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北京市青年拔尖团队带头人,从事神经内科临床工作30年,中山大学医学博士,美国匹兹堡大学博士后(3年),主要从事认知障碍疾病临床诊治和发病机制研究。牵头建立国家神经疾病中心血管性认知障碍队列(P3队列),及认知障碍疾病生物标志物与生活方式研究队列(CIBL队列)。率先开展阿尔茨海默病的靶向TNFα-炎症小体途径,营养四级预防贯穿全生命周期,以及清除衰老小胶质细胞的免疫-代谢干预新策略研究。以第一或通讯作者发表SCI论文59篇,中文核心期刊论文140余篇,主持国家自然科学基金课题 6 项,十四五科技创新2030课题1项,科技部重大慢病课题1项,部省级课题20项,累计经费2300余万。获授权发明专利 6项,软件著作权23项;获省级科技奖5项。出版科普专著2部,第三主编专著1部,参编/翻译专著6部。现任中国老年医学学会认知障碍分会副会长、中华医学会肠外肠内营养分会脑健康营养专委会主委、中国卒中学会(一级)脑健康分会副主委、中国微循环学会神经变性病专委会FTLD学组副主委、 北京神经变性病学会FTLD专委会副主委。
团队内有博士研究生7人,硕士研究生6人。
年 度 | 基金种类 | 项目名称 | 金额 |
2025-2028 | 科技创新2030 (SQ2023AAA031458) Noncommunicable Chronic Diseases-National Science and Technology Major Project | 以影像学为核心的脑血管病相关认知障碍中医药作用机制及干预靶点研究(项目名称:基于形神一体理论脑血管病相关认知障碍的多维评价及中医药干预方案优化研究) | 940万 |
2025-2029 | 国家重点研发计划( 2024YFF0507503) National Key Research and Development Program of China | 神经环路时空演变规律与多靶点感觉-中枢协同调控策略(项目名称:卒中神经调控重塑机制及个体化智能康复基础问题研究) | 150万 |
2025-2028 | 国家自然科学基金 面上项目(82471212) | CSF1R小胶质细胞脑病的cGAS-STING与线粒体质子泄漏的互作机制及TERT靶向干预探索 | 49万 |
2021-2024 | 科技部重点研发项目 (2021YFC2500103) National Key Research and Development Program of China | 血管性认知障碍的生物标志物谱系评价体系和智能诊疗研究:血管性认知障碍影像标志物及智能分级诊疗标准的建立 | 400万 |
SCI文章:
1. Jiwei Jiang, Tianlin Jiang, Xiaohong Wang, Min Zhao, Hanping Shi, Huiying Zhang, Wenyi Li, Shirui Jiang, Xiaoli Zhang, Jiawei Zhou, Qiwei Ren, Linlin Wang, Shiyi Yang, Zeshan Yao, Yaou Liu, Jun Xu*. Malnutrition exacerbating neuropsychiatric symptoms in Alzheimer's continuum is relevant to cAMP signaling pathway: human and mouse studies. Alz Dement. 2024. DOI:10.1002/alz.14506 (IF=14.5, 中科院一区, JCR: Q1)
2. Linlin Wang, Yong Jiang, Siding Chen, Wei Huang, Gaifen Liu, Jiwei Jiang, Shirui Jiang, Wenyi Li, Qiwei Ren, Shiyi Yang, Min Zhao, Huiying Zhang, Tianlin Jiang, Junya Zhou, Wei Shen, Xiaoyan Xu, Jianjian Liu, Cuicui Zhang, Yuzhen Xu, Jinbiao Zhang, Mei Cui, Qiang Dong, Jun Xu*, P3 Investigators. Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicenter prospective registry. Aging Med. 2024. DOI: 10.1002/agm2.12377 (IF=2.2, 中科院三区, JCR: Q3)
3. Jiwei Jiang, Kun Zhao*, Wenyi Li, Peiyang Zheng, Shirui Jiang, Qiwei Ren, Yunyun Duan, Huiying Yu, Xiaopeng Kang, Junjie Li, Ke Hu, Tianlin Jiang, Min Zhao, Linlin Wang, Shiyi Yang, Huiying Zhang, Yaou Liu, Anxin Wang, Yong Liu*, Jun Xu*, Xiaoli Zhang. A comprehensive multiomics study reveals potential relationships and biological mechanisms linking macroscale structural covariance network dysfunction with neuropsychiatric symptoms across the Alzheimer’s disease continuum. Biol Psych. 2024 Oct 15:S0006-3223(24)01666-4. DOI: 10.1016/j.biopsych.2024.08.027 (IF=10.6, 中科院一区, JCR: Q1)
