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葛献鹏,首都医科大学宣武医院副教授,入选国家和北京市高层次青年人才项目。2012-2021年在美国哈佛医学院、麻省大学医学院从事博士后研究,曾任耶鲁大学医学院副研究员(Associate Research Scientist)。课题组主要从事骨骼干细胞和骨关节炎的基础与转化研究,目前课题经费充足。
目前团队成员7人,是一个积极向上、团结协作、致力于前沿科学的Group。
目前课题组有多项国际前沿课题正在开展,课题经费充足,团队朝气有活力。
1、国家自然科学基金优秀青年科学基金项目(海外)
2、北京市高层次青年人才项目
3、北京市自然科学基金面上项目
4.、宣武医院“汇智”人才工程拔尖人才项目
发表论文:
1. Fan Zhang, Yuanyuan Wang,Ying Zhao, Manqi Wang, Bin Zhou, Bin Zhou, Xianpeng Ge. NFATc1 marksarticular cartilage progenitors and negatively determines articular chondrocytedifferentiation. Elife 2023,12:e81569.
2. Yuanyuan Wang,Jiangdong Ren, Guojin Hou, Xianpeng Ge. NFATC1 and NFATC2 expressionpatterns in human osteochondromas. Heliyon 2023,9(1):e13018.
3. Lin Qiu, Anqi Tao,Xiaoqian Sun, Fei Liu, Xianpeng Ge, Cuiying Li. Comprehensivebioinformatics analysis and experimental validation: An anoikis-related geneprognostic model for targeted drug development in head and neck squamous cellcarcinoma. Oncology Research 2023;31(5):715-52.
4. Lin Qiu, AnqiTao, Fei Liu, Xianpeng Ge, Cuiying Liu. Potential prognostic value of aeight ferroptosis-related lncRNAs model and the correlative immune activity inoral squamous cell carcinoma. BMC Genom Data 2022;23(1):80.
5. Xianpeng Ge, Lizhi He, Haibo Liu, Cole M. Haynes, Jae-Hyuck Shim. The ESCRT proteinCHMP5 restrains skeletal progenitor cell senescence by preservingendo-lysosomal-mitochondrial network. bioRxiv 2020.08.03.233874. doi: https://doi.org/10.1101/2020.08.03.233874
6. Jung-Min Kim,Yeon-Suk Yang, Kwang Hwan Park, Xianpeng Ge, Ren Xu, Na Li, MinkyungSong, Hyunho Chun, Seoyeon Bok, Julia F Charles, Odile Filhol-Cochet, BrigitteBoldyreff, Teresa Dinter, B Yu Paul, Ning Kon, Wei Gu, Takeshi Takarada, MatthewB. Greenblatt, and Jae-Hyuck Shim. A RUNX2stabilization pathway mediates physiologic and pathologic bone formation. Nature Communications 2020;11 (1):1-17.
7. Xianpeng Ge, Ruirui Shi, Xuchen Ma. The secreted protein WNT5A regulates condylarchondrocyte proliferation, hypertrophy and migration. Archives of Oral Biology 2017;82:171-9.
8. Xianpeng Ge, Kelly Tsang,Lizhi He, Roberto A. Garcia, Joerg Ermann, Fumitaka Mizoguchi, Minjie Zhang,Bin Zhou, Bin Zhou, and Antonios O. Aliprantis. NFAT restricts osteochondromaformation from entheseal progenitors. JCIInsight 2016;1(4):e86254.
9. Xianpeng Ge, Susan Ritter,Kelly Tsang, Ruirui Shi, Kohtaro Takei, Antonios O. Aliprantis. Sex-specific protection of osteoarthritis bydeleting cartilage acidic protein 1. PLoSOne 2016;11(7):e0159157.
10. WilliamO’Brien, Brian Fissel, Yukiko Garrison, Jing Yan, Xianpeng Ge, Ellen Gravallese, Antonios O. Aliprantis, Julia F.Charles. Receptor activator of nuclear factor kappa-B (RANK) independentosteoclast formation and bone erosion in inflammatory arthritis. Arthritis & Rheumatology2016;68(12):2889-900.
11. Xian-Peng Ge, Ye-Hua Gan,Chen-Guang Zhang, Kang-Tao Ma, Chun-Yan Zhou, Juan-Hong Meng, Xu-Chen Ma.Requirement of the NF-κB pathway for induction of Wnt-5A by interleukin-1β incondylar chondrocytes of the temporomandibular joint: functional crosstalkbetween the Wnt-5A and NF-κB signaling pathways. Osteoarthritis and Cartilage 2011;19(1):111-7.
12. Xianpeng Ge, Xuchen Ma,Juanhong Meng, Chenguang Zhang, Kangtao Ma, Chunyan Zhou. Role of Wnt-5A ininterleukin-1beta-induced matrix metalloproteinase expression in rabbittemporomandibular joint condylar chondrocytes. Arthritis & Rheumatology 2009;60(9):2714-22.
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