团队致力于研究视网膜疾病的再生治疗，基于自体诱导干细胞及碱基编辑等关键技术，努力解决我国及全球最主要不可逆盲的眼底疾病。

擅长的关键技术：1）视网膜类器官；2）自体诱导干细胞；3）视网膜移植；4）基因碱基编辑及递送；5）非人灵长类动物模型

国家自然科学基金杰出青年基金

北京市自然科学基金重点专题

1.        LiYP, Wang YT, Wang W, Zhang X, Shen RJ, Jin K, Jin LW, Jin ZB*. Second Hit Impels Oncogenesis of Retinoblastoma inPatient-iPSC-derived Retinal Organoids: Direct Evidence for Knudson’s Theory. PNASNexus. 2022 in press.

2.        Zhou R, Mawatari G, Cai XB, Shen RJ, WangYH, Wang YT, Guo YM, Guo FY, Yuan J, Pan D*, Nao-i N*, Jin ZB*. CLEC3B Is A Novel Causative Gene forMacular-retinal Dystrophy. Genetics in Medicine. 2022 Mar21:S1098-3600(22)00664-5. 

3.        Gao ML#, Zhang X#, Han F, Xu J, Yu SJ, JinK, Jin ZB*. FunctionalMicroglia Derived From Human Pluripotent Stem Cells Empower Retinal Organ. SCIENCECHINA Life Sciences. 2022 Jun;65(6):1057-1071. Cover story, Research highlight.

4.        Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ,Shen RJ, Wang T, Janesick A, Chen BB, Gong SS, Kachar B, Jin ZB*, He DZ*. Mutation ofSLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated bylysosomal dysfunction. Science Advances. 2022 Apr8;8(14):eabk0942.

5.        Zhang X, Zhang BW, Xiang L, Wu H, AlexanderSAS, Zhou P, Dai MZ, Wang X, Xiong W, Zhang Y, Jin ZB*, Deng LW*. MLL5 is involved in retinal photoreceptormaturation through facilitating CRX-mediated photoreceptor genetransactivation. iScience. 2022 Mar 11;25(4):104058.

6.        Pan SH#, Zhao N#, Feng X, Jie Y, Jin ZB*. Conversion of mouseembryonic fibroblasts into neural crest cells and functional corneal endotheliaby defined small molecules. Science Advances. 2021 Jun4;7(23):eabg5749.

7.        Liu H#, Zhang Y#, Zhang YY, Li YP, Hua ZQ,Zhang CJ, Wu KC, Yu F, Zhang Y, Su J*, JinZB*. Human Embryonic Stem Cell-Derived OrganoidRetinoblastoma Reveals a Cancerous Origin. Proc Natl Acad Sci U S A. 2020Dec 29;117(52):33628-33638. Direct submission.

8.        Deng WL#, Gao ML#, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY,Chen YC, Li YP, Pan D, Xue T, JinZB*. Gene Correction Reverses Ciliopathy and PhotoreceptorLoss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. StemCell Reports. 2018;10:1267-81. BEST OF2018-2019.

9.        Jin ZB*, Gao ML, Deng WL, WuKC, Sugita S, Mandai M, Takahashi M. Stemming retinal regeneration with pluripotent stem cells. Progressin Retinal and Eye Research 2019;69:38-56. Invited review.

10.    Pan D, Xia XX, Zhou H, Jin SQ, Lu YY, Liu H, Gao ML, Jin ZB*. COCO enhances the efficiency of photoreceptorprecursor differentiation in human pluripotent stem cell-derived retinalorganoids. Stem Cell Research & Therapy 2020Aug 24;11(1):366.

11.    Jiang D, Chen FX, Zhou H, Lu YY, Tan H, Yu SJ, Yuan J, Liu H, MengW, Jin ZB*. Bioenergetic crosstalk between mesenchymalstem cells and various ocular cells through intercellular trafficking ofmitochondria. Theranostics 2020;10(16):7260-7272.Front Cover story.

