杜静教授在首都医科大学附属北京安定医院建立了由科研助手、博士生和硕士生组成的八人团队，并且和临床医生密切合作，主要工作方向是在精神疾病的新药开发领域。她带领团队锐意创新，团队的工作的定位在基础精神药理学，用蛋白组学、代谢组学、神经细胞分子生物学、动物行为学、AVV基因敲除或过表达等研究方法，在细胞分子生物学层面，特别是在线粒体功能、神经免疫炎症小体功能、神经突触形成及功能的层面，深入探究各类精神疾病（包括抑郁症、焦虑症、自闭症、老年痴呆症、精神分裂症早期发育）病理机制，并深入探讨植物药物单体及非药物治疗手段（如电刺激）对于动物大脑的精神健康保护机制，揭示新的分子单体药物机理和靶点，为临床试验打下基础，为精神疾病患者提供新的诊疗方法做出应有的贡献。

[1]科技创新2030重大项目：焦虑障碍的发病机制及干预技术研究。（项目编号2021ZD0202000） 2021.2-2026.11,参与。80万元。在研。

[2] 国家自然科学基金，（项目编号：81760651 ）《灵芝酸A受体介导的调节神经免疫和神经可塑性的抗抑郁药物机理》2018.01-2021.12, 主持，37万元。顺利结题。

[3] 国家自然科学基金，（项目编号：31560274），《FKBP51在糖皮质激素调节线粒体功能和线粒体蛋白转录因子表达中的作用》，2016.1-2019.12，主持，46.8万元。顺利结题。

[4] 国家自然科学基金，（项目编号：31650005），《腺苷受体介导的神经免疫M1（炎症）向M2（抗炎）状态的转变对抑郁和自杀相关行为的影响。》2017.01-2017.12，主持，15万元。顺利结题。

[5]云南省科技厅高端人才引进项目，（编号：2012HA004）精神疾病的药理研究。2012.12-2017.12，主持，200万元。顺利结题。

[6]云南省千人外专人才引进项目，（编号：2018-010）精神疾病的新药研发。2018.12-2021.12，主持，100万元。结题。

1. Han Wang, Wei-Jing Kan, Yuan Feng, Lei Feng, Yang Yang, Pei Chen, Jing-Jie Xu, Tian-Mei Si, Ling Zhang, Gang Wang, Jing Du*. Nuclear Receptors Modulating Inflammasomes in the Pathophysiology and Treatment of Major Depressive Disorder. World Journal of Psychiatry, 2021 Dec 19;11(12):1191-1205. doi: 10.5498/wjp.v11.i12.1191. 

2. Jing Du*; Weijing Kan; Hongkun Bao; Yue Jia; Jian Yang; Hongxiao Jia. Interactions Between Adenosine Receptors and Cordycepin (3'-Deoxyadenosine) from Cordyceps Militaris: Possible Pharmacological Mechanisms for Protection of the Brain and the Amelioration of Covid-19 Pneumonia. J Biotechnol Biomed, 2021, 4(2): 26-62.

3. Hongkun Bao#*, Haoran Li#, Yue Jia#, Yuhuan Xiao, Shaolei Luo S, Dandan Zhang, Li Han, Lili Dai, Chunjie Xiao, Lei Feng, Yuan Feng, Yang Yang, Han Wang, Gang Wang, Jing Du*. Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity. Biochem Pharmacol. 2021 Jun;188:114561. doi: 10.1016/j.bcp.2021.114561. Epub 2021 Apr 20. PMID: 33857491. 

4. Yue Jia, Dan Zhang D, Hua Yin, Haoran Li, Jing Du*, Hongkun Bao*. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. Neurochem Res. 2021 Apr 5. doi: 10.1007/s11064-021-03303-3. Epub ahead of print. PMID: 33821438.

5. Haoran Li, Yuhuan Xiao, Li Han, Yue Jia, Shaolei Luo, Dandan Zhang, Ling Zhang, Ping Wu, Chunjie Xiao, Kan Wang, Jing Du*, Hongkun Bao*. Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system. Brain Res Bull. 2021 Jun;171:16-24. doi: 10.1016/j.brainresbull.2021.03.002. Epub 2021 Mar 8. PMID: 33705858. 

