课题组主要针对典型环境污染物的健康效应，从事毒性效应和机制研究。主要研究内容：

1.  大气颗粒物心肺毒性作用及机制研究

2.  纳米颗粒有害生物效应及毒性机理研究

3.  新兴污染物的环境健康风险和毒性效应评估

[1] miR-494-3p靶向UBQLN1调控巨噬细胞激活在纳米二氧化硅致肺纤维化中的作用及机制研究（课题号：82273658），国家自然科学基金面上项目，2023.01-2026.12，负责人

[2] 纳米二氧化硅经miR-292-3p/MICAL2诱导心肌收缩功能障碍的作用及调控机制研究（课题号：82073591），国家自然科学基金面上项目，2021.01- 2024.12，负责人

[1] miR-494-3p靶向UBQLN1调控巨噬细胞激活在纳米二氧化硅致肺纤维化中的作用及机制研究（课题号：82273658），国家自然科学基金面上项目，2023.01-2026.12，负责人

[2] 纳米二氧化硅经miR-292-3p/MICAL2诱导心肌收缩功能障碍的作用及调控机制研究（课题号：82073591），国家自然科学基金面上项目，2021.01- 2024.12，负责人

[3] 大气污染对呼吸和心血管系统影响的早期效应标志物评价（课题号：2017YFC0211604），国家重点研发专项子任务，2017.7-2021.12，负责人

[4] 内质网应激介导纳米二氧化硅颗粒促进巨噬细胞泡沫化在动脉粥样硬化中的作用及机制研究（课题号：7162021），北京市自然科学基金面上项目，2016.1-2018.12，负责人

[5] IL-6/STAT3/NF-κB对无定形纳米二氧化硅诱导肺上皮间质转化的调控作用及机制研究（课题号：81573176），国家自然科学基金面上项目，2016.1-2019.12，负责人

[6] 纳米二氧化硅致支气管上皮细胞DNA损伤响应机制研究（课题号：KM201510025005），北京市教委面上项目，2015.1-2017.12，负责人

[7] MAPK信号通路介导纳米二氧化硅颗粒诱导动脉粥样硬化（课题号：YETP1670），北京高等学校“青年英才计划”，2013.1-2015.12，负责人

[8]无定形纳米SiO2诱导细胞恶性转化及其相关机制研究 (课题号：81202242)，国家自然科学基金青年基金项目，2013.1-2015.12，负责人

【部分学术论文】

[1]    CaixiaGuo, Xinying Zhao, Ru Ma, Lingnan Zhu, Yueyue Chen, Zhu Yang, Zongwei Cai,Zhiwei Sun, Yanbo Li*. Silica nanoparticles promoted pro-inflammatorymacrophage and foam cell transformation via ROS/PPARγ/NF-κB signaling. SciTotal Environ, 2023, 881: 163430.

[2]    Yufan Liu, Yan Li, Hailin Xu, Xinying Zhao, Yawen Zhu, Bosen Zhao, Qing Yao, Huawei Duan, Caixia Guo*, Yanbo Li*.Pre- and postnatal particulate matter exposure and blood pressure in childrenand adolescents: A systematic review and meta-analysis. Environ Res, 2023,223: 115373.

[3]    Alimire Abulikemu#,Xinying Zhao#, Hailin Xu, Yan Li, Ru Ma, QingYao, Ji Wang, Zhiwei Sun, YanboLi*, Caixia Guo*. Silica nanoparticles aggravated the metabolic associatedfatty liver disease through disturbed amino acid and lipid metabolisms-mediatedoxidative stress. Redox Biology, 2023, 59: 102569.

[4]    Xinying Zhao, Hailin Xu, Yan Li, Ru Ma, Yi Qi, Min Zhang, Caixia Guo*, Zhiwei Sun, Yanbo Li*.Proteomic profiling reveals dysregulated mitochondrial complex subunitsresponsible for myocardial toxicity induced by SiNPs. Sci Total Environ, 2023,857(Pt1): 159206.

[5]    YanLi, YawenZhu, BosenZhao, QingYao, HailinXu, SongqingLv, JiWang, ZhiweiSun, YanboLi* , CaixiaGuo*.Amorphous silica nanoparticlescaused lung injury through the induction of epithelial apoptosis viaROS/Ca2+/DRP1-mediated mitochondrial fission signaling. Nanotoxicology, 2022,16(6-8): 713-732.

[6]    Xinying Zhao, Hailin Xu, Yan Li , Yufan Liu, Xueyan Li, Wei Zhou, Ji Wang, Caixia Guo*, Zhiwei Sun, Yanbo Li*.Silica nanoparticles perturbed mitochondrial dynamics and induced myocardialapoptosis via PKA-DRP1-mitochondrial fission signaling. Sci Total Environ,2022, 842: 156854.

