首都医科大学宣武医院衰老与再生研究中心成立于2017年，依托于首都医科大学宣武医院国家老年疾病临床医学研究中心，是一支基础研究与临床应用紧密结合、优势互补的研究队伍。王思研究员任中心执行主任，目前中心人员共13人，其中正高级职称2人、副高级职称2人、中级职称2人、初级职称7人；现有博士生导师1名，硕士生导师1名，在读博士生8名，在读硕士生8名。

      中心基于人类干细胞及模式动物（包括灵长类）衰老研究体系，联合基因编辑、单细胞及多层次组学分析等技术，开展器官及干细胞衰老的机制与干预研究，为衰老及相关疾病的干预提供了潜在的新型分子标志物以及干预靶标。在此基础上，团队探索并发展了一系列针对衰老及相关疾病的基因干预、细胞及衍生物干预、小分子干预、主动健康等新型干预手段，为衰老相关疾病的临床治疗提供新思路新路径，以期推动衰老及其相关疾病的基础研究向临床治疗的转化应用。

1.     2024-2027，国家自然科学基金面上项目，项目负责人

2.     2021-2022，北京市医院管理中心青苗计划，项目负责人

3.     2019-2023，北京市自然科学基金重点研究专题，课题负责人

4.     2017-2019，国家自然科学基金青年项目，项目负责人

1.    Lingling Geng, Jiale Ping, Ruochen Wu, Haoteng Yan, Hui Zhang, Yuan Zhuang, Taixin Ning, Jun Wang, Chuqian Liang, Jiachen Zhang, Qingqing Chu, Jing Zhang, Yifan Wen,Yaobin Jing, Shuhui Sun, Qin Qiao, Qian Zhao, Qianzhao Ji, Shuai Ma, Yusheng Cai,Yandong Zheng, Zhiran Zou, Zhiqing Diao, Mingheng Li, Hao Zhang, Jianli Hu, Liangzheng Fu, Wang Kang, Ruijun Bai, Hongkai Zhao, Sheng Zhang, Yingjie Ding,Jinghui Lei, Wei Wang, Yun Ji, Bo Gou, Guoqiang Sun, Jian Yin, Pengze Yan, HaoLi, Zehua Wang, Shikun Ma, Zunpeng Liu, Hezhen Shan, Qiaoran Wang, Tianling Cao, Shanshan Yang, Cui Wang, Ping Yang, Yanling Fan, Yanxia Ye, Jinghao Hu,Mengmeng Jiang, Ye Wang, Kan Liu, Yujing Li, Yuanxiang Li, Jingyi Li, Weimin Ci, Zi-Bing Jin, Xiaobing Fu, Xu Zhang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Si Wang*, Moshi Song*, Weiqi Zhang*, Jing Qu*, Guang-Hui Liu*, Systematic profiling reveals betaine as an exercise mimetic forgeroprotection, Cell. 2025, 188(19):5403-5425.e33.

2.    Shuai Ma, Zhejun Ji, Bin Zhang, Lingling Geng, Yusheng Cai, Chao Nie, Jiaming Li, Yuesheng Zuo, Yuzhe Sun, Gang Xu, Beibei Liu, Jiaqi Ai, Feifei Liu, Liyun Zhao, Jiachen Zhang, Hui Zhang,Shuhui Sun, Haoyan Huang, Yiyuan Zhang, Yanxia Ye, Yanling Fan, Fangshuo Zheng,Jinghao Hu, Baohu Zhang, Jingyi Li, Xin Feng, Feng Zhang, Yuan Zhuang, Tianjie Li, Yang Yu, Zhaoshi Bao, Sipei Pan, Concepcion Rodriguez Esteban, Zhili Liu,Haohao Deng, Feng Wen, Moshi Song, Si Wang, Guodong Zhu, Jiayin Yang, TaoJiang, Weihong Song, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, YingGu*, Guang-Hui Liu*, Systemic spatial transcriptomic landscape unveils immunoglobin-associatedsenescence as a hallmark of aging, Cell. 2024, 187(24):7025-7044.e34.

3.    Shuai Ma, Shuhui Sun, Lingling Geng, Moshi Song, Wei Wang, Yanxia Ye, Qianzhao Ji, Zhiran Zou, Si Wang, Xiaojuan He, WeiLi, Concepcion Rodriguez Esteban, Xiao Long, Guoji Guo, Piu Chan, Qi Zhou, JuanCarlos Izpisua Belmonte*, Weiqi Zhang*, Jing Qu*, Guang-Hui Liu*, Caloricrestriction reprograms the single-cell transcriptional landscape of rattusnorvegicus aging, Cell. 2020, 180(5): 984-1001.e22. 

4.    Zunpeng Liu, Wei Li, Lingling Geng, Liang Sun, Qiaoran Wang, Yang Yu, Pengze Yan, Chuqian Liang, Jie Ren, Moshi Song, Qian Zhao, Jinghui Lei, Yusheng Cai, Jiaming Li, Kaowen Yan, Zeming Wu, QunChu, Jingyi Li, Si Wang, Chunyi Li, Jing-Dong J. Han, Reyna Hernandez-Benitez, Ng Shyh-Chang, Juan Carlos Izpisua Belmonte, Weiqi Zhang*, Jing Qu*, Guang-Hui Liu*, Cross-species metabolomic analysis identifies uridine as a potentregeneration promoting factor, Cell Discovery. 2022, 8(1):6. 

5.    Lingling Geng, Bin Zhang, Haisong Liu, Si Wang, Yusheng Cai, Kuan Yang, Zhiran Zou, Xiaoyu Jiang, Zunpeng Liu, Wei Li, Zeming Wu, Xiaoqian Liu, Qun Chu, Guang-Hui Liu*, Jing Qu*, Weiqi Zhang*, Acomparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats, Life medicine. 2022, 2(1):lnac045. 

6.    Lingling Geng, Zunpeng Liu, Si Wang, Shuhui Sun,Shuai Ma, Xiaoqian Liu, Piu Chan, Liang Sun, Moshi Song*, Weiqi Zhang*, Guang-Hui Liu*, Jing Qu*, Low-dose quercetin positively regulates mouse healthspan, Protein Cell. 2019, 10(10):770–775. 

7.    Lingling Geng, Zunpeng Liu, Weiqi Zhang, Wei Li, Zeming Wu, Wei Wang, Ruotong Ren, Yao Su, Peichang Wang, Liang Sun, Zhenyu Ju,Piu Chan, Moshi Song*, Jing Qu*, Guang-HuiLiu*, Chemical screen identifies a geroprotective role of quercetin in premature aging, Protein Cell. 2018,10(6):417–435. 

8.    Hezhen Shan, Lingling Geng, Xiaoyu Jiang, Moshi Song, Jianxun Wang, Zunpeng Liu, Xiao Zhuo, Zeming Wu, ZhejunJi, Si Wang, Piu Chan, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*, Large-scale chemical screen identifies gallic acid as a geroprotector for human stem cells, Protein Cell. 2021,13(7):532-539. 

9.    Zhichu Xiang, Xiaoliang Yang, Junjie Xu, Wenjia Lai, Zihua Wang, Zhiyuan Hu*, Jiesheng Tian*, Lingling Geng*, Qiaojun Fang*, Tumor detection using magnetosome nanoparticles functionalized with anewly screened EGFR/HER2 targeting peptide, Biomaterials. 2017,115:53-64.

10.  Qi Xin, Qian Liu, Lingling Geng, Qiaojun Fang*, Jian Ru Gong*, Chiral nanoparticle as a new efficient antimicrobial nanoagents, Advanced Healthcare Materials. 2017, 6(4):1601011.