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孙广永，医学研究中心，研究员，教授，博士研究生导师。主要从事肝脏疾病的免疫学发病机制、免疫干预治疗研究。以第一/通讯作者在Signal Transduct Target Ther、Cell Rep Med、Cell Rep (2018, 2023)、Nat Commun、Sci Bull等杂志发表SCI论文二十余篇。参与编写论著1部。获国家发明专利七项。先后主持国家自然科学基金项目3项，省部级、局级课题10余项。入选北京市“凤凰计划”青年人才、北京市卫健委高创计划“青苗”人才，北京市医管中心“青苗”计划人才，首都医科大学优秀青年人才等项目。美国肝病学会青年研究学者，亚太肝病学会青年研究学者，北京免疫学会青年研究学者。Frontiers in Immunology杂志Review Editor，Exploration杂志、eGastroenterology杂志青年编委，北京慢性病防治与健康教育研究会糖尿病专业委员会委员，国家自然科学基金通讯评审专家。
项目（课题/任务）名称 | 立项编号 | 项目来源 | 起止 年月 | 经费 (万元) | 本人 作用 | |
1 | Spp1/CD44信号通过AMPK-ZEB2通路下调双阴性T调节细胞线粒体自噬促进NASH发病的研究 | 82370578 | 国家自然科学基金面上项目 | 2024.01-2027.12 | 49 | 项目负责人 |
2 | 氧化磷酸化调控双阴T细胞免疫抑制功能影响非酒精性脂肪性肝炎发病的研究 | 81970503 | 国家自然科学基金面上项目 | 2020.01-2023.12 | 55 | 项目负责人 |
3 | IFITM1通过调控线粒体自噬改善双阴性T调节细胞功能抑制NASH发病的研究 | 7232034 | 北京市自然科学基金面上项目 | 2023.01-2025.12 | 20 | 项目负责人 |
4 | 北京市高创计划“青苗”人才 | 北京市卫健委 | 2025.08-2028.08 | 90 | 项目负责人 | |
5 | 首都医科大学优秀青年人才项目 | 1220090119 | 首都医科大学 | 2022.01-2024.12 | 100 | 项目负责人 |
6 | 北京市医管局“青苗”计划人才项目 | QML20230101 | 北京市医院管理中心 | 2023.01-2014.12 | 14 | 项目负责人 |
7 | 北京市呼吸疾病研究所自主创新人才项目 | Ggyfz202510 | 北京市呼吸疾病研究所 | 2025.01-2027.12 | 60 | 项目负责人 |
8 | 北京友谊医院青才计划人才项目 | YYQC202105 | 北京友谊医院 | 2021.01-2023.12 | 20 | 项目负责人 |
9 | 免疫共刺激分子OX40/OX40L调控脂肪细胞促进肥胖及胰岛素抵抗的机制研究 | 7192046 | 北京市自然科学基金面上项目 | 2019.01-2021.12 | 20 | 项目负责人 |
10 | 双阴性T细胞中OX40的表达调控及其在1型糖尿病免疫调节中的应用 | 81500598 | 国家自然科学基金青年项目 | 2016.01-2018.12 | 21.6 | 项目负责人 |
11 | 免疫共刺激分子OX40/OX40L调控肝脏局部免疫影响NASH诱发的肝纤维化的机制探讨 | WBE20161054 | 王宝恩肝纤维化基金项目 | 2017.01-2018.12 | 5.0 | 项目负责人 |
12 | 北京友谊医院种子计划人才项目 | YYZZ2017A05 | 北京友谊医院 | 2018.01-2020.12 | 3.0 | 项目负责人 |
1. Li S, Wang Y, Zhang Z, Xu H, Wu S, Jin H, Han X, Liu Y, Wen X, Wu Y, Zhang Z, Hu L, Hu L, Zhang C, Wang J, Yan R, Chen M, Xiao G, Sun GY (Co-corresponding author), Zhang D, Wang S. Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance. Signal Transduct Target Ther. 2025 Oct 2;10(1):323. IF = 52.7,中科院1区
2. Sun GY, Zhao XY, Li MY, Zhang CP, Jin H, Li CY, Liu LW, Wang YN, Shi W, Tian D, Xu HF, Tian Y, Wu YL, Liu K, Zhang ZT, Zhang D. CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis. Nature Communications. 2021 Jan 28;12(1):650. IF = 14.7，中科院1区
3. Jin H, Li MY, Wang XY, Yang L, Zhong XJ, Zhang ZH, Han XT, Zhu JJ, Li MY, Wang SL, Simon CR, Sun GY (Co-corresponding author), Zhang D. Purinergic signaling by TCRαβ+ double-negative T regulatory cells ameliorates liver ischemia-reperfusion injury. Sci Bull (Beijing). 2025 Jan 30;70(2):241-254. IF = 21.1，中科院1区
4. Li XH, Zheng SM, Xu HZ, Zhang ZH, Han XT, Wei YX, Jin H, Du XN, Xu HF, Li MY, Zhang ZT, Wang SL, Sun GY (Co-corresponding author), Zhang D, The direct and indirect inhibition of pro-inflammatory adipose tissue macrophages by acarbose in diet-induced obesity. Cell Rep Med. 2025 Jan 21;6(1):101883. IF = 11.7，中科院1区