4. Runzhi Li, Zhizheng Zhuo, Zeshan Yao, Zhaohui Li, Yanli Wang, Jiwei Jiang, Linlin Wang, Wenyi Li, Yanling Zhang, Jun Sun, Junjie Li, Yunyun Duan, Yi Liu, Hongyuan Shao, Yang li, Yechuan Zhang, Jinglong Chen, Hanping Shi, Hui Huang, Yaou Liu*, Jun Xu*. Neuroimaging analysis reveals distinct cerebral perfusion responses to fasting-postprandial metabolic switching in Alzheimer's disease patients. CNS Neurosci Ther. 2024;30:e70014. (IF=4.8, 中科院一区, JCR: Q1)
5. Gaoyang Wang, Aihua Qu, Maozhong Sun,* Jun Xu*, and Hua Kuang. Chemical Mechanisms and Biological Effects of Chiral Nanomaterials. Accounts Mat Res. 2024. DOI: 10.1021/accountsmr.4c00158. (IF=14.0, 中科院一区, JCR: Q1)
6. Jiwei Jiang, Zhizheng Zhuo, Anxin Wang, Wenyi Li, Shirui Jiang, Yunyun Duan, Qiwei Ren, Min Zhao, Linlin Wang, Shiyi Yang, Maher Un Nisa Awan, Yaou Liu*, Jun Xu*. Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer's continuum. Alzheimers Res Ther. 2024, Jul 3; 16(1): 149. doi: 10.1186/s13195-024-01520-w. (IF=7.9, 中科院一区, JCR: Q1)
7. Xiaohong Wang#, Yanli Wang#, Tianlin Jiang#, Jiwei Jiang, Linlin Wang, Shiyi Yang, Mengfan Sun, Yuan Zhang, Ziyan Jia, Wenyi Li, Qiwei Ren, Cuicui Zhang, Jianjian Liu, Yinwei Zhu, Jun Xu*. Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor (csf1r) P853T/+ in CSF1R-microglial encephalopathy. Genes & Diseases. 2024. DOI: 10.1016/j.gendis.2024.101289. in press. (IF=6.8, 中科院一区, JCR: Q1)
8. Runzhi Li#, Zhizheng Zhuo#, Yin Hong#, Zeshan Yao, Zhaohui Li, Yanli Wang, Jiwei Jiang, Linlin Wang, Ziyan Jia, Mengfan Sun, Yuan Zhang, Wenyi Li, Qiwei Ren, Yanling Zhang, Yunyun Duan, Yi Liu, Hongen Wei, Yechuan Zhang, Michael Chappell, Hanping Shi, Yaou Liu, Jun Xu*. Effects of the Fasting-Postprandial State on Arterial Spin Labeling MRI-Based Cerebral Perfusion Quantification in Alzheimer's Disease. JMRI. 2024 DOI: 10.1002/jmri.29348. (IF=5.1, 中科院二区, JCR: Q1/2)
9. Jiwei Jiang, Anxin Wang, Hanping Shi, Shirui Jiang, Wenyi Li, Tianlin Jiang, Linlin Wang, Xiaoli Zhang, Mengfan Sun, Min Zhao, Xinying Zou, Jun Xu *. Clinical and neuroimaging association between neuropsychiatric symptoms and nutritional status across the Alzheimer's disease continuum: a longitudinal cohort study. J Nutr Health Aging. 2024 Feb 8:100182. (IF=5.8, 中科院三区, JCR: Q1)
10. Meiru Lu, Changlong Hao, Liguang Xu, Feng Yu, Jiwei Jiang, Yanli Wang, Jun Xu*, Hua Kuang, Chuanlai Xu, Maozhong Sun*. TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer’s disease. Sci China Chem. 2024, https://doi.org/10.1007/s11426-023-1859-4 (IF=9.6, 中科院一区, JCR: Q1)
