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主任医师 教授 博士研究生导师,首都医科大学附属北京天坛医院 神经外科颅脑创伤病区副主任
国家神经系统疾病临床医学研究中心PI
国家创伤医学中心颅脑创伤专业委员会副主任委员
中国康复医学会颅脑创伤康复专业委员会常务委员
中华医学会神经外科分会神经创伤学组委员
中国医师协会神经修复学专委会颅脑创伤学组委员
中国医师协会神经外科分会神经创伤专委会委员
《Chinese Journal of Traumatology》 《中华神经创伤外科电子杂志》《中华脑科疾病与康复杂志》《神经疾病与精神卫生》等杂志编委;《Chinese Medical Journal》、《Chinese Neurosurgical Journal》《中华神经外科杂志》《neurosurgical review 》《clinical neurology and neurosurgery》 《 Frontiers in Neurology 》等中外杂志审稿专家
(1) 中华人民共和国科学技术部, 国家重点研发计划, 2024YFF0507503, 神经环路时空演变规律与多靶点感觉-中枢协同调控策略, 2024-12 至 2029-11, 440万元, 在研, 主持
(2) 北京市卫生健康委, 首都卫生发展科研专项重点攻关, 2024-1-2042, 急性颅脑创伤救治多层级疗效比较优化临床多中心研究, 2024-01 至 2026-12, 130万元, 在研, 主持
(3) 中华人民共和国科学技术部, 国家重点研发计划颠覆性技术创新课题, 2022YFF1501501, 颅骨/颅骨骨髓生物物理特征图谱的构建, 2022-11 至 2024-10, 120万元, 结题, 主持
(4) 北京市卫生与健康委员会, 科技成果和适宜技术推广项目, BHTPPP202034, 轻型颅脑创伤规范诊治和管理的适宜技术推广, 2021-01 至 2021-12, 8万元, 结题, 主持
1: Gao X, Liu X, Wang N, Cui C, Liu W, Yang M, Li Q, Ou Y, Ning A, Wei X, Zhang
M, Qiu S, Lei Y, Fu D, Li H, Sun L, Lu M, Zhang M, Wang Y. Nanoparticles hijack
calvarial immune cells for CNS drug delivery and stroke therapy. Cell. 2026 Mar
5;189(5):1341-1355.e17. doi: 10.1016/j.cell.2025.12.008. Epub 2026 Jan 16. PMID:
41547354.
2: Wu L, Li Y, Sun M, Ye P, Zhang Z, Liu W. Global, regional, and national
burdens of mild traumatic brain injuries from 1990 to 2019: findings from the
Global Burden of Disease Study 2019 - a cross-sectional study. Int J Surg. 2025
Jan 1;111(1):160-170. doi: 10.1097/JS9.0000000000001837. PMID: 38913425; PMCID:
PMC11745685.
3: Wu L, Gao G, Liu W. Surgical treatment for chronic subdural haematoma. Lancet
Neurol. 2024 Dec;23(12):1184. doi: 10.1016/S1474-4422(24)00397-1. PMID:
39577910.
4: Guo X, Wu L, Ou Y, Yu X, Zhu B, Yang C, Liu W. Postoperative pneumocephalus
and recurrence and outcome of chronic subdural hematoma: a systematic review and
meta-analysis. Neurosurg Rev. 2022 Dec 9;46(1):13. doi:
10.1007/s10143-022-01925-x. PMID: 36481957.
5: Liu Z, Hu L, Wang Q, Zhao X, Liu W, Zhang B, Pan W, Song W, Chen X, Zhang C,
Wang J, Wang S, Zhou J. Inorganic nitrate attenuates neuroinflammation after
traumatic brain injury via Sialin. Tissue Cell. 2025 Oct;96:102955. doi:
10.1016/j.tice.2025.102955. Epub 2025 May 10. PMID: 40373612.