12.     Xiang P, Wu KC, Zhu Y, Xiang L, LiC, Chen DL, Chen F, Xu G, Wang A, Li M*, JinZB*. A novel Bruch's membrane-mimetic electrospun substrate scaffoldfor human retinal pigment epithelium cells. Biomaterials.2014;35:9777-88.

13.    Jin ZB*#, Wu J#, Huang XF, Feng CY, Cai XB, Mao JY,Xiang L, Wu KC, Xiao X, Kloss BA, Li Z, Liu Z, Huang S, Shen M, Cheng FF, ChengXW, Zheng ZL, Chen X, Zhuang W, Zhang Q, Young TL, Xie T, Lu F*, Qu J*. Trio-based exome sequencing arrests denovo mutations in early-onset high myopia. Proc Natl Acad Sci U S A. 2017;114:4219-24. Directsubmission.

14.    JinZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen JF, Huang CJ, Wu J, Lu F, QuJ*. SLC7A14 linked to autosomalrecessive retinitis pigmentosa. Nature Communications.2014;5:3517.

15.    JinZB, Li Z, Liu Z, Jiang Y, Cai XB, Wu J*. Identificationof de novo germline mutations and causal genes for sporadic diseases usingtrio-based whole-exome/genome sequencing. Biological Reviews 2018;93:1014-31.Invited review.

16.    Huang XF, Huang F, Wu KC, Wu J, Chen J, Pang CP, Lu F, Qu J, and Jin ZB*. Genotype-phenotype correlation and mutationspectrum in a large cohort of inherited retinal dystrophy patients revealed bynext-generation sequencing. Genetics in Medicine. 2015;7:271-8.

17.    Ran X, Cai WJ, Huang XF, Liu Q, LuF, Qu J, Wu J* and Jin ZB*. RetinoGenetics: A Comprehensive Mutation Database for Genes Related to InheritedRetinal Degeneration. Database (Oxford). 2014;2014.

18.    HuangX, Wu J, Lv J, Zhang X, Jin ZB*.Identification of false-negative mutations missed by next-generation sequencingin retinitis pigmentosa patients: a complementary approach to clinical geneticdiagnostic testing. Genetics in Medicine. 2015;17:307-11.

19.    Cai XB#, Wu KC#, Zhang X#, Lv JN, Jin GH, Xiang L, Chen J, HuangXF, Pan D, Lu B, Lu F, Qu J, Jin ZB*. Whole exome sequencingidentified ARL2 as a novel candidate gene for MRCS (microcornea, rod-conedystrophy, cataract, and posterior staphyloma) syndrome. ClinicalGenetics 2019;96:61-71. Highlight& Cover story.

20.    Huang XF#, Xiang L#, Fang XL, Liu WQ, Zhuang YY, Chen ZJ, Shen RJ,Cheng W, Han RY, Zheng SS, Chen XJ, Liu X, Jin ZB*. Functional characterization of CEP250 variant identified in non-syndromicretinitis pigmentosa. Human Mutation. 2019;40:1039-1045.

21.    Chen ZJ, Lin KH, Lee SH, Shen RJ, Feng ZK, Wang XF, Huang XF, HuangZQ, Jin ZB*. Mutation Spectrum and Genotype-PhenotypeCorrelation of Inherited Retinal Dystrophy in Taiwan. Clinical andExperimental Ophthalmology 2020;48(4):486-499.

22.    Rao FQ, Cai XB, Cheng FF, Cheng W, Fang XL, Li N, Huang XF, Li LH,Jin ZB*. Mutations in LRP5, FZD4,TSPAN12, NDP, ZNF408 or KIF11 genes account for 38.7% Chinese patients withfamilial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci.2017 May 1;58(5):2623-2629.

23.    Lin R, Shen M, Pan D, Xu SZ, Shen RJ, Shao Y, Shi C, Lu F*, Jin ZB*. Relationship Between Cone Loss andMicrovasculature Change in Retinitis Pigmentosa. Invest OphthalmolVis Sci 2019 Nov 1;60(14):4520-4531.

