主持国家级科研项目2项，主持北京市优秀人才青年骨干个人项目1项，主持环境毒理学北京市重点实验室2017年青年科研基金项目1项

1. 国家自然科学基金委员会，面上项目，82073498，单核细胞源性的组织定居巨噬细胞在石英致肺上皮细胞间质转化中的作用机制，2021-01至2024-12，55万元，在研，主持

2. 国家自然科学基金委员会,青年科学基金项目，81703197，部分上皮间质转化在矽肺纤维化中的作用机制，2018-01至2020-12，20万元，已结题，主持

一、发表论文：

(1)   Lin Hou; Zhonghui Zhu; Fuyang Jiang; Jing Zhao; Qiyue Jia; Qiyue Jiang; Hongwei Wang; Wenming Xue; Yan Wan*; Lin Tian*; Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis, Ecotoxicology and Environmental Safety, 2023, 251:114537.

(2) Qiuyue Li; Siling Li; Chunjie Xu; Jing Zhao; Lin Hou; Fuyang Jiang;Zhonghui Zhu*; Yan Wang*;Lin Tian*; microRNA-149-5p mediates the PM2.5-induced inflammatoryresponse by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and invitro, Cell Biology Toxicology, 2023, 39(3):703-717.

(3) Yan Wang; Siling Li; JingZhao; Qiuyue Li; Chunjie Xu; Huihui Wu; Zhonghui Zhu*; Lin Tian*;Snail-mediated partial epithelial mesenchymal transition augments thedifferentiation of local lung myofibroblast, Chemosphere, 2021, 267: 128870.

(4) Zhonghui Zhu; Qiuyue Li; Chunjie Xu; Jing Zhao; Siling Li; Yan Wang*; Lin Tian*;Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis inrats via activation of the Nrf2 and thioredoxin system.Environmental Toxicologyand Pharmacology, 2020, 80:103461.

(5) Jingping Sun; Qiuyue Li; XimengLian; Zhonghui Zhu; Xiaowei Chen;Wanying Pei; Siling Li; Ali Abbas; YanWang*; Lin Tian*; MicroRNA-29b Mediates LungMesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the SilicosisModel, Molecular Therapy Nucleic Acids,2019, 14: 20–31.

二、获奖情况

空气颗粒物致肺组织损伤的发生机制 首都医科大学科学技术奖 三等奖 202107