在研项目

2022/1-2024/12 北京市自然科学基金面上项目 (7222080) 负责人: 戚智锋； 自由基响应的脑靶向纳米载体提高药物向脑缺血半暗带靶向递送和释放研究

2023/01-2026/12 国家自然科学基金 (82271308) 负责人: 戚智锋 脑缺血微环境游离锌离子在血脑屏障损伤中的作用与机制研究

2024/01-2025/12 北京市卫健委首都医学科技创新成果转化优促计划培育项目 负责人: 戚智锋 血脑屏障损伤标记物Occludin试剂盒研制及预估脑卒中出血转化的概念验证

1、2013/01-2015/12国家自然科学基金 (81200928)负责人: 戚智锋，神经元线粒体损伤调控脑缺血过程中血脑屏障通透性的机制研究，

2、2014/07-2017/06北京市科技新星计划 (Z141107001814045)负责人: 戚智锋，脑缺血血脑屏障损伤中线粒体稳态调控机制

3、2015/03-2016/03国家公派高级研究学者及访问学者项目 (201409110073)负责人: 戚智锋

4、2016/01-2019/12国家自然科学基金 (81571175)负责人: 戚智锋神经元锌离子调控脑缺血血脑屏障通透性的机制研究

5、2019/11-2021/10北京市科技新星交叉合作项目 (Z191100001119002)负责人: 戚智锋；合作者：杜立波 (中国科学院化学研究所)

自由基靶向纳米载药系统在急性脑缺血动物模型中的应用和治疗效果评价

6、2022/1-2024/12北京市自然科学基金面上项目 (7222080)负责人: 戚智锋；自由基响应的脑靶向纳米载体提高药物向脑缺血半暗带靶向递送和释放研究

7、2023/01-2026/12国家自然科学基金 (82271308)负责人: 戚智锋脑缺血微环境游离锌离子在血脑屏障损伤中的作用与机制研究

8、2024/01-2025/12 北京市卫健委首都医学科技创新成果转化优促计划培育项目 负责人: 戚智锋血脑屏障损伤标记物Occludin试剂盒研制及预估脑卒中出血转化的概念验证

获奖

2018年 教育部科技进步奖一等奖 上肢远隔缺血适应新技术的建立及其防治缺血性脑卒中的临床应用

2020年 北京市科技进步二等奖 基于血流再通的缺血性卒中脑保护救治关键技术研发及应用推广

2020年 中华医学科技奖一等奖 缺血性脑卒中非药物防治新技术的创研与应用

2022年 第5届（2022）中国医疗器械创新创业大赛医院专场赛二等奖 用于检测脑微血管早期损伤的抗体和应用

发表SCI论文 40篇

1.Qi Z, Bu X, Huang P, Zhang N, Han S, Fang L, Li J: Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Neurochemical Research 2007;32(9):1450-1459.

2.Huang P, Qi Z，Bu X, Zhang N, Han S, Fang L, Li J: Neuron-specific phosphorylation of mitogen- and stress-activated protein kinase-1 involved in cerebral hypoxic preconditioning of mice. Journal of Neuroscience Research 2007;85:1279-1287.

3.Bu X, Huang P, Qi Z，Zhang N, Han S, Fang L, Li J: Cell type-specific activation of p38 MAPK in the brain regions of hypoxic preconditioned mice. Neurochemistry International 2007;51:459-466.

4.Qi Z，Yang W, Liu Y, Cui T, Gao H, Duan C, Lu L, Zhao C, Zhao H, Yang H: Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochemistry International 2011;59(5):572-581.

5.Cui T, Fan C, Gu L, Gao H, Liu Q, Zhang T, Qi Z，Zhao C, Zhao H, Cai Q, Yang H: Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells. Brain Research 2011;1394:1-13.

6.Qi ZF，Luo YM, Liu XR, Wang RL, Zhao HP, Yan F, Song ZJ, Luo M, Ji XM: AKT/GSK3beta-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model. CNS Neuroscience & Therapeutics 2012; 18(12):965-973.

7.Gao H, Yang W, Qi Z，Lu L, Duan C, Zhao C, Yang H: DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. Journal of Molecular Biology 2012;423:232-248.

