本团队既往研究重点是基于血流动力学定量脑血管造影技术（iflow）平台，由三个横向、三个纵向方向构成的3*3多维度结构网络组成，横向方向包括脑动静脉畸形BAVM、动脉瘤性蛛网膜下腔出血aSAH、以及脑心共患病三个方向，纵向方向包括临床研究（血流动力学为主）、基础研究、人工智能相关研究三个方向。具体列举如下：

     血流动力学定量脑血管造影技术（iflow）平台的建立：利用彩色编码脑血管造影形成定量的测量血流动力学参数，可以广泛应用于临床脑血管病的疾病病因分析，诊断，治疗决策以及预后预测模型的建立等。通过医工结合，继续深入挖掘该项技术的应用场景和参数。目前该项技术已经被应用于脑动脉瘤破裂出血的预后预测模型《World Neurosurg 2018》，脑动静脉畸形的治疗方法选择《Stroke 2017》，脑动静脉畸形的栓塞治疗效果评价《J Neurointerv Surg 2021》，颅内巨大动脉瘤搭桥方法的选择评估《Stroke and vascular neurology.2021》以及烟雾病颅内外血管搭桥效果评价上等《Transl Stroke Res》。本人将继续把该项技术应用推广到更多脑血管病场景，同时拟应用人工智能方法进行多中心验证开发人工智能定量脑血管造影评价技术。

        脑动静脉畸形BAVM的临床研究，包括个体化、标准化科学临床管理方案的建立，以及BAVM的定量血流动力学研究。本人的既往研究中对目前临床管理中存在较大争议的老年BAVM、脑干BAVM等特殊类型患者的临床诊疗方案进行探索，认为对于特定的老年BAVM采取干预治疗仍然是可取的；放射外科治疗等微创干预手段对于脑干BAVM可获取更优的获益风险比，相关研究成果相继发表于《Frontiers in Aging Neuroscience》、《Stroke and Vascular Neurology》上，为此类患者科学临床管理方案的建立提供了重要依据。此外，本人对BAVM新型干预策略也进行了探索，首次对SM III-V级BAVM采取一站式栓塞+切除的复合手术新策略进行队列研究，发现其在控制手术出血以及手术时间方面优于传统手术切除，相关研究成果发表于《Frontiers in Neurology》,研究成果极大的推动了复合手术在国内的推广应用，为复杂BAVM患者提供了一种新的有较大应用前景的治疗策略。在血流动力学研究方面，本人在既往研究中利用DSA-iFlow技术对BAVM的破裂机制进行了探索，研究发现微出血阳性BAVM的平均通过时间MTT显著缩短，引流静脉通过时间延长与BAVM的破裂显著相关，病灶内缩短的MTT与降低的周细胞覆盖率正相关，相关研究成果相继发表于《Stroke》、《Journal of Neurosurgery》、《World Neurosurgery》等期刊，为BAVM的破裂血流动力学机制研究提供了途径，为后续的基础以及人工智能相关研究建立了基础。

          动脉瘤性蛛网膜下腔出血aSAH的临床研究，主要致力于aSAH诊疗体系的完善，从患者接诊到治疗，从并发症防治到预后识别，为患者提供个性化诊疗。建立国内高质量aSAH前瞻性观察队列 (LongTEAM)，比较接受不同治疗方式患者的预后差异，找寻导致患者预后不良的可能原因，为进一步诊疗模式的改善提供临床证据，相关研究成果发表在《Journal of Neurosurgery》,揭示了住院期间肺炎和迟发性脑缺血的发生是导致患者预后不良的主要原因。关注动脉瘤破裂后早期脑损伤的发生，从接诊患者时的临床状态，影像学及实验室指标出发，多角度对早期脑损伤进行定义，并探索早期脑损伤指标对预后的影响，通过建立预后预测模型加深临床医生对早期脑损伤这一特殊临床阶段的理解，相关研究成果发表在《Translational Stroke Research》，揭示了术前临床状态，影像学评分及白细胞计数这三个维度指标的联合预测结局效能出色.关注aSAH术后患者心脏事件的发生，相关成果发表在《Frontiers in Neurology》，揭示了术前心肌肌钙蛋白I对术后心脏事件的发生具有良好的预测价值。团队还在颅内压监测的临床应用上发表独特见解，相关研究成果发表在《Frontiers in aging neurosciences》,揭示了术后颅内压监测的使用可以指导临床决策，减少严重并发症的发生。除此之外，团队还在进行原创性探索，目前正在早期脑保护领域开展前瞻性临床对照试验，希望通过减轻早期脑损伤程度避免严重并发症的发生，以期改善患者预后。

