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刘光慧，中国科学院动物研究所研究员，中国医学科学院学术咨询委员会学部委员，国际生理科学联合会生理学院会士，国家自然科学基金委基础科学中心项目首席科学家。长期致力于衰老生物学及老年基础医学的系统性研究。在Cell，Nature，Science等杂志发表通讯作者文章百余篇，引用逾两万次，H指数82，连续入选Elsevier中国高被引学者（2020-2024）及全球前2%顶尖科学家榜单，授权发明专利35项（含2项PCT）。代表成果入选中国科学十大进展（2020；2023），中国生命科学十大进展（2018；2020；2023；2024），衰老相关成果入选国家“十三五科技创新成就展”基础研究领域重大成果。积极推动学科发展与科学传播，现任国际健康与寿命研究学会创会理事，中国抗衰老促进会副理事长，中国细胞生物学学会衰老细胞生物学分会会长，Life Medicine（JCR, Q1）主编，Protein & Cell副主编，Cell Reports编委，Aging Cell编委，PLoS Biology编委，“老顽童说”科普平台总编。获全国创新争先奖章、何梁何利基金科学与技术奖、谈家桢生命科学创新奖、中国科学院杰出科技成就奖、中国青年科技奖特别奖、科学探索奖、侨界贡献一等奖。
1. Lei J, Xin Z, Liu N, Ning T, JingY, QiaoY, He Z, Jiang M, Yang Y, Zhang Z, Zhao L, Li J, Lv D, Yan Y, Zhang H,Xiao L, Zhang B, Huang H, Sun S, Zheng F, Jiang X, Lu H, Dong X, Yue S, Ma C,Shuai J, Ji Z, Liu F, Ye Y, Yan K, Hu Q, Xu G, Zhao Q, Wu R, Cai Y, Fan Y,Jing Y, Wang Q, Reddy P, Lu X, Zheng Z, Liu B, Haghani A,Ma S, Suzuki K, Rodriguez Esteban C, Yang J, Song M, Horvath S, Zhang W, Li W,Xiang AP, Zhu L, Fu X, Zhao G, Izpisua Belmonte JC, Qu J*, WangS*, Liu GH*. Senescence-resistant human mesenchymal progenitor cellscounter aging in primates. Cell. 2025.188(18):5039-5061.
2. Geng L, Ping J, Wu R, Yan H, ZhangH, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y,Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, ZhangH, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, GouB, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, YangS, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J,Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*, Song M*, ZhangW*, Qu J*, Liu GH*. Systematic profiling reveals betaine as an exercisemimetic for geroprotection. Cell. 2025. 188(19):5426-5428.
3. Ding Y, Zuo Y, Zhang B, Fan Y, XuG, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, XiongM, Li J, Han Z, Sun S, Wang S, He F, Yang J*, Qu J*, Zhang W*, Liu GH*.Comprehensive human proteome profiles across a 50-year lifespan reveal agingtrajectories and signatures. Cell. 2025. 188(20): 5763-5784.
4. Yang Y, Lu X, Liu N, Ma S, ZhangH, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M,Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, LiJ, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhu G, Song W, Horvath S,Esteban CR, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J*, ZhangW*, Liu GH*. Metformin Decelerates Aging Clock in MaleMonkeys. Cell. 2024. 187(22):6358-6378.
5. Ma S, Ji Z, Zhang B, Geng L, CaiY, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, ZhangH, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X,Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F,Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*,Gu Y*, Liu GH*. Spatial Transcriptomic Landscape UnveilsImmunoglobin-associated Senescence as a Hallmark of Aging. Cell.2024. 187(24):7025-7044.
6. Sun S, Li J, Wang S, Li J, Ren J,Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z,Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ,Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J*,Zhang W*, Liu GH*. CHIT1-positive microglia drive motor neuron ageing inthe primate spinal cord. Nature. 2023. 624(7992):611-620.
7. Liu X, Liu Z, Wu Z, Ren J, Fan Y,Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L,Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, SongM, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, LiuGH*. Resurrection of endogenous retroviruses during aging reinforcessenescence. Cell. 2023. 186(2):287-304.
8. Wang S, Zheng Y, Li J, Yu Y,Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P,Qiao J, Zhou Q, Belmonte JC*, Qu J*, Tang F*, Liu GH*. Single-CellTranscriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600.
9. Ma S, Sun S, Geng L, Song M, WangW, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G,Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. CaloricRestriction Reprograms the Single-Cell Transcriptional Landscape of RattusNorvegicus Aging. Cell. 2020. 180(5):984-1001.
10. Zhang W, WanH, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y,Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 DeficiencyResults in Developmental Retardation in Cynomolgus Monkeys. Nature. 2018.560(7720):661-665.
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