8.Qi Z，Liu W, Luo Y, Ji X, Liu KJ: Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke. Medical Gas Research 2013; 1(3):2

9.Qi Z，Yan F, Shi W, Zhang C, Dong W, Zhao Y, Shen J, Ji X, Liu KJ, Luo Y. AKT-related autophagy contributes to the neuroprotective efficacy of Hydroxysafflor Yellow A against ischemic stroke in rats. Translational Stroke Research. 2014;5(4):501-509 .

10.Chen F, Qi Z，Luo Y, Hinchliffe T, Ding G Xia Y, Ji X. Non-pharmaceutical therapies for stroke: mechanisms and clinical implications. Progress in Neurobiology 2014; 115(4): 246-269.

11.Li YN, Pan R, Qin XJ, Yang WL, Qi Z，Liu W, Liu KJ. Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression. Journal of Neurochemistry. 2014; 129(1): 120-129.

12.Zhao Y, Pan R, Li S, Luo Y, Yan F, Yin J, Qi Z，Yan Y, Ji X, Liu KJ. Chelating intracellularly accumulated zinc decreased ischemic brain injury through reducing neuronal apoptotic death. Stroke. 2014; 45(4) :1139-1147.

13.Liu Y, Sun Z, Sun S, Duan Y, Shi J, Qi Z，Meng R, Sun Y, Zeng X, Chui D, Ji X. Effects of hypoxic preconditioning on synaptic ultrastructure in mice. Synapse. 2015; 69(1):7-14.

14.Wang R, Wu X, Liang J, Qi Z，Liu X, Min L, Ji X, Luo Y, Zhao H. Intra-artery infusion of recombinant human erythropoietin reduces blood-brain barrier disruption in rats following cerebral ischemia and reperfusion. The International Journal of Neuroscience. 2015; 125(9):693-702

15.Zhao H, Wang R, Wu X, Liang J, Qi Z，Liu X, Min L, Ji X, Luo Y. Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. Journal of Neuroimmune Pharmacology. 2015;10(1):153-61.

16.Qi Z，Dong W, Shi W, Wang R, Zhang C, Zhao Y, Ji X, Liu KJ , Luo Y. Bcl-2 Phosphorylation Triggers Autophagy Switch and Reduces Mitochondrial Damage in Limb Remote Ischemic Conditioned Rats After Ischemic Stroke. Translational Stroke Research. 2015; 6:198–206.

17.Liang J, Qi Z，Liu W, Wang P, Shi W, Dong W, Ji X, Luo Y, Liu KJ, Normobaric hyperoxia slows ischemic BBB damage and expands the therapeutic time window for tPA treatment in focal cerebral ischemia, Stroke, 2015, 46: 1344-1351.

18.Dong W, Qi Z，Liang J, Shi W, Zhao Y, Luo Y, Ji X, Liu KJ, Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model, Experimental Neurology, 2015, 272:181-189.

19.Shi S, Qi Z，Luo Y, Ji X, Liu KJ, Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective, Medical Gas Research, 2016;6(3),147-153.

20.Qi Z，Liang J, Pan R, Dong W, Shen J, Yang Y, ZhaoY, Shi W, Luo Y, Ji X, Liu KJ, “Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption”, Neurobiology of Disease, 2016, 95:12-21.

21.Qi Z，Liu KJ, “Pathophysiological role of zinc in brain ischemia”, Oncotarget 2017;8(4),5670-5671.

22.Shi S, Qi Z，Ma Q, Pan R, Timmins G, Zhao Y, Shi W, Zhang Y, Ji X, Liu KJ. Normobaric hyperoxia reduces blood occludin fragments in rats and patients with acute ischemic stroke, Stroke. 2017;48:2848-2854

23.Zhao Y, Yan F, Pan R, Shi W, Qi Z，Li S, LuoY, Ji X, Liu KJ. Synergistic interaction between zinc and reactive oxygen species amplifies ischemic brain injury in rats. Stroke. 2018 49(9):2200-2210.

24.Li W, Pan R, Qi Z，Liu KJ. Current progress in searching for clinically useful biomarkers of blood brain barrier damage following cerebral ischemia. Brain Circulation 2018;4(4):145-152.