          动脉瘤性蛛网膜下腔出血aSAH的基础研究。蛛网膜下腔出血后72h内的早期脑损伤（early brain injury，EBI）已成为基础研究的热点。近期，该领域基础研究进展迅速，尤其是针对EBI的表型之一氧化应激的相关研究。本人回顾近5年的抗氧化应激研究的进展、绘制抗氧化应激策略图并将成果发表于《Frontiers in Aging Neuroscience》。综述过程中发现氢氧混合吸入气体对多种疾病具有治疗作用，主要通过抗氧化、抗炎等作用机制实现。2007年，Ohsawa首次提出氢气可通过选择性抗氧化途径发挥脑保护作用。我们课题组拟探索氢氧混合吸入气体诱导线粒体自噬改善氧化应激所致的细胞凋亡。

       脑心共患病的临床研究，本人既往研究发现aSAH患者的肌钙蛋白水平与患者的心脑不良事件发生率显著相关，相关研究成果发表于《Frontiers in Neurology》，这意味着脑、心两者之间存在着某种相关性。在此基础上，本人基于十四五国家重点研发计划—脑心共患病的临床诊疗体系建立及关键技术应用研究—基于医院和社区的脑心共患病临床研究大数据仓库建设，已完成天坛医院近10年数据汇总，样本量达20余万，后续将在全国范围内的合作单位进行数据汇总，开展流行病学研究，探索国内脑心共患病的流行病学特点以及相关心脑卒中事件风险，研究成果将提升我国脑心共患病现状的认识与理解，并推动对脑心共患病的科学诊疗。

       本团队目前在上述研究领域中处于学术前沿，依靠北京天坛医院这一国家级神经外科诊疗中心以及庞大的临床资源，本团队既往以及正在进行的相关成果可极大的推动现代化临床诊疗的进步，改善患者神经功能预后，提升临床医疗治疗，带动基层医院发现，并最终促进我国BAVM、aSAH、脑心共患病的科学化、个体化、规范化的临床诊疗

1) 国家卫生健康委国家科技重大专项，2023ZD0505100，中国人群颅内动脉瘤的综合智能诊疗体系建立研究，2024/08-2028/07，6000万元，在研，项目负责人

2) 国家卫生健康委国家科技重大专项，2023ZD0505106，血压管理改善动脉瘤性蛛网膜下腔出血预后的安全性和有效性研究，2024/08-2028/07，360万元，在研，课题负责人

3) 国家自然科学基金面上项目，82471302，基于QDSA的定量血流动力学分析建立脑动静脉畸形介入栓塞智能化术中预警模型的研究，2025/01-2028/12，49万元，在研，项目主持人

4) 首都卫生发展科研专项，建立自动化定量早期CT灌注评估动脉瘤性蛛网膜下腔出血迟发性脑梗死的系统研究，2024/1-2026/12，80.4万元，在研，课题负责人

5) 中央引导地方科技发展资金专项，2025ZY042，高原地区脑心共患疾病诊疗研究体系建设，2025/01-2025/12,   260万元，在研，合作单位负责人

6) 首都医科大学附属北京天坛医院横向科研项目，HX-A-2023023, 舒血宁注射液预防动脉瘤性蛛网膜下腔出血患者术后脑血管痉挛的疗效研究：随机、双盲安慰剂平行对照临床试验，2024-01-2024-12，36.5万元，在研，课题负责人

7) 首都医科大学附属北京天坛医院横向科研项目，HX-A-2021016, 早期氢氧混合吸入疗法对动脉瘤性蛛网膜下腔出血患者的治疗作用：一项随机、对照的临床试验，2022-06-2024-02，10万元，在研，课题负责人

8) 首都医科大学附属北京天坛医院横向科研项目，HX-A-2023050, 动脉瘤性蛛网膜下腔出血术后认知障碍的音频辅助治疗的疗效研究：一项前瞻性随机对照试验，2024-01-2024-12，1万元，在研，课题负责人

1) 国家卫生健康委国家科技重大专项，2023ZD0505100，中国人群颅内动脉瘤的综合智能诊疗体系建立研究，2024/08-2028/07，6000万元，在研，项目负责人

