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梁庆丰,男,眼科学博士,北京同仁医院眼科主任医师,教授,博士生导师,享受国务院政府特殊津贴。担任中华医学会眼科学分会角膜学组委员、中国医师协会角膜学组委员以及中国医促会老年保健分会委员等职务。《中华眼科杂志》、《中华实验眼科杂志》、《眼科》等杂志编委。2014-2015年留学法国国立眼科医院、2017-2018年留学美国加州大学洛杉矶分校Stein眼科研究所做高级访问学者,2015年入选北京市高层次卫生技术人才学科骨干,2017年入选北京市高创计划领军人才,2019年入选国家百千万人才工程,授予“有突出贡献中青年专家”荣誉称号。
长期从事感染性眼病病原学及发病机制研究,并探索新型抗感染及干细胞角膜修复治疗方法,对于疑难感染性眼病的诊断及手术治疗具有较深造诣。目前为北京同仁医院眼科研究所副所长、PI,拥有病原微生物实验室诊断、分子诊断、及病原微生物细胞共培养三大平台,建立了全国最大的感染性眼病临床研究数据库及病原微生物资源库。本实验室在国内首次分离出沙眼衣原体、棘阿米巴原虫及非结核分枝杆菌等病原体,在微生物领域做出重大贡献;建立并标准化沙眼衣原体、棘阿米巴等难培养病原体的培养体系;牵头组织并执笔完成我国首部《感染性眼病的病原微生物实验室诊断专家共识》,主要科研成果居于国内领先水平。近年来,团队重点探究眼表微生态及干细胞在眼健康与疾病中的作用,研究具有创新性和国际前瞻性。
先后承担国家自然科学基金4项、国家重点研发计划2项。在知名期刊Microbiome、Ebiomedicine、Ocular Surface、AJO、IOVS等杂志发表SCI论文68篇,在《中华眼科杂志》等学术期刊发表论文92篇,授权专利5项,主编或主译专著6部。目前在读博士研究生9名、硕士研究生7名。




长期致力于致盲性角膜疾病、感染性角膜炎及眼表免疫机制的基础与转化研究。先后主持国家自然科学基金、国家重点研发计划、北京市卫健委卓越临床项目及罕见病公益课题等。聚焦微量病原体精准培养、角膜缘干细胞修复、免疫微环境调控及AI多模态诊疗,系统解析棘阿米巴、细菌及难培养病原体在角膜炎中的免疫逃逸与代谢重编程机制,并开发靶向干预策略。
1.难培养和微量病原体靶向培养技术研究(2021YFC2301000),国家重点研发计划,国家重点研发计划病原学与防疫技术体系研究专项
2.微导管微力感知技术及其递送系统研制(2017YFB1302703),国家重点研发计划,国家重点研发计划智能机器人重点专项
3.microRNA跨物种调控阿米巴角膜炎宿主中性粒细胞代谢重编程的机制研究(82471041),国家自然科学基金面上项目
4.CCL2/MTAC4单抗嵌合体靶向调控阿米巴角膜炎免疫逃逸机制研究(82171017),国家自然科学基金面上项目
5.高渗环境下眼表微生态变化激活TLR-NF-κB通路触发干眼免疫性炎症的机制研究(81970765),国家自然科学基金面上项目
6.光动力学疗法对细菌性角膜炎中的角膜基质修复及细菌生物膜形成的干预研究(81470607),国家自然科学基金面上项目
7.角膜缘干细胞移植治疗致盲性角膜疾病(BRWEP2024W172050103),北京市卫生健康委员会,研究型病房卓越临床研究计划
8.可视化热脉冲睑板腺干眼治疗仪的开发研究(Z181100001918031),北京市科委医药协同重点专项
9.3D打印角膜缘治疗PAX6基因相关角膜缘干细胞缺乏的实验研究(YCXJ-JZ-2023-019),2023年罕见病科研课题资助公益项目
10.棘阿米巴单克隆抗体嵌合体靶向调控阿米巴角膜炎免疫逃逸机制及应用研究(YCXJ-JZ-2022-007),2022年罕见病科研课题资助公益项目
1.Jiang S, Wang L, Zhang Z, Wei Z, Cao K, Liang Q. Corneal Transplantation Strategies for Acanthamoeba Keratitis: A Systematic Review and Meta-Analysis. Journal of Infection and Public Health, 2025-12-17: 103114.