25.Qi Z，Liu KJ. The interaction of zinc and the blood-brain barrier under physiological and ischemic conditions. Toxicology and Applied Pharmacology, 2019, 364, 114-119.

26.Qi Z，Shi W, Zhao Y*, Ji X, Liu KJ. Zinc accumulation in mitochondria promotes ischemia-induced BBB disruption through Drp1-dependent mitochondria fission. Toxicology and Applied Pharmacology. 2019, 377, 114601

27.Pan R*, Liu KJ, Qi Z. Zinc causes the death of hypoxic astrocytes by inducing ROS production through mitochondria dysfunction. Biophysics Reports. 2019, 5(4):209–217.

28.Li W, Ding J, Sui X, Qi Z, Wu L, Sun C, Ji K, Ma Q, Ji X, Liu KJ. Prognosis and risk factors for reocclusion after mechanical thrombectomy. Annals of Clinical and Translational Neurology. 2020, 7(4): 420-428.

29.Li W, Qi Z ，Kang H, Qin X, Song H, Sui X, Ren Y, Ji X, Ma Q, Liu KJ. Serum Occludin as a Biomarker to Predict the Severity of Acute Ischemic Stroke, Hemorrhagic Transformation and Its Prognosis. Aging and Disease 2020, 11(6) 395-1406.

30.Li Y, Zhang X, Qi Z*, Guo X, Liu X, Shi W, Liu Y*, Du L* The enhanced protective effects of salvianic acid A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier. Nano Research 2020, 13(10) 2791-2802.

31.Yuan S, Liu KJ, Qi Z. Occludin regulation of blood–brain barrier and potential therapeutic target in ischemic stroke, Brain Circulation 2020, 6(3): 152-162.

32.Qi Z*, Yuan S, Zhou X, Ji X, Liu KJ. Isobaric Tags for Relative and Absolute Quantitation-Based Quantitative Serum Proteomics Analysis in Ischemic Stroke Patients With Hemorrhagic Transformation. Frontiers in Cellular Neuroscience. 2021, 15:710129.

33.Yuan S, Li W, Hou C, Kang H, Ma Q, Ji X, Qi Z*, Liu KJ*. Serum occludin level combined with NIHSS score predicts hemorrhage transformation in ischemic stroke patients with reperfusion. Frontiers in Cellular Neuroscience. 2021, 15:714171

34.Qi Z#, Yuan S#, Liu KJ, Ji X*. Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes. CNS Neuroscience & Therapeutics, 2022, 28:1509-1518

35.Li W#, Qi Z#, Ma Q, Ding J, Wu C, Song H, Yang Q, Duan J, Liu L, Kang H, Wu L, Ji K, Zhao W, Li C, Sun C, Li N, Fisher M, Ji X*, Liu KJ. Normobaric Hyperoxia Combined with Endovascular Treatment for Patients with Acute Ischemic Stroke: A Randomized Controlled Clinical Trial. Neurology. 2022, 99(8) e824-e834

36.Qi Z, Liu KJ. Opportunities for neuroprotecitve drugs in the era of vascular recanalization. Translational Stroke Research. 2023

37.Li W, Yang X, Ding M, Shi W, Huang Y, An Q, Qi Z* and Zhao Y* Zinc accumulation aggravates cerebral ischemia/reperfusion injury by promoting inflammation. Front. Cell. Neurosci. 2023, 17:1065873.

38.Gao D, Yuan S, Ji X, Su Y*, Qi Z*. The neuroprotective role of prolonged normobaric oxygenation applied during ischemia and in the early stage of reperfusion in cerebral ischemic rats. Brain Research. 2023 (1816) 148464

39.Yuan S, Ma Q, Hou C, Zhao Y, Liu KJ, Ji X*, Qi Z*. Association of serum occludin levels and perihematomal edema volumes in intracranial hemorrhage patients. CNS Neuroscience & Therapeutics 2023 online.

40.Qi Z, Zhou X, Dong W, Timmins G, Pan R, Shi W, Yuan S, Zhao Y, Ji X, Liu KJ. Neuronal zinc transporter ZnT3 modulates cerebral ischemia-induced blood-brain barrier disruption. Aging and disease 2023 online