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粟斌,留法病毒学博士,首都医科大学附属北京佑安医院研究员、首都医科大学教授、博士生导师。担任科技部中法艾滋病研究联合实验室主任、北京佑安医院中心实验室主任、艾滋病实验室主任、科技成果转化中心副主任、以及首都医科大学艾滋病临床诊疗与研究中心(佑安)执行副主任。曾任国家自然科学基金委员会医学科学部医学科学六处感染科学/检验医学流动编制项目主任。入选科技部首批中法杰出青年科研人员、国家重点研发计划“政府间国际科技创新合作”重点专项首席科学家、北京市第十二批海外高层次人才、北京市特聘专家、首都高层次公共卫生技术人才-病原鉴定、诊断和检测专业方向学科带头人、北京市科学技术进步奖和江苏省科学技术奖二等奖获得者,以及2023年度全球前2%顶尖科学家(病毒学领域)入选者。担任中华医学会医学病毒学分会常务委员和青年学组副组长、北京医学会医学病毒学分会常务委员兼秘书、中国免疫学会感染免疫分会常务委员、北京防痨协会结核病基础专业分会常务委员、北京海外高层次人才协会理事,及国家卫生健康委员会全球卫生人才后备库成员等社会职务。
粟斌2010年博士毕业于法国巴黎第七大学,2011-2015年在法国斯特拉斯堡大学和法国国家健康与医学研究院(INSERM)从事HIV感染发病机制及艾滋病疫苗的研发工作。2015年底归国后长期从事HIV感染与免疫应答、艾滋病功能性治愈,以及新发突发传染病的研究工作,主持科技部2023年国家重点研发计划(项目和课题负责人)、国家“十三五”传染病重大专项(子任务负责人)、国家自然科学基金面上项目(3项),以及北京市自然科学基金重点研究专题项目等20余项国家级和省部级项目。已在Blood、Cell、Lancet GH、Lancet RH-WP、NEJM、Nat Commun等国际学术专业期刊上发表SCI论文150余篇,其中以第一或通讯作者(含并列)发表SCI论文84篇,中文核心58篇,被邀请作为The Lancet HIV, Chinese Medical Journal,中国艾滋病性病 等30余个中外期刊的副主编、编委和审稿人。
自2019年获得首都医科大学研究生招生资格至今,粟斌老师已招收学术型博士7名,学术型硕士10余名。学生们在学术上积极探讨、刻苦钻研;在生活中也能互帮互助、相处融洽。科研方面,粟斌老师对学生们耐心指导,循循善诱,鼓励学生们开拓思维,并给予科研和实践上的鼎力支持。生活中,粟斌老师非常关心学生的实际困难及心理状态,充分理解和帮助学生。导师与学生们共同组建成了一个活泼共建,温馨互助的课题组。整个团队成员组成结构合理,学术氛围浓厚,协同合作,协力并进。
1. 2024年度国家自然科学基金(NSFC)面上项目:Akt抑制剂调控TEMRA亚群细胞线粒体功能及代谢对HIV感染者T细胞免疫衰老影响的研究;课题编号:82472266,2025/01-2028/12,在研。
2. 2023年科技部国家重点研发计划“政府间国际科技创新合作”重点专项(2023年度第二批,指南方向:2.0 中国和欧洲国家联合实验室合作项目);项目名称:中法艾滋病研究联合实验室(2023YFE0116000);2023/12-2026/11,在研。
3. 2023年科技部国家重点研发计划“病原学与防疫技术体系研究”重点专项;项目名称:重大传染病病原体变异株的快速识别技术及诊疗决策智能支持系统开发与评价;课题2负责人:重大传染病病原体关键变异及分子机制研究(2023YFC2308302);2023/12-2026/11,在研。
4. 2022年度北京市自然科学基金-海淀原始创新联合基金,海淀前沿项目:HIV感染者接种新冠灭活疫苗诱导的T细胞免疫应答特征;资助编号:L222068;北京市自然科学基金委员会;2023/01-2025/12;在研。
5. 2022年度北京市自然科学基金重点研究专题资助项目,项目名称:cGAS-STING信号通路在HIV合并结核分枝杆菌感染中的作用机制及转化研究;资助编号:Z220018;北京市自然科学基金委员会;2022/10-2026/10;在研。
6. 2022年度首批首都“高层次公共卫生技术人才建设项目”(北京市卫生系统高层次公共卫生技术人才-学科带头人),病原鉴定、诊断和检测专业方向,学科带头人,培养计划编号:2022-2-018;北京市卫生健康委员会;2022/04-2025/04;在研。
7. 2019年度国家自然科学基金(NSFC)面上项目:记忆性CD8+ T细胞亚群的功能在艾滋病患者免疫重建中的分子机制研究;课题编号:81974303,2020/01-2023/12,结题。
