主持国家、省部级以上课题如下：

1.     补体C3a在心肌梗死后心脏重塑中的作用机制研究，国家自然科学基金青年项，2016.01-2018.12

2.     细胞因子IL-33调控巨噬细胞功能促进骨骼肌再生的分子机制研究，国家自然科学基金面上项目，2019.01-2022.12

3.     免疫蛋白酶体亚基β5i调节巨噬细胞表型转化促进骨骼肌损伤再生的分子机制，国家自然科学基金面上项目，2023.01-2026.12

4.     基于单细胞多组学图谱的心力衰竭精准诊断与干预研究，北京市自然科学基金重点研究专题-课题，2020.10-2024.10    

5.     细胞因子受体ST2相关信号通路调控骨骼肌萎缩的作用机制研究，北京市医管局“青苗计划”，2020.01-2021.12

6.     补体C3a信号通路在心肌梗死后心脏重塑的作用机制研究，     北京市卫计委“优秀人才”计划，2016.01-2018.12

1. Zhang C, Li Y, Wu Y, Wang L,Wang X, Du J*. Interleukin-6/signal transducer and activator of transcription 3(STAT3) pathway is essential for macrophage infiltration and myoblastproliferation during muscle regeneration. J Biol Chem, 2013, 288(3):1489-99.

2. Zhang C, Li Y, Wang C, Wu Y, Cui W, Takashi M, Sayaka S, Song WC*, Du J*. Complement C5a receptor mediates AngII-induced cardiac inflammation and remodeling. Arterioscler Thromb Vasc Biol, 2014,34(6):1240-8.

3. Zhang C, Li Y, Wang C, Wu Y, Du J*. Antagonist of C5a Rprevents cardiac remodeling in Ang II-induced hypertension. Am JHyper, 2014, 27(6):857-64.

4. Zhang C, Wang C, Li Y, Miwa T, Liu C, Cui W, Song WC*, Du J*. Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking. Nat Commun, 2017,8(1): 2078.

5. Zhang C, Cheng N, Qiao B, Zhang F, Wu J, Liu C, Li Y, Du J*. Age-related decline of IFN-gamma responses in macrophage impairs satellite cell proliferation and regeneration. J Cachexia Sarcopenia Muscle, 2020, 11(5):1291-1305.

6. Cheng N, Liu C, Li Y, Gao S, Han YC, Wang X, Du J*,Zhang C*. MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice. J Biol Chem. 2020 ;295(30):10212-10223.

7. Gao S, Li G, Shao Y, Wei Z, Huang S, Qi F, Jiao Y, Li Y, Zhang C*,Du J*. FABP5 Deficiency Impairs Mitochondrial Function and Aggravates Pathological Cardiac Remodeling and Dysfunction. Cardiovasc Toxicol. 2021;21(8):619-629.

8.Zhang F, Cheng N, Du J, Zhang H*, Zhang C*.MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 inatherosclerosis. BMC Cardiovasc Disord.2021;21(1):172.

9.Zhang F, Cheng N, Han Y, Zhang C*,Zhang H*. miRNA expression profiling uncovers a role of miR-139-5p in regulating the calcification of human aortic valve interstitial cells.Frontiers in Genetics. 2021;12:722564.

10. Gao S, Huang S, Zhang Y, Fang G, Liu Y, Zhang C*, Li Y*, Du J*. The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5. J Biol Chem. 2023, 299(10):105226.

11. Zhang F, Yao K, Liu Y, Zhou M, Zhang Y, Hong S, Wu J,Zhang C*. Complement C3a/C3aR inhibition alleviates the formation of aortic aneurysmin Marfan syndrome mice. BMC Cardiovasc Disord. 2024;24(1):417.

12. Zhang C#*, Li G#, Zhang F#, Zhang Y, Hong S, Gao S, Liu Y, Du J, Li Y*. IL-33 facilitates Fibro-adipogenic progenitors to establish the pro-regenerative niche after muscle injury. Adv Sci (Weinh). 2024, 11(35):e2405299.