课题组主要从事纳米材料、大气颗粒物、微塑料等常见环境和职业有害因素的健康损害效应、分子机制及防治研究，为环境污染物毒性效应评估、职业接触限值、标准的制订提供实验依据。

国家自然科学基金面上项目，miR-92b-3p/SLC7A11调控铁死亡在纳米二氧化硅致肺纤维化中的作用及机制研究，82173551，2022/01-2025/12，55万元，在研，主持。

[1]   国家自然科学基金面上项目，miR-92b-3p/SLC7A11调控铁死亡在纳米二氧化硅致肺纤维化中的作用及机制研究，82173551，2022/01-2025/12，55万元，在研，主持。

[2]   国家自然科学基金面上项目，81872648，纳米二氧化硅颗粒调控线粒体SIRT3/ROS/CaMKⅡ致心律失常作用及机制研究，2019/01-2022/12，57万元，已结题，主持。

[3]   北京市属高校高水平教师队伍建设支持计划青年拔尖人才培育计划，CIT&TCD201804090，大气细颗粒物致癌性的尺度效应及其机制研究， 2018/01-2020/12，45万元，已结题，主持。

[4]   北京市教育委员会科技计划一般项目，KM201810025007，氧化应激介导线粒体动力学失衡调控大气细颗粒物肺损伤，2018/01-2020/12，15万元，已结题，主持。

[5]   北京市自然科学基金面上项目，7162022，miRNA调控p53介导无定形纳米二氧化硅致人肺支气管上皮细胞恶性转化研究，2016/01-2018/12，18万元，已结题，主持。

[6]   国家自然科学基金青年项目，81102095，纳米二氧化硅对动脉粥样硬化的影响及其作用机制研究，2012/01-2014/12，20万元，已结题，主持。

[1]    Caixia Guo, Xinying Zhao, Ru Ma, LingnanZhu, Yueyue Chen, Zhu Yang, Zongwei Cai, Zhiwei Sun, Yanbo Li*. Silica nanoparticles promoted pro-inflammatory macrophage and foam cell transformationvia ROS/PPARγ/NF-κB signaling. Sci Total Environ, 2023, 881: 163430.

[2]    Yufan Liu, Yan Li, Hailin Xu, Xinying Zhao, Yawen Zhu, Bosen Zhao, Qing Yao, Huawei Duan, Caixia Guo*, Yanbo Li*. Pre- and postnatal particulate matter exposure andblood pressure in children and adolescents: A systematic review andmeta-analysis. Environ Res, 2023, 223: 115373.

[3]    Alimire Abulikemu#, Xinying Zhao#, Hailin Xu, Yan Li, Ru Ma, QingYao, Ji Wang, Zhiwei Sun, Yanbo Li*, Caixia Guo*. Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress. Redox Biology, 2023, 59: 102569.

[4]    Xinying Zhao, Hailin Xu, Yan Li, Ru Ma, Yi Qi, Min Zhang, Caixia Guo*, Zhiwei Sun, Yanbo Li*. Proteomic profiling reveals dysregulated mitochondrial complex subunits responsible for myocardial toxicity induced bySiNPs. Sci Total Environ, 2023, 857(Pt1): 159206.

[5]    Yan Li, Yawen Zhu, Bosen Zhao, Qing Yao, Hailin Xu, Songqing Lv, Ji Wang, Zhiwei Sun, Yanbo Li* , Caixia Guo*.Amorphous silica nanoparticles caused lung injury through the induction ofepithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling. Nanotoxicology, 2022, 16(6-8): 713-732.

[6]    Xinying Zhao, Hailin Xu, Yan Li , Yufan Liu, Xueyan Li, Wei Zhou, Ji Wang, Caixia Guo*, Zhiwei Sun, Yanbo Li*. Silica nanoparticles perturbed mitochondrial dynamics and induced myocardial apoptosis via PKA-DRP1-mitochondrial fission signaling. Sci Total Environ, 2022, 842: 156854.

[7]    Yi Qi#, Hailin Xu#, Xueyan Li, Xinying Zhao, Yan Li, Xianqing Zhou, Siyu Chen, Ning Shen, Rui Chen, Yanbo Li*, Zhiwei Sun, Caixia Guo*. Silica nanoparticles induce cardiac injuryand dysfunction via ROS/Ca2+/CaMKII signaling. Sci Total Environ,2