8. 2017年艾滋病和病毒性肝炎等重大传染病防治,重大传染病新型治疗技术及方案研究;项目名称:艾滋病功能性治愈策略与临床研究;子任务负责人:基因治疗对抗病毒疗效以及HIV感染者免疫应答研究;课题编号: 2017ZX10202102-005-003,2017/01-2020/12,结题。
9. 2017年度国家自然科学基金(NSFC)面上项目:记忆性B细胞亚群在艾滋病患者免疫重建中的变化规律、功能及其机制研究;课题编号:81772165,2018/01-2021/12,结题。
10. 2016年度高层次留学人才回国资助,中华人民共和国人力资源和社会保障部及北京市人力资源和社会保障局,2016/05-2019/05,结题。
1. 国际上首次合作在人体内探索了基于CRISPR/Cas9技术的成体造血干细胞基因编辑技术,证实了其在患有艾滋病合并白血病患者中移植的可行性和安全性(NEJM 2019),为艾滋病的临床治愈带来了跨越性进展;
2. 阐明了HIV 感染的免疫发病机制,代谢、转录后调控等与HIV 感染者免疫重建不良的发生机制及其影响因素,填补了相关领域空白(Infection 2024, Chin Med J 2024, 2023&2022, J Med Virol 2023&2022, JAMA Netw Open 2022, Front Immunol 2025, 2022&2021, Lancet Glob Health 2021, J Leukoc Biol 2020, Blood 2012);
3. 围绕国家重大战略需求,以临床问题为导向,开展多项全国多中心艾滋病药物III期临床试验,促进我国原研抗艾新药迈出国门,让患者有了更多的用药选择(Chin Med J 2024, Lancet Reg Health West Pac 2023, J Infect 2022, Chin Med J 2020, Front Pharmacol 2019);
4. 通过高通量单细胞测序快速筛选出强效的抗病毒全人源单克隆中和抗体,并联合参与组建“新冠肺炎单细胞研究中国联盟”,揭示了新冠病毒感染发病机制和免疫学特征等(Cell 2021&2020, Chin Med J 2022, Front Immunol 2021, Sci China Life Sci 2021, Cell Mol Immunol 2020)。
1. Xu P#, Yuan D#, Moog C*, Su B*. Efforts toward achieving the goal of ending AIDS by 2030: from antiretroviral drugs to HIV vaccine and cure research. SCIENCE CHINA LIFE SCIENCES, 2025 Mar 4. doi: 10.1007/s11427-024-2840-4.
2. Xiao J#, Wang F#, Yan H, Wang B, Su B*, Lu X*, Zhang T*. Memory stem CD8+ T cells in HIV/Mtb mono- and co-infection: characteristics, implications, and clinical significance. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024 Dec 10:14:1485825.
3. Han X#, Wang X#, Han F#, Yan H, Sun J, Zhang X, Moog C, Zhang C*, Su B*. The cGAS-STING pathway in HIV-1 and Mycobacterium tuberculosis coinfection. INFECTION, 2024 Nov 7. doi: 10.1007/s15010-024-02429-0.
4. He X#, Wang X#, Li S, Li N, Li W, Hu Y, Guo N, Zheng Y*, Zheng H*, Su B*. Immunosenescence and its related comorbidities in older people living with HIV. INFECTIOUS DISEASES & IMMUNITY, 2024 Aug 21; DOI: 10.1097/ID9.0000000000000134.