5. Wei Y, Jiang Y, Zhu J, Zhang Z, Li M, Zheng S, Wang X, Sun J, Li C, Shi W, Wang S, Liu X, Lin M, Zhang Z, Zhang D, Sun G (Corresponding author). CD36-mediated uptake of oxidized LDL induces double-negative regulatory T cell ferroptosis in metabolic dysfunction-associated steatotic liver disease. Metabolism. 2025 Mar;164:156127. IF = 11.9，中科院1区
6. Xu N, Fang P, Zhou L, Han X, Jiang Y, Wang X, Zhu J, Li B, Zhang Z, Jin H, Du X, Sun G (Corresponding author), Zhang D. SLAMF7 promotes TCRαβ+ double negative T cell antitumor activity through enhancing glutamine metabolism. J Exp Clin Cancer Res. 2025 Oct 30;44(1):297. IF = 12.8，中科院1区
7. Wang H, Zhao Y, Pan Y, Yang A, Li C, Wang S, Dong Z, Li M, Wang S, Zhang Z, Zhu Y, Zhang D, Sun G (Corresponding author). Inhibition of phospholipase D1 ameliorates hepatocyte steatosis and non-alcoholic fatty liver disease. JHEP Reports. 2023 Mar 9;5(6):100726. IF = 9.5，中科院1区
8. Sun GY, Jin H, Zhang CP, Meng H, Zhao XY, Wei D, Ou XJ, Wang QY, Li SX, Wang TQ, Sun XJ, Shi W, Tian D, Liu K, Xu HF, Tian Y, Li XM, Jia JD, Zhang ZT, Zhang D. OX40 regulates both innate and adaptive immunity and promotes nonalcoholic steatohepatitis. Cell Reports. 2018 Dec 26;25(13):3786-3799. IF = 7.5，中科院1区
9. Sun GY, Wang Y, Yang L, Shen Z, Zhang Z, Han X, Du X, Jin H, Li C, Wang S, Zhang Z, Zhang D. Rebalancing liver-infiltrated CCR3+ and CD206+ monocytes by melatonin improves diets induced NAFLD. Cell Reports. 2023 Jul 25;42(7):112753. IF = 7.5，中科院1区
10. Li C, Du X, Shen Z, Wei Y, Wang Y, Han X, Jin H, Zhang C, Li M, Zhang Z, Wang S, Zhang D, Sun G (Corresponding author). The critical and diverse roles of CD4-CD8- double negative T cells in nonalcoholic fatty liver disease. Cell Mol Gastroenterol Hepatol. 2022 Mar 2;13(6):1805-1827. IF = 7.4，中科院1区
11. Sun GY, Sun XJ, Li W, Liu K, Tian D, Dong YR, Sun XL, Xu HF, Zhang D. Critical role of OX40 in the expansion and survival of CD4 T cell-derived double negative T cells. Cell Death Dis. 2018 May 23;9(6):616. IF = 9.6，中科院1区
12. Zhao XY, Sun GY (Co-first author), Sun XJ, Tian D, Liu K, Liu TH, Cong M, Xu HF, Li XM, Shi W, Tian Y, Yao JY, Guo HB, Zhang D. A novel differentiation pathway from CD4(+) T cells to CD4(-) T cells for maintaining immune system homeostasis. Cell Death Dis. 2016 Apr 14;7:e2193. IF = 9.6，中科院1区
13. Wang Y, Sun X, Han X, Sun J, Li L, Zhang D, Sun G (Corresponding author). Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway. Biomed Pharmacother. 2023 Apr;160:114358. IF = 6.9，中科院1区
14. Zhang C, Jin H, Wang Y, Li C, Zhao X, Li Y, Shi W, Tian Y, Xu H, Tian D, Liu K, Jia J, Sun G (Co-corresponding author), Zhang D. Critical role of OX40 in drug-induced acute liver injury. Br J Pharmacol. 2020 Jul;177(14):3183-3196. doi: 10.1111/bph.15041. Epub 2020 Apr 5. IF = 6.8，中科院2区
15. Liu B, Yu HC, Sun GY (Co-first author), Sun XJ, Jin H, Zhang CP, Shi W, Tian D, Liu K, Xu HF, Li XM, Yin J, Hong X, Zhang D. OX40 promotes obesity-induced adipose inflammation and insulin resistance. Cell Mol Life Sci. 2017 Oct;74(20):3827-3840. IF = 6.2，中科院2区
