1. 国家科技重大专项课题：基于无创脑机接口的多模态生理信息采集与检测系统及大数据平台构建（No.2025ZD0215401）, 2025.9-2030.8，750万，主持，在研

2. 国家自然科学基金面上项目：HSPB1特定位点O-GlcNAc糖基化修饰介导p62/SQSTM1自噬调控在肌萎缩侧索硬化中的神经保护机制研究 (No:82471451)，2025.1-2028.12，48万元，主持，在研

3. 北京自然科学基金面上项目：基于O-糖基化修饰的肌萎缩侧索硬化发病机制及山茱萸环烯醚萜苷的神经保护作用研究（No: 7222082）2022.1-2024.12，20万元，主持，结题

4. 国家自然科学基金面上项目：ET-1介导的Jagged1/Notch1通路激活在肌萎缩侧索硬化中的作用和机制研究 (No:81971200)，2020.1-2023.12，55万元，主持，结题

5. 河北省自然科学基金：星形胶质细胞ET-1在肌萎缩侧索硬化小鼠发病中的作用（No:H2017206101）2017.01-2019.12，6万元，主持，结题

6. 河北省人社厅留学人员择优资助项目：鞘内注射AAVrh10载体介导的hSOD1-RNA干扰对ALS小鼠的保护作用（CY201605）2016.01-2018.12，3万元，主持，结题

7. 国家自然科学基金青年项目：ALS治疗的新探索——Nrf2-ARE通路激活剂与riluzole联合应用的前景及作用机制(No:30900460)，2010.01-2012.12，19万元，主持，结题

8. 河北省科技厅重点基础项目：姜黄素及其类似物在肌萎缩侧索硬化治疗中的前景及机制研究（No:11966122D）2011.1-2013.12, 30万元，主持，结题

9. 河北省科技厅重点基础项目：核转录因子Nrf2在肌萎缩侧索硬化转基因小鼠中的作用研究（No:08966105D），2008.01-2010.12，6万元，主持，结题

以第一作者或通讯作者发表中英文论文53篇，其中SCI 34篇。研究成果获河北省科技进步二等奖2项、三等奖1项。参编著作3部。

近5年代表性论文：

1. Cheng S#, Hou C#,Wu Y, Du X, Liu H, Li R, Lei S, Yue X, Guo Y*. Psychometric comparisonand score conversion between World Health Organization DisabilityAssessment Schedule 2.0 and activities of daily living scalesin community‑dwelling older adults. Eur Geriatr Med. 2025 Sep15; doi:10.1007/s41999-025-01306-9

2. Zhang X, Liu Y, Luo W, GuoY*. Application of augmented reality and surgical robotic navigation intotal hip and knee replacement. Frontiers in surgery. 2025; 12 :1591756. 2024IF=1.8

3. Chang J, Wu Y, Zhao Y, Gao X,Xing Y, Wang Z, Qin Q, Ni W, Ying Y, Liu X, Leng L, Ma L, Guo Y*, Peng G*,You Y*, Ding J*, Xu J*, Tang Y*. Cohort profile:China healthy aging cohort study (China-Aging). J Alzheimers Dis. 2025 Jul 15;13872877251360028. Q2, 2024IF=3.1

4. Cheng S, Du X, Hou C, Liu H,Lei S, Wu Y, Yue X*, Guo Y*. Beijing Longitudinal DisabilitySurvey in Community Elderly (BLINDSCE): protocol for a community-basedprospective longitudinal cohort study about disability prediction model. BMJ Open. 2025;15:e091955. Q1, 2024IF=2.3

5. Wu Y, Hu J, Zhao Y, Ju D, CaoS, Guo J, Song W, Mo R, Lei S, Wu Y, Zuo Y, Meng S, Jiang Z, Ma G, Zhong L*, GuoY*. The neutrophil-to-lymphocyte ratio is associated with functionaloutcome among single small subcortical infarction: Mediating effects of whitematter hyperintensities. Journal of Stroke & Cerebrovascular Diseases. 2025May 07;:108341. Q3，2024IF=1.8