[7]    Yi Qi#, Hailin Xu#, Xueyan Li, Xinying Zhao, Yan Li, Xianqing Zhou, Siyu Chen, Ning Shen, Rui Chen, Yanbo Li*, Zhiwei Sun, Caixia Guo*. Silica nanoparticles inducecardiac injury and dysfunction via ROS/Ca2+/CaMKII signaling. Sci TotalEnviron, 2022, 837: 155733.

[8]    Xueyan Li, Yan Li, Songqing Lv, Hailin Xu, Ru Ma, Zhiwei Sun, Yanbo Li*, Caixia Guo*. Long-term respiratory exposureto amorphous silica nanoparticles promoted systemic inflammation andprogression of fibrosis in a susceptible mouse model. Chemosphere, 2022,300: 134633.

[9]     XinyingZhao, Hailin Xu, Xueyan Li, Yan Li,Songqing Lv, Yufan Liu, Caixia Guo*, ZhiweiSun, Yanbo Li*. Myocardial toxicity induced by silica nanoparticles in atranscriptome profile. Nanoscale,2022, 14(16): 6094-6108.

[10]  Alimire Abulikemu#,Xinying Zhao#, Yi Qi, Yufan Liu, Ji Wang, Wei Zhou, Huawei Duan, Yanbo Li,Zhiwei Sun, Caixia Guo*. Lysosomal impairment-mediated autophagy dysfunctionresponsible for the vascular endothelial apoptosis caused by silicananoparticle via ROS/PARP1/AIF signaling pathway. Environ Pollut, 2022, 304:119202.

[11]  Guo C#, Lv S#, Liu Y, LiY*. Biomarkers for the adverse effects on respiratory system health associatedwith atmospheric particulate matter exposure. J Hazard Mater, 2022, 421:126760.

[12]  Xinying Zhao#, AlimireAbulikemu#,Songqing Lv, Yi Qi, Junchao Duan, Jie Zhang, Rui Chen, CaixiaGuo*,Yanbo Li*, Zhiwei Sun. Oxidative stress- and mitochondrial dysfunction-mediatedcytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective.Chemosphere, 2021, 275: 129969.

[13]  Guo C#, Liu Y#, Li Y*.Adverse effects of amorphous silica nanoparticles: Focus on humancardiovascular health. J Hazard Mater, 2021, 406: 124626.

[14]  Ma R, Qi Y, Zhao X, LiX, Sun X, Niu P, Li Y*, Guo C*, Chen R, Sun Z. Amorphous silica nanoparticlesaccelerated atherosclerotic lesion progression in ApoE(-/-) mice throughendoplasmic reticulum stress-mediated CD36 up-regulation in macrophage. PartFibre Toxicol, 2020, 17(1): 50.

[15] Xiaoying Liu, Xinying Zhao, Xueyan Li, Songqing Lv, Ru Ma, Yi Qi, Alimire Abulikemu, Huawei Duan, Caixia Guo*, Yanbo Li*, Zhiwei Sun.PM2.5 triggered apoptosis in lungepithelial cells through the mitochondrial apoptotic way mediated by aROS-DRP1-mitochondrial fission axis. J Hazard Mater, 2020, 397: 122608.

[16] Yi Qi#, RuMa#, Xueyan Li, Songqing Lv, Xiaoying Liu, AlimireAbulikemu, Xinying Zhao, Yanbo Li*, Caixia Guo*, ZhiweiSun. Disturbed mitochondrial quality control involved in hepatocytotoxicityinduced by silica nanoparticles. Nanoscale, 2020, 12(24): 13034-13045.

[17]  Yanbo Li, Ru Ma, Xiaoying Liu, Yi Qi, Alimire Abulikemu, Xinying Zhao, Huawei Duan, Xianqing Zhou, Caixia Guo*, Zhiwei Sun. Endoplasmic reticulumstress-dependent oxidative stress mediated vascular injury induced bysilicananoparticles in vivo and in vitro. NanoImpact, 2019, 14: 100169.

[18]  Caixia Guo, Ru Ma,Xiaoying Liu, Yinye Xia, Piye Niu, Junxiang Ma, Xianqing Zhou, Yanbo Li*,Zhiwei Sun. Silica nanoparticles induced endothelial apoptosis via endoplasmicreticulum stress-mitochondrial apoptotic signaling pathway. Chemosphere, 2018,210:183-192.

[19] Guo C, Ma R,Liu X, Chen T, Li Y, Yu Y, Duan J, Zhou X, Li Y*, Sun Z*. Silica nanoparticles promote oxLDL-induced macrophagelipid accumulation and apoptosis via endoplasmic reticulum stress signaling. Sci Total Environ,2018, 631-632: 570-579.

[20] Guo C, Wang J, Jing L, Ma R, Liu X, Gao L, Cao L, Duan J, Zhou X, Li Y*, Sun Z. Mitochondrial dysfunction, perturbations of mitochondrialdynamics and biogenesis involved in endothelial injury induced by silicananoparticles. Environ Pollut, 2018, 236: 926-936.