6. Yue Jia#, Dandan Zhang#, Haoran Li#, Shaolei Luo, Yuhuan Xiao, Li Han, Fuchun Zhou, Chuanyue Wang, Lei Feng, Gang Wang, Peng Wu, Chunjie Xiao, Haijing Yu, Jing Du* and Hongkun Bao* Activation of FXR by Ganoderic Acid A Promotes Remyelination in Multiple Sclerosis via Anti-inflammation and Regeneration Mechanism. Biochemical Pharmacology 2021,185:114422. 

7. Ping Liu, Jing Du*. Oridonin is an antidepressant molecule working through the PPAR-γ/AMPA receptor signaling pathway. Biochem Pharmacol. 2020,180:114136. 

8. Shaolei Luo#, Yangyang Hou#, Yaping Zhang#, Lei Feng#, Richard G Hunter, Peixiong Yuan, Yue Jia, Haoran Li, Gang Wang, Husseini K Manji, Bruce S McEwen, Chunjie Xiao, Hongkun Bao*, Jing Du*. Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. J Neurochem. 2020. doi: 10.1111/jnc.15211. Epub ahead of print. PMID: 33025573. 

9. 杜 静#*，阚伟京，杨 健，贾竑晓。腺苷受体及蛹虫草虫草素在新冠肺炎防治中相关的药理机制。（中文）, 世界科学技术-中医药现代化。（中文核心杂志）2020年4月14日发表，doi: 10.11842/wst.20200304008. p.1-11.

10. Yue Jia#, Haoran Li#, Hongkun Bao#, Dandan Zhang, Lei Feng, Yuhuan Xiao, Keming Zhu, Yangyang Hou, Shaolei Luo, Yaping Zhang, Le Xiao, Xu Chen, Jiaojiao Zhou, Changming Wang, Gang Wang, Haijing Yu, Chunjie Xiao*, and Jing Du*. Cordycepin promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination. International Immunopharmacology, 2019, 75:105777.

11. Tangxin Gao, Bai Li, Yangyang Hou, Yi Ma, Jun Nie, Shaolei Luo, Chunjie Xiao and Jing Du. The Interleukin-4 Signalling Pathway Underlies the Anxiolytic Effect Induced by 3-Deoxyadenosine.Psychopharmacology, 2019,236(10):2959-2973.DOI:10.1007/s00213 .

12. Bai Yao#, Chen lingling#,Yao Chen, Xinmeng Chen, Yilong Dong, Shangyong Zheng, Lei Zhang, Weiyuan Li, Jing Du and Hongliang Li. A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-b clearance. RSC Advances, 2019. 9:37127-37135.

13. Yangyang Hou, Shaolei Luo, Yaping Zhang, Bai Li, Tangxin Gao, Yue Jia, Haoran Li, Yuhuan Xiao, Jiaojiao Zhou,Xu Chen, Yuan Feng, Lei Feng,Gang Wang,Chunjie Xiao, Hongkun Bao*, and Jing Du*. Contrasting Effects of Acute and Long-term Corticosterone Treatment on Aβ, BACE1 Expression and NFκB Nuclear Translocation. The Journal of Integrative Neuroscience. 18 (4), 393-400. 2019 Dec 30.

14. Bai Li, Tangxin Gao, Jing Du*. Neuroimmune Balance:The Key for the treatment of anxiety disorder? Journal of Immunological Sciences, 2019 3(3): 14-16.

15. Linlin Fan, Lingling Chen, Zhi Liang, Hongkun Bao, Dan Wang, Shangyong Zhen, Yilong Dong, Chunjie Xiao, Jing Du* and Hongliang Li*. A Polysaccharide Extract from Maitake Ameliorates learning and memory function In Aluminum Chloride-Induced amnesia in Mice. International Journal of Medicinal Mushrooms, 2019 , 21(11):1065 –1074 (2019)