团队名称：贡鸣教授心力衰竭与瓣膜外科专家团队

团队专长：心脏移植与心室辅助、瓣膜病、冠心病、主动脉疾病、先心病外科治疗

1. 基于心脏外科、心脏介入复合手术平台脑心共患病人群治疗策略的临床研究，中华人民共和国科学科技部国家重点研发课题，2021.12-2024.11

2. 凝血因子ⅩⅡa-uPAR信号通路在低温停循环后急性肺损伤中的作用机制研究，国家自然科学基金委员会，2024.01-2027.12

3. 心脑血管及胃部疾病大模型微调技术研发与验证，北京市科学技术委员会，2024.09-2027.08

4. 机械循环支持装置泵导管及流出道优化研究，北京市自然科学基金委员，2024.10-2027.09

5. 基于5G+人工智能技术的实时多通道冠脉搭桥术中信息处理平台建设及其对围术期死亡风险的预警研究，首都卫生发展科研专项，2022.01-2024.12

6. 基于5G+人工智能关键技术的实时多通道术中协同及质控系统，工业和信息化部，2021.05-2023.05

重要学术论文

1. Jia S, Wang M, Liu Y, Gong M, Jiang W, Zhang H. Effect of Asymptomatic Common Carotid Artery Dissection on the Prognosis of Patients With Acute Type A Aortic Dissection. J Am Heart Assoc. 2024;13(1):e031542. doi:10.1161/JAHA.123.031542

2. Lu Y, Zhao S, Han J, et al. Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device. iScience. 2025;28(2):111764. Published 2025 Jan 7. doi:10.1016/j.isci.2025.111764

3. Jia S, Wang M, Gong M, Zhang H, Jiang W. Midterm outcomes of simultaneous carotid revascularization combined with coronary artery bypass grafting. BMC Cardiovasc Disord. 2022;22(1):535. Published 2022 Dec 8. doi:10.1186/s12872-022-02986-y

4. Guan X, Li L, Li J, et al. High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery. Exp Physiol. 2023;108(5):683-691. doi:10.1113/EP091054

5. Zhao S, Liu Z, Wen M, et al. Association between preoperative D-dimer with morphologic features and surgical outcomes of acute type A aortic dissection. Interdiscip Cardiovasc Thorac Surg. 2024;39(6):ivae193. doi:10.1093/icvts/ivae193

6. Wang M, Jia S, Pu X, Sun L, Gong M, Zhang H. Mid-term Patency of the Great Saphenous Bypass to Aorta vs. Non-aortic Arteries in Stanford Type A Aortic Dissection Surgery With Concomitant CABG. Front Cardiovasc Med. 2021;8:743562. Published 2021 Oct 26. doi:10.3389/fcvm.2021.743562

7. Wang M, Jia S, Pu X, et al. A scoring model based on clinical factors to predict postoperative moderate to severe acute respiratory distress syndrome in Stanford type A aortic dissection. BMC Pulm Med. 2023;23(1):515. Published 2023 Dec 21. doi:10.1186/s12890-023-02736-6

8. Wang M, Li L, Li J, et al. Influence of Dynamic and Static Obstructive Renal Artery on Early Prognosis in Stanford Type A Aortic Dissection. Heart Lung Circ. 2022;31(6):882-888. doi:10.1016/j.hlc.2021.11.002

9. Wen M, Li J, Jia S, et al. CAS-OPCABG vs OPCABG-alone in patients with asymptomatic carotid Stenosis: Multi-center experience. Int J Cardiol Heart Vasc. 2024;56:101497. Published 2024 Dec 14. doi:10.1016/j.ijcha.2024.101497

10. Li J, Li L, Wang M, et al. Comparison of Prognosis Between Hybrid Debranching Surgery and Total Open Arch Replacement With Frozen Elephant Trunk for Type A Acute Aortic Syndrome Patients. Front Cardiovasc Med. 2021;8:689507. Published 2021 Jul 27. doi:10.3389/fcvm.2021.689507

11. Zhao S, Li Q, Liu Z, et al. Protective effect of high-density lipoprotein in infective endocarditis patients after valve surgery. Int J Cardiol Heart Vasc. 2025;60:101755. Published 2025 Jul 22. doi:10.1016/j.ijcha.2025.101755

12. Wang M, Fan R, Gu T, et al. Short-term outcomes of acute coronary involvement in type A aortic dissection without myocardial ischemia: a multiple center retrospective cohort study. J Cardiothorac Surg. 2021;16(1):107. Published 2021 Apr 23. doi:10.1186/s13019-021-01469-z

13. Li J, Gong M, Joshi Y, et al. Machine Learning Prediction Model for Acute Renal Failure After Acute Aortic Syndrome Surgery. Front Med (Lausanne). 2022;8:728521. Published 2022 Jan 17. doi:10.3389/fmed.2021.728521