24.    Cai XB, Zheng YH, Chen DF, Zhou FY, Xia LQ, Wen XR, Yuan YM, HanF, Piao SY, Zhuang W, Lu F, Qu J*, Yu AY*, JinZB*. Expanding thePhenotypic and Genotypic Landscape of Nonsyndromic High Myopia: ACross-Sectional Study in 731 Chinese Patients. Invest Ophthalmol VisSci 2019;60:4052-4062.

25.    Xiang L#, Chen XJ#, Wu KC, Zhang CJ, ZhouGH, Lv JN, Sun LF, Cheng FF, Cai XB, JinZB*. miR-183/96 plays a pivotal regulatory role inmouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017;114:6376-81. Directsubmission.

26.    Zhang CJ, Xiang L, Wang XY, Chen XJ, Wu KC, Zhang BW, Chen DF, JinGH, Chen YC, Liu WQ, Zhang H, Li ML, Ma Y, JinZB*. Ablation of maturemiR-183 leads to retinal dysfunction in mice. Invest Ophthalmol VisSci 2020 Mar 9;61(3):12.

27.    Wu KC, Chen XJ, Jin GH, Wang XY, Yang DD, Li YP, Xiang L, ZhangBW, Zhou GH, Zhang CJ, Jin ZB*. Deletion of miR-182 leads to retinal dysfunction in mice. InvestOphthalmol Vis Sci 2019;60:1265-1274.

28.    Sun LF, Chen XJ, Jin ZB*. Emerging roles of noncoding RNAs in retinaldiseases. Clinical and Experimental Ophthalmology 2020 Nov;48(8):1085-1101. Invited review.

29.    Chen XJ#, Zhang ZC#, Wang XY#, Zhao HQ, Li ML, Ma Y, Ji YY, ZhangCJ, Wu KC, Xiang L, Sun LF, Zhou M*, Jin ZB*. The circular RNome of developmental retina inmice. Molecular Therapy - Nucleic Acids 2019 Nov26;19:339-349.

30.    Sun LF#, Zhang B#, Chen XJ#, Wang XY, Zhang BW, Ji YY, Wu KC, WuJY*, Jin ZB*. Circular RNAs in human and vertebrate neuralretinas. RNA Biology 2019Jun;16(6):821-829. 

31.    Chen XJ, Li ML, Wang HY, Mou H, Wu Z, Wang XY, Zhang CJ, Xue X, Jin ZB*. Abundant Neural circRNA Cdr1as Is NotIndispensable for Retina Maintenance. Frontiers in Cell andDevelopmental Biology 2020 Nov 6;8:565543. IF=5.216, 2区

32.    Sun LF#, Ma Y#, Ji YY, Wu Z,Wang YH, Mou H, Jin ZB*.Circular Rims2 Deficiency Causes Retinal Degeneration. Advanced Biology. 2021Nov 5:e2100906. Cover story.

33.    Chen XJ, Zhang CJ, WangYH, Jin ZB*. RetinalDegeneration Caused by Ago2 Disruption. Invest Ophthalmol Vis Sci. 2021 Sep2;62(12):14. 

34.    Wu KC, Lv JN, Yang H, Yang FM,Lin R, Lin Q, Shen RJ, Wang JB, Duan WH, Hu M, Zhang J, He ZL, Jin ZB*. Nonhuman Primate Modelof Oculocutaneous Albinism with TYR and OCA2 Mutations. Research(Wash D C). 2020 Mar 11;2020:1658678. 

35.    ZhangH#, Su B#, Jiao L#, Xu ZH, Zhang CJ, Nie J, Gao ML*, Zhang YV*, Jin ZB*. Transplantationof GMP-grade human iPSC-derived retinal pigment epithelial cells in rodentmodel: the first pre-clinical study for safety and efficacy in China. Annalsof Translational Medicine 2021 Feb;9(3):245.