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等离子体作为物质的“第四态”,其生物医学应用在近几年得到了越来越多的关注。我们团队一直致力于等离子体医学的基础和应用研究工作,目前的主要从事等离子体在神经系统疾病中的应用的交叉学科研究,在国际上较早发现和证实了等离子体的活性粒子与其生物医学效应的关系,从而建立了等离子体与生物医学应用的直接联系。以(共同)第一/(共同)通讯作者发表论文17篇,累计他引次数达到500余次,参与编写英文专著1项,研究成果被American Institute ofPhysics作为Scilights进行专题报道。
1. 北京市卫生健康委员会项目,治疗复杂颅底肿瘤的等离子体设备研发,2022-01至2022-12,50万元,在研,主持
2. 国家自然科学基金委员会,面上项目,52077006,大气压等离子体改善缺血性脑卒中的治疗效果及机制研究,2021-01至2024-12,59万元,在研,主持
3. 北京市神经外科研究所人才创新基金(计划),可用于缺血性脑卒中治疗的大气压等离子体射流装置的研究,2021-01至2021-12,15万元,已结题,主持
4. 国家自然科学基金委员会,青年科学基金项目,51707012,大气压等离子体通过激活细胞自噬保护神经细胞的机制研究,2018-01至2020-12,26万元,已结题,主持
1. Chen Y#,Yang B#, Xu L, Shi Z, Han R, Yuan F, Ouyang J*, Yan X*, Ostrikov K. Inhalation of Atmospheric-Pressure Gas PlasmaAttenuates Brain Infarction in Rats With Experimental Ischemic Stroke[J]. Frontiersin Neuroscience, 2022, 16: 875053. (IF=5.152)
2. Yan X*, Yang B,Ouyang J, et al. Mechanisms of atmospheric pressure plasma protection ofneuronal cells under simulated ischemic stroke conditions[J]. AIP Advances,2022, 12(2): 025114. (IF=1.697)
3. Yan X*, ZhangC, Ouyang J, et al. Atmospheric pressure plasma treatments protect neural cellsfrom ischemic stroke‐relevant injuries by targeting mitochondria[J]. Plasma Processes andPolymers, 2020: e2000063. (封面论文) (IF=3.877)
4. Yan X*, OuyangJ, Zhang C, et al. Plasma medicine for neuroscience—an introduction[J]. Chinese Neurosurgical Journal, 2019,5(1): 1-8.
5. Yan X*, Zhang C, Ouyang J, et al.Cytoprotective effect of atmospheric pressure helium plasma on oxygen andglucose deprivation-induced cell death in H9C2 cardiac myoblasts and primaryneonatal rat cardiomyocytes[J]. Journal of Physics D: Applied Physics, 2019 , 52: 135401(IF=3.409)
6. Yan X*, Meng Z, Ouyang J, et al. Cytoprotective effects ofatmospheric-pressure plasmas against hypoxia-induced neuronal injuries [J].Journal of Physics D: Applied Physics, 2018, 51(8): 085401(IF=3.409)
7. Xu Yan, Hongjin Wu, Jianxun Ren, et al. Shenfu Formulareduces cardiomyocytes apoptosis in heart failure rats by regulating microRNAs.Journal of Ethnopharmacology, 2018, 227: 105-112. (IF=5.195)
8. Yan X*, QiaoY, Ouyang J, et al. Protective effect of atmospheric pressure plasma onoxidative stress-induced neuronal injuries: an in vitro study. Journal ofPhysics D: Applied Physics, 2017, 50(9): 095401.(IF=3.409)
9. Xu Yan*,Zhaozhong Meng, Jiting Ouyang, et al. New application of an atmosphericpressure plasma jet as a neuro-protective agent against glucosedeprivation-induced injury of SH-SY5Y cells. Journal of Visualized Experiments, 2017, 128, e56323 (IF=1.355)
10. Yan X, ShiZF, Xu LX, et al. Glutamate Impairs Mitochondria Aerobic Respiration Capacityand Enhances Glycolysis in Cultured Rat Astrocytes. Biomedical andEnvironmental Sciences, 2017, 30(1): 44-51.(IF=2.831)
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