025.01.033
2、Wang, Rui et al. “Association between ventilation-perfusion matching improvement during initial prone positioning and ICU mortality in patients with moderate to severe ARDS: a prospective two-center study.” Annals of intensive care vol. 15,1 69. 21 May. 2025, doi:10.1186/s13613-025-01489-1
3、Lyu, Wen-Rui et al. “Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study.” Journal of intensive carevol. 12,1 43. 29 Oct. 2024, doi:10.1186/s40560-024-00756-w
4、Wang, Rui et al. “Early reapplication of prone position during venovenous ECMO for acute respiratory distress syndrome: a prospective observational study and propensity-matched analysis.” Annals of intensive care vol. 14,1 127. 20 Aug. 2024, doi:10.1186/s13613-024-01365-4
5、Tang, Xiao et al. “Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study.” Frontiers in cellular and infection microbiology vol. 14 1378379. 28 Mar. 2024, doi:10.3389/fcimb.2024.1378379
6、Tang, Xiao et al. “Psittacosis caused severe community-acquired pneumonia accompanied by acute hypoxic respiratory failure: a multicenter retrospective cohort study from China.” BMC infectious diseases vol. 23,1 532. 14 Aug. 2023, doi:10.1186/s12879-023-08283-z
7、Li, Xuyan et al. “Comparative Dosing of Adjunctive Corticosteroids Therapy for PneumocystisPneumonia with ARDS in Non-HIV Immunocompromised Patients.” Infection and drug resistance vol. 17 5545-5555. 11 Dec. 2024, doi:10.2147/IDR.S493298
8、Tang, Xiao et al. “Psittacosis caused severe community-acquired pneumonia accompanied by acute hypoxic respiratory failure: a multicenter retrospective cohort study from China.” BMC infectious diseases vol. 23,1 532. 14 Aug. 2023, doi:10.1186/s12879-023-08283-z
9、Tang, Xiao et al. “Modern thromboprophylaxis protocol based on guidelines applied in a respiratory intensive care unit: a single-center prospective cohort study.” Thrombosis journal vol. 20,1 76. 12 Dec. 2022, doi:10.1186/s12959-022-00439-2
10、Yuan, Xue et al. “The Effects of Combining Two Postures and Two Ventilator Flow Waveforms on the Cuff Leak Test.” Respiratory care vol. 67,3 (2022): 353-359. doi:10.4187/respcare.09415
11、Wang, Rui et al. “Modified high-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients undergoing bronchoscopy: a randomized clinical trial.” BMC pulmonary medicine vol. 21,1 367. 14 Nov. 2021, doi:10.1186/s12890-021-01744-8
12、Tang, Xiao et al. “Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial.” Respiration; international review of thoracic diseasesvol. 100,2 (2021): 116-126. doi:10.1159/000512063
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