1)    “KCNT钾通道功能上调参与脑外伤后癫痫形成发病机制研究”，北京市自然科学基金，主持，2023～2025

2)    “基于NBC活性抑制的新型脑保护剂联合tPA溶栓治疗缺血性卒中应用策略”，绍兴上虞武汉理工高等研究院，主持，2023～2027

3)    “ITPKA/IP4与PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究”，国家自然科学基金，主持， 2019～2022

1)    “KCNT钾通道功能上调参与脑外伤后癫痫形成发病机制研究”，北京市自然科学基金，主持，2023～2025

2)    “基于NBC活性抑制的新型脑保护剂联合tPA溶栓治疗缺血性卒中应用策略”，绍兴上虞武汉理工高等研究院，主持，2023～2027

3)    “ITPKA/IP4与PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究”，国家自然科学基金，主持， 2019～2022

1)     Liu R, Sun L, Du L, Guo X, Jia M, Wang Q*, Wu J*. Enhanced KNa1.1 channel aggravates seizure susceptibility and elevates neuronal excitability after traumatic brain injury.  eLife  2023.

2)     Liu R, Sun L, Shi XR, Guo X, Wang YT, Xu Y, Wang X, Zhang K, Wang Q, Wang Y, Wu J*. Increased KNa1.2 Channel Regulated by MAPK Pathway Reduces Neuronal Excitability on Traumatic Brain Injury Mouse. Neurochem Res 2023.

3)     Zahra A, Liu R, Wang J, Wu J*. Identifying the mechanism of action of the Kv7 channel opener, retigabine in the treatment of epilepsy. Neurol Sci. 2023 Jul 13. doi: 10.1007/s10072-023-06955-x.

4)     Guo X, Liu R, Jia M, Wang Q, Wu J*. Ischemia Reperfusion Injury Induced Blood Brain Barrier Dysfunction and the Involved Molecular Mechanism. Neurochem Res. 2023 Aug;48(8):2320-2334. doi: 10.1007/s11064-023-03923-x. 

5)     Liu R, Sun L, Wang YF, Wang Q, Wu J*. New use for an old drug: quinidine in KCNT1-related epilepsy therapy. Neurol Sci. 2023 Apr; 44(4):1201-1206. doi: 10.1007/s10072-022-06521-x.  

6)     Zahra A, Liu R, Han W, Meng H, Wan Q, Wang Y, Campbel SL, Wu J*. KCa-Related Neurological Disorders: Phenotypic Spectrum and Therapeutic Indications. Curr Neuropharmacol. 2023;21(7):1504-1518. doi: 10.2174/1570159X21666221208091805.  

7)     Xiong H, Wu J*, Qin HL*. [3+2]Cycloaddition for the assembly of indolizine-based heterocyclic sulfonyl fluorides. Org Chem Front 2022 Nov 22. doi: 10.1039/D2QO01466A

8)     Wang J, Zahra A, Wang Y, Wu J*. Understanding the physiological role of electroneutral Na+-coupled HCO3− cotransporter and its therapeutic implications. Pharmaceuticals (Basel). 2022,15, 1082. doi.org/10.3390/ph15091082.

9)     Zhang Q, Jia M, Zahra A, Wang Y, Wang Q, Campbell SL, Wu J*. Cell death in cerebral ischemia-reperfusion injury. Neurochem Res. 2022 Aug 17. doi: 10.1007/s11064-022-03697-8.

10)  Xia H, Zahra A, Jia M, Wang Q, Wang Y, Campbell SL, Wu J*. Na+/H+ exchanger 1, a potential therapeutic drug target for cardiac hypertrophy and heart failure. Pharmaceuticals (Basel). 2022 Jul 15;15(7). doi: 10.3390/ph15070875.

11)  Jia M, Zhang Q, Guo X, Liu R, Liu S, Chen N, Wang YF, Wang Q, Wu J*, Campbell SL. Na+/HCO3- Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil's Hippocampus. CNS Neurol Disord Drug Targets. 2022 May 17; doi: 10.2174/1871527321666220517121135. 

12)  Zahra A, Wang Y, Wang Q, Wu J*. Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability. Behav Neurol. 2022; 2022:5893519. doi: 10.1155/2022/5893519. 

13)  Zahra A, Du L, Jia M, Butt MU, Wang Q, Wang Y, Wu J*. Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. J Integr Neurosci.2022 Mar 23;21(2):61. doi: 10.31083/j.jin2102061. 

14)  Sun L, Liu R, Yang H, Yu T, Wu J*, Wang Q*. Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats. Neurochem Res. 2022 Feb 1;. doi: 10.1007/s11064-022-03542-y. 

15)  Liu R, Sun L, Wang Y, Jia M, Wang Q, Cai X*, Wu J*. Double-edged Role of KNa Channels in Brain Tuning: Identifying Epileptogenic Network Micro-Macro Disconnection. Curr Neuropharmacol. 2022;20(5):916-928. doi: 10.2174/1570159X19666211215104829. 

16)  Du L, Zahra A, Jia M, Wang Q, Wu J*. Understanding the Functional Expression of Na+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review. Brain Sci. 2021 Sep 26;11(10). doi: 10.3390/brainsci11101276. 

17)  Sun L, Shan W, Yang H, Liu R, Wu J*, Wang Q*. The Role of Neuroinflammation in Post-traumatic Epilepsy. Front Neurol. 2021;12:646152. doi: 10.3389/fneur.2021.646152. 

18)  Lu M, Jia M, Wang Q, Guo Y, Li C, Ren B, Qian F, Wu J*. The electrogenic sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases. Life Sci. 2021 Apr 1;270:119153. doi: 10.1016/j.lfs.2021.119153. 

19)  Martinez-Espinosa PL#, Wu J#, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ. Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife. 2015 Nov 11;4. doi: 10.7554/eLife.10013. 

20)  Thornell IM, Wu J, Liu X, Bevensee MO. PIP2 hydrolysis stimulates the electrogenic Na+-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes. J Physiol. 2012 Dec 1;590(23):5993-6011. doi: 10.1113/jphysiol.2012.242479. 

21)  Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL. ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3888-93. doi: 10.1073/pnas.0913001107. 

22)  Wu J, McNicholas CM, Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes. Proc Natl Acad Sci USA. 2009 Aug 18;106(33):14150-5. doi: 10.1073/pnas.0906303106. 

23)  Wu J, Hablitz JJ. Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons. J Neurosci. 2005 Jul 6;25(27):6322-8. doi: 10.1523/JNEUROSCI.1405-05.2005. 

24)  Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F, Jiang C. Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP. J Cell Physiol. 2004 Jan;198(1):73-81. doi: 10.1002/jcp.10388. 

25)  Wu J, Xu H, Yang Z, Wang Y, Mao J, Jiang C. Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. J Membr Biol. 2002 Nov 15;190(2):105-16. doi: 10.1007/s00232-002-1029-1. 

26)  Wu J, Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C. Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. J Physiol. 2002 Sep 1;543(Pt 2):495-504. doi: 10.1113/jphysiol.2002.025247.