帕金森医学中心做为神经康复中心的二级科室，是医院的特色学科，也是医院计划单列特殊设置，在学科引领方面被全院寄予厚望。

回望帕金森医学中心2017年10月成立以来的发展历程，从起步伊始帕金森病患者零的突破，到逐渐被患者及同行认可，以及在全国帕金森病康复领域拥有较高的知名度，一路上团队成员携手并肩，始终以执着的信念、饱满的热情、担当的精神，不断创新前行。

回望5年来，我们感谢医院、神经康复中心及全院各部门的大力支持和协助，是大家的帮助才让我们迅速成长壮大；我们感谢每一位患者、家属及同道的信任，是你们的信任让我们笃定前行；我们感谢每一位同事的付出，是你们的辛勤工作，为学科的发展注入了源源不断的动力；我们感谢每一次机遇与挑战，在不断历练的过程中夯实了基础、构筑了平台。

君子务本，本立而道生；敬事而信，直道而事人。帕金森医学中心将继续以脚踏实地的实干精神，与医院共同成长！

近五年主持或参加的国家自然科学基金项目/课题：

(1) 国家自然科学基金委员会, 联合基金项目, U20A20191, 基于柔性微针传感的生理与运动信息融合模型 及在帕金森病个体化康复中的应用研究, 2021-01-01 至 2024-12-31, 70万元, 在研,

(2) 国家自然科学基金委员会, 面上项目, 81870950, GFAP-IgG阳性脑膜脑脊髓炎分子分型及发病机制研 究, 2019-01-01 至 2022-12-31, 56万元，结题, 

(3) 中华人民共和国科学技术部, 国家重点研发计划重点专项子课题, 2018YFC0115405, 闭环生物反馈和 无创深部电刺激调控协同系统研发与帕金森病治疗应用研究-主被动生物反馈及神经调控协同治疗系统评估与临 床验证, 2018-08 至 2021-10, 100万元, 结题, 

(4)国家重点研发计划主动健康和人口老龄化科技应对专项，2022YFC3602603，面向家庭和社区场景的数字化老年人失能风险预防干预技术研发，2022/12-2025/12/, 460万，在研，主持

近五年主持或参加的国家自然科学基金项目/课题：

(1) 国家自然科学基金委员会, 联合基金项目, U20A20191, 基于柔性微针传感的生理与运动信息融合模型 及在帕金森病个体化康复中的应用研究, 2021-01-01 至 2024-12-31, 70万元, 在研,

(2) 国家自然科学基金委员会, 面上项目, 81870950, GFAP-IgG阳性脑膜脑脊髓炎分子分型及发病机制研 究, 2019-01-01 至 2022-12-31, 56万元, 结题,

(3) 中华人民共和国科学技术部, 国家重点研发计划重点专项子课题, 2018YFC0115405, 闭环生物反馈和 无创深部电刺激调控协同系统研发与帕金森病治疗应用研究-主被动生物反馈及神经调控协同治疗系统评估与临 床验证, 2018-08 至 2021-10, 100万元, 结题,

(4)国家重点研发计划主动健康和人口老龄化科技应对专项，2022YFC3602603，面向家庭和社区场景的数字化老年人失能风险预防干预技术研发，2022/12-2025/12/, 460万，在研，主持

一、代表性论著：

1. Ke-Ke Chen, Zhao-Hui Jin, Lei Gao, Lin Qi, Qiao-Xia Zhen, Cui Liu, Ping Wang, Yong-Hong Liu, Rui-Dan Wang, Yan-Jun Liu, Jin-Ping Fang, Yuan Su, Xiao-Yan Yan, Ai-Xian Liu, Bo-Yan Fang#. Efficacy of short-term multidisciplinary intensive rehabilitation in patients with different Parkinson's disease motor subtypes: a prospective pilot study with 3-month follow-up. Neural Regen Res. 2021 Jul;16(7):1336-1343.

2. Tiantian Liu, Yan Yan, Jing Ai, Duanduan Chen, Jinglong Wu, Boyan Fang#, Tianyi Yan#. Disrupted rich-club organization of brain structural networks in Parkinson's disease. Brain Struct Funct 2021 Sep;226(7):2205-2217.

3. Yongshi Wang, Lei Gao, Hongjiao Yan, Zhaohui Jin, Jinping Fang, Lin Qi, Qiaoxia Zhen, Cui Liu, Ping Wang, Yonghong Liu, Ruidan Wang, Yanjun Liu, Yuan Su, Aixian Liu, Boyan Fang#. Efficacy of C-Mill gait training for improving walking adaptability in early and middle stages of Parkinson's disease. Gait Posture. 2022 Jan; 91:79-85.

4. Lei Liu, Boyan Fang#, Zhixin Qiao, Xiaomeng Di, Qiuying Ma, Jingxiao Zhang, Jiawei Wang. Clinical Manifestation, Auxiliary Examination Features and Prognosis of GFAP Autoimmunity：a Chinese Cohort Study. Brain Sci. 2022 Dec 3;12(12):1662.