6. He J, Liu Q, Guo J, Wu D*,Guo Y*. Circulatory factors in stroke protection and recovery. BrainRes. 2025;1855: 149594. Q3，2024IF=2.6

7. Cheng S, Qin J, Hou C, Wu Y,Du X, Liu H, Lei S, Li R, Yue X*, Guo Y*. Linking Cognitive ScreeningTests in Community-Dwelling Older Adults: Crosswalk Between the MontrealCognitive Assessment-Basic and the Mini-Mental State Examination. J Am Med DirAssoc. 2025; 26(5):105550. Q2，2024IF=3.8

8. Hao Y, Li Z, Du X, Xie Q, LiD, Lei S, Guo Y*. Characterization and chemoproteomic profiling ofprotein O-GlcNAcylation in SOD1-G93A mouse mode. Mol Med. 2025;31(1):82.  Q1，2024IF=6.4

9. Li Z, Zhang Y, Li D, Du X, Chen L, Guo Y*. Microglialupregulation of CD109 expression in spinal cord of amyotrophic lateralsclerosis mouse model and its role in modulating inflammation and TGFβ/SMADpathway. Neuroscience. 2025;564:202-213. Q2，2024IF=2.8

10. Zhao X, Liu J, Shao Z,Liu X, Wang Z, Yuan K, Zhang B, Li Y, Sheng X, Zhu Y, Guo Y*. Restorationof abnormal sleep EEG power in patients with insomnia disorder after 1Hz rTMSover left DLPFC. Front Psychiatry. 2024; 15: 1431837  2区，2024IF=3.2

11. WuY, Cheng S, Lei S, Li D, Li Z, Guo Y*. The Association Between the CompositeDietary Antioxidant Index and Frailty Symptoms: Mediating Effects of OxidativeStress. Clin Interv Aging. 2024;19:163-173. WOS分区3区，2024IF=3.7

12. WuY#, Lei S, Li D, Li Z, Zhang Y, Guo Y*. Relationship of Klotho withcognition and dementia: Results from the NHANES 2011-2014 and Mendelianrandomization study. Transl Psychiat. 2023; 13(1):337. WOS分区1区，2023IF=5.8

13. LiZ#，Zhao J#,Hou C，Sun F, Dong J, Guo Y*, Chu X*. Factorsrelated to plasma homocysteine concentration in young adults: a retrospectivestudy based on checkup populations. J Clin Med. 2023;12:1656. WOS分区2区，2023IF: 3.0.

14.Chen L, Wang N, Zhang Y, Li D, He C, Li Z, Zhang J, Guo Y*. Proteomics analysis indicates the involvement of immunityand inflammation in the onset stage of SOD1-G93A mouse model of ALS. JProteomics. 2023;272:104776.  JCR2区 2023IF：2.8

15. Zhang Y, Chen L, Li Z, LiD, Wu Y, Guo Y*. Endothelin-1,over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cellsthrough complicated molecular mechanism revealed by quantitative proteomicsanalysis. Front Cell Neurosci. 2022; 16: 1069617 JCR2区 2022IF：5.3

16. Zhang J, Li D, Yang G,Zhang X, Chen L, Zhang Y, Qi X, Li Y, GuoY*. Oxymatrine extends survival by attenuating neuroinflammation in a mousemodel of amyotrophic lateral sclerosis. Neuroscience. 2021;46:11-22. JCR3区 2021IF：3.708

17.Zhao J#, Li Z#, Hou C#, Sun F, Dong J, Chu X*, Guo Y*. Gender differences in risk factors for high plasmahomocysteine levels based on a retrospective checkup cohort using a generalizedestimating equation analysis. Lipids Health Dis. 2021; 20(1):31.  JCR2区  2021IF：4.315