14. Wang S, Zhao F, Bu D, et al. LINS: A general medical Q&A framework for enhancing the quality and credibility of LLM-generated responses. Nat Commun. 2025;16(1):9076. Published 2025 Oct 13. doi:10.1038/s41467-025-64142-2

15. Zhao S, Liu C, Wang J, et al. CH-VAD left ventricular assist implantation combined with the Bentall procedure and coronary artery bypass grafting. ESC Heart Fail. 2024;11(4):2405-2409. doi:10.1002/ehf2.14769

16. Li J, Wang M, Wang M, et al. Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway. iScience. 2024;27(6):110075. Published 2024 May 22. doi:10.1016/j.isci.2024.110075

17. Li L, Wang M, Li J, et al. Short Term Prognosis of Renal Artery Stenosis Secondary to Acute Type B Aortic Dissection With TEVAR. Front Cardiovasc Med. 2021;8:658952. Published 2021 Apr 23. doi:10.3389/fcvm.2021.658952

18. Wen M, Zhao S, Wang H, et al. Comparative analysis of perioperative renal function in patients undergoing heart transplantation and left ventricular assist device implantation: a multicenter retrospective study. J Thorac Dis. 2025;17(2):676-686. doi:10.21037/jtd-24-1682

19. Liu T, Fu Y, Liu J, et al. Body mass index is an independent predictor of acute kidney injury after urgent aortic arch surgery for acute DeBakey Type I aortic dissection. J Cardiothorac Surg. 2021;16(1):145. Published 2021 May 26. doi:10.1186/s13019-021-01533-8

20. Wu ZN, Guan XL, Xu SJ, et al. Does preoperative serum creatinine affect the early surgical outcomes of acute Stanford type A aortic dissection?. J Chin Med Assoc. 2020;83(3):266-271. doi:10.1097/JCMA.0000000000000264

21. Gong M, Wu Z, Xu S, et al. Protocol for creation of a risk scoring system for acute type A aortic dissection surgery. Int J Surg Protoc. 2019;14:19-23. Published 2019 Feb 25. doi:10.1016/j.isjp.2019.02.004

22. Gong M, Wu Z, Guan X, Jiang W, Zhang H. Comparison of prognostic ability of perioperative myocardial biomarkers in acute type A aortic dissection. Medicine (Baltimore). 2019;98(43):e17023. doi:10.1097/MD.0000000000017023

23. Ding T, Zeng X, Cheng B, et al. Platelets in Acute Coronary Syndrome Patients with High Platelet Reactivity after Dual Antiplatelet Therapy Exhibit Upregulation of miR-204-5p. Ann Clin Lab Sci. 2019;49(5):619-631.

24. Gong M, Li L, Liu Y, et al. Moderate Hypothermic Circulatory Arrest Is Preferable During Cardiopulmonary Bypass. Ther Hypothermia Temp Manag. 2020;10(2):114-121. doi:10.1089/ther.2019.0005

25. Xu S, Liu J, Li L, et al. Cardiopulmonary bypass time is an independent risk factor for acute kidney injury in emergent thoracic aortic surgery: a retrospective cohort study. J Cardiothorac Surg. 2019;14(1):90. Published 2019 May 7. doi:10.1186/s13019-019-0907-x

26. Gong M, Wu Z, Xu S, et al. Increased risk for the development of postoperative severe hypoxemia in obese women with acute type a aortic dissection. J Cardiothorac Surg. 2019;14(1):81. Published 2019 Apr 25. doi:10.1186/s13019-019-0888-9

27. Li J, Guan X, Liu O, et al. Changes in coagulation factor XII and its function during aortic arch surgery for acute aortic dissection-a prospective observational study. J Thorac Dis. 2018;10(7):4006-4016. doi:10.21037/jtd.2018.06.127

28. Gong M, Ma WG, Guan XL, et al. Moderate hypothermic circulatory arrest in total arch repair for acute type A aortic dissection: clinical safety and efficacy. J Thorac Dis. 2016;8(5):925-933. doi:10.21037/jtd.2016.02.75

29. 王龙飞,唐文杰,贡鸣.急性A型主动脉夹层术前主动脉CT血管成像撕裂程度指标与D-二聚体的相关性分析[J].中国医刊,2025,60(03):308-311.

30. 温明修,贡鸣.冠心病合并严重颈动脉狭窄患者的颈动脉支架治疗策略研究[J].中国医刊,2024,59(10):1133-1137.

31. 温明修,赵双雷,刘周,等.心脏移植与左心室辅助装置植入患者围术期肾功能比较的回顾性队列研究[J].中国胸心血管外科临床杂志,2024,31(11):1594-1598.

32. 田白羽,王坚刚,贡鸣,等.二尖瓣后叶折叠修复技术10年临床效果总结[J].中国心血管病研究,2024,22(04):331-335.