5. Detao Meng, Zhaohui Jin, Lei Gao, Yixuan Wang, Ruidan Wang, Jinping Fang, Lin Qi, Yuan Su, Aixian Liu, Boyan Fang#. The quality of life in patients with Parkinson's disease: Focus on gender difference. Brain Behav. 2022 Mar;12(3):e2517.

6. Detao Meng, Zhaohui Jin, Keke Chen, Xin Yu, Yixuan Wang, Wenjun Du, Jingran Wei, Jianing Xi, Boyan Fang#. Quality of life predicts rehabilitation prognosis in Parkinson's disease patients: Factors influence rehabilitation prognosis: Factors influence rehabilitation prognosis. Brain Behav. 2022 May;12(5):e2579.

7. Keke Chen, Zhaohui Jin, Jinping Fang, Lin Qi, Cui Liu, Ruidan Wang, Yuan Su, Hongjiao Yan, Aixian Liu, Jianing Xi, Qiping Wen, Boyan Fang#. The impact of cerebral small vessel disease burden and its imaging markers on gait, postural control, and cognition in Parkinson's disease. Neurol Sci. 2023 Apr;44(4):1223-1233.

8. Keke Chen, Zhaohui Jin, Jinping Fang, Lin Qi, Cui Liu, Ruidan Wang, Yuan Su, Hongjiao Yan, Aixian Liu, Jianing Xi, Boyan Fang#. Lacunes may Worsen Cognition but not Motor Function in Parkinson’s Disease. Brain Behav. 2023 Feb;13(2):e2880.

9. Xin Yu, Hong-Ying Jiang, Chen-Xi Zhang, Zhao-Hui Jin, Lei Gao, Rui-Dan Wang, Jin-Ping Fang, Yuan Su, Jia-Ning Xi, Bo-Yan Fang#. The Role of the Diaphragm in Postural stability and Visceral Function in Parkinson’s Disease. Front Aging Neurosci. 2021 Dec 23;13:785020.

10. Zhang T, Meng DT, Lyu DY, Fang BY#. The Efficacy of Wearable Cueing Devices on Gait and Motor Function in Parkinson Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Phys Med Rehabil. 2023 Aug 1:S0003-9993(23)00419-7.

11. Jin ZH, Wang YX, Meng DT, Qin Y, Duan YN, Fang JP, Wang RD, Liu YJ, Liu C, Wang P, Yan HJ, Zhen Y, An X, Chen KK, Yu X, Lyu D, Yan XY, Fang BY#. Intermittent theta-burst stimulation combined with physical therapy as an optimal rehabilitation in Parkinson's disease: study protocol for a randomised, double-blind, controlled trial. Trials. 2023 Jun 16;24(1):410.

12. Yu X, Wang HJ, Zhen QX, Zhang QR, Yan HJ, Zhen Y, An X, Xi JN, Qie SY, Fang BY#. Added forearm weights for gait pattern normalization in patients with Parkinson's disease. J Clin Neurosci. 2023 Aug;114:17-24.

13. Lyu D, Lyu X, Huang L, Fang B#. Effects of three kinds of anti-amyloid-β drugs on clinical, biomarker, neuroimaging outcomes and safety indexes: A systematic review and meta-analysis of phase II/III clinical trials in Alzheimer's disease. Ageing Res Rev. 2023 Jul;88:101959.

14. Meng D, Jin Z, Wang Y, Fang B#. Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms. CNS Neurosci Ther. 2023 Aug;29(8):2259-2266.

15. Duan Y, Wang Y, Liu Y, Jin Z, Liu C, Yu X, Chen K, Meng D, Xi J, Fang B#. Circular RNAs in Parkinson's Disease: Reliable Biological Markers and Targets for Rehabilitation. Mol Neurobiol. 2023 Jun;60(6):3261-3276.

16. Li T, Wang L, Piao Z, Chen K, Yu X, Wen Q, Suo D, Zhang C, Funahashi S, Pei G, Fang B#, Yan T#. Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease. J Neurosci. 2023 Feb 15;43(7):1256-1266.

17. Pei G, Liu X, Huang Q, Shi Z, Wang L, Suo D, Funahashi S, Wu J, Zhang J, Fang B#. Characterizing cortical responses to short-term multidisciplinary intensive rehabilitation treatment in patients with Parkinson's disease: A transcranial magnetic stimulation and electroencephalography study. Front Aging Neurosci. 2022 Nov 3;14:1045073.

18. Wang Y, Liu Y, Jin Z, Liu C, Yu X, Chen K, Meng D, Liu A, Fang B#. Association Between Mitochondrial Function and Rehabilitation of Parkinson's Disease: Revealed by Exosomal mRNA and lncRNA Expression Profiles. Front Aging Neurosci. 2022 Jun 16;14:909622.

二、论著之外的代表性研究成果和学术奖励：

 (1) 方伯言(3/6); 穿戴式神经反馈干预系统的研发与产业化应用, 中国发明协会, 发明创新创业一等奖, 其他, 2021(闫天翼; 陈端端; 方伯言; 裴广盈; 王丽; 石悦 ) (科研奖励)

(2)方伯言(7/11)，靶向调控免疫功能脑损伤康复策略与关键技术创新研究，中国康复医学会，科学技术一等奖，2022