5. Ye J#, Dong Y#, Lan Y#, Chen J#, Zhou Y#, Liu J#, Yuan D#, Lu X#, Guo W#, Zheng M#, Yang H#, Song X#, Liu C#, Zhou Q#, Zheng C#, Guo Q#, Yang X#, Zhang L#, Ge Z#, Liu L#, Yu F#, Han Y#, Huang H#, Hao M#, Ruan Y#, Wu J#, Li J#, Chen Q#, Ning Z#, Ling X#, Zhou C#, Liu X#, Bai J#, Gao Y#, Tong X#, Zhou K#, Mei F#, Yang Z#, Wang A#, Wei W#, Qiao R#, Luo X#, Huang X#, Wang J#, Shen X#, Hu F#, Zhang L#, Tan W#, Fan J#, Tu A#, Yu G#, Fang Y#, He S#, Chen X#, Wu D#, Zhang X#, Xin R#, He X#, Ren X#, Xu C#, Sun Y#, Li Y#, Liu G#, Li X#, Duan J#, Huang T#, Shao Y#, Feng Y#, Pan Q#, Su B#, Jiang T#, Zhao H#, Zhang T#, Chen F#, Hu B#, Wang H#, Zhao J#, Cai K#, Sun W#, Gao B#, Ning T#, Liang S#, Huo Y#, Fu G#, Li F#, Lin Y*, Xing H*, Lu H*. Trends and Patterns of HIV Transmitted Drug Resistance in China From 2018 to 2023. THE JOURNAL OF INFECTIOUS DISEASES, 2024 Aug 27:jiae303.
6. Ye J#, Lan Y#, Wang J#, Feng Y#, Lin Y#, Zhou Y#, Liu J#, Yuan D#, Lu X#, Guo W#, Zheng M#, Song X#, Zhou Q#, Yang H#, Zheng C#, Guo Q#, Yang X#, Yang K#, Zhang L#, Ge Z#, Liu L#, Yu F#, Han Y#, Huang H#, Hao M#, Chen Q#, Ling X#, Ruan Y#, Dong Y#, Zhou C#, Liu X#, Bai J#, Tong X#, Gao Y#, Yang Z#, Wang A#, Wei W#, Mei F#, Qiao R#, Luo X#, Huang X#, Chen J#, Hu F#, Shen X#, Tan W#, Tu A#, Zhang X##, He S, Ning Z#, Fan J#, Liu C#, Xu C#, Ren X#, Sun Y#, Li Y#, Liu G#, Li X#, Li J#, Duan J#, Huang T#, Liu S#, Yu G#, Wu D#, Shao Y#, Pan Q#, Zhang L#, Su B#, Wu J#, Jiang T#, Zhao H#, Zhang T#, Chen F#, Cai K#, Hu B#, Wang H#, Zhao J#, Gao B#, Sun W#, Ning T#, Li J#, Liang S#, Huo Y#, Fu G#, Chen X#, Li F*, Xing H*, Lu H*. Improvement in the 95-95-95 Targets Is Accompanied by a Reduction in Both the Human Immunodeficiency Virus Transmission Rate and Incidence in China. THE JOURNAL OF INFECTIOUS DISEASES, 2024 Nov 15;230(5):1202-1214.
7. Fang D#, Liu Y#, Dou D, Su B*. The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapies. VIROLOGICA SINICA, 2024 Oct;39(5):709-718.
8. Wang X#, Li Y#, Jin J, Chai X, Ma Z, Duan J, Zhang G, Huang T, Zhang X, Zhang T, Wu H, Cao Y, Su B*. Severe acute respiratory syndrome coronavirus 2-specific T-cell responses are induced in people living with human immunodeficiency virus after booster vaccination. CHINESE MEDICAL JOURNAL, 2024 Nov 20;137(22):2734-2744.
9. Yuan D#, Zhao F#, Liu S, Liu Y, Yan H, Liu L, Su B#,*, Wang B*. Dual Infection of Different Clusters of HIV in People Living with HIV Worldwide: A Meta-Analysis Based on Next-Generation Sequencing Studies. AIDS PATIENT CARE AND STDS, 2024 Aug;38(8):348-357.
10. Han X#, Sun J#, Zhang Y#, Jiang T#, Zheng Q, Peng H, Wang Y, Xia W, Zhang T, Sun L, Yun X, Qin H*, Wu H*, Su B*. Population pharmacokinetics of Ainuovirine and exposure-response analysis in human immunodeficiency virus-infected individuals. CHINESE MEDICAL JOURNAL, 2024 Oct 20;137(20):2473-2482.
