(1) 国家自然科学基金青年科学基金, 81703796, 葛根对选择性毒蕈碱M3受体拮抗剂治疗膀胱过度活动症的增效减毒机制, 2018-01 至 2020-12, 24万,  结题, 主持.

(2) 北京市自然科学基金面上项目, 7182159, 基于毒蕈碱M3受体的大豆黄卷抑制逼尿肌过度活跃的药效物质基础及药理机制研究, 2018-01 至 2020-12, 20万, 结题, 主持.

重要奖项

1. 基于临床的中药性效整合模式构建与转化应用. 2024年中华中医药学会科技奖一等奖, 排名12/15. 

2. 药用鼠尾草活性成分代谢特征与药理作用的系统研究, 2021年中华医学科技奖三等奖,  排名2/8。

近五年代表性论文

[1] Jiawei Wang#, Qichao Hu#, Jianying Wang#, Liwei Lang, Shizhang Wei, Haotian Li, Manyi Jing, Xiao Ma***, Yanling Zhao**, Xuelin Zhou*. Role of gut microbiota and fecal metabolites in the protective effect of soybean pulp-rich diet against estrogen-induced cholestasis in rats. Current Research in Food Science. 2025, 10(6):100990.

[2] Yi Wu#, Yi Ma#, Qiang Li, Jing Li, Di Zhang, Yuxin Zhang, Yue Li, Xiaorong Li, Pingxiang Xu, Lu Bai, Xuelin Zhou*, Ming Xue*. Multi-omics analysis reveals phenylalanine enhance mitochondrial function and hypoxic endurance via LKB1/AMPK activation. Journal of Translational Medicine. 2024, 22: 920.

[3] Yan Tie#, Jihan Liu#, Yushan Wu#, Yining Qiang, Ge’Er Cai’Li, Pingxiang Xu, Ming Xue, Liping Xu, Xiaorong Li*, Xuelin Zhou*. A Dataset for Constructing the Network Pharmacology of Overactive Bladder and Its Application to Reveal the Potential Therapeutic Targets of Rhyncholphylline. Pharmaceuticals. 2024, 17, 1253.

[4] Qiang Li, Zhengchao Xia, Yi Wu, Yi Ma, Di Zhang, Sihan Wang, Jingxin Fan, Pingxiang Xu, Xiaorong Li, Lu Bai, Xuelin Zhou**, Ming Xue*. Lysophospholipid acyltransferase-mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation. FEBS Journal. 2024, 291(14): 3191-3210.

[5] Mingchang Cheng, Yining Qiang, Yushan Wu, Xinyi Tong, Yan Tie, Zhihui Sun, Shenghan Guan, Liping Xu, Pingxiang Xu, Xiaorong Li, Ming Xue, Xuelin Zhou*. Multi-omic approaches provide insights into the molecular mechanisms of Sojae semen germinatum water extract against overactive bladder. Food Research International. 2024, 175: 113746.  

[6] Yan Tie, Zhihui Sun, Xinyi Tong, Mingchang Cheng, Yushan Wu, Zhilong Shi, Pingxiang Xu, Ming Xue, Liping Xu**, Xuelin Zhou*. Multi-Omic analysis revealed the therapeutic mechanisms of Alpinia Oxyphylla Fructus water extract against bladder overactivity in spontaneously hypertensive rats. Phytomedicine, 2024, 123: 155154.

[7] Zhihui Sun, Yan Tie, Xinyi Tong, Mingchang Cheng, Yushan Wu, Pingxiang Xu, Ming Xue, Liping Xu**, Xuelin Zhou*. Multi-omics approaches revealed the therapeutic mechanisms of Suo-Quan-Wan for treating overactive bladder in spontaneously hypertensive rats. Journal of Ethnopharmacology. 2024, 318(Pt B): 117066.

[8] Shuying Xie, Shizhang Wei, Xiao Ma, Ruilin Wang, Tingting He, Zhao Zhang, Ju Yang, Jiawei Wang, Lei Chang, Manyi Jing, Haotian Li, Xuelin Zhou* and Yanling Zhao*. Primary Biliary Cholangitis: Molecular Pathogenesis Perspectives and Therapeutic Potential of Natural Products. Frontiers in Pharmacology. 2023, 14: 1173542. (Review)

[9] Jiawei Wang, Jianxia Wen, Xiao Ma, Ju Yang, Zhao Zhang, Shuying Xie, Shizhang Wei, Manyi Jing, Haotian Li, Liwei Lang, Xuelin Zhou*, Yanling Zhao*. Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics. European Journal of Pharmacology. 2022, 935: 175331.

[10] Yining Qiang, Lu Bai, Shuran Tian, Yi Ma, Pingxiang Xu, Mingchang Cheng, Yi Wu, Xiaorong Li, Ming Xue, XuelinZhou*. Daidzein is the in vivo active compound of Puerariae Lobatae Radix water extract for muscarinic receptor-3 inhibition against overactive bladder. Frontiers in Pharmacology. 2022, 13: 924251.