首都医科大学附属北京潞河医院内分泌代谢与免疫性疾病中心目前为首都医科大学博士及硕士研究生培养点、首都医科大学博士后流动站、北京市糖尿病防治研究重点实验室、北京市重点临床专科（内分泌）、国家标准化代谢性疾病管理中心(MMC)、国家内分泌代谢科肥胖诊疗联盟成员单位、中国研究型医院学会糖尿病临床技能培训中心、首都医科大学糖尿病研究所、首都医科大学糖尿病心肾并发症基础-临床联合实验室、北京市住院医师规范化培训基地、通州区科技创新团队，是京东地区集医、教、研、防于一体的内分泌医疗中心。

        本中心拥有医护人员及科研人员总共91人。医生和研究人员博士及在读比例占70%，高级职称14人。本中心是首都医科大学内分泌代谢专业博士及硕士研究生培养点、博士后流动站。目前教授3名、博士生导师2名，副教授/硕士生导师8名。团队主持国家级课题13项，包括科技部科技创新2030重大项目分课题、国自然青年及面上项目；省部级课题23项，校局级课题26项，区级课题76项，以及院级课题76项，总计获批课题206项，累计科研经费3386.78万元。同时荣获国家级发明专利及实用新型专利数十项。科室揽获多项人才荣誉与奖项，包括：北京市科技新星计划1项、北京市优秀人才培养项目2项、北京市青年托举人才计划1项、首都医科大学青年学者1项、首都医科大学自然科学技术奖2项，以及通州区高层次领军人才、运河人才、科技创新人才等多类别奖项共计7项。科室先后获得北京市模范集体，共青团北京市委员会“青年文明号”，中华妇女联合会“巾帼文明岗”，国家卫计委“改善医疗服务行动计划优秀服务岗”。 

        自2017年起，每年作为国家卫生计生委医政医管局县域内分泌学科发展助力工程试点项目交流基地(“蓝色县域”）。作为国家标准化代谢性疾病(MMC)省级管理中心和示范基地，接待来自全国各省市数百家医院的内分泌科室参观访问，累及培训千余人。

1. 国家自然科学基金面上项目，82170454，高糖下调血管平滑肌细胞中PDZK1促进糖尿病动脉粥样硬化的机制研究，2022.1-2025.1，主持，55万，在研。

2. 国家卫生健康委能力建设和继续教育中心，GWJJ2020100202，基于孕产记录及电子病历的妊娠期糖尿病机器学习模型构建及效果评估，2020.9.30- 2021.10.31，主持，2万，在研。

3. 北京市自然科学基金委员会，面上项目，7212055，PDZK1通过与EGFR相互作用抑制糖尿病动脉粥样硬化的研究，2021.1-2023.12，主持，20万，在研。

4. 北京市教委科技一般项目，KM202110025001，PDZK1通过抑制EGFR活化而抑制糖尿病心肌纤维化的研究，2021.1-2023.12，主持，15万，在研。

5. 北京慢性病防治与健康教育研究会，北京市科协项目，糖尿病专家科普宣传下乡送健康活动，2022.1-2022.12，主持，5万，结题。

6. 北京市通州区科学技术委员会，2023年度通州区卫生发展科研储备重点项目，基于城市副中心人群的全生命周期“三高共管”系统的构建与应用，KJ2023CX020，2023.1-2024.12，主持，10万，在研。

7. 北京市通州区科技计划， KJ2020CX001，潞河医院标准化代谢性疾病管理中心建设的相关研究，2020.1-2021.5，主持，225万，在研。

8. 北京市通州区科技计划（临床特色），KJ2019CX012-34，基于柔性传感器的“智慧袜”设计及其在糖尿病足患者中的初步应用，2019.1-2020.5，主持，5万。

