个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
朱钟慧，首都医科大学公共卫生学院 副教授/硕士生导师，主要从事大气颗粒物和生产性粉尘等常见环境及职业性有害因素的健康损害研究，主持国家自然科学基金2项。近五年研究成果以第一及通讯作者（含共同）发表在Free Radical Biology and Medicine，Chemophere, Science of the Total Environment等杂志上。美国匹兹堡大学访问学者。
1. 国家自然科学基金面上项目，基于3D肺微球模型探讨Nrf2/Bax调控通路在矽结节形成过程中的作用及机制，2020/01-2023/12，主持
2. 国家自然科学基金青年科学基金项目，Nrf2/miR-29b调控轴在拮抗石英致肺纤维化中的机制研究，2017/01-2019/12，主持
1. Jia Q, Li Q, Wang Y, Zhao J, Jiang Q, Wang H, Xue W, Zhu Z, Tian L. Lung microbiome and transcriptome reveal mechanisms underlying PM2.5 induced pulmonary fibrosis. Sci Total Environ. 2022 Jul 20;831:154974. doi: 10.1016/j.scitotenv.2022.154974. Epub 2022 Apr 1. PMID: 35378184.
2.Zhu Z, Chen X, Sun J, Li Q, Lian X, Li S, Wang Y, Tian L. Inhibition of nuclear thioredoxin aggregation attenuates PM2.5-induced NF-κB activation and pro-inflammatory responses. Free Radic Biol Med. 2019 Jan;130:206-214. doi: 10.1016/j.freeradbiomed.2018.10.438. Epub 2018 Oct 26. PMID: 30420332.
3.Zhu Z, Li Q, Xu C, Zhao J, Li S, Wang Y, Tian L. Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system. Environ Toxicol Pharmacol. 2020 Nov;80:103461. doi: 10.1016/j.etap.2020.103461. Epub 2020 Jul 29. PMID: 32738294.
4.Li Q, Sun J, Chen X, Li S, Wang Y, Xu C, Zhao J, Zhu Z, Tian L. Integrative characterization of fine particulate matter-induced chronic obstructive pulmonary disease in mice. Sci Total Environ. 2020 Mar 1;706:135687. doi: 10.1016/j.scitotenv.2019.135687. Epub 2019 Nov 22. PMID: 31785907.
5.Wang Y, Li S, Zhao J, Li Q, Xu C, Wu H, Zhu Z, Tian L. Snail-mediated partial epithelial mesenchymal transition augments the differentiation of local lung myofibroblast. Chemosphere. 2021 Mar;267:128870. doi: 10.1016/j.chemosphere.2020.128870. Epub 2020 Nov 4. PMID: 33172668.
6.Xu C, Zhao J, Li Q, Hou L, Wang Y, Li S, Jiang F, Zhu Z, Tian L. Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model. Stem Cell Res Ther. 2020 Nov 25;11(1):503. doi: 10.1186/s13287-020-02023-9. PMID: 33239075; PMCID: PMC7687745.
7.Li Q, Li S, Xu C, Zhao J, Hou L, Jiang F, Zhu Z, Wang Y, Tian L. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Cell Biol Toxicol. 2021 Jul 31. doi: 10.1007/s10565-021-09638-5. Epub ahead of print. PMID: 34331613.
文件上传中...