6: Ou Y, Fan W, Yu X, Wu L, Liu W. A Single-Center Analysis of Sex Differences
in Patients With Chronic Subdural Hematoma in China. Front Neurol. 2022 May
17;13:888526. doi: 10.3389/fneur.2022.888526. PMID: 35655622; PMCID: PMC9152211.
7: Zhu B, Ou Y, Guo X, Liu W, Wu L. A low prognostic nutritional index is
associated with chronic subdural hematoma recurrence. Neurosurg Rev. 2023 Jun
9;46(1):139. doi: 10.1007/s10143-023-02042-z. PMID: 37296275.
8: Sun J, Ou Y, Liu X, Sun H, Guo Z, Qi F, Lan Y, Liu W, Sun W. LC-MS-based
urine metabolomics analysis of chronic subdural hematoma for biomarker
discovery. Proteomics Clin Appl. 2024 Jan;18(1):e2200107. doi:
10.1002/prca.202200107. Epub 2023 Sep 11. PMID: 37697649.
9: Wu L, Guo X, Ou Y, Yu X, Zhu B, Yang C, Liu W. Efficacy analysis of
neuroendoscopy-assisted burr-hole evacuation for chronic subdural hematoma: a
systematic review and meta-analysis. Neurosurg Rev. 2023 Apr 28;46(1):98. doi:
10.1007/s10143-023-02007-2. PMID: 37115314.
10: Xu L, Sun H, Zhang Y, Guo Z, Xiao X, Zhou X, Hu K, Sun W, Wang B, Liu W.
Proteomic analysis of human frontal and temporal cortex using iTRAQ-based 2D LC-
MS/MS. Chin Neurosurg J. 2021 May 5;7(1):27. doi: 10.1186/s41016-021-00241-5.
PMID: 33952343; PMCID: PMC8101246.
11: Wu L, Guo X, Ou Y, Yu X, Zhu B, Li Y, Liu W. Seizure after chronic subdural
hematoma evacuation: associated factors and effect on clinical outcome. Front
Neurol. 2023 May 9;14:1190878. doi: 10.3389/fneur.2023.1190878. PMID: 37228408;
PMCID: PMC10203208.
12: Zhu B, Yu X, Ou Y, Guo X, Liu W, Wu L. Nutritional and inflammatory
peripheral blood markers for risk assessment of chronic subdural hematoma: a
case-control study. Clin Neurol Neurosurg. 2023 Apr;227:107640. doi:
10.1016/j.clineuro.2023.107640. Epub 2023 Feb 25. PMID: 36870089.
13: Zhu B, Ou Y, Guo X, Liu W, Wu L. Poor nutritional status is associated with
incomplete functional recovery in elderly patients with mild traumatic brain
injury. Front Neurol. 2023 Apr 4;14:1131085. doi: 10.3389/fneur.2023.1131085.
PMID: 37082444; PMCID: PMC10110901.
14: Wang N, Zhang M, Yang M, Liu W, Liu W, Ou Y, Zhou M, Wang X, Sun Z, Pan Y,
Wang Y, Wang Y. Efficacy and safety of Y-3 intracalvariosseous injection versus
intravenous injection in the treatment of acute large hemispheric infarction
(SOLUTION-2): rationale and design of a multicentre, prospective, randomised,
open-label, blind endpoint (PROBE) trial. Stroke Vasc Neurol. 2026 Mar
4;11(1):130-135. doi: 10.1136/svn-2024-004011. PMID: 40461153.
15: Zhang S, Gao G, Liu W. Craniectomy versus craniotomy: What can we do for
acute subdural hematoma? Aging Med (Milton). 2024 Jun 14;7(3):276-278. doi:
10.1002/agm2.12322. PMID: 38975314; PMCID: PMC11222726.
16: Wu L, Li Y, Sun M, Yao N, Zhang Z, Liu W. Reduced Masseter Muscle Area
Predicts the 6-Month Outcome After Mild Traumatic Brain Injury in Older Adults.