16. Wei Y, Sun GY (Co-first author), Yang Y, Li M, Zheng S, Wang X, Zhong X, Zhang Z, Han X, Cheng H, Zhang D, Mei X. Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδlow T cells. J Transl Med. 2024 Apr 2;22(1):328. IF = 6.1，中科院2区
17. Wang TQ, Sun GY (Co-first author), Wang YN, Li SX, Zhao XY, Zhang CP, Jin H, Tian D, Liu K, Shi W, Tian Y, Zhang D. The immunoregulatory effects of CD8 T-cell derived perforin on diet-induced nonalcoholic steatohepatitis. FASEB J. 2019 Jul;33(7):8490-8503. IF = 4.4，中科院2区
18. Sun J, Xu H, Li B, Deng W, Han X, Zhong X, Zhu J, Jiang Y, Wang Z, Zhang D, Sun G (Corresponding author). IFITM1 aggravates ConA-Induced autoimmune hepatitis by promoting NKT cell activation through increased AMPK-Dependent mitochondrial function. Int Immunopharmacol. 2024 Nov 26;144:113692. IF = 4.8，中科院2区
19. Shi W, Wang Y, Zhang C, Jin H, Zeng Z, Wei L, Tian Y, Zhang D, Sun G (Corresponding author). Isolation and purification of immune cells from the liver. Int Immunopharmacol. 2020 Aug;85:106632. IF = 4.8，中科院2区
20. Zhang Z, Fang P, Zhu J, Sun G (Corresponding author). ZNF623 contributes to breast carcinoma progress by recruiting CtBP1 to regulate NF-κB pathway. Biochem Biophys Res Commun. 2024 Oct 8;728:150314. IF = 2.5，中科院3区
21. Sun G, Wei Y, Zhu J, Zheng S, Zhang Z, Zhang D. The transcription factor T-bet promotes the pathogenesis of nonalcoholic fatty liver disease by upregulating intrahepatic inflammation. Biochem Biophys Res Commun. 2023 Nov 19;682:266-273. IF = 2.5，中科院3区
22. Sun GY, Dong LY, An W. Involvement of hepatic stimulator substance in the regulation of hepatoblast maturation into hepatocytes in vitro. Stem Cells Dev. 2014 Jul 15;23(14):1675-87. IF = 2.5，中科院3区
23. Wu Y, Han X, Zhou L, Liu X, Zhang D, Sun G (Corresponding author). The T-box transcription factor plays an important role in regulating the immunoregulatory function of double-negative T cells. Biochem Biophys Res Commun. 2025 Mar 8;752:151492. IF = 2.5，中科院3区
24. Jin H, Zhong X, Zhang C, Wu Y, Sun J, Wang X, Wang Z, Zhu J, Jiang Y, Du X, Zhang Z, Zhang D, Sun G (Corresponding author). CD73 promotes the immunoregulatory functions of hepatic Tregs through enzymatic and nonenzymatic pathways in MASLD development. Mol Metab. 2025 Mar 24:102131. IF = 7.0，中科院2区
25. Zhang C, Sun GY (Co-first author), Jin H, Wei Y, Zheng S, Wang X, Zhao X, Zhang D, Jia J. Double-negative T cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice. BMC Med. 2025 Apr 7;23(1):209. IF = 8.3，中科院1区
26. Du X*, Han X*, Zhu J, Zhang Z, Jin H, Zhang D#, Sun G#. Rapamycin ameliorates intrahepatic inflammation in MASLD by increasing macrophage fatty acid oxidation levels. Int Immunopharmacol. 2025 Jul 29;163:115288. IF = 4.7，中科院2区
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