2.Qudsi AI, Wei Z, Zhang Z, Shi Q, Wei M, Cheng Z, Wang Z, Zhang Y, Chen K, Xu X, Lu X, Liang Q. Pediatric Fungal Keratitis: Predisposing Factors, Clinical Features, and Outcomes During a 24-Year Study. Transl Vis Sci Technol. 2025;14(12):22.
3.Chen Q, Wang L, Wei Y, Xu X, Wei Z, Peng Y, Pang J, Peng B, Shi Q, Qudsi AI, Liang Q. Sodium butyrate modulates ocular surface microbiome and attenuates inflammation of meibomian gland dysfunction in ApoE-/- mice. Microbiome. 2025 Dec 16.
4.Chen Q, Wei Y, Pang J, Wei Z, Peng Y, Qudsi AI, Zhang Z, Lu X, Wang Z, Zhang Y, Chen K, Liang Q. Differentiating Ocular Pathogenic Staphylococcus epidermidis Isolates Using a Human Corneal Epithelial Cell Coculture Model. Transl Vis Sci Technol. 2025 Nov 3;14(11):21.
5.Wei Y, Chen Q, Xu X, Peng Y, Pang J, Wei Z, Liang Q. Chlamydia trachomatis infection induces ferroptosis and enhances chlamydial replication. Microb Pathog. 2025 Aug;205:107656.
6.Shi Q, Wei Z, Pang J, Qudsi AI, Wei M, Zhang Z, Zhang Y, Wang Z, Chen K, Xu X, Lu X, Liang Q. Achromobacter in the Conjunctival Sac Microbiota: Potential Association With Acanthamoeba Keratitis Related to Orthokeratology Lenses. Invest Ophthalmol Vis Sci. 2025 Jul 1;66(9):71.
7.Wei Z, Yuan J, Chen Q, Pang J, Shi Q, Peng B, Wei M, Wei Y, Zhang Z, Lu X, Lin X, Liang Q. Bifunctional chemokine-nanobody fusion protein enhances neutrophil recruitment to impede Acanthamoeba immune evasion. EBioMedicine. 2025 May;115:105685.
8.Shi Q, Mao D, Zhang Z, Qudsi AI, Wei M, Cheng Z, Zhang Y, Wang Z, Chen K, Xu X, Lu X, Liang Q. Epidemiological and Antimicrobial Resistance Trends in Bacterial Keratitis: A Hospital-Based 10-Year Study (2014-2024). Microorganisms. 2025 Mar 17;13(3):670.
9.Liu J, Kang M, Wei Y, Zhang Z, Pang J, Chen Q, Xu X, Wei Z, Zhang Y, Chen K, Wang Z, Lu X, Liang Q. kexB Gene Correlates with Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis. Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):42.
10.Wang L, Nie X, Wei Y, Chen Q, Sun Y, Zhao X, Xu X, Liu W, Liang Q. 3D printed biomimetic bilayer limbal implants for regeneration of the corneal structure in limbal stem cell deficiency. Acta Biomater. 2025 Jan 24;193:157-170.
11.Peng Y, Chen Q, Wei Y, Wang L, Zhang Z, Wei Z, Pang J, Peng B, Shi Q, Wang Z, Zhang Y, Chen K, Xu X, Liang Q. Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis. Transl Vis Sci Technol. 2025 Jan 2;14(1):23.
12.Cheng Z, Shi Q, Peng B, Zhang Z, Wei Z, Wang Z, Zhang Y, Chen K, Xu X, Lu X, Liang Q. Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of Streptococcal Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China. Antibiotics (Basel). 2024 Dec 6;13(12):1190.
13.Shi Q, Peng B, Cheng Z, Zhang Z, Wei Z, Wang Z, Zhang Y, Chen K, Xu X, Lu X, Cao K, Wei X, Liang Q. Direct Cost Analysis of Microbial Keratitis in North China: A Hospital-Based Retrospective Study. Pathogens. 2024 Aug 7;13(8):666.
14.Guo X, Zhang Z, Chen Q, Wang L, Xu X, Wei Z, Zhang Y, Chen K, Wang Z, Lu X, Liang Q. Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):26.
15.Chen Q, Wang L, Wei Y, Xu X, Guo X, Liang Q. Ferroptosis as a Potential Therapeutic Target for Reducing Inflammation and Corneal Scarring in Bacterial Keratitis. Invest Ophthalmol Vis Sci. 2024 Feb 1;65(2):29.