2) 国家卫生健康委国家科技重大专项，2023ZD0505106，血压管理改善动脉瘤性蛛网膜下腔出血预后的安全性和有效性研究，2024/08-2028/07，360万元，在研，课题负责人

3) 国家自然科学基金面上项目，82471302，基于QDSA的定量血流动力学分析建立脑动静脉畸形介入栓塞智能化术中预警模型的研究，2025/01-2028/12，49万元，在研，项目主持人

4) 首都卫生发展科研专项，建立自动化定量早期CT灌注评估动脉瘤性蛛网膜下腔出血迟发性脑梗死的系统研究，2024/1-2026/12，80.4万元，在研，课题负责人

5) 中央引导地方科技发展资金专项，2025ZY042，高原地区脑心共患疾病诊疗研究体系建设，2025/01-2025/12,  260万元，在研，合作单位负责人

6) 首都医科大学附属北京天坛医院横向科研项目，HX-A-2023023, 舒血宁注射液预防动脉瘤性蛛网膜下腔出血患者术后脑血管痉挛的疗效研究：随机、双盲安慰剂平行对照临床试验，2024-01-2024-12，36.5万元，在研，课题负责人

7) 首都医科大学附属北京天坛医院横向科研项目，HX-A-2021016, 早期氢氧混合吸入疗法对动脉瘤性蛛网膜下腔出血患者的治疗作用：一项随机、对照的临床试验，2022-06-2024-02，10万元，在研，课题负责人

8) 首都医科大学附属北京天坛医院横向科研项目，HX-A-2023050, 动脉瘤性蛛网膜下腔出血术后认知障碍的音频辅助治疗的疗效研究：一项前瞻性随机对照试验，2024-01-2024-12，1万元，在研，课题负责人

9)科技部十四五国家重点研发计划“常见多发病防治研究”专项，2021YFC2501101，基于医院和社区的脑心共患病临床研究大数据仓库建设，2021/12-2024/11, 316万，结题，课题负责人

10) 科技部十三五“主动健康和老龄化科技应对”专项，2020YFC2004701，老年人多病共患临床数据的采集与存储标准研究，2020/07-2023/06, 个人经费32万，结题，合作单位负责人

11) 国家自然科科学基金青年项目，81801140，基于QSM定量成像分析铁沉积影响脑血管畸形出血及癫痫发生风险的机制研究，2019/01-2021/12，21万元，结题，参加

12) 国自然青年基金，81500995，血流动力学调控人脑动静脉畸形内皮细胞表达酪氨酸激酶家族ephrinB2-EPHB4的机制研究，2016/01-2018/12，17.5万元,结题，项目主持人

13) 国家自然科学基金面上项目，81571110，巨噬细胞介导炎症反应诱发脑动静脉畸形破裂出血机制研究，2016/01-2019/12，57万元，结题，项目参与者

14)国家自然科学基金面上项目，81271313，酪氨酸激酶家族配体EphrinB2调控脑动静脉畸形血管生成的机制研究，2013-2016，65万元, 结题，第一参与人

l  发表SCI文章（第一作者或通讯作者）

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3. Ma L, Chen Y, Chen P, Ma L, Yan D, Li R, Li Z, Zhang H, Han H, Yuan K, Li R, Lin F, Zhao Y, Chen X*. Quantitative hemodynamics of draining veins in brain arteriovenous malformation: a preliminary study based on computational fluid dynamics. Front Neurol. 2024 Dec 11;15:1474857. doi: 10.3389/fneur.2024.1474857. PMID: 39726760; PMCID: PMC11670193. (IF 2.7)

4. Li R, Chen Y, Chen P, Ma L, Han H, Li Z, Zhou W, Zhou Y, Wang M, Sun S, Zhao Y, Chen X*. Lesion filling index predicts brain arteriovenous malformation obliteration after Gamma knife radiosurgery: a hemodynamic analysis. Neurosurg Rev. 2024 Dec 6;47(1):889. doi: 10.1007/s10143-024-03135-z. PMID: 39641868. (IF 2.5)

5. Yang J, Lu J, Li R, Lin F, Chen Y, Han H, Li R, Li Z, Zhang H, Yuan K, Li H, Zhang L, Shi G, Wang S, Chen X*. Extubation timing and risk of extubation failure in aneurysmal subarachnoid hemorrhage patients. Chin Neurosurg J. 2024 Nov 20;10(1):32. doi: 10.1186/s41016-024-00384-1. PMID: 39568022; PMCID: PMC11577864. (IF 0)

