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施炯教授，博士生导师。在神经科从事医教研工作20多年，主要从事脑衰老神经退行性疾病的分子神经生物学机制的研究，从基因、蛋白质、细胞、动物以及临床层面进行临床前与早期干预跨学科重大项目组织和研究。主持参加了超过50个临床试验. 包括关键的临床试验的开发来造福患者。在转化研究方面, 研究并发现新的有关阿尔茨海默病早期诊断的生物标记和靶点化合物，并且取得了专利。已经发表了70多篇SCI论著, 担任国家自然科学基金重点项目评委，和SCI杂志及各种基金项目评委， 比如Lancet Neurology，Annals of Neurology, Neurology, FASEB, The Journal of Pathology, Journal of Alzheimer’s disease等。担任中华医学会神经病学分会痴呆与认知障碍学组副组长 ，中国卒中学会脑健康分会主任委员。
项目名称及编号 | 所属计划 | 起止年月 |
神经精神疾病临床队列研究与整合平台建设----认知障碍临床研究平台研究 | 北京市科学技术委员会北方脑计划 | 2018/01-2022/11 |
认知障碍性疾病临床队列建设及基础转化研究 | 中国科学院战略性先导科技专项（B类） | 2019/01-2024/12 |
探寻重复经颅磁刺激（rTMS）对于阿尔茨海默病治疗的安全性及有效行的探索研究试验 | 与中国科学院生物医学研究所合作 | 2019-至今 |
TRPC6核酸扩增检测试剂盒（荧光PCR法）对于AD血液检测的可靠性 | 与军事科学院合作 | 2019.12至最后一例患者完成项目 |
血清外泌体检测对阿尔茨海默病的诊断意义 | 与贝格尔公司合作 | 2020-至今 |
(1) Zhang C, Wang Y, Li S, Pan Y, Wang M, Liao X, Shi J, Wang Y. Infarct location and cognitive change in patients after acute ischemic stroke: The ICONS study. J Neurol Sci. 2022 Jul 15;438:120276.
(2) Yang Y, Wang W, Tian Y, Shi J. Sirtuin 3 and mitochondrial permeability transition pore (mPTP): A systematic review. Mitochondrion. 2022 May;64:103-111. doi: 10.1016/j.mito.2022.03.004. Epub 2022 Mar 25. PMID: 35346868.
(3) Zhang C, Shi J. 7T MRI for Intracranial Vessel Wall Lesions and Its Associated Neurological Disorders: A Systematic Review. Brain Sci. 2022 Apr 21;12(5):528. doi: 10.3390/brainsci12050528. PMID: 35624915; PMCID: PMC9139315.
(4) Wang Y, Li S, Pan Y, Wang M, Liao X, Shi J, Wang Y. The effects of blood pressure on post stroke cognitive impairment: BP and PSCI. J Clin Hypertens (Greenwich). 2021 Dec;23(12):2100-2105. doi: 10.1111/jch.14373. Epub 2021 Nov 20. PMID: 34800332; PMCID: PMC8696235.
(5) Yang Y, Tian Y, Guo X, Li S, Wang W, Shi J. Ischemia Injury induces mPTP opening by reducing Sirt3. Neuroscience. 2021 Aug 1;468:68-74. doi: 10.1016/j.neuroscience.2021.06.003. Epub 2021 Jun 11. PMID: 34119577.
(6) Guo X, Tian Y, Yang Y, Li S, Guo L, Shi J. Pituitary Adenylate Cyclase-Activating Polypeptide Protects Against Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion. Mol Neurobiol. 2021 Sep;58(9):4309-4322. doi: 10.1007/s12035-021-02381-2. Epub 2021 May 17. PMID: 33999349.
(7) Shi J, Sabbagh MN, Vellas B. Alzheimer's disease beyond amyloid: strategies for future therapeutic interventions. BMJ. 2020 Oct 9;371:m3684.
(8) Yin J, Reiman EM, Beach TG, Serrano GE, Sabbagh MN, Nielsen M, Caselli RJ, Shi J. Effect of ApoE isoforms on mitochondria in Alzheimer disease. Neurology. 2020 Jun 9;94(23):e2404-e2411. doi: 10.1212/WNL.0000000000009582. Epub 2020 May 26. PMID: 32457210; PMCID: PMC7455369.
(9）Yin J, Nielsen M, Li S*,Shi J*. Ketones improves Apolipoprotein E4-related memory deficiency viasirtuin 3. Aging (Albany NY). 2019, 11: 4579-4586.
(10) Yin J, Nielsen M, Carcione T, Li S, Shi J. Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway. Aging (Albany NY). 2019 Dec 6;11(23):11148-11156. doi: 10.18632/aging.102516.
(11) Li S, Yin J, Nielsen M, Beach TG, Guo L, Shi J. Sirtuin 3 Mediates Tau Deacetylation. J Alzheimers Dis. 2019;69(2):355-362. doi: 10.3233/JAD-190014. PMID: 30958373.
(12) Cao R, Li S, Yin J, Guo L, Shi J. Sirtuin 3 promotes microglia migration by upregulating CX3CR1. Cell Adh Migr. 2019 Dec;13(1):229-235. doi: 10.1080/19336918.2019.1629224. PMID: 31208274; PMCID: PMC6601551.
(13) Yin J, Li S, Nielsen M,Carcione T, Liang WS, Shi J. Sirtuin 3 attenuates amyloid-βinduced neuronal hypometabolism. Aging (Albany NY), 2018, 10(10): 2874-2883.
(14) Yin J, Han P, Song M,Nielsen M, Beach TG, Serrano GE, Liang WS, Caselli RJ, Shi J. Amyloid-βIncreases Tau by Mediating Sirtuin 3 in Alzheimer's Disease. Mol Neurobiol. 2018,55(11): 8592-8601.
(15) Yin J, Li S, Nielsen M, Carcione T, Liang WS, Shi J. Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism. Aging (Albany NY). 2018 Oct 23;10(10):2874-2883. doi: 10.18632/aging.101592. PMID: 30362958; PMCID: PMC6224231.
(16) Yin JX, Maalouf M, HanP, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, ReimanEM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition inan Alzheimer's model. Neurobiol Aging. 2015, 39:25-37.
(17) Han P, Caselli RJ,Baxter L, Serrano G, Yin J, Beach TG, Reiman EM, Shi J. Association ofPituitary Adenylate Cyclase-Activating Polypeptide With Cognitive Decline in MildCognitive Impairment Due to Alzheimer Disease. JAMA Neurol. 2015, Mar;72(3):333-9.
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