9. 北京市通州区科技计划 (临床特色)， KJ2019CX013，内分泌与免疫转化医学研究，2019.1-2020.5， 主持，81.5万。

10. 北京市通州区医疗卫生科技专项，KJ2018CX007，骨髓间充质干细胞治疗糖尿病的机制研究，2018.1.1-2019-5-31，主持，145万。

11. 北京市通州区科委（临床特色），KJ2018CX009-46，基于医学影像大数据的甲状腺结节智能筛查和诊断系统的研究，2018.1-2019.5，主持，5万。

12. 北京市卫生和计划生育委员会北京市卫生与健康科技成果和适宜技术推广项目，TG-2017-23，以区医疗中心为核心的社区糖尿病管理模式社区推广应用，2017.1.15- 2017.7.1，主持，2.8万。

13. 北京通州区科技计划，KJ2017CX041，内分泌代谢相关疾病发病机制探讨与临床防治应用研究，2017.1-2018.5，主持，80万。

14. 北京市通州区科技计划，KJ2016CX030，糖尿病及其并发症发病机制探讨与临床防治应用研究，2016.01-2017.5，主持，100万。

15. 北京通州区科技计划，KJ2016CX025，干细胞治疗糖尿病国家级超净GMP实验室建设，2016.1-2017.5，主持，300万。

16. 北京市科委 首都市民健康培育项目， Z131100006813018，北社区2型糖尿病不同管理模式的对比研究，2013.10-2015.12，主持，15 万。

17. 首都医科大学 糖尿病防治研究北京市重点实验室开放课题，同卵双生子2型糖尿病易感基因研究， 2013.5-2014.12，主持，2.5万。

18. 首都卫生发展科研专项项目，首发2014-3-7081，北京人群2型糖尿病和妊娠期糖尿病相关性的分子遗传学研究，2014.6-2017.5 ，5 万。

19. 首都医科大学糖尿病防治研究北京市重点实验室开放课题， 2014TNBF03，青少年发病的成人型糖尿病家系遗传学研究  2014.1-2015.6，2.5万。

1. 国家级重大重点，科技部科技创新2030“癌症、心血管、呼吸和代谢性疾病防治研究”重大项目子课题——2型糖尿病标准化防控方案的优化与应用评价，项目编号：2023ZD0508100，2024.08-2028.07，100万，在研。

2. 国家级重大重点，国家重点研发计划“主动健康和人口老龄化科技应对”重点专项子课题——慢性肾脏病与代谢性疾病特征谱及共病诊断标准研究，项目编号：2024YFC3607400，2025.05-2028.04，100万，在研。

3. 国家自然科学基金面上项目，血管生成素样蛋白2调控炎症和糖脂代谢促进糖尿病心肌病的机制研究，项目编号：82370356，2024.01- 2027.12，49万，在研。

4. 国家自然科学基金面上项目，高糖下调血管平滑肌细胞中PDZK1促进糖尿病动脉粥样硬化的机制研究，项目编号：82170454，2022.01- 2025.12，55万，在研。

5. 北京自然科学基金面上项目，PDZK1通过与EGFR相互作用抑制糖尿病动脉粥样硬化的研究，项目编号：7212055，2021.1-2023.12，20万，结题。

6. 北京市教委科技一般项目，PDZK1通过抑制EGFR活化而抑制糖尿病心肌纤维化的研究，项目编号：KM202110025001，2021.1-2023.12，15万，结题。

代表性论文：

1.       Yanan Cheng, Yan Wang, Ruili Yin, Yongsong Xu, Yuechao Xu, Jianan Lang,Lingling Wei, Yuanyuan Zhang, Jing Ke, Dong Zhao*, Longyan Yang*; Reducedexpression of PDZK1 mediates fibroblast activation and cardiac fibrosis viaEGFR phosphorylation in diabetic cardiomyopathyLife sciences 2025 Aug13;379:123916 doi:10.1016/j.lfs.2025.123916

