个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
从事虫媒病毒与宿主相互作用研究，主要方向为虫媒病毒所需关键宿主因子的鉴定及靶向新治疗方法的开发。承担国自然面上项目3项。在Nature Communications、Cell Reports、Emerging Microbes & Infection、PLoS Pathogens、Journal of Virology、Cell Discovery及病毒学报等杂志发表中英文论文二十余篇。
1. 国家自然科学基金面上项目，“S100A4+巨噬细胞亚群在寨卡病毒感染引起睾丸损伤中的作用及机制研究”，81871641，2019/01-2022/12，57万元，主持
2. 国家自然科学基金面上项目，“乙型脑炎病毒结合并利用生长激素及其受体穿越血脑屏障的机制研究”，82172266，2022/01-2025/12，55万元，主持
3. 国家自然科学基金面上项目，“ApoE+精母细胞在维持寨卡病毒感染睾丸过程中的作用及机制研究”，82372251，2024/01-2027/12，48万元，主持
1. Yang, W., Liu, L. B., Liu, F. L., Wu, Y. H.,Zhen, Z. D., Fan, D. Y., Sheng, Z. Y., Song, Z. R., Chang, J. T., Zheng, Y. T.*,An, J.*, Wang, P. G.* Single-cell RNA sequencing reveals the fragility of malespermatogenic cells to Zika virus-induced complement activation. Naturecommunications 14, 2476, (2023).
2. Liu, L. B., Yang, W., Chang, J. T., Fan, D. Y.,Wu, Y. H., Wang, P. G.*, An, J.* Zika virus infection leads to hormonedeficiencies of the hypothalamic-pituitary-gonadal axis and diminishedfertility in mice. Journal of virology 97, (2023).
3. Sheng, Z. Y., Li, M., Yang, R., Liu, Y. H.,Yin, X. X., Mao, J. R., Brown, H. E., An, J.*, Zhou, H. N.*, Wang, P. G.*COVID-19 prevention measures reduce dengue spread in Yunnan Province, China,but do not reduce established outbreak. Emerging microbes & infections 11,240-249, (2022).
4. Wang, Y. S., Liu, D., Wang, X., Luo, Q. L.,Ding, L., Fan, D. Y., Cai, Q. L., Tang, C. Y., Yang, W., Guan, Y. G., Li, T.F., Wang, P. G.*, Luan, G. M.*, An, J.* Rasmussen's encephalitis ischaracterized by relatively lower production of IFN-beta and activatedcytotoxic T cell upon herpes viruses infection. Journal of neuroinflammation19, 70, (2022).
5. Liu, L. B., Li, M., Gao, N., Shen, J. Y.,Sheng, Z. Y., Fan, D. Y., Zhou, H. N., Yin, X. X., Mao, J. R., Jiang, J. Y.*,Wang, P. G.*, An, J.* Epidemiological and clinical characteristics of thechikungunya outbreak in Ruili City, Yunnan Province, China. Journal of medicalvirology 94, 499-506, (2022).
6. Yang, W., Zhang, C., Wu, Y. H., Liu, L. B.,Zhen, Z. D., Fan, D. Y., Song, Z. R., Chang, J. T., Wang, P. G.*, An, J.* Mice3D testicular organoid system as a novel tool to study Zika virus pathogenesis.Virologica Sinica, (2022).
7. Sheng, Z., Gao, N., Fan, D., Wu, N., Zhang,Y., Han, D., Tan, W., Wang, P.*, An, J.* Zika virus disrupts the barrierstructure and Absorption/Secretion functions of the epididymis in mice. PLoSneglected tropical diseases 15, e0009211, (2021).
8. Wang, Z. Y., Zhen, Z. D., Fan, D. Y., Qin, C.F., Han, D. S., Zhou, H. N., Wang, P. G.*, An, J*. Axl Deficiency Promotes theNeuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1alpha Productionfrom Pyroptotic Macrophages. Journal of virology 94, (2020).
9. Wang, P. G., Tang, D. J., Hua, Z., Wang, Z.,An, J. Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2partially by inhibiting AP2M1 phosphorylation. Cell discovery 6, 71, (2020).
10. Yang, W., Wu, Y. H., Liu, S. Q., Sheng, Z.Y., Zhen, Z. D., Gao, R. Q., Cui, X. Y., Fan, D. Y., Qin, Z. H., Zheng, A. H.,Wang, P. G.*, An, J*. S100A4+ macrophages facilitate zika virus invasion andpersistence in the seminiferous tubules via interferon-gamma mediation. PLoSpathogens 16, e1009019, (2020).
11. Wu, Y. H., Cui, X. Y., Yang, W., Fan, D. Y.,Liu, D., Wang, P. G.*, An, J*. Zika Virus Infection in Hypothalamus CausesHormone Deficiencies and Leads to Irreversible Growth Delay and MemoryImpairment in Mice. Cell reports 25, 1537-1547 e1534, (2018).
12. Li, M. Y., Grandadam, M., Kwok, K., Lagache,T., Siu, Y. L., Zhang, J. S., Sayteng, K., Kudelko, M., Qin, C. F.,Olivo-Marin, J. C., Bruzzone, R.*, Wang, P. G.* KDEL Receptors Assist DengueVirus Exit from the Endoplasmic Reticulum. Cell reports 10, 1496-1507, (2015).
13. Kudelko, M., Brault, J. B., Kwok, K., Li, M.Y., Pardigon, N., Peiris, J. S. M., Bruzzone, R., Despres, P., Nal, B.*, Wang,P. G.* Class II ADP-ribosylation factors are required for efficient secretionof dengue viruses. The Journal of biological chemistry 287, 767-777,(2012).
文件上传中...
