课题组主要从事纳米材料、臭氧、大气颗粒物、微塑料等常见环境和职业有害因素的健康损害效应、分子机制及防治研究，为环境污染物毒性效应评估、职业接触限值、标准的制订提供实验依据。

国家自然科学基金面上项目，细胞命运决定因子Numb介导睾丸支持细胞自噬在臭氧暴露致雄性生殖损伤中的作用及机制研究，82574131，2026/01-2029/12，49万元，在研，主持。

国家自然科学基金面上项目，miR-92b-3p/SLC7A11调控铁死亡在纳米二氧化硅致肺纤维化中的作用及机制研究，82173551，2022/01-2025/12，55万元，在研，主持。

[1]   国家自然科学基金面上项目，细胞命运决定因子Numb介导睾丸支持细胞自噬在臭氧暴露致雄性生殖损伤中的作用及机制研究，82574131，2026/01-2029/12，49万元，在研，主持。

[2]    国家自然科学基金面上项目，miR-92b-3p/SLC7A11调控铁死亡在纳米二氧化硅致肺纤维化中的作用及机制研究，82173551，2022/01-2025/12，55万元，在研，主持。

[3]   国家自然科学基金面上项目，81872648，纳米二氧化硅颗粒调控线粒体SIRT3/ROS/CaMKⅡ致心律失常作用及机制研究，2019/01-2022/12，57万元，已结题，主持。

[4]   北京市属高校高水平教师队伍建设支持计划青年拔尖人才培育计划，CIT&TCD201804090，大气细颗粒物致癌性的尺度效应及其机制研究， 2018/01-2020/12，45万元，已结题，主持。

[5]   北京市教育委员会科技计划一般项目，KM201810025007，氧化应激介导线粒体动力学失衡调控大气细颗粒物肺损伤，2018/01-2020/12，15万元，已结题，主持。

[6]   北京市自然科学基金面上项目，7162022，miRNA调控p53介导无定形纳米二氧化硅致人肺支气管上皮细胞恶性转化研究，2016/01-2018/12，18万元，已结题，主持。

[7]   国家自然科学基金青年项目，81102095，纳米二氧化硅对动脉粥样硬化的影响及其作用机制研究，2012/01-2014/12，20万元，已结题，主持。

[1]    Caixia Guo#, Xinying Zhao#, Yan Li, Donglei Wang, Hailin Xu, Songqing Lv, Xueyan Li, Yanbo Li*Immune activation contributes recovery following pulmonary impairments bysilica nanoparticles. Journal of Hazardous Materials, 2025, 496: 139403.

[2]    CaixiaGuo#, Yawen Zhu#, Xinying Zhao, Hailin Xu, Yan Li, Ruohui Chen, Yanbo Li*. Regulationof ferroptosis ameliorates silica nanoparticle-induced lunginjury by inhibitingNCOA4-mediated ferritinophagy. Chem Biol Interact, 2025, 418: 111611.

[3]    Hailin Xu, Yurou Zhu, Lingnan Zhu, Donglei Wang, Songqing Lv, Xueyan Li, Caixia Guo*, Yanbo Li* .Warning on the inhalation of silica nanoparticles: Experimental evidence forits easy passage through the air-blood barrier, resulting in systemic distribution andpathological injuries. Chem Biol Interact, 2025, 409: 111423.

[4]    Hailin Xu, Yan Li, Xinying Zhao,Caixia Guo*, Yanbo Li*. Respiratory toxicity of amorphous silica nanoparticles: a review. EnvironmentalChemistry Letters, 2025, 23: 271-319.  

[5]    Yan Li, Qing Yao, Hailin Xu, Jiaze Ren,Yurou Zhu, Caixia Guo*, Yanbo Li*. Lung Single-Cell Transcriptomics OffersInsights into the Pulmonary Interstitial Toxicity Caused by SilicaNanoparticles. Environment & Health, 2024, 2(11):786-801.

[6]    Songqing Lv#, Yan Li#,Xueyan Li, Lingnan Zhu, Yurou Zhu, Caixia Guo*, Yanbo Li*. Silica nanoparticles triggeredepithelial ferroptosis via miR-21-5p/GCLM signaling to contribute to fibrogenesisin the lungs. Chem Biol Interact, 2024, 399: 111121.

[7]    Yan Li, Hailin Xu, Ying Wang, Yurou Zhu, Kun Xu, Zhu Yang, Yanbo Li*, Caixia Guo*. Epithelium-derived exosomes promote silicananoparticles-induced pulmonary fibroblast activation and collagendeposition via modulating fibrotic signaling pathways and theirepigenetic regulations. J Nanobiotechnology, 2024, 22(1): 331.