2.       Xiaotong Feng, Yongsong Xu, Lin Zhu, Kun Li, Lin Mao, Huan Dong, DongZhao*, Jing Ke*; Age and Gender Difference in the Association of MetabolicSyndrome and Peripheral Artery Disease Among Patients With Type 2 DiabetesMellitusInternational journal of vascular medicine 2025;2025:5572344doi:10.1155/ijvm/5572344

3.       Zhaohui Zheng, Bin Cao, Jing Ke*, Dong Zhao*; The effect of long-termglycemic burden on the incidence of diabetic foot ulcers: A retrospectivestudyJournal of diabetes and its complications 2025 Feb;39(2):108901doi:10.1016/j.jdiacomp.2024.108901

4.   Lu Wang, Simo Liu, Jing Ke, Bin Cao, Di Wang,Qianqian Zhao, Haolin Gong, Yuan Fang, Zhaohui Zheng, Caiguo Yu, Nannan Wu, YanMa, Ke Yu, Longyan Yang, Dong Zhao*; Association between metabolic visceral fatscore and left ventricular hypertrophy in individuals with type 2diabetesDiabetology & metabolic syndrome 2025 Mar 06;17(1):81doi:10.1186/s13098-025-01648-1

5.       Xianhua Li,Yingxiang Wang, Xiaotong Feng, Lin Mao, Jing Ke, Dong Zhao*; U-ShapedAssociation of Visceral Fat Area With Diabetic Peripheral NeuropathyJournal ofdiabetes research 2025;2025:3291418 doi:10.1155/jdr/3291418

6.  Longyan Yang,Ruili Yin, Ziyu Shan, Anqi Feng, Kun Li, Yan Wang, Ke Yu, Yongsong Xu, Lin Mao,Jianan Lang, Baoyu Zhang*, Dong Zhao*; Adipocyte-secreted ANGPTL2 promoteshyperuricemia through inhibiting AKT/ABCG2 signalingFree radical biology &medicine 2025 Jun;233:209-225 doi:10.1016/j.freeradbiomed.2025.03.048

7.  Simo Liu, JingKe, Xiaotong Feng, Yongsong Xu, Lin Zhu, Longyan Yang, Dong Zhao; Diabeticmicrovascular complications are associated with left ventricular hypertrophy inpatients with type 2 diabetes mellitusJournal of diabetes and its complications2025 Feb;39(2):108947 doi:10.1016/j.jdiacomp.2024.108947

8.       Lin Mao, RuiliYin, Longyan Yang, Dong Zhao; Elucidating the function of clusterin in theprogression of diabetic kidney diseaseFrontiers in pharmacology 2025;16:1573654doi:10.3389/fphar.2025.1573654

9.   Yuehong Liu#, Bin Cao#, Xinyu Wang, Jiali Zhong,Zhenyu Li, Ruchen Peng, Dong Zhao*, Ning Gu*, Qi Yang*. Ferumoxytol-enhanced MRvenography for mapping lower-extremity venous networks and evaluating varicoseveins in patients with diabetes. European radiology. 2024;doi:10.1007/s00330-024-10772-x

10.  Yan Wang,Ruili Yin, Xin Li, Baoyu Zhang, Yuan Wang, Lijie Zhang, Yanan Cheng, Dong Zhao;Morroniside Attenuates Rheumatoid Arthritis by Inhibiting RheumatoidSynoviocytes Invasion through the NF-κB/MMPs PathwayAnnals of clinical andlaboratory science 2024 Sep;54(5):604-617 

11.   Di Wang, LinMao, Kun Li, Lu Wang, Yan Wang, Longyan Yang; sJAM-C as a Potential Biomarkerfor Coronary Artery Stenosis: Insights from a Clinical Study in Coronary HeartDisease PatientsDiabetes, metabolic syndrome and obesity : targets and therapy2024;17:4857-4865 doi:10.2147/DMSO.S478526

