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时红波,医学博士,研究员,博士生导师,北京市科技新星,北京市卫生系统高层次卫生技术人才。本科和硕士毕业于华中科技大学同济医学院,博士毕业于首都医科大学,曾在美国南加州大学做访问学者,现为首都医科大学附属北京佑安医院人工肝实验主任。
长期从事慢性肝病临床与基础研究。以第一完成人主持国家重点研发计划子课题、国家自然科学基金、北京市自然科学基金、北京市留学归国人员择优资助项目等多项课题,作为技术骨干参与了973、863、十一五、十二五、十三五等国家重大课题的研究工作。以第一作者或通讯作者发表论文40余篇,其中SCI论文17篇。研究论文获得2018年度第十四届北京青年优秀科技论文二等奖,2017和2020年度丰台青年优秀科技论文一等奖。现为中华医学会肝病学分会第八届委员会终末期肝病学组委员,欧美同学会医师协会传染病学分会委员。
1. 边境热点地区传染病发病机制与诊疗技术研究(2022YFC2305002),资助额度:330万,国家重点研发计划项目子课题,202212-202511.
2. 细胞自噬介导的糖代谢在新型冠状病毒感染T细胞免疫应答中的作用和机制(课题编号:M22030),资助额度:30万,北京市自然科学基金面上专项,202201-202312
3. ASPP2 介导的自噬信号通路在药物性肝损伤及肝衰竭中的作用机制(课题编号:7172102),资助额度:20万,北京市自然科学基金面上项目,201701-201912
4. 自噬在肝再生增强因子保护重型肝炎肝衰竭中的新作用及机制(课题编号:81300349),资助额度:23万,国家自然科学基金青年基金项目,201401-201612
5. 北京市卫生系统高层次卫生技术人才培养项目(课题编号:2014-3-090),资助额度:42万,北京市卫生和计划生育委员会,201412-201712.
6. 北京市科技新星计划(课题编号:Z131107000413016),资助额度:35万,北京市科委,201307-201707
7. ALR介导的自噬在重型肝炎肝衰竭中的新作用及机制(课题编号:7144216),资助额度:8万,北京市自然科学基金青年基金项目,201401-201512
8. ALR化学发光检测新方法的建立及在ACLF预后评估中的应用,资助额度:8万元,北京市人力资源和社会保障局,北京市留学归国人员择优资助项目,201401-201512
1) Zhang W, Zhang J, Shi H, Liu F, Yu H*, Shi H*. Exosome GLUT1 derived from hepatocyte identifies the riskof non-alcoholic steatohepatitis and fibrosis. Hepatol Int. 2023 Jun 6. doi:10.1007/s12072-023-10520-1.
2) Yao J, Yang H, Wang H, Shi H, Jiao Y, Zhang Y, Chen D, Shi H*. ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α. Front Pharmacol. 2022 Mar 28;13:865389.
3) Jiao Y#, Lu W#, Xu P, Shi H, Chen D, Chen Y*, Shi H*, Ma Y*. Hepatocyte-derived exosome may be as a biomarker of liver regeneration and prognostic valuation in patients with acute-on-chronic liver failure. Hepatol Int. 2021; 15(4):957-969.
4) Yao J#, Zhou X#, Yuan L, Niu LY, Zhang A, Shi H*, Duan Z*, Xu J*. Prognostic value of the third lumbar skeletal muscle mass index in patients with liver cirrhosis and ascites. Clin Nutr. 2020; 39(6): 1908-1913.
5) Shi H#, Wang W#, Yin J, Ouyang Y, Pang L, Feng Y, Qiao L, Guo X, Shi H, Jin R*, Chen D*. The Inhibition of IL-2/IL-2R Gives Rise to CD8 + T Cell and Lymphocyte Decrease Through JAK1-STAT5 in Critical Patients With COVID-19 Pneumonia. Cell Death Dis. 2020;11(6): 429.
6) Gao Y#, Li Q#, Shi H#, Feng Y, Zhang T, Chen Y, Liang L, Chen D, Wu H, Jin R, Huang X*. Preliminary Exploration of the Cause of Liver Disorders During Early Stages in COVID-19 Patients. Front Med (Lausanne). 2020; 7: 501.
7) Jiao Y, Xu P, Shi H, Chen D, Shi H*. Advances on liver cell-derived exosomes in liver diseases. J Cell Mol Med. 2021; 25(1):15-26.
8) Xu P#, Yao J#, Ji J, Shi H, Jiao Y, Hao S, Chen D, Shi H*. Deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by CCl4 via autophagy. Toxicol Lett. 2019; 316: 85-93.
9) Ji J, Zhou X, Xu P, Li Y, Shi H, Chen D, Li R*, Shi H*. Deficiency of apoptosis-stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia reperfusion in mice through upregulation of autophagy. J Cell Mol Med. 2019; 23(4):2457-2467.
10) Shi H*, Zhang Y, Ji J, Xu P, Shi H, Yue X, Ren F, Chen Y, Duan Z, Chen D*. Deficiency of apoptosis-stimulating protein two of p53 promotes liver regeneration in mice by activating mammalian target of rapamycin. Sci Rep. 2018; 8(1):17927.
11) Shi H, Han W, Shi H, Ren F, Chen D, Chen Y*, Duan Z*. Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice. Oncotarget. 2017; 8(8): 12637-12648.
12) Shi H, Shi H, Ren F, Chen D, Chen Y*, Duan Z*. Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin. J Cell Mol Med. 2017; 21(3): 500-509.
13) Shi HB#, Sun HQ#, Shi HL, Ren F, Chen Y, Chen DX, Lou JL, Duan ZP*. Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells.World J Gastroenterol. 2015; 21(17): 5250-5258.
14) Ren F#, Shi H#, Zhang L, Zhang X, Wen T, Xie B, Zheng S, Chen Y, Li L, Chen D, Duan Z. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. J Viral Hepat. 2016; 23(1):23-31.
15) Hongbo S, Yu C, Ming K, Honglin S, Ping HY, Ping DZ*. Augmenter of liver regeneration may be a candidate for prognosis of HBV related acute-on-chronic liver failure as a regenerative marker. Hepatogastroenterology, 2012; 59(118): 1933-1938.
16) Shi H#, Xie L#, Shi H, Yan L, Duan Z*. Characterization and Application of Monoclonal Antibody Against Hepatitis C Virus Nonstructual Protein Three. Hybridoma, 2012; 31(1): 54-59.
17) Hongbo Shi, Ming Kong, Gong Chen, Jun Zhao, Honglin Shi, Yu Chen, Frenk G Rowan. Compound pollen protein nutrinent increases albumin in cirrhotic rats. Gastroenterology Research, 2010; 3(6): 253-261.
1)时红波,张兴娜,刘超楠,卢旺,时红林.一种刺激树突状细胞成熟的方法及培养基,首都医科大学附属北京佑安医院,专利号:ZL202210338128.3.
2)时红波,陈德喜,焦彦,许萍,时红林.一种检测血浆中肝细胞来源外泌体的方法. 20190626,专利号:ZL201910559220.0
3)时红波,陈煜,陈德喜,时红林,焦彦,许萍. 一种检测和评估肝再生的标志物及其用途. 20190918,专利号:ZL201910882787.1
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