本课题组目前主要从事干细胞来源的小细胞外囊泡对疾病的干预治疗作用及其机制研究。

1. 国家自然科学基金：人鼻黏膜间充质干细胞分化中分泌的sEVs对锰致神经损伤的修复作用及机制研究

2. 国家自然科学基金：职业接触十溴二苯乙烷的甲状腺激素干扰效应研究

3. 国家自然科学基金子课题：线粒体损伤在大气细颗粒物致鼻腔黏膜上皮细胞纤毛运动功能损伤中的作用及机制研究

4. 北京市组织部：NLRP3炎性体在PM2.5致动脉粥样硬化中的作用及机制研究

1. 国家自然科学基金：人鼻黏膜间充质干细胞分化中分泌的sEVs对锰致神经损伤的修复作用及机制研究（82173489，2022-2025）。

2. 北京市自然科学基金：RVG修饰的hnMSCs-sEVs携带BDNF对锰致神经干细胞损伤的修复作用研究（7232234 ，2023-2025）。

1)  Xueting Wang, Xin Yang, Weifeng He, Xin Song, Gaoman Zhang, Piye Niu and Tian Chen*. The association of serum neurofilament light chains with early symptoms related to Parkinson's disease: A cross-sectional study. Journal of Affective Disorders. 2023,343: 144-152.

2)  Weiwei Wang#, Xueting Wang#, Jiao Xia, Xin Yang, Menglong Li, Piye Niu, Chunguang Ding, Yifei Hu*, Shusheng Gong*, Tian Chen*. The association between nasal mucosa bacteria and serum metals in children with nasal diseases. Ecotoxicology and Environmental Safety, 2023, 262: 115343.

3) Tian Chen#, Xueting Wang#, Jiaxin Jia, Dejun Wang, Yanxin Gao, Xin Yang, Shixuan Zhang, Piye Niu*, Zhixiong Shi*. Reduced mitochondrial DNA copy number in occupational workers from brominated flame retardants manufacturing plants. Science of The Total Environment. 2021:151086. 

4) Tian Chen, Dong Yu, Luping Yang, Shaofeng Sui, Shibo Lv, Yi Bai, Wen Sun, Yuwei Wang, Li Chen, Zhiwei Sun, Lin Tian, Dejun Wang*, Piye Niu*, Zhixiong Shi*. Thyroid function and decabromodiphenyl ethane (DBDPE) exposure in Chinese adults from a DBDPE manufacturing area. Environment International. 2019, 133:105179. 

5) Jiaxin Jia#, Jiao Xia#, Ruxiang Zhang, Yi Bai, Shen Liu, Ma Dan, Ting Li, Tenglong Yan, Li Chen, Shusheng Gong, Piye Niu*, Tian Chen*. Investigation of the impact of PM2.5 on the ciliary motion of human nasal epithelial cells. Chemosphere, 2019, 233:309-318. 

6) Tian Chen#, Piye Niu#, Fanlin Kong, Yuwei Wang, Yi Bai, Dong Yu, Jiaxin Jia, Luping Yang, Zhongjian Fu, Renbo Li, Jingguang Li, Lin Tian, Zhiwei Sun, Dejun Wang*, Zhixiong Shi*. Disruption of thyroid hormone levels by decabrominated diphenyl ethers (BDE-209) in occupational workers from a deca-BDE manufacturing plant. Environment International. 2018, 120: 505-515.