12.   Xianhua Li, Haibin Wen, Jing Ke, Dong Zhao; Associationof constipation with all-cause mortality among individuals with type 2diabetes: A retrospective cohort studyJournal of diabetes investigation 2025Mar;16(3):501-509 doi:10.1111/jdi.14375

13.   Hongling Zhao, Ruili Yin, Yan Wang, Zihang Wang, LijieZhang, Yongsong Xu, Di Wang, Jianbo Wu, Lingling Wei, Longyan Yang, Dong Zhao;Association between blood heavy metals and diabetic kidney disease among type 2diabetic patients: a cross-sectional studyScientific reports 2024 1105;14(1):26823 doi:10.1038/s41598-024-77996-1

14.   Yali Wu, Xin Li, Jing Ke, Baoyu Zhang, Dong Zhao;Increased expression of omentin-1 is associated with synovitis and bonedestruction in rheumatoid arthritisClinical and experimental rheumatology 202407;42(7):1442-1450 doi:10.55563/clinexprheumatol/7pcgv7

15.   Bin Cao, Kun Li, Jing Ke, Dong Zhao; Trajectories ofRemnant Cholesterol are Associated with Diabetic Foot Ulcer in Adult Patientswith Type 2 Diabetes: A Retrospective Cohort StudyDiabetes, metabolic syndromeand obesity: targets and therapy 2024;17:3043-3051 doi:10.2147/DMSO.S461330

16.   Shuting Li, Jing Ke, Jiaxue Cheng, Dong Zhao, Ke Yu;Effect of Sleeve Gastric Surgery on Body Weight and Hypothalamic-Pituitary AxisHormone Levels in Patients with Polycystic Ovary SyndromeObesity surgery 2024Jul;34(7):2375-2382 doi:10.1007/s11695-024-07273-7

17.   Bin Cao, KunLi, Jing Ke, Dong Zhao; Impaired Sensitivity to Thyroid Hormones Is AssociatedWith the Change of Abdominal Fat in Euthyroid Type 2 Diabetes Patients: ARetrospective Cohort StudyJournal of diabetes research 2024;2024:8462987doi:10.1155/2024/8462987

18.   Yan Wang, KunLi, Shasha Yuan, Caiguo Yu, Ruili Yin, Di Wang, Yongsong Xu, Lijie Zhang,Lingling Wei, Yanan Cheng, Lin Mao, Dong Zhao, Longyan Yang; Angiopoietin-like4 is a potential biomarker for diabetic kidney disease in type 2 diabetespatientsJournal of diabetes investigation 2024 Dec;15(12):1763-1772doi:10.1111/jdi.14304

19.   Cai-Guo Yu, BinCao, Hao-Lin Gong, Jing Ke, Shao-Zhong Xian, Nan-Nan Wu, Dong Zhao; Primaryaldosteronism with postoperative elevation of aldosterone treated effectivelyby finerenone: A case reportJournal of clinical hypertension (Greenwich, Conn.)2024 Sep;26(9):1116-1120 doi:10.1111/jch.14877

20.    Kun Li, Longyan Yang*, Dong Zhao*. The relationshipbetween HbA1c control pattern and atherosclerosis progression of diabetes: aprospective study of Chinese population. Diabetology & metabolic syndrome.2024;16(1):127. doi:10.1186/s13098-024-01370-4

21.    Lijie Zhang, Yuanyuan Zhang, Lingling Wei, DanTian, Dong Zhao*, Longyan Yang*. Gestational diabetes mellitus affects thedifferentiation of hematopoietic stem cells in neonatal umbilical cord blood.Archives of gynecology and obstetrics. 2024; doi:10.1007/s00404-024-07513-2

22.    Yuehong Liu, Bin Cao, Xinyu Wang, Jiali Zhong,Zhenyu Li, Ruchen Peng, Dong Zhao, Ning Gu, Qi Yang; Ferumoxytol-enhanced MRvenography for mapping lower-extremity venous networks and evaluating varicoseveins in patients with diabetesEuropean radiology 2024 Nov;34(11):7197-7207doi:10.1007/s00330-024-10772-x