Aging Med (Milton). 2025 Aug 14;8(4):294-302. doi: 10.1002/agm2.70040. PMID:
40896274; PMCID: PMC12399341.
17: Ou Y, Yu X, Wu L, Zhang D, Liu W. Recurrence of Chronic Subdural Hematoma Is
Independent of ABO Blood Type: A Retrospective Cohort Study. Front Neurol. 2022
May 20;13:833958. doi: 10.3389/fneur.2022.833958. PMID: 35669879; PMCID:
PMC9163317.
18: Wu L, Ou Y, Zhu B, Guo X, Yu X, Xu L, Li J, Feng E, Li H, Wang X, Chen H,
Sun Z, Liu Z, Yang D, Zhang H, Liu Z, Tang J, Zhao S, Zhang G, Yao J, Ma D, Sun
Z, Zhou H, Liu B, Liu W; ECHO Trial Collaborators. Exhaustive drainage versus
fixed-time drainage for chronic subdural hematoma after one-burr hole
craniostomy (ECHO): study protocol for a multicenter randomized controlled
trial. Trials. 2023 Mar 20;24(1):207. doi: 10.1186/s13063-023-07250-y. PMID:
36941714; PMCID: PMC10029260.
19: Yu X, Wu L, Ou Y, Xu L, Guo X, Yang C, Liu W. Clinical characteristics and
outcomes of chronic subdural hematoma in patients with a history of antiplatelet
therapy. Clin Neurol Neurosurg. 2021 Sep;208:106817. doi:
10.1016/j.clineuro.2021.106817. Epub 2021 Jul 10. PMID: 34388598.
20: Wu L, Ou Y, Liu W. Letter to the Editor Regarding "Subdural Air Increases
Postoperative Recurrence of Chronic Subdural Hematoma After Initial Burr-Hole
Surgery Only in the Very Elderly: A Pilot Study". World Neurosurg. 2022
Aug;164:462. doi: 10.1016/j.wneu.2022.04.052. PMID: 35941773.
21: Li Y, Liu W, Wu L. Letter to the Editor Regarding "Backup Frontal Drainage
System for Urgent Tension Pneumocephalus Management After Chronic Subdural
Hematoma Surgery: A Retrospective Cohort Study". World Neurosurg. 2024
Oct;190:535. doi: 10.1016/j.wneu.2024.05.072. PMID: 39425282.
22: Li KN, Liu WM, Hou YZ, Tian RF, Zhang S, Wu L, Xu L, Qiu JJ, Tong YP, Yang
T, Fan YP. Nonsurgical Treatment of Chronic Subdural Hematoma Patients with
Chinese Medicine: Case Report Series. Chin J Integr Med. 2025
Oct;31(10):937-941. doi: 10.1007/s11655-025-3840-y. Epub 2025 Jul 25. PMID:
40707805.
23: Mao X, Xu L, Liu W, Hao S, Liu B. Local Skull Thinning is One of Risks for
the Ruptured Arachnoid Cysts With Chronic Subdural Hematoma in Adults: Thirty-
two Clinical Reports. J Craniofac Surg. 2022 Mar-Apr 01;33(2):e102-e105. doi:
10.1097/SCS.0000000000007957. PMID: 34260457.
24: Wu L, Yan Y, Deng Y, Li Y, Liu W, Gao G; URANUS Trial Collaborators.
Neuroendoscopy-assisted drainage versus burr hole drainage for chronic subdural
hematoma (URANUS): study protocol for a multicenter randomized controlled trial.
Trials. 2026 Mar 17. doi: 10.1186/s13063-026-09629-z. Epub ahead of print. PMID:
41845395.
25: Yuan J, Zeng H, Wu Q, Liu W, Ou Y. Predictive value of temporal muscle
thickness in patients with chronic subdural hematoma. Front Neurol. 2026 Jan
7;16:1704557. doi: 10.3389/fneur.2025.1704557. PMID: 41573389; PMCID:
PMC12819276.

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