16.Wei Y, Xu X, Wang L, Chen Q, Li J, Liu X, Wei Z, Pang J, Peng Y, Guo X, Cheng Z, Wang Z, Zhang Y, Chen K, Lu X, Liang Q. A suitable and efficient optimization system for the culture of Chlamydia trachomatis in adult inclusion conjunctivitis. Pathog Dis. 2024 Feb 7;82:ftae020.
17.Pang J, Wei Z, Wang L, Guo X, Chen Q, Wei Y, Peng Y, Zhang Z, Zhang Y, Liu J, Cheng Z, Wang Z, Zhang Y, Chen K, Xu X, Lu X, Liang Q. Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations. Transl Vis Sci Technol. 2024 Feb 1;13(2):5.
18.Chen Q, Wang L, Zhang Y, Xu X, Wei Z, Zhang Z, Wei Y, Pang J, Guo X, Cao K, Liang Q. Corneal Epithelial Dendritic Cells: An Objective Indicator for Ocular Surface Inflammation in Patients with Obstructive Meibomian Gland Dysfunction? Ocul Immunol Inflamm. 2024 Jan;32(1):79-88.
19.Chen D, Wang L, Guo X, Zhang Z, Xu X, Jin ZB, Liang Q. Evaluation of Limbal Stem Cells in Patients With Type 2 Diabetes: An In Vivo Confocal Microscopy Study. Cornea. 2024 Jan 1;43(1):67-75.
20.Wang L, Xu X, Chen Q, Wei Y, Wei Z, Jin ZB, Liang Q. Extracellular Vesicle MicroRNAs From Corneal Stromal Stem Cell Enhance Stemness of Limbal Epithelial Stem Cells by Targeting the Notch Pathway. Invest Ophthalmol Vis Sci. 2023 Sep 1;64(12):42.
21.Liu J, Guo X, Wei Z, Zhang Y, Zhang Z, Xu X, Liang Q. Infectious Keratitis After Keratorefractive Surgery: Update and Review of the Literature. Eye Contact Lens. 2023 Jul 1;49(7):275-282.
22.Wang L, Wang X, Chen Q, Wei Z, Xu X, Han D, Zhang Y, Chen Z, Liang Q. MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway. Ocul Surf. 2023 Apr;28:131-140.
23.Xu X, Wei Y, Pang J, Wei Z, Wang L, Chen Q, Wang Z, Zhang Y, Chen K, Peng Y, Zhang Z, Liu J, Zhang Y, Jin ZB, Liang Q. Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):6.
24.Wei Z, Wang S, Wang Z, Zhang Y, Chen K, Gong L, Li G, Zheng Q, Zhang Q, He Y, Zhang Q, Chen D, Cao K, Pang J, Zhang Z, Wang L, Ou Z, Liang Q. Development and multi-center validation of machine learning model for early detection of fungal keratitis. EBioMedicine. 2023 Feb;88:104438.
25.Wei Z, Zhang Y, Chen Q, Xu X, Pan Z, Jin ZB, Liang Q. SLAMF7/STAT6 Pathway Inhibits Innate Immune Response in Late-Stage Human Acanthamoeba Keratitis: A Comparative Transcriptome Analysis. Microorganisms. 2023 Feb 1;11(2):365.
26.Liu J, Wei Z, Cao K, Zhang Z, Xu X, Liang Q. Trends of ocular fungal infections in North China (2001-2020). J Infect Public Health. 2023 Jan;16(1):71-77.
27.Zhang Y, Xu X, Wei Z, Cao K, Zhang Z, Liang Q. The global epidemiology and clinical diagnosis of Acanthamoeba keratitis. J Infect Public Health. 2023 Jun;16(6):841-852.
主编或主译著作6部:
1.《裂隙灯显微镜临床应用与照相技巧》主编 人民卫生出版社 2024-08出版
2.《眼科学》副主编 中国医药科技出版社 2023-01出版
3.《眼前节疾病裂隙灯图像解读》主编 人民卫生出版社 2022-06出版
4.《眼科临床指南解读 干眼》主编 人民卫生出版社 2022-02出版
5.《眼科检查与诊断手册》主译 人民军医出版社 2015-03出版
6.《同仁角膜病例精粹》 副主编 人民军医出版社 2014-06出版
参编著作4部:
1.《CORNEA》中文版的部分81、82章节翻译工作 人民卫生出版社 2018-05出版
2.《沙眼》人民卫生出版社 2015-09出版
3.《整合眼科学》人民卫生出版社 2015-07出版
4.《眼表共聚焦显微镜》人民军医出版社 2014-09出版

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