23.    Simo Liu#, Jing Ke#, Xiaotong Feng, Zongwei Wang,Xin Wang, Longyan Yang*, Dong Zhao*. The Effect of Canagliflozin onHigh-Density Lipoprotein Cholesterol and Angiopoietin-Like Protein 3 in Type 2Diabetes Mellitus. Journal of diabetes research. 2024; 2024:2431441.doi:10.1155/2024/2431441

24.    Longyan Yang#, Yan Wang#, Yongsong Xu, Kun Li,Ruili Yin, Lijie Zhang, Di Wang, Lingling Wei, Jianan Lang, Yanan Cheng, LuWang, Jing Ke*, Dong Zhao*. ANGPTL3 is a novel HDL component that regulates HDLfunction. Journal of translational medicine. 2024;22(1):263.doi:10.1186/s12967-024-05032-x

25.    Yan Wang, Yue Zhang, Jinglong Xue, Leqiang Gao,Xiangyang Li, Moxuan Zhao, Dong Zhao*, Xianqing Zhou*. Ferroptosis mediatesdecabromodiphenyl ether-induced liver damage and inflammation. Ecotoxicologyand environmental safety. 2023; 255:114771. doi:10.1016/j.ecoenv.2023.114771

26.    Kun Li#, Bin Cao#, Huan Dong, Longyan Yang*, DongZhao*. Trajectories of glycated hemoglobin of T2DM and progress of arterialstiffness: a prospective study. Diabetology & metabolic syndrome.2023;15(1):135. doi:10.1186/s13098-023-01108-8

27.    Kun Li#, Bin Cao#, Xiaojing Wang#, Tao Chai, JingKe, Dong Zhao*. Sex differences in the non-linear association between BMI andLDL cholesterol in type 2 diabetes.Frontiers in endocrinology 2023;14:1180012doi:10.3389/fendo.2023.1180012

28.    Kun Li#, Bin Cao#, Jing Ke, Longyan Yang, DongZhao*. Association of Hyper-Triglyceridemic Waist Phenotype and DiabeticVascular Complication in the Chinese Population. Diabetes, metabolic syndromeand obesity: targets and therapy 2023;16:2233-2241 doi:10.2147/DMSO.S416668

29.    Kun Lv#, Chunmei Cui#, Rui Fan#, Xiaojuan Zha,Pengyu Wang, Jun Zhang, Lina Zhang, Jing Ke, Dong Zhao*, Qinghua Cui*, LimingYang*. Detection of diabetic patients in people with normal fasting glucoseusing machine learning. BMC medicine. 2023;21(1):342.doi:10.1186/s12916-023-03045-9

30.    Yanan Cheng#, Yan Wang#, Ruili Yin, Yongsong Xu,Lijie Zhang, Yuanyuan Zhang, Longyan Yang*, Dong Zhao*. Central role of cardiacfibroblasts in myocardial fibrosis of diabetic cardiomyopathy. Frontiers inendocrinology. 2023; 14:1162754.

31.    Lin Mao#, Ruili Yin#, Longyan Yang*, Dong Zhao*.Role of advanced glycation end products on vascular smooth muscle cells underdiabetic atherosclerosis. Frontiers in endocrinology. 2022; 13:983723

32.    Wang Y#, Yang L#, Mao L, Zhang L, Zhu Y, Xu Y,Cheng Y, Sun R, Zhang Y, Ke J*, Zhao D*. SGLT2 inhibition restrains thyroidcancer growth via G1/S phase transition arrest and apoptosis mediated by DNAdamage response signaling pathways. Cancer Cell Int, 2022, 22(1).

33.    Kun Li, Ruili Yin, Yan Wang, Dong Zhao*.Associations between exposure to polycyclic aromatic hydrocarbons and metabolicsyndrome in U.S. adolescents: Cross-sectional results from the National Healthand Nutrition Examination Survey (2003-2016) data. Environmental research2021;202:111747. doi:10.1016/j.envres.2021.111747.