6. Li Z, Han H, Ma L, Li R, Li A, Zhang H, Zhu Q, Yuan K, Wang K, Wang C, Zhang Y, Zhao Y, Yan D, Lu J, Chen P, Zhou W, Zhao Y, Chen X*, Chen Y; Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH). Venous aneurysms in unruptured supratentorial brain arteriovenous malformations: a protective factor against hemorrhagic stroke and insights into hemodynamic mechanisms. Eur Radiol. 2024 Oct 29. doi: 10.1007/s00330-024-11137-0. Epub ahead of print. PMID: 39470793. (IF 4.7)

7. Zhou Y, Wang K, Li R, Lin F, Chen Y, Yang J, Han H, Li T, Jia Y, Yuan K, Zhang H, Li R, Li Z, Li C, Zhao Y, Hao Q, Chen X*, Zhao Y. Dynamic changes of platelets before and after surgery predict the prognosis of patients with aneurysmal subarachnoid hemorrhage. Heliyon. 2024 Sep 10;10(18):e37706. doi: 10.1016/j.heliyon.2024.e37706. PMID: 39381250; PMCID: PMC11458939. (IF 3.4)

8. Li Z, Zhang J, Han H, Gao D, Jin H, Ma L, Li R, Li A, Zhang H, Yuan K, Wang K, Zhu Q, Wang C, Yan D, Lu J, Zhang Y, Zhao Y, Li Y, Sun S, Zhao Y, Chen Y, Chen X*; Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH). Association of the combined stereotactic radiosurgery and embolization strategy and long-term outcomes in brain arteriovenous malformations with a volume >10 ml: A nationwide multicenter observational prospective cohort study. Radiother Oncol. 2024 Nov;200:110530. doi: 10.1016/j.radonc.2024.110530. Epub 2024 Sep 7. PMID: 39251110. (IF 4.9)

9. Li T, Li R, Lin F, Chen X*. A Mediation Analysis of the Association Between Systemic Inflammation Response Index, in-Hospital Complications, and Poor Long-Term Functional Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: Insights from a Large Prospective Cohort Study. J Inflamm Res. 2024 Jun 10;17:3697-3708. doi: 10.2147/JIR.S460364. PMID: 38882185; PMCID: PMC11178086. (IF 4.2)

10. Lin F, Li R, Chen Y, Yang J, Wang K, Jia Y, Han H, Hao Q, Shi G, Wang S, Zhao Y, Chen X*. Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial. Trials. 2024 Jun 11;25(1):377. doi: 10.1186/s13063-024-08231-5. PMID: 38863026; PMCID: PMC11167899. (IF 2.0)

11. Li T, Zhang J, Li R, Lin F, Chen Y, Yang J, Han H, Wang K, Jia Y, Zhao Y, Wang S, Zhao Y, Chen X*. Elevated markers of early fibrinolysis disorder as predictors of poor 90-day prognosis in patients with aneurysmal subarachnoid hemorrhage: A large prospective cohort study. J Stroke Cerebrovasc Dis. 2023 Dec;32(12):107433. doi: 10.1016/j.jstrokecerebrovasdis.2023.107433. Epub 2023 Oct 31. PMID: 38847809. (IF 2.0)

12. Zhang H, Han H, Ma L, Li R, Li Z, Li A, Yuan K, Zhu Q, Wang C, Zhang Y, Zhang H, Gao D, Guo G, Kang S, Ye X, Li Y, Sun S, Wang H, Hao Q, Chen Y, Wang R, Chen X*, Zhao Y. A comprehensive analysis of patients with cerebral arteriovenous malformation with headache: assessment of risk factors and treatment effectiveness. J Headache Pain. 2024;25:72 PMID: 38714978 DOI: 10.1186/s10194-024-01774-7 (IF 7.3)

13. Li T, Lu J, Li R, Lin F, Chen Y, Yang J, Han H, Wang K, Wang S, Zhao Y, Chen X*. Elevated cortical blood flow insufficiency volume as a predictor of adverse outcomes in aneurysmal subarachnoid hemorrhage: a large prospective quantitative computed tomography perfusion study. Eur J Radiol. 2024 Jun;175:111456. doi: 10.1016/j.ejrad.2024.111456. Epub 2024 Apr 10. PMID: 38640823. (IF 3.2)