11. Jiwei Jiang, Yaou Liu, Anxin Wang, Zhizheng Zhuo, Hanping Shi, Xiaoli Zhang, Wenyi Li, Mengfan Sun, Shirui Jiang, Yanli Wang, Xinying Zou, Yuan Zhang, Ziyan Jia, Jun Xu*. Development and validation of a nutrition-related genetic-clinical-radiological nomogram associated with behavioral and psychological symptoms in Alzheimer's disease. Chin Med J (Engl). 2023 Nov 29. (IF=6.1, 中科院二区,JCR: Q1)
12. Tianlin Jiang, Jiahua Wang, Yanli Wang, Jiwei Jiang, Jiawei Zhou, Xiaohong Wang, Deke Zhang, Jun Xu*. Mitochondrial protein prohibitin promotes learning memory recovery in mice following intracerebral hemorrhage via CAMKII/CRMP signaling pathway. Neurochem Int. 2023 Nov 3:171:105637. DOI: 10.1016/j.neuint.2023.105637. (IF=4.2, 中科院三区, JCR: Q2)
13. Wenyi Li, Jiwei Jiang, Xiangchang Yin, Yuan Zhang, Xinying Zou, Mengfan Sun, Jianjun Jia, Baiping Ma, Jun Xu*. Mediation of Regional Cerebral Blood Flow in the Relationship between Specific Gut Microbiota and Cognition in Vascular Cognitive Impairment. J Alzheimers Dis. 2024;97(1):435-445. (IF=4.16, 中科院二区, JCR: Q2)
14. Jiwei Jiang, Anxin Wang, Yaou Liu, Zeshan Yao, Mengfan Sun, Tianlin Jiang, Wenyi Li, Shirui Jiang, Xiaoli Zhang, Yanli Wang, Yuan Zhang, Ziyan Jia, Xinying Zou, Jun Xu*. Spatiotemporal characteristics of regional brain perfusion associated with neuropsychiatric symptoms in patients with Alzheimer’s disease. J Alzheimers Dis. 2023 Aug 23. doi: 10.3233/JAD-230499. (IF=4.16, 中科院二区, JCR: Q2)
15. Yuzhen Xu, Ulises Gomez-Pinedo, Jun Liu, Daojun Hong, Jun Xu*. Editorial: Current advances in genetic presentations of dementia and aging, volume II. Front Aging Neurosci. 2023 May 31;15:1202532. doi: 10.3389/fnagi.2023.1202532. (IF=4.8, 中科院二区,JCR: Q2)
16. Yuzhen Xu, Shenfeng Qiu, Wenjun Tu, Jun Xu*. Editorial: Molecular biomarkers in the prediction, diagnosis, and prognosis of neurodegenerative diseases. Front Neurosci. 2023 Jun 8;17:1226675. doi: 10.3389/fnins.2023.1226675. (IF=4.3, 中科院二区,JCR: Q2)
17. Jiwei Jiang#, Yin Hong#, Wenyi Li, Anxin Wang, Shirui Jiang, Tianlin Jiang, Yanli Wang, Linlin Wang, Shiyi Yang, Qiwei Ren, Xinying Zou, Jun Xu*. Chain Mediation Analysis of the Effects of Nutrition and Cognition on the Association of Apolipoprotein E Allele 4 with Neuropsychiatric Symptoms in Alzheimer’s Disease. J Alzheimers Dis. 2023;96(2):669-681. doi: 10.3233/JAD-230577. (IF=4.2, 中科院二区,JCR: Q2)
18. Jiwei Jiang, Hanping Shi, Shirui Jiang, Anxin Wang, Xinying Zou, Yanli Wang, Wenyi Li, Yuan Zhang, Mengfan Sun, Qiwei Ren, Jun Xu*. Nutrition in Alzheimer's disease: a review of an underappreciated pathophysiological mechanism. Sci China Life Sci. 2023 Oct;66(10):2257-2279. doi: 10.1007/s11427-022-2276-6. (IF 10.37 中科院一区,JCR: Q1)
