1. 北京自然科学基金面上项目：基于O-糖基化修饰的肌萎缩侧索硬化发病机制及山茱萸环烯醚萜苷的神经保护作用研究（No: 7222082）2022.1-2024.12，20万元，主持，在研

2. 国家自然科学基金面上项目：ET-1介导的Jagged1/Notch1通路激活在肌萎缩侧索硬化中的作用和机制研究 (No:81971200)，2020.1-2023.12，55万元，主持，已结题

3. 河北省自然科学基金：星形胶质细胞ET-1在肌萎缩侧索硬化小鼠发病中的作用（No:H2017206101）2017.01-2019.12，6万元，主持，已结题

4. 河北省人社厅留学人员择优资助项目：鞘内注射AAVrh10载体介导的hSOD1-RNA干扰对ALS小鼠的保护作用（CY201605）2016.01-2018.12，3万元，主持，已结题

5. 国家自然科学基金青年项目：ALS治疗的新探索——Nrf2-ARE通路激活剂与riluzole联合应用的前景及作用机制(No:30900460)，2010.01-2012.12，19万元，主持，已结题

6. 河北省科技厅重点基础项目：姜黄素及其类似物在肌萎缩侧索硬化治疗中的前景及机制研究（No:11966122D）2011.1-2013.12, 30万元，主持，已结题

7. 河北省科技厅重点基础项目：核转录因子Nrf2在肌萎缩侧索硬化转基因小鼠中的作用研究（No:08966105D），2008.01-2010.12，6万元，主持，已结题

以第一作者或通讯作者发表中英文论文42篇，其中SCI 23篇。研究成果获河北省科技进步二等奖2项、三等奖1项。参编著作3部。

近5年代表性论文：

1. Wu Y, Cheng S, Lei S, Li D,Li Z, Guo Y*. The Association Between the Composite Dietary Antioxidant Indexand Frailty Symptoms: Mediating Effects of Oxidative Stress. Clin Interv Aging.2024;19:163-173.

2.Wu Y, Lei S, LiD, Li Z, Zhang Y, Guo Y*. Relationship of Klotho with cognition and dementia:Results from the NHANES 2011-2014 and Mendelian randomization study. TranslPsychiat. 2023; 13(1):337.

3. Li Z^#，Zhao J^#, Hou C，Sun F, Dong J, Guo Y*, Chu X*. Factors related to plasma homocysteineconcentration in young adults: a retrospective study based on checkuppopulations. J Clin Med. 2023;12:1656.

4. Chen L, Wang N, Zhang Y, LiD, He C, Li Z, Zhang J, Guo Y*. Proteomicsanalysis indicates the involvement of immunity and inflammation in the onsetstage of SOD1-G93A mouse model of ALS. J Proteomics. 2023;272:104776.

5.Zhang Y, Chen L, Li Z, LiD, Wu Y, Guo Y*. Endothelin-1,over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cellsthrough complicated molecular mechanism revealed by quantitative proteomicsanalysis. Front Cell Neurosci. 2022; 16: 1069617

6.Zhang J, Li D, Yang G,Zhang X, Chen L, Zhang Y, Qi X, Li Y, GuoY*. Oxymatrine extends survival by attenuating neuroinflammation in a mousemodel of amyotrophic lateral sclerosis. Neuroscience. 2021;46:11-22.

7. Zhao J^#, Li Z^#, Hou C^#, SunF, Dong J, Chu X*, Guo Y*. Genderdifferences in risk factors for high plasma homocysteine levels based on aretrospective checkup cohort using a generalized estimating equation analysis.Lipids Health Dis. 2021; 20(1):31.

8. Liu C^#, Li D^#, Lv C, Gao Z, Qi Y, Wu H, Tian Y, Guo Y*. Activation of the Notch Signaling Pathway andCellular Localization of Notch Signaling Molecules in the Spinal Cord ofSOD1-G93A ALS Model Mice. Neuroscience. 2020; 432: 84-93.