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15. Zhou Y, Li R, Wang K, Lin F, Chen Y, Yang J, Han H, Li T, Jia Y, Yuan K, Zhang H, Li R, Li Z, Zhao Y, Hao Q, Chen X*, Zhao Y. A retrospective study on the relationship between serum electrolyte disorder and delayed cerebral infarction after aneurysmal subarachnoid hemorrhage. J Stroke Cerebrovasc Dis. 2024 Apr;33(4):107579. doi: 10.1016/j.jstrokecerebrovasdis.2024.107579. Epub 2024 Jan 12. PMID: 38325032. (IF 2.0)

16. Wang J, Lin F, Zeng M, Liu M, Zheng M, Ren Y, Li S, Yang X, Chen Y, Chen X*, Sessler DI, Peng Y. Intraoperative blood pressure and cardiac complications after aneurysmal subarachnoid hemorrhage: a retrospective cohort study. Int J Surg. 2024 Feb 1;110(2):965-973. doi: 10.1097/JS9.0000000000000928. PMID: 38016131; PMCID: PMC10871595. (IF 12.5)

17. Han H, Chen Y, Ma L, Li R, Li Z, Zhang H, Yuan K, Wang K, Jin H, Meng X, Yan D, Zhao Y, Zhang Y, Jin W, Li R, Lin F, Hao Q, Wang H, Ye X, Kang S, Gao D, Sun S, Liu A, Li Y, Chen X*, Zhao Y, Wang S. Comparison of conservative management, microsurgery only, and microsurgery with preoperative embolization for unruptured arteriovenous malformations: A propensity score weighted prospective cohort study. CNS Neurosci Ther. 2024 Apr;30(4):e14533. doi: 10.1111/cns.14533. Epub 2023 Nov 21. PMID: 37990420; PMCID: PMC11017441. (IF 4.8)

18. Hao Q, Zhang H, Han H, Jin H, Ma L, Li R, Li Z, Li A, Yuan K, Zhu Q, Wang K, Li R, Lin F, Wang C, Zhang Y, Zhang H, Zhao Y, Jin W, Gao D, Guo G, Yan D, Pu J, Kang S, Ye X, Li Y, Sun S, Wang H, Chen Y, Chen X*, Zhao Y; Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH). Recurrence of Cerebral Arteriovenous Malformation Following Complete Obliteration Through Endovascular Embolization. Transl Stroke Res. 2023 Nov 13. doi: 10.1007/s12975-023-01215-8. Epub ahead of print. PMID: 37957446. (IF 3.8)

19. Yuan K, Chen Y, Yan D, Li R, Li Z, Zhang H, Wang K, Han H, Zhao Y, Ma L, Hao Q, Ye X, Jin H, Meng X, Liu A, Gao D, Sun S, Kang S, Wang H, Li Y, Wang S, Chen X*, Zhao Y. Re-rupture in ruptured brain arteriovenous malformations: a retrospective cohort study based on a nationwide multicenter prospective registry. J Neurointerv Surg. 2024 Oct 14;16(11):1145-1151. doi: 10.1136/jnis-2023-020650. PMID: 37903561; PMCID: PMC11503091. (IF 4.5)

20. Jia Y, Lin F, Li R, Chen Y, Yang J, Han H, Wang K, Yuan K, Zhao Y, Lu J, Li T, Nie Z, Zhou Y, Shi G, Li Y, Zhao Y, Chen X*, Wang S. Insular cortex Hounsfield units predict postoperative neurocardiogenic injury in patients with aneurysmal subarachnoid hemorrhage. Ann Clin Transl Neurol. 2023 Dec;10(12):2373-2385. doi: 10.1002/acn3.51926. Epub 2023 Oct 18. PMID: 37853930; PMCID: PMC10723248. (IF 4.4)

21. Wang K, Yuan K, Li R, Lin F, Chen Y, Yang J, Han H, Li T, Jia Y, Zhou Y, Zhang H, Li R, Li Z, Zhao Y, Hao Q, Chen X*, Zhao Y. Prediction of stress-related gastrointestinal bleeding in patients with aneurysmal subarachnoid hemorrhage using caudate Hounsfield unit value in ASPECT score. Front Neurol. 2023 Sep 13;14:1237310. doi: 10.3389/fneur.2023.1237310. PMID: 37780721; PMCID: PMC10533991. (IF 2.7)