19. Mengfan Sun, Yan-li Wang, Runzhi Li, Jiwei Jiang,Yanling Zhang, Wenyi Li, Yuan Zhang, Ziyan Jia, Michael Chappell and JunXu*. Potential diagnostic applications of multi-delay arterial spinlabeling in early Alzheimer's disease: the CIBL study. Frontiers in Neurosci.2022 Jun (IF 4.086) Q2/3rd district)
20. Yan-li Wang, Mengfan Sun, Fangze Wang, XiaohongWang, Ziyan Jia, Yuan Zhang, Runzhi Li, Jiwei Jiang, Linlin Wang, Wenyi Li,Yongan Sun, Jinglong Chen, Cuicui Zhang, Shi Bao-Lin, Jianjian Liu, XiangrongLiu and Jun Xu*.Mediation of the APOE associations with cognition through cerebral blood flow:the CIBL study. Front Aging Neurosci. 2022 Jun (IF 5.702) Q1/2nd district
21. Jiwei Jiang, Wenyi Li, Xiaohong Wang,Zhongli Du, Jinlong Chen, Yaou Liu, Wei Li, Zhonghua Lu, Yan-li Wang and JunXu*. Two Novel Intronic Mutations in the CSF1R Gene in Two Familieswith CSF1R-Microglial Encephalopathy. Front. Cell Dev. Biol (IF 6.081) Q1/2nd district.
22. Yan-LiWang, Fang-ZeWang, Yuan Zhang, Jiwei Jiang, Ziyan Jia, Xiangrong Liu, JianWang, JunXu. Association of migraine with patent foramen ovale closure: asystematic review and meta-analysis.IJC Heart & Vasculature. 2022, DOI:10.1016/j.ijcha.2022.100992
23. Yan-LiWang, Fang-Ze Wang, Runzhi Li, Jiwei Jiang, Xiangrong Liu, Xu Jun*.Recent Advances in Basic Research for CSF1R-Microglial Encephalopathy. Front Aging Neurosci
2021 Dec 9;13:792840. DOI: 10.3389/fnagi.2021.792840 (IF 5.702) Q1/2nd district
24. Runzhi Li, Haoyi Weng, Yuesong Pan, XiaMeng, Xiaoling Liao, Mengxing Wang, Yuan Zhang, Yi Sui, Lijun Zuo, Yanli Wang,Ziyan Jia, Mengfan Sun, Wenyi Li, Yaou Liu, Jinglong Chen, Jun Xu*,Yongjun Wang*. Relationship Between Homocysteine Levels and Post-StrokeCognitive Impairment in Female and Male Population: From a ProspectiveMulticenter Study. J Transl Intern Med. 2021. Dec 31; 9(4): 264-272. DOI:10.2478/jtim-2021-0035 (IF 3.772) Q2
25. JiweiJiang, Xiuli Shang, Xiaoting Wang, Hanze Chen, Wenyi Li, Yanli Wang, XuJun*. Nitrous oxide-related neurological disorders: Clinical,laboratory, neuroimaging, and electrophysiological findings. Brain andBehavior. 2021 Nov 10; e2402. DOI: 10.1002/brb3.2402 (IF 3.405) Q3/4th district
重要奖项:
2022 | 江苏省科学技术奖(二等奖) | 神经毒性大分子清除代谢失稳态在神经退行性疾病中的作用及新靶标 |
2017 | 江苏省医学科技奖(科普)(2017-B-100100P4-1) | 对中风说不,对痴呆说不 |
2017 | 江苏省医学新技术引进奖(二等)(2017-181) | 综合认知能力评价量表在神经认知障碍中的应用 |
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