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蒋宏峰,首都医科大学附属北京安贞医院教授,博导,北京市特聘专家,长期从事心血管代谢相关疾病的发病机制、临床转化与分子诊断研究,在质谱代谢组学、心血管疾病相关蛋白的修饰与功能机制、疾病干预靶点筛选等方面做了一系列工作。现为中国病理生理学会、中国生物化学与分子生物学会、美国生物化学与分子生物学会、美国质谱学会等多家学会与专委会的会员、委员、常委,多家专业杂志审稿人,发表SCI论文70余篇,总影响因子逾300,被引用超过5000次。
(1)北京市自然科学基金委,京津冀基础研究合作专项,J190010,腹主动脉瘤代谢分型和诊治的精准医学研究,2019-10到2022-09,20万元,在研,主持。
(2)国家自然基金委, 国自然面上项目, 81970392, IL-1β激活巨噬细胞TRAF6-YAP通路促进动脉粥样硬化的发生及其机制研究, 2020-01到2023-12, 60.5万元, 在研, 主持。
1. Wang B. Tang X. Yao L. Wang Y. Chen Z. Li M. Wu N. Wu D. Dai X. Jiang H. Ai D. Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis. J Clin Invest. 2022 May 16;132(10):e154217.
2. Li B. Zhang T. Liu M. Cui Z. Zhang Y. Liu M. Liu Y. Sun Y. Li M. Tian Y. Yang Y. Jiang H. Liang D. RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice. Elife. 2022 Jan 10;11:e69906.
3. Dong T. Zhang S. Chang Y. Bai R. Jiang Y. Ma S. Li Y. Jiang HF. Lu WJ. The establishment of a homozygous SNTA knockout human embryonic stem cell line (WAe009-A-50) using the CRISPR/Cas9 system. Stem Cell Res. 2021 Mar;5:096. doi: 0.06/j.scr.0.096.
4. Chang Y. Li YN. Bai R. Wu F. Ma S. Saleem A. Zhang S. Jiang Y. Dong T. Guo T. Hang C. Lu WJ. Jiang H. Lan F. hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation. Stem Cell Res Ther. 2021 May 7;12(1):278. doi: 10.1186/s13287-021-02346-1.
5. Liu T. Zhang S. Huang C. Ma S. Bai R. Li Y. Chang Y. Hang C. Saleem A. Dong T. Guo T. Jiang Y. Lu W. Zhang L. Jianwen L. Jiang H. Lan F. Microscale grooves regulate maturation development of hPSC-CMs by the transient receptor potential channels (TRP channels). J Cell Mol Med. 2021 Apr;25(7):3469-3483. doi: 10.1111/jcmm.16429.
6. Liu M. Yan M. Lv H. Wang B. Lv X. Zhang H. Xiang S. Du J. Liu T. Tian Y. Zhang X. Zhou F. Cheng T. Zhu Y. Jiang H. Cao Y. Ai D. Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis. Cell Rep. 2020 Aug 4;32(5):107990. doi: 10.1016/j.celrep.2020.107990.
7. Yan M. Cai WB. Hua T. Cheng Q. Ai D. Jiang HF. Zhang X. Lipidomics reveals the dynamics of lipid profile altered by omega-3 polyunsaturated fatty acid supplementation in healthy people. Clin Exp Pharmacol Physiol. 2020 Jul;47(7):1134-1144. doi: 10.1111/1440-1681.13285.
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