11. Li L#, Feng X#, Zhao F, Yuan D, An X, Tian X, Wu H, Su B*, Zhang T*, Liu L*. Real-world performance of HIV low viral load values in diagnosing acute HIV infection in a tertiary care hospital in Beijing, China. BMC INFECTIOUS DISEASES, 2024 Jun 15;24(1):587.
12. Sun J#, Han X#, Yan H#, Zhang X, Jiang T, Zhang T, Wu H, Kaminskiy G, Ma Y*, Karamov E*, Su B*. Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis. BIOSAFETY AND HEALTH, 2024 Apr 26. doi:10.1016/j.bsheal.2024.04.003.
13. Yuan L#, Liu Z#, Zhang X, Wei F, Guo S, Guo N, Liu L, Ma Z, Ji Y, Wang R, Lu X, Li Z, Xia W, Wu H, Zhang T*, Su B*. Development of a droplet digital polymerase chain reaction assay for the sensitive detection of total and integrated HIV-1 DNA. CHINESE MEDICAL JOURNAL, 2024 Mar 20;137(6):729-736.
14. Wang Y#, Lan X#, Qiao Y#, Huo Y#, Wang L, Liang S, Yu M, Song M, Yan Y*, Su B*, Xu J*. Safety and immunogenicity of homologous prime-boost CoronaVac vaccine in people living with HIV in China: A multicenter prospective cohort study. JOURNAL OF MEDICAL VIROLOGY, 2024 Jan;96(1):e29395.
15. Lin L, Zhu A, Su B*, Moog C*. Role of Fc-mediated Ab functions in HIV and SARS-CoV-2 vaccine prevention. INFECTION CONTROL, 2024;1(1):26-31.
16. Wang X#, Zhang X#, Lu X, Li Z, Liu L, Wu H, Zhang T, Su B*. Glut1 expression on CD8dim T cells is associated with immune recovery in HIV-1-infected individuals. CHINESE MEDICAL JOURNAL, 2023 Dec 20;136(24):2999-3001.
17. Jin J#, Wang X#, Li Y, Yang X, Wang H, Han X, Sun J, Ma Z, Duan J, Zhang G, Huang T, Zhang T, Wu H, Zhang X*, Su B*. Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine. CHINESE MEDICAL JOURNAL, 2023 Dec 20;136(24):2938-2947.
18. Li S#, Wang H#, Guo N#, Su B*, Lambotte O*, Zhang T*. Targeting the HIV Reservoir: Chimeric Antigen Receptor Therapy for HIV Cure. CHINESE MEDICAL JOURNAL, 2023 Nov 20;136(22):2658-2667.
19. Wang H#, Xu S#, Li S#, Su B*, Sherrill-Mix S*, Liang G*. Virome in immunodeficiency: What we know currently. CHINESE MEDICAL JOURNAL, 2023 Nov 20;136(22):2647-2657.
20. Li S#, Su B#, Wu H, He Q*, Zhang T*. Integrated analysis of gut and oral microbiome in men who have sex with men with HIV Infection. MICROBIOLOGY SPECTRUM, 2023 Oct 18:e0106423.
21. Li X#, Su B#, Yang L#, Kou Z#, Wu H, Zhang T, Liu L, Han Y, Niu M, Sun Y*, Li H*, Jiang T*. Highly sensitive and rapid point-of-care testing for HIV-1 infection based on CRISPR-Cas13a system. BMC INFECTIOUS DISEASES, 2023 Sep 25;23(1):627.
22. Wu X#, Wu G#, Ma P#, Wang R#, Li L#, Chen Y, Xu J, Li Y, Li Q, Yang Y, Wang L, Xin X, Qiao Y, Fu G*, Huang X*, Su B*, Zhang T*, Wang H*, Zou H*. Associations of modern initial antiretroviral therapy regimens with all-cause mortality in people living with HIV in resource-limited settings: a retrospective multicenter cohort study in China. NATURE COMMUNICATIONS, 2023 Sep 2;14(1):5334.