22. Han H, Gao D, Ma L, Li R, Li Z, Zhang H, Yuan K, Wang K, Zhang Y, Zhao Y, Jin W, Jin H, Meng X, Yan D, Li R, Lin F, Hao Q, Wang H, Ye X, Kang S, Pu J, Shi Z, Chao X, Lin Z, Lu J, Li Y, Zhao Y, Sun S, Chen Y, Chen X*, Wang S; Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH). Long-term outcomes of microsurgery and stereotactic radiosurgery as the first-line treatment for arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data. Int J Surg. 2023 Dec 1;109(12):3983-3992. doi: 10.1097/JS9.0000000000000751. PMID: 37720924; PMCID: PMC10720861. (IF 12.5)

23. Song Z, Lin F, Chen Y, Li T, Li R, Lu J, Han H, Li R, Yang J, Li Z, Zhang H, Yuan K, Wang K, Zhou Y, Jia Y, Chen X*. Inflammatory Burden Index: Association Between Novel Systemic Inflammatory Biomarkers and Prognosis as Well as in-Hospital Complications of Patients with Aneurysmal Subarachnoid Hemorrhage. J Inflamm Res. 2023 Sep 4;16:3911-3921. doi: 10.2147/JIR.S416295. PMID: 37692059; PMCID: PMC10488670. (IF 4.2)

24. Chen Y, Han H, Jin H, Meng X, Ma L, Li R, Li Z, Yan D, Zhang H, Yuan K, Wang K, Zhao Y, Zhang Y, Jin W, Li R, Lin F, Hao Q, Wang H, Ye X, Kang S, Gao D, Pu J, Shi Z, Chao X, Lin Z, Lu J, Li J, Sun S, Liu A, Chen X*, Li Y, Zhao Y, Wang S; Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH). Association of embolization with long-term outcomes in brain arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data. Int J Surg. 2023 Jul 1;109(7):1900-1909. doi: 10.1097/JS9.0000000000000341. PMID: 37226884; PMCID: PMC10389468. (IF 12.5)

25. Wang J, Li R, Li S, Ma T, Zhang X, Ren Y, Chen X*, Peng Y. Intraoperative arterial pressure and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage after surgical clipping: A retrospective cohort study. Front Neurosci. 2023 Feb 17;17:1064987. doi: 10.3389/fnins.2023.1064987. PMID: 36875639; PMCID: PMC9982002. (IF 3.2)

26. Chen Y, Han H, Meng X, Jin H, Gao D, Ma L, Li R, Li Z, Yan D, Zhang H, Yuan K, Wang K, Zhang Y, Zhao Y, Jin W, Li R, Lin F, Chao X, Lin Z, Hao Q, Wang H, Ye X, Kang S, Li Y, Sun S, Liu A, Wang S, Zhao Y, Chen X*. Development and Validation of a Scoring System for Hemorrhage Risk in Brain Arteriovenous Malformations. JAMA Netw Open. 2023 Mar 1;6(3):e231070. doi: 10.1001/jamanetworkopen.2023.1070. PMID: 36857052; PMCID: PMC9978947. (IF 10.5)

27. Lu J, Wang L, Li R, Lin F, Chen Y, Yan D, Yang J, Li R, Li Z, Zhang H, Han H, Yuan K, Wang K, Ren Y, Chen X*, Zhao Y, Zhao J. Timing of operation for poor-grade aneurysmal subarachnoid hemorrhage: Relationship with delayed cerebral ischemia and poor prognosis. CNS Neurosci Ther. 2023 Apr;29(4):1120-1128. doi: 10.1111/cns.14088. Epub 2023 Jan 10. PMID: 36627811; PMCID: PMC10018093. (IF 4.8)

28. Li R, Zhao Y, Chen X*, Hao Q. Predictive Values of White Blood Cell Count in Peripheral Blood at Admission on In-Hospital Complications and 90-Day Outcomes of Patients with Aneurysmal Subarachnoid Hemorrhage: Insights from the LongTEAM Registry. J Inflamm Res. 2022 Nov 28;15:6481-6494. doi: 10.2147/JIR.S386558. PMID: 36467991; PMCID: PMC9717606. (IF 4.2)

29. Zhang H, Peng H, Yan D, Wang K, Yuan K, Chen Y, Li Z, Li R, Li R, Lu J, Chen X*, Ye X, Wang H, Zhao Y, Hao Q. The micro-pathological characteristics in cerebral arteriovenous malformations (cAVMs). Microvasc Res. 2023 Jan;145:104452. doi: 10.1016/j.mvr.2022.104452. Epub 2022 Nov 8. PMID: 36356687. (IF 2.9)

