1. 钙黏蛋白CDH26对慢性鼻窦炎伴鼻息肉嗜酸性粒细胞浸润的调控作用及机制研究，北京市自然科学基金面上项目，2025.01-2027.12

2. 基于多组学联用探究中药小分子治疗慢性鼻窦炎作用及其分子机制，北京市科技新星计划交叉合作课题，2024.09-2026.09

3. HDAC9调控鼻黏膜上皮紧密连接屏障功能参与慢性鼻窦炎伴鼻息肉发病的机制研究，北京市自然科学基金面上项目，2021.01-2023.12

4. MiR-34在慢性鼻窦炎黏液纤毛障碍中的功能及机制研究，北京市自然科学基金面上项目，2017.01-2019.12

重要学术论文：

1. Zhuang M#, Jiao J#, Zhang Q, Pan S,Zhang Y, He T, Li Y, Zheng M, Wang X*, Zhang L*, Bachert C. Ruxolitinib, anovel JAK/STAT-targeted therapy through restoring mucosal homeostasis forchronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2025;156(5):1219-1233.

2. Zhang Q#, Jiao J#, Pan S, He T, ZhuangM, Zhang Y, Li Y, Wang X*, Zhang L*. BDNF as a Key Mediator in EosinophilicInflammation in CRSwNP: Insights from Transcriptomic and Functional Analysis. IntForum Allergy Rhinol. 2025;15(11):1217-1227.

3. Pan S#, Zhuang M#, Wang X, Zhang Q, HeT, Li Y, Jiao J*, Zhang L*. Targeting PDK1: A novel approach to combathypoxia-induced epithelial-mesenchymal transition in chronic rhinosinusitiswith nasal polyps. Clin Transl Allergy. 2025;15(4):e70048.

4. Wang L#, Liu C#, Yang B#, Zhang H#, JiaoJ#, Zhang R, Liu S, Xiao S, Chen Y, Liu B, Ma Y, Duan X, Guo Y, Guo M, Wu B,Wang X, Huang X, Yang H, Gui Y, Fang M, Zhang L*, Duo S*, Guo X*, Li W*.SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity. J Cell Biol.2022;221(7):e202108015.

5. Jiao J#, Hu P#, Zhuang M, Li Y, Cai C,Wang X*, Zhang L*. Transcriptome sequencing reveals altered ciliogenesis underhypoxia in nasal epithelial cells from chronic rhinosinusitis with nasalpolyps. Clin Transl Allergy. 2022;12(6):e12168.

重要奖项：

1.      慢性鼻窦炎免疫机制和诊疗技术的研究和应用  北京市科学技术奖二等奖 201712

2.      慢性鼻窦炎发病机制及关键诊疗技术的创新与应用 华夏医学科技奖 一等奖 201910