23. Wu X#, Wu G#, Ma P#, Wang R#, Li L#, Sun Y, Xu J, Li Y, Zhang T, Li Q, Yang Y, Wang L, Xin X, Qiao Y, Fang B, Lu Z, Zhou X, Chen Y, Liu Q, Fu G, Wei H*, Huang X*, Su B*, Wang H*, Zou H*. Immediate and long-term outcomes after treat-all among people living with HIV in China: an interrupted time series analysis. INFECTIOUS DISEASES OF POVERTY, 2023 Aug 14;12(1):73.
24. Kuang YQ, Sun C, Ram DR, Moog C, Su B*. Editorial: Challenges and solutions for the incomplete immune restoration in HIV-infected patients under antiretroviral therapy. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023 Jun 14;13:1232699.
25. Su B#, Gao G#, Wang M#, Lu Y#, Li L#, Chen C#, Chen Y#, Song C, Yu F, Li Y, Liu Y, Luo Y, He H, Cheng C, Xu L, Zhang T, Sun L, Liu A, Xia W, Qin Y, Zhao Q*, Wei H*, Cai W*, Chen Y*, Zhang F*, Wu H*. Efficacy and safety of ainuovirine versus efavirenz combination therapies with lamivudine/tenofovir disoproxil fumarate for medication of treatment-naïve HIV-1-positive adults: week 48 results of a randomized controlled phase 3 clinical trial followed by an open-label setting until week 96. THE LANCET REGIONAL HEALTH - WESTERN PACIFIC, 2023 Apr 24;36:100769.
26. Su B, Vanham G*. Effectiveness of COVID-19 primary and booster vaccination in HIV-infected individuals. AIDS, 2023 Apr 1;37(5):837-839.
27. Wang H#, Zhu Z#, Zhang Y#, Jiang T, Zhang M, Wang Z, Zhang Y*, Zhao A*, Su B*. New insight into immune checkpoint inhibitors in the treatment of advanced renal cell carcinoma. SCIENCE CHINA LIFE SCIENCES, 2023 Apr;66(4):875-878.
28. Liu Y#, Li Z#, Lu X#, Kuang YQ#, Kong D, Zhang X, Yang X, Wang X, Mu T, Wang H, Zhang Y, Jin J, Xia W, Wu H, Zhang T, Moog C, Su B*. Dysregulation of memory B cells and circulating T follicular helper cells is a predictor of poor immune recovery in HIV-infected patients on antiretroviral therapy. JOURNAL OF MEDICAL VIROLOGY, 2023 Feb;95(2):e28559.
29. Zhang X#, Wang X#, Qin L#, Lu X, Liu Z, Li Z, Yuan L, Wang R, Jin J, Ma Z, Wu H, Zhang Y*, Zhang T*, Su B*. Changing roles of CD3+CD8low T cells in combating HIV-1 infection. CHINESE MEDICAL JOURNAL, 2023 Feb 20;136(4):433-445.
30. Jiang T#, Hou J#, Wei J, Mu T, Zhu G, Wang X, Qu D, Wu H, Zhang T, Su B*. A moderated serial mediation analysis of the association between HIV stigma and sleep quality in people living with HIV: a cross-sectional study. TRANSLATIONAL BEHAVIORAL MEDICINE, 2023 Jan 20;13(1):25-33.
31. Mu T#, Wei J#, Sun J, Jin J, Zhang T, Wu H, Su B*. Association of apolipoprotein E epsilon 4 and cognitive impairment in adults living with human immunodeficiency virus: a meta-analysis. CHINESE MEDICAL JOURNAL, 2022 Nov 20;135(22):2677-2686.
32. Li S#, Moog C#, Zhang T*, Su B*. HIV reservoir: antiviral immune responses and immune interventions for curing HIV infection. CHINESE MEDICAL JOURNAL, 2022 Nov 20;135(22):2667-2676.
33. Li S, Yang X, Moog C, Wu H, Su B*, Zhang T*. Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity. FRONTIERS IN IMMUNOLOGY, 2022 Nov 10;13:1015775.
34. Jin J, Wang X, Carapito R, Moog C*, Su B*. Advances in Research on COVID-19 Vaccination for People Living With HIV. INFECTIOUS DISEASES & IMMUNITY, 2022 Oct;2(4):213-218.
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