30. Chen Y, Han H, Ma L, Li R, Li Z, Yan D, Zhang H, Yuan K, Wang K, Zhao Y, Zhang Y, Jin W, Li R, Lin F, Meng X, Hao Q, Wang H, Ye X, Kang S, Jin H, Li Y, Gao D, Sun S, Liu A, Wang S, Chen X*, Zhao Y. Multimodality treatment for brain arteriovenous malformation in Mainland China: design, rationale, and baseline patient characteristics of a nationwide multicenter prospective registry. Chin Neurosurg J. 2022 Oct 17;8(1):33. doi: 10.1186/s41016-022-00296-y. PMID: 36253875; PMCID: PMC9575306. (IF 0)

31. Yan D, Hao Q, Chen Y, Li Z, Zhang H, Yuan K, Li R, Li R, Zhao Y, Wang K, Peng H, Zhang D, Chen X*, Zhao Y. mTOR-FABP4 signal is activated in brain arteriovenous malformations in humans. J Mol Med (Berl). 2022 Sep;100(9):1287-1297. doi: 10.1007/s00109-022-02237-9. Epub 2022 Jul 25. PMID: 35876909. (IF 4.8)

32. Li R, Lin F, Chen Y, Lu J, Yang J, Han H, Yuan K, Wang K, Yan D, Li R, He S, Li Z, Zhang H, Chen X, Ma L, Zhao Y, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Li Y, Wang S, Chen X*, Zhao Y. The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis. Neurosurg Rev. 2022 Oct;45(5):3339-3347. doi: 10.1007/s10143-022-01836-x. Epub 2022 Jul 23. PMID: 35870093. (IF 2.5) 

33. Li R, Chen X*, Zhao Y. Potential triggering factors associated with aneurysmal subarachnoid hemorrhage: A large single-center retrospective study. J Clin Hypertens (Greenwich). 2022 Jul;24(7):861-869. doi: 10.1111/jch.14485. Epub 2022 Jun 23. PMID: 35739460; PMCID: PMC9278573. (IF 2.7)

34. Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X*, Zhao Y. A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score. Transl Stroke Res. 2023 Apr;14(2):200-210. doi: 10.1007/s12975-022-01033-4. Epub 2022 May 14. PMID: 35567655. (IF 3.8)

35. Han H, Chen Y, Li R, Lin F, Lu J, Chen X*, Wang S. The value of early CT perfusion parameters for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Neurosurg Rev. 2022 Aug;45(4):2517-2531. doi: 10.1007/s10143-022-01779-3. Epub 2022 Apr 4. PMID: 35377027. (IF 2.5)

36. Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X*, Zhao Y. Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage. Neurosurg Rev. 2022 Aug;45(4):2689-2699. doi: 10.1007/s10143-022-01780-w. Epub 2022 Apr 2. PMID: 35366711. (IF 2.5) 

37. Yang J, Lu J, Li R, Lin F, Chen Y, Han H, Yan D, Li R, Li Z, Zhang H, Yuan K, Li H, Zhang L, Shi G, Zhou J, Wang S, Zhao Y, Chen X*. Application of Intracranial Pressure-Directed Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Front Aging Neurosci. 2022 Mar 14;14:831994. doi: 10.3389/fnagi.2022.831994. PMID: 35360218; PMCID: PMC8964287. (IF 4.1)

38. Lin F, Li R, Tu WJ, Chen Y, Wang K, Chen X*, Zhao J. An Update on Antioxidative Stress Therapy Research for Early Brain Injury After Subarachnoid Hemorrhage. Front Aging Neurosci. 2021 Dec 6;13:772036. doi: 10.3389/fnagi.2021.772036. PMID: 34938172; PMCID: PMC8686680. (IF 4.1)

39. Li Z, Chen Y, Chen P, Li R, Ma L, Yan D, Zhang H, Han H, Zhao Y, Zhang Y, Meng X, Jin H, Li Y, Chen X*, Zhao Y. Quantitative evaluation of hemodynamics after partial embolization of brain arteriovenous malformations. J Neurointerv Surg. 2022 Nov;14(11):1112-1117. doi: 10.1136/neurintsurg-2021-018187. Epub 2021 Dec 6. PMID: 34872987. (IF 4.5)

40. Lu J, Xue C, Hu X, Zhao Y, Zhang D, Chen X*, Zhao JZ. Quantitative angiographic haemodynamic evaluation of bypasses for complex aneurysms: a preliminary study. Stroke Vasc Neurol. 2022 Feb;7(1):54-61. doi: 10.1136/svn-2021-000858. Epub 2021 Oct 12. PMID: 34642254; PMCID: PMC8899645. (IF 4.4)

