首都医科大学宣武医院衰老与再生研究中心成立于2017年，依托于首都医科大学宣武医院国家老年疾病临床医学研究中心，是一支基础研究与临床应用紧密结合、优势互补的研究队伍。王思研究员任中心执行主任，目前中心人员共13人，其中正高级职称2人、副高级职称2人、中级职称2人、初级职称7人；现有博士生导师1名，硕士生导师1名，在读博士生8名，在读硕士生8名。

      中心基于人类干细胞及模式动物（包括灵长类）衰老研究体系，联合基因编辑、单细胞及多层次组学分析等技术，开展器官及干细胞衰老的机制与干预研究，为衰老及相关疾病的干预提供了潜在的新型分子标志物以及干预靶标。在此基础上，团队探索并发展了一系列针对衰老及相关疾病的基因干预、细胞及衍生物干预、小分子干预、主动健康等新型干预手段，为衰老相关疾病的临床治疗提供新思路新路径，以期推动衰老及其相关疾病的基础研究向临床治疗的转化应用。

学术论文

1.      Lei J, Xin Z, Liu N,Ning T, Jing Y, Qiao Y, He Z, Jiang M, Yang Y, Zhang Z, Zhao L, Li J, Lv D, YanY, Zhang H, Xiao L, Zhang B, Huang H, Sun S, Zheng F, Jiang X, Lu H, Dong X,Yue S, Ma C, Shuai J, Ji Z, Liu F, Ye Y, Yan K, Hu Q, Xu G, Zhao Q, Wu R, CaiY, Fan Y, Jing Y, Wang Q, Reddy P, Lu X, Zheng Z, Liu B, Haghani A, Ma S,Suzuki K, Rodriguez Esteban C, Yang J, Song M, Horvath S, Zhang W, Li W, XiangAP, Zhu L, Fu X, Zhao G, Belmonte JCI, Qu J*, Wang S*, Liu GH*.Senescence-resistant human mesenchymal progenitor cells counter aging inprimates. Cell. 2025. 188(18):5039-5061.e35.

2.      Geng L, Ping J, WuR, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J,Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, DiaoZ, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, WangW, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q,Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y,Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*,Song M*, Zhang W*, Qu J*, Liu GH*. Systematic profiling reveals betaine as anexercise mimetic for geroprotection. Cell. 2025. 188(19):5426-5428.

3.      Sun G, He Z, Lv D,Wang Q, Xu G, Liu F, Wang P, Luo B, Zheng Y, Hu J, Sun S, Ma S, Esteban CR,Yang J, Fu X, Belmonte JCI, Zhang W*, Qu J*, Wang S*, Liu GH*. Reprogrammingthe GRHL2-CDK19axis by gene therapy alleviates prostate aging. Nature Aging.2026. 6(1):252-269.

4.      Lu H, Cai L, Lv D,Sun G, Lei J, Ning T, Xin Z, Huang H, Jing Y, Huang D, Sun S, Ma S, Zhang W,Gao F, Chen R, Qin Y, Song W, Xiang AP, Izpisua Belmonte JC, Liu GH*, Qu J*,Wang S*. Restoring the FOXO1 geroprotective pathway via seno-resistantmesenchymal progenitor cells alleviates primate epididymal aging. Protein Cell.2026. doi: 10.1093/procel/pwag020.

5.      Zhao Q, Jing Y,Jiang X, Zhang X, Liu F, Huang H, Zhang Z, Wang H, Sun S, Ma S, Zhang W, Yu Y,Fu X, Zhao G, Qu J*, Wang S*, Liu GH*. SIRT5 safeguards against primateskeletal muscle ageing via desuccinylation of TBK1. Nature Metabolism. 2025.7(3):556-573.

6.      Jing Y, Lu H, Li J,He Z, Zhao L, Zhang C, Huang Z, Liu L, Sun S, Ma S, Rodriguez Esteban C, Fu X,Zhao G, Izpisua Belmonte JC, Zhang W*, Qu J*, Wang S*, Liu GH*. Vitamin Cconveys geroprotection on primate ovaries. Cell Stem Cell. 2025.32(11):1723-1740.e9.

7.      Sun G, Fu X, ZhengY, Hong G, Liu Z, Luo B, Lei J, Lv D, Chang M, Xiao Y, Guo S, Ma S, Lu L, ZhangW, Belmonte JCI, Qu J*, Wang S*, Chai R*, Liu GH*. Single-cell profilingidentifies hair cell SLC35F1 deficiency as a signature of primate cochlearaging. Nature Aging. 2025. 5(9):1862-1879.

8.      Sun G, Li K, Ping J,Zhao L, Cui C, Wu J, Xie L, Yao X, Xu G, Ma S, Fan Y, Wang Q, Yang D, Luo B,Liu H, Yang J, Zhang W, Song W, Zhao G, Fu X, Bian XW, Qu J*, Wang S*, Chen H*,Liu GH*.A single-cell transcriptomic atlas reveals senescence and inflammationin thepost-tuberculosis human lung. Nature Microbiology. 2025. 10(8):2073-2091.

9.      Zheng F, Lei J, HeZ, Ning T, Sun S, Cai Y, Zhao Q, Ma S, Zhang W, Qu J*, Liu GH*, Wang S*.FOXO3-engineeredhuman mesenchymal stem cells efficiently enhance post-ischemicstroke functional rehabilitation. Protein Cell. 2025. 16(5):365-373.

10.   Wang S*, Ren J, JingY, Qu J*, Liu GH*. Perspectives on biomarkers of reproductive aging forfertility and beyond. Nature Aging. 2024. 4(12):1697-1710.

11.   Lu H, Jing Y, ZhangC, Ma S, Zhang W, Huang D, Zhang B, Zuo Y, Qin Y, Liu GH*, Yu Y*, Qu J*, WangS*. Aging hallmarks of the primate ovary revealed by spatiotemporaltranscriptomics. Protein Cell. 2024. 15(5):364-384.

12.   Jing Y, Zuo Y, SunL, Yu ZR, Ma S, Hu H, Zhao Q, Huang D, Zhang W, Belmonte JCI, Yu Y*, Qu J*, LiuGH*, Wang S*. SESN1 is a FOXO3 effector that counteracts human skeletal muscleageing. Cell Proliferation. 2023. 56(5):e13455.

13.   Wang S, Zheng Y, LiJ, Yu Y, Zhang W, SongM, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, EstebanCR, Chan P, Qiao J, Zhou Q, Izpisua Belmonte JC*, Qu J*, Tang F*, Liu GH*.Single-cell transcriptomic atlas of primate ovarian aging. Cell.2020.180(3):585-600.

荣誉奖励

1.    第三十六届北京青年五四奖章

2.    2025年度中国科学十大进展

3.    2025年度CSSCR干细胞卓越青年研究员