[8]    Xueyan Li#, Hailin Xu#, Xinying Zhao, Yan Li, Songqing Lv, Wei Zhou, Ji Wang, Zhiwei Sun, Yanbo Li*, Caixia Guo*. Ferroptosis contributing to cardiomyocyteinjury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling. PartFibre Toxicol, 2024, 21(1): 17.

[9]     ZhaoX, Zhu Y, Yao Q, Zhao B, Lin G, Zhang M, Guo C*, Li Y*. Lipidomics Investigation Reveals the Reversibility of Hepatic Injuryby Silica Nanoparticles in Rats After a 6-Week RecoveryDuration. Small Methods, 2024, 8(9):e2301430.

[10]  Xinying Zhao, Ru Ma, Alimire Abulikemu, Yi Qi, Xiaoying Liu, Ji Wang, Kun Xu, Caixia Guo*, Yanbo Li*.Proteomics revealed composition- and size-related regulators for hepaticimpairments induced by silica nanoparticles. Sci Total Environ, 2024, 922:170584.

[11]  Bosen Zhao, Palizhati Rehati, Zhu Yang, Zongwei Cai, Caixia Guo*, Yanbo Li*.The potential toxicity of microplastics on human health. Sci Total Environ, 2024,912: 168946.

[12]  Caixia Guo, Xinying Zhao, Ru Ma, LingnanZhu, Yueyue Chen, Zhu Yang, Zongwei Cai, Zhiwei Sun, Yanbo Li*. Silica nanoparticles promoted pro-inflammatory macrophage and foam cell transformationvia ROS/PPARγ/NF-κB signaling. Sci Total Environ, 2023, 881: 163430.

[13]    Yufan Liu, Yan Li, Hailin Xu, Xinying Zhao, Yawen Zhu, Bosen Zhao, Qing Yao, Huawei Duan, Caixia Guo*, Yanbo Li*. Pre- and postnatal particulate matter exposure andblood pressure in children and adolescents: A systematic review andmeta-analysis. Environ Res, 2023, 223: 115373.

[14]    Alimire Abulikemu#, Xinying Zhao#, Hailin Xu, Yan Li, Ru Ma, QingYao, Ji Wang, Zhiwei Sun, Yanbo Li*, Caixia Guo*. Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress. Redox Biology, 2023, 59: 102569.

[15]    Xinying Zhao, Hailin Xu, Yan Li, Ru Ma, Yi Qi, Min Zhang, Caixia Guo*, Zhiwei Sun, Yanbo Li*. Proteomic profiling reveals dysregulated mitochondrial complex subunits responsible for myocardial toxicity induced bySiNPs. Sci Total Environ, 2023, 857(Pt1): 159206.

[16]    Yan Li, Yawen Zhu, Bosen Zhao, Qing Yao, Hailin Xu, Songqing Lv, Ji Wang, Zhiwei Sun, Yanbo Li* , Caixia Guo*.Amorphous silica nanoparticles caused lung injury through the induction ofepithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling. Nanotoxicology, 2022, 16(6-8): 713-732.

[17]    Xinying Zhao, Hailin Xu, Yan Li , Yufan Liu, Xueyan Li, Wei Zhou, Ji Wang, Caixia Guo*, Zhiwei Sun, Yanbo Li*. Silica nanoparticles perturbed mitochondrial dynamics and induced myocardial apoptosis via PKA-DRP1-mitochondrial fission signaling. Sci Total Environ, 2022, 842: 156854.

[18]    Yi Qi#, Hailin Xu#, Xueyan Li, Xinying Zhao, Yan Li, Xianqing Zhou, Siyu Chen, Ning Shen, Rui Chen, Yanbo Li*, Zhiwei Sun, Caixia Guo*. Silica nanoparticles induce cardiac injuryand dysfunction via ROS/Ca2+/CaMKII signaling. Sci Total Environ,2022, 837: 155733.

[19]   Xinying Zhao, Hailin Xu, Xueyan Li, Yan Li, Songqing Lv, Yufan Liu, Caixia Guo*, Zhiwei Sun, Yanbo Li*. Myocardialtoxicity induced by silica nanoparticles in a transcriptome profile. Nanoscale,2022, 14(16): 6094-6108.

[20]  Alimire Abulikemu#, Xinying Zhao#,Yi Qi, Yufan Liu, Ji Wang, Wei Zhou, Huawei Duan, Yanbo Li, Zhiwei Sun, CaixiaGuo*. Lysosomal impairment-mediatedautophagy dysfunction responsible for the vascular endothelial apoptosis caused by silica nanoparticle via ROS/PARP1/AIF signaling pathway. Environ Pollut, 2022, 304: 119202.