41. Lu J, Xue C, Hu X, Zhao Y, Zhang D, Chen X*, Zhao JZ. Quantitative angiographic haemodynamic evaluation of bypasses for complex aneurysms: a preliminary study. Stroke Vasc Neurol. 2022 Feb;7(1):54-61. doi: 10.1136/svn-2021-000858. Epub 2021 Oct 12. PMID: 34642254; PMCID: PMC8899645. (IF 2.7)

42. Chen Y, Chen X#, Ma L, Deng X, Li Z, Ye X, Wang H, Kang S, Zhang Y, Wang R, Zhang D, Cao Y, Zhao Y, Wang S, Zhao J. Management protocol for emergency aneurysm craniotomy clipping in non-major COVID-19 epidemic areas in Beijing, China. Chin Neurosurg J. 2020 Dec 22;6(1):38. doi: 10.1186/s41016-020-00217-x. PMID: 33349249; PMCID: PMC7752522. (IF 0)

43. Chen Y, Yan D, Li Z, Ma L, Zhao Y, Wang H, Ye X, Meng X, Jin H, Li Y, Gao D, Sun S, Liu A, Wang S, Chen X*, Zhao Y. Long-Term Outcomes of Elderly Brain Arteriovenous Malformations After Different Management Modalities: A Multicenter Retrospective Study. Front Aging Neurosci. 2021 Feb 18;13:609588. doi: 10.3389/fnagi.2021.609588. PMID: 33679374; PMCID: PMC7930621. (IF 4.1) 

44. Lu J, Zhao Y, Li M, Ma L, Chen Y, Wang R, Ye X, Wang H, Chen X*, Zhao Y. Clinical Implications of the "Brush Sign" in Susceptibility-Weighted Imaging for Moyamoya Disease. Cerebrovasc Dis. 2021;50(2):147-155. doi: 10.1159/000511936. Epub 2021 Feb 8. PMID: 33556948. (IF 2.2)

45. Chen Y, Li R, Ma L, Zhao Y, Yu T, Wang H, Ye X, Wang R, Chen X*, Zhao Y. Single-Stage Combined Embolization and Resection for Spetzler-Martin Grade III/IV/V Arteriovenous Malformations: A Single-Center Experience and Literature Review. Front Neurol. 2020 Oct 29;11:570198. doi: 10.3389/fneur.2020.570198. PMID: 33193013; PMCID: PMC7658368. (IF 2.7) 

46. Ma L, Zhang S, Li Z, Wu CX, Wang Z, Zhan L, Hao Q, Wang H, Ye X, Chen X*, Liu YO, Wang S, Zhao YL. Morbidity After Symptomatic Hemorrhage of Cerebral Cavernous Malformation: A Nomogram Approach to Risk Assessment. Stroke. 2020 Oct;51(10):2997-3006. doi: 10.1161/STROKEAHA.120.029942. Epub 2020 Sep 21. PMID: 32951540. (IF 7.9)

47. Chen Y, Meng X, Ma L, Zhao Y, Gu Y, Jin H, Gao D, Li Y, Sun S, Liu A, Zhao Y, Chen X*, Wang S. Contemporary management of brain arteriovenous malformations in mainland China: a web-based nationwide questionnaire survey. Chin Neurosurg J. 2020 Sep 1;6:26. doi: 10.1186/s41016-020-00206-0. PMID: 32922955; PMCID: PMC7461270. (IF 0)

48. Chen Y, Ma L, Chen X*. Responses to "Letter to Quantitative Angiographic Hemodynamic Evaluation After Revascularization Surgery for Moyamoya Disease". Transl Stroke Res. 2020 Dec;11(6):1173-1174. doi: 10.1007/s12975-020-00812-1. Epub 2020 Apr 17. PMID: 32303990. (IF 3.8)

49. Chen Y, Ma L, Yang S, Burkhardt JK, Lu J, Ye X, Jiang W, Ren Z, Wang R, Chen X*, Zhao Y. Quantitative Angiographic Hemodynamic Evaluation After Revascularization Surgery for Moyamoya Disease. Transl Stroke Res. 2020 Oct;11(5):871-881. doi: 10.1007/s12975-020-00781-5. Epub 2020 Feb 13. PMID: 32056157; PMCID: PMC7496042. (IF 3.8)