34.    Xin Wang#, Jing Ke#, Yingjun Zhu, Bin Cao, RuiliYin, Yan Wang, Lingling Wei, Lijie Zhang, Longyan Yang*, Dong Zhao*. Dipeptidylpeptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation ofdiabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway.Cell Death Discov. 2021;7.

35.    Wang X#,Ma Y#,Yang LY*, Zhao D*. MicroRNA-20a-5pAmeliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression ofCD36. Front Cell Dev Biol 2020, 8: 596329.

36.    Ning Zhang#, Jing Ke, Dawei Zhang, Yuanyuan Zhang,Ying Fu, Bin Cao*, Dong Zhao*. A Dynamic Nomogram for Predicting DiabeticMacular Edema in Type 2 Diabetes Patients Based on Plasma Cytokines. Aging,2021.

37.    Longyan Yang#, Caiguo Yu#, Xuhong Wang, ShashaYuan, Lijie Zhang, Dong Zhao*, Yingmei Feng*. Angiopoietin-Like Protein 4 Is aHigh-Density Lipoprotein (HDL) Component for HDL Metabolism and Function inNondiabetic Participants and Type-2 Diabetic Patients, J Am Heart Assoc, 2017,23,6(6).

38.    Zongwei Wang#, Yuxian Yang#, Simo Liu#, Juan Feng,Yuanyuan Zhang, Jing Ke*, Dong Zhao*. CD26/DPP4 levels in peripheral blood andT cells in Hashimoto's thyroiditis with normal thyroid function, InternationalImmunopharmacology. 2019, 77:105941.

39.    Longyan Yang#, Ruili Yin#, Zongwei Wang, XuhongWang, Yuanyuan Zhang*, Dong Zhao*. Circulating Angptl3 and Angptl8 AreIncreased in Patients with Hypothyroidism, Biomed Res Int, 2019, 2019:3814687.

40.    Longyan Yang#, Rongxin Sun#, Yan Wang#, Ying Fu,Yuanyuan Zhang, Zhaohui Zheng, Zhili Ji*, Dong Zhao*. Expression of ANGPTL2 andits impact on papillary thyroid cancer, Cancer Cell Int, 2019, 19:204.

41.    Bin Cao#, Ning Zhang, Yuanyuan Zhang, Ying Fu, DongZhao*. Plasma cytokines for predicting diabetic retinopathy among type 2diabetic patients via machine learning algorithms. Aging (Albany NY). 2020.

42.    Zhao Dong#, Yang, Long-Yan#, Wang, Xu-Hong, Yuan,Sha-Sha, Yu, Cai-Guo, Wang, Zong-Wei, Lang, Jia-Nan, Feng, Ying-Mei*. Differentrelationship between ANGPTL3 and HDL components in female non-diabetic subjectsand type-2 diabetic patients, CARDIOVASCULAR DIABETOLOGY, 2016.9.13, 15.

43.    Gao M#, Zhao D#, Schouteden S, Sorci-Thomas MG, VanVeldhoven PP, Eggermont K, Liu G, Verfaillie CM*, Feng Y*. Regulation ofhigh-density lipoprotein on hematopoietic stem/progenitor cells inatherosclerosis requires scavenger receptor type BI expression,Arteriosclerosis, Thrombosis, and Vascular Biology, 2014.9, 34(9): 1900~1909.

44.   Liu L#, Jiang Q#, Wang X#, Zhang Y, Lin RC, Lam SM, Shui G, Zhou L, Li P,Wang Y, Cui X, Gao M, Zhang L, Lv Y, Xu G, Liu G*, Yang H*, Zhao D*.Adipose-Specific Knokout of Seipin/Bscl2 Results in Progressive Lipodystrophy,Diabetes, 2014.7, 63(7): 2320~2331.