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主要从事耳科学基础和临床研究，擅长各类中耳炎性疾病的手术治疗及听力障碍者听力重建及听觉植入。从事咽鼓管功能障碍、中耳炎发病机制等相关临床研究，以及听觉生理及耳聋分子生物学等方面的基础研究。先后赴美国Creighton大学医学院、美国House Ear Institute及宾州大学医学院耳鼻咽喉科系访问学者。现担任北京市职业病鉴定专家,北京市卫健委科普专家。中国医师协会耳鼻咽喉科专业委员会耳外科学组 委员，北京医学会耳鼻咽喉头颈外科分会青年委员，中国研究型医院学会听觉医学专业委员会委员，中国优生科学协会听觉医学分会委员，中国医疗保健促进会人工听觉分会委员，中国医疗保健促进会听力学分会委员，北京整合医学学会常务委员。《中华耳科学杂志》、《Journal of otology》、《Journal of Otorhinolaryngology》编委。先后承担国家自然科学基金两项, 省部级课题一项，参与编写、翻译专业著作5部，发表各类学术论文40余篇
1.Liu H, Giffen KP, Chen L, Henderson HJ, Cao TA, Kozeny GA, Beisel KW, Li Y, He DZ (2022) Molecular and cellular manifestations of biological aging of cochlear inner and outer hair cells. Cell Rep 39 (2), 110665. doi.org/10.1016/j.celrep.2022.110665.
2.Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ, Shen RJ, Wang TY, Janesick A, Chen BP, Gong SS, Kachar B, Jin ZB, He DZ (2022). Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction. Sci Adv 8, eabk0942. doi: https://doi.org/10.1101/2021.06.10.21258486.
3.Zhao XC, Henderson HJ, Wang TY, Bo Liu B, Li Y (2021). Deletion of clusterin protects cochlear hair cells against hair cell aging and ototoxicity. Neural Plast 9979157. doi: 10.1155/2021/9979157
4.Y Qi, W Xiong, S Yu, Z Du, T Qu, L He, W Wei, L Zhang, K Liu, Y Li, DZ He, Gong SS (2021). Deletion of C1ql1 causes hearing loss and abnormal auditory nerve fibers in the mouse cochlea. Front Cell Neurosci 15: 713651. doi: https://doi.org/10.3389/fncel.2021.713651.
5.Liu HZ, Giffen KP, Grati MH, Morrill SW, Li Y, Liu XZ, Briegel KJ, He DZ (2021). Transcription co-factor Lbh is necessary for survival of cochlear hair cells. J Cell Sci 134 (7): jcs254458. doi: https://doi.org/10.1242/jcs.254458.
6.Li Y, Liu HZ, Zhao XC, He DZ (2020). Endolymphatic potential measured from developing and adult mouse inner ear. Front Cell Neurosci 14: 584928. https://doi.org/10.3389/fncel.2020.584928
7.Liu H, Chen L, Giffen KP, Stringham ST, Li Y, Judge PD, Beisel KW, He DZZ (2018). Cell-specific transcriptome analysis shows that adult pillar and Deiters' cells express genes encoding machinery for specializations of cochlear hair cells. Front Mol Neurosci 11: 356. doi: 10.3389/fnmol.2018.00356.
8.Li Y, Zou Q, Zhang J (2018). Vincamine exerts protective effect on spiral ganglion neurons in endolymphatic hydrops guinea pig models. Am J Transl Res 10 (11): 3650-3663. doi: 10.12998/wjcc.v7.i12.1403.
9.Li Y, Liu H, Giffen KP, Chen L, Beisel KW, He DZZ (2018). Transcriptomes of cochlear inner and outer hair cells from adult mice. Sci Data 5: 180199. doi: 10.1038/sdata.2018.199.
10.Barta CL, Liu H, Chen L, Giffen KP, Li Y, Kramer KL, Beisel KW, He DZ (2018). RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells. Sci Data 5: 180005. doi: 10.1038/sdata.2018.5.
11.Li Y, Jia SP, Liu HZ, Tateya T. Guo WW, Yang SM, Beisel KW, He DZ (2018). Characterization of hair cell-like cells converted from supporting cells after Notch inhibition in cultures of the organ of Corti from neonatal gerbils. Front Cell Neurosci 12: 73. doi: 10.3389/fncel.2018.00073.
12.Li J, Zhao SQ, Yang L, Li Y, Ma XB, Wang DN, Ren R, Li Y (2017). Preoperative evaluation and intraoperative protection of the facial nerve in congenital aural atresia. Ear, Nose Throat J 96(12): E38-E43.
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