研究方向：医学数据挖掘与统计建模

研究内容：针对动脉粥样硬化、2型糖尿病、高血压、血脂异常、代谢综合征等慢性疾病的环境、行为、遗传等数据，进行数据挖掘及因果推断研究，为人群早期干预及临床诊疗提供科学依据。

主持国家自然科学基金项目、国家科技部“十二五”重大专项子课题、北京市优秀青年骨干个人项目、北京高等学校高水平人才交叉培养计划项目等10余项。已发表学术论文50余篇；主编或参编教材专著10余部；担任多个中英文杂志审稿人；兼任中国青年统计学家协会理事、北京预防医学会流行病学专委会委员和全国工业统计学教学研究会健康医疗大数据学会理事。

团队目前有在读硕士研究生6名。

近5年主持的主要科研项目：

1.国家自然科学基金面上项目，血脂成分与颈动脉粥样硬化发生发展的动态因果推断模型研究（82073668），2021/01-2024/12，57万元，在研，主持。

2.国家自然科学基金面上项目，基于动态贝叶斯网络构建代谢综合征发生及逆转的双向因果推断模型研究（81872708），2019/01-2022/12，58万元，已结题，主持。

3.国家自然科学基金青年项目， 基于概率图模型的代谢综合征风险评估及演变规律研究（81502886），2016/01-2018/12，21.6万元，结题，主持。

4.国家科技部“十二五”重大专项子任务，呼吸道传染病病原体快速检测技术与新型筛查技术转化研究（2014ZX10004005），2014/01-2017/12，24.3万元，已结题，主持。

5.北京高等学校高水平人才交叉培养计划毕业设计（科研）项目，基于机器学习的智能空气质量预报技术，2018/01-2018/12，6万元，结题，主持。

6.北京高等学校高水平人才交叉培养计划大创深化项目，基于多状态马尔科夫模型的代谢综合征风险预测研究，2018/01-2018/12，2万元，结题，主持。

7.北京高等学校高水平人才交叉培养计划毕业设计（科研）项目，基于大数据分析方法研究环境对脑卒中入院影响的短期效应，2017/01-2017/12，6万元，结题，主持。

8.首都医科大学基础-临床科研合作基金项目，治疗性低温对急性缺血性脑卒中接受血管内再通治疗患者神经功能影响的研究（15JL20），2015/03-2017/03，5万元，结题，乙方负责人。

近5年发表的代表性论文：

1.Jinqi Wang#, Rui Jin#, Xiaohan Jin, Zhiyuan Wu, Haiping Zhang, Ze Han, Zongkai Xu, Yue Liu, Xiaoyu Zhao, Xiuhua Guo, Lixin Tao. Separate and joint associations of remnant cholesterol accumulationand variability with carotid atherosclerosis: A prospective cohort study. Journalof the American Heart Association. 2023,12(14):e029352.

2.Zhiyuan Wu#, Jinqi Wang#, Haiping Zhang,Pan HY, Li ZW, Liu Y, Miao XL, Han Z, Kang XP, Li X, Guo XH*, Tao LX*, Wang W*. Longitudinalassociation of remnant cholesterol with joint arteriosclerosis and atherosclerosisprogression beyond LDL cholesterol. BMC Medicine 2023, 21(1): 42.

3.Zhiyuan Wu, Haiping Zhang, Wang Y, Zhiwei Li, Xia Li, Lixin Tao*, Xiuhua Guo*. Temporal andBidirectional Association Between Blood Pressure Variability and ArterialStiffness: Cross-Lagged Cohort Study. JMIR Public Health Surveill. 2023,4;9:e45324.

4.Zhiyuan Wu, Yue Jiang, Qian Zhu, Haiping Zhang, Zhiwei Li, Jinqi Wang, Huiying Pan, Guo Z, Zheng Y, Xia Li, Lixin Tao*, Bo Gao*, Xiuhua Guo*. Combined Evaluation of ArterialStiffness and Blood Pressure Promotes Risk Stratificationof Peripheral Arterial Disease. JACC Asia. 2023,18;3(2):287-297.

5.Ze Han, Xiaoyu Zhao, Zongkai Xu, Jinqi Wang, Rui Jin, Yue Liu, Zhiyuan Wu, Zhang J, Xia Li, Xiuhua Guo, Lixin Tao. Associations of time-weighted individualexposure to ambient particulate matter with carotid atherosclerosis in Beijing,China. Environmental Health. 2023 29;22(1):45.

6. Zhiyuan Wu, Siqi Yu, Xiaoping Kang, Yue Liu, Zongkai Xu,Zhiwei Li, Jinqi Wang, Xinlei Miao, Xiangtong Liu, Xia Li, Jingbo Zhang, WeiWang, Lixin Tao*, Xiuhua Guo*. Association of visceral adiposity index withincident nephropathy and retinopathy: a cohort study in the diabeticpopulation. Cardiovascular Diabetology, 2022, 21(1): 32.

7. Zhiyuan Wu#, Di Zhou#, Yue Liu, Zhiwei Li, Jinqi Wang, ZeHan, Xinlei Miao, Xiangtong Liu, Xia Li, Wei Wang, Xiuhua Guo*; Lixin Tao*.Association of TyG index and TG/HDL-C ratio with arterial stiffness progressionin a non-normotensive population. Cardiovascular Diabetology, 2021, 20: 134.

8. Ze Han#, Xiaoping Kang#, Jie Zhang, Jinqi Wang, Yue Liu, JiaLiu, Zhiyuan Wu, Xia Li, Xiaoyu Zhao, Xiuhua Guo, Shuo Chen*, Lixin Tao*.Glycated Hemoglobin and Risk of Arterial Stiffness in a Chinese Han Population:A Longitudinal Study. Front Endocrinol (Lausanne), 2022, 13: 854875.