33. 赵双雷,刘周,王宾,等.343例感染性心内膜炎外科治疗临床疗效的单中心回顾性研究[J].中国胸心血管外科临床杂志,2025,32(08):1133-1139.

34. 赵双雷,温明修,李前贤,等.植入式左心室辅助装置在缺血性心力衰竭患者中的应用与进展[J].中国胸心血管外科临床杂志,2024,31(11):1663-1669.

35. 胡熠,温明修,赵双雷,等.冠状动脉旁路移植术围术期脑保护的现有策略及进展[J].中国医刊,2023,58(12):1277-1281+1272.

36. 赵双雷,刘彤,温明修,等.植入式左心室辅助装置在我国的应用与发展[J].中国医刊,2023,58(12):1282-1285.

37. 郭可泉,孟旭,韩杰,等.异种心脏移植的研究进展[J].中国医刊,2023,58(12):1290-1292.

38. 李前贤,贡鸣.急性主动脉夹层手术灌注策略对术后急性肾损伤发生影响的研究[J].心肺血管病杂志,2022,41(12):1300-1303.

39. 武玉多,蔡月日,翟羿,等.5G+人工智能在外科手术过程中的应用探讨[J].中国数字医学,2022,17(06):6-9.

40. 贡鸣,李嘉晨,关欣亮,等.凝血因子Ⅻ及Ⅷ在主动脉夹层围术期凝血功能中的作用研究[J].中国医药,2019,14(06):842-846.

41. 贡鸣,李磊,李嘉晨,等.急性A型主动脉夹层患者肾损伤与超重的相关性研究[J].心肺血管病杂志,2019,38(01):30-35+51.

42. 李嘉晨,关欣亮,刘欧,等.内源性凝血物质在急性Stanford A型主动脉夹层围手术期的变化[J].心肺血管病杂志,2017,36(07):528-533.

43. 贡鸣,许士俊,张宏家.心脏外科专业学位硕士研究生培训的问题及思考[J].中国医药,2016,11(11):1731-1734.

44. 贡鸣,黄小勇,王晓龙,等.StanfordB型主动脉夹层胸主动脉腔内修复术后Ⅰ型内漏的治疗[J].临床心血管病杂志,2014,30(06):513-516.DOI:10.13201/j.issn.1001-1439.2014.06.015.

45. 贡鸣,张宏家,王晓龙,等.左颈总动脉至左锁骨下动脉转流加支架象鼻术治疗复杂Stanford B型主动脉夹层[J].心肺血管病杂志,2012,31(05):506-508.

46. 贡鸣,孟旭,张宏家,等.先天性右心房憩室并阵发性房扑1例[J].中华胸心血管外科杂志,2007,23(05):351.

47. 赵双雷,韩杰,姜文剑,等. 植入式左心室辅助装置的综合手术策略[J]. 中华胸心血管外科杂志,2024,40(12):764-768.

48. 胡秋明,吴凯胜,张文博,等. 极简式经导管卵圆孔未闭封堵术的临床应用及短期随访研究[J]. 中华胸心血管外科杂志,2025,41(2):65-71.

49. 温明修,贾崧淏,王世攀,等. 颈动脉支架置入术在合并无症状颈动脉重度狭窄的冠状动脉旁路移植术中的应用[J]. 中华胸心血管外科杂志,2023,39(12):735-739.

50. 贡鸣,许士俊,付煜伟,等. 300例马方综合征患者及其家系成员FBN1基因突变谱及基因型与临床表型之间的关联研究[J]. 中华胸心血管外科杂志,2019,35(1):33-40.

51. 贡鸣,关欣亮,王晓龙,等. 37例急性A型主动脉夹层累及冠状动脉患者的手术治疗[J]. 中华胸心血管外科杂志,2018,34(8):465-468.

52. 贡鸣,张宏家,孙立忠. 主动脉瓣置换术后发生A型主动脉夹层的危险因素[J]. 中华胸心血管外科杂志,2013,29(12):714-717.

53. 贡鸣,刘欧,王晓龙,等. 候选基因单核苷酸多态性与胸主动脉夹层的遗传易感性分析[J]. 中国医药,2011,06(z2):62.

主编或副主编的著作/译著：

1. 北医《外科学（第四版）》 编委 北京大学医学部 2019年

2. 《心脏外科学》 编委 人民卫生健康出版社 2020年

3. 《心血管外科诊疗规范》 编委 中国医药科技出版社 2012年

重要奖项：

1. 急性主动脉综合征精准诊断及临床疗效提升技术创新与推广，北京市科学技术奖，一等奖，2024.04

2. 急性主动脉综合征全病程防治新技术，华夏医学科技奖，一等奖，2023.12

3. MIRACQ手术协同机器人，北京市医院管理中心第七届科技创新大赛，一等奖，2025.09

4. 术中协作与手术质控机器人系统，第八届临床创新与发明大赛，一等奖，2023.05