[21]  Guo C#,Lv S#, Liu Y, Li Y*. Biomarkers for the adverse effects onrespiratory system health associated with atmospheric particulate matterexposure. J Hazard Mater, 2022, 421: 126760.

[22]  Xinying Zhao#, Alimire Abulikemu#,Songqing Lv, Yi Qi, Junchao Duan, Jie Zhang, Rui Chen, Caixia Guo*,Yanbo Li*, ZhiweiSun. Oxidative stress- and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomicperspective. Chemosphere, 2021, 275: 129969.

[23]  Guo C#,Liu Y#, Li Y*. Adverse effects of amorphous silica nanoparticles:Focus on human cardiovascular health. J Hazard Mater, 2021, 406: 124626.

[24]  Ma R, Qi Y, Zhao X,Li X, Sun X, Niu P, Li Y*, Guo C*, Chen R, Sun Z. Amorphous silicananoparticles accelerated atherosclerotic lesion progression in ApoE(-/-) mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage.Part Fibre Toxicol, 2020, 17(1): 50.

[25] Xiaoying Liu, Xinying Zhao, Xueyan Li, Songqing Lv, Ru Ma, Yi Qi, Alimire Abulikemu, Huawei Duan, Caixia Guo*, Yanbo Li*, Zhiwei Sun.PM2.5 triggered apoptosis in lung epithelial cells through the mitochondrial apoptotic way mediated by a ROS-DRP1-mitochondrial fission axis.J Hazard Mater, 2020, 397: 122608.

[26] Yi Qi#, Ru Ma#, XueyanLi, Songqing Lv, Xiaoying Liu, Alimire Abulikemu, XinyingZhao, Yanbo Li*, Caixia Guo*, Zhiwei Sun. Disturbed mitochondrialquality control involved in hepatocytotoxicity induced by silica nanoparticles.Nanoscale, 2020, 12(24): 13034-13045.

[27]  Yanbo Li, Ru Ma, Xiaoying Liu, Yi Qi, Alimire Abulikemu, Xinying Zhao, Huawei Duan, Xianqing Zhou, Caixia Guo*, Zhiwei Sun. Endoplasmic reticulum stress-dependent oxidative stress mediated vascular injury induced by silica nanoparticles in vivo and in vitro. NanoImpact, 2019, 14: 100169.

[28]  Caixia Guo, Ru Ma, Xiaoying Liu, Yinye Xia, Piye Niu, Junxiang Ma, Xianqing Zhou, Yanbo Li*, Zhiwei Sun.Silica nanoparticles induced endothelial apoptosis via endoplasmic reticulum stress-mitochondrial apoptotic signaling pathway. Chemosphere, 2018, 210:183-192.

[29] Guo C, Ma R, Liu X, Chen T, Li Y, Yu Y, Duan J, Zhou X, Li Y*, Sun Z*. Silica nanoparticles promote oxLDL-induced macrophage lipid accumulation and apoptosis via endoplasmic reticulum stress signaling. SciTotal Environ, 2018, 631-632: 570-579.

[30] Guo C, Wang J, Jing L, Ma R, Liu X, Gao L, Cao L, Duan J, Zhou X, Li Y*, Sun Z. Mitochondrial dysfunction, perturbations of mitochondrial dynamics and biogenesis involved in endothelial injury induced by silica nanoparticles. Environ Pollut, 2018, 236: 926-936.

[31]  Guo C, Wang J, Yang M, Li Y, Cui S, Zhou X, Li Y*, Sun Z*. Amorphous silica nanoparticles induce malignanttransformation and tumorigenesis of human lung epithelial cells via P53 signaling. Nanotoxicology, 2017,11(9-10): 1176-1194.

[32]  Guo C, Yang M, Jing L, Wang J, Yu Y, Li Y, Duan J, Zhou X, Li Y*, Sun Z*, Amorphous silica nanoparticles trigger vascular endothelialcell injury through apoptosis and autophagy via reactive oxygenspecies-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling. Int J Nanomedicine,2016, 11: 5257-5276.

[33]  Guo C, Xia Y, Niu P, Jiang L, DuanJ, Yu Y, Zhou X, Li Y*, Sun Z*. Silica nanoparticles induce oxidative stress,inflammation, and endothelial dysfunction in vitro via activation of theMAPK/Nrf2 pathway and nuclear factor-κB signaling. Int J Nanomedicine, 2015,10: 1463-1477.