9. Wu Zhiyuan, Zhang Haiping, Miao Xinlei, Li Haibin, PanHuiying, Zhou Di, Liu Yue, Li Zhiwei, Wang Jinqi Liu X, Zheng Deqiang, Li Xia,Wang Wei, Guo Xiuhua*, Tao Lixin*. High-intensity physical activity is notassociated with better cognition in the elder: evidence from the China Healthand Retirement Longitudinal Study. Alzheimers Research & Therapy. 2021,3;13(1):182.

10. Xiangtong Liu#, Zhiwei Li#, Jie Zhang,Moning Guo, Feng Lu, Xiaolin Xu, Aklilu Deginet, Mengmeng Liu, Zhaomin Dong,Yaoyu Hu, Mengyang Liu, Yutong Li, Mengqiu Wu, Yanxia Luo, Lixin Tao*, HualiangLin*, Xiuhua Guo*The association between ozone and ischemic stroke morbidityamong patients with type 2 diabetes in Beijing, China. Science of Total Environment.2021:151733.

11. Dianqin Sun, Yue Liu, Jie Zhang, Jia Liu, Zhiyuan Wu,Mengyang Liu, Xia Li, Xiuhua Guo*, Lixin Tao*. Long-term effects of fineparticulate matter exposure on the progression of arterial stiffness.Environmental Health, 2021, 20(1): 2.

12. Zhiyuan Wu#, Haiping Zhang#, Xinlei Miao, Haibin Li, HuiyingPan, Di Zhou, Yue Liu, Zhiwei Li, Jinqi Wang, Xiangtong Liu, Deqiang Zheng, XiaLi, Wei Wang, Xiuhua Guo*, Lixin Tao*. High-intensity physical activity is notassociated with better cognition in the elder: evidence from the China Healthand Retirement Longitudinal Study. Alzheimers Research & Therapy, 2021,13(1): 182.

13. Mengyang Liu, Zhiwei Li, Mengmeng Liu, Yingxuan Zhu,Yue Liu,Mandela William Nzoyoum Kuetche, Jianpeng Wang, Xiaonan Wang, Xiangtong Liu,Xia Li, Wei Wang,Xiuhua Guo*, Lixin Tao*. Association between temperature andCOVID-19 transmission in 153 countries. Environmental Science and PollutionResearch. 2021,29(11):16017-16027. 

14. Zhiyuan Wu#, Jinqi Wang#, Zhiwei Li, Ze Han, Xinlei Miao,Xiangtong Liu, Xia Li , Wei Wang , Xiuhua Guo*, Lixin Tao*. Triglycerideglucose index and carotid atherosclerosis incidence in the Chinese population:A prospective cohort study. Nutrition Metabolism and Cardiovascular Diseases.2021,31(7):2042-2050.

15. Bo Liu, Guanqun Chen, Ruijie Zhao, Dan Huang ,Lixin Tao*.Temporal trends in the prevalence of metabolic syndrome among middle-aged andelderly adults from 2011 to 2015 in China: the China health and retirementlongitudinal study (CHARLS). BMC Public Health. 2021,21(1):1045.

16. Yue Liu#, Lixin Tao#, Jie Zhang, Jia Liu, Haibin Li,Xiangtong Liu, Yanxia Luo, Jingbo Zhang, Wei Wang, Xiuhua Guo*. Impact ofCommuting Mode on Obesity Among a Working Population in Beijing, China:Adjusting for Air Pollution. Diabetes Metabolic Syndrome and Obesity.2020,13:3959-3968.

17. Tao Lixin, Li Xia, Zhang Jie, Liu Jia, Liu Yue, Li Haibin,Liu Xiangtong, Luo Yanxia, Guo Xiuhua*. Association of commuting mode withdyslipidemia and its components after accounting for air pollution in theworking population of Beijing, China. Bmc Public Health. 2019,19(1):622.

18. Sun Dianqin, Sun Xiaoming, Xu Yingying, Wu Tianjun, TaoLixin*. Superoxide dismutase activity and risk of cognitive decline in olderadults: Findings from the Chinese Longitudinal Healthy Longevity Survey.Experimental gerontology. 2019,118:72-77.

19. Tao Lixin#, Yang Kun#, Wu Jie, Gehendra Mahara, Zhang Jie,Zhang JingBo, Ping Zhao, Guo Xiuhua*. Association between Plasma Homocysteineand Hypertension: Results from a Cross-sectional and Longitudinal Analysis inBeijing`s adult population from 2012 to 2017. The journal of clinicalhypertension. 2018,20(11):1624-1632.

20. Liu Jia, Zhao Zhan, Mu Yongmin, Zou Xiaoping, Zou Dechun,Zhang Jingbo, Chen Shuo, Lixin Tao*, Xiuhua Guo*. Gender Differences in theAssociation between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal CohortStudy. International journal of environmental research and public health.2018,15(7):1560.

21. Tao Lixin, Yang Kun, Huang Fangfang, Liu Xiangtong, Li Xia,Luo Yanxia, Wu Lijuan, Guo Xiuhua*. Association of Waist Circumference Gain andIncident Prediabetes Defined by Fasting Glucose: A Seven-Year LongitudinalStudy in Beijing, China. International journal of environmental research andpublic health. 2017,14(10):e1208.

22. 陶丽新，毛琦，郭秀花，孙殿钦，田飞飞，闫炎*. 北京市体检人群平均血红蛋白浓度与糖尿病的关系. 首都医科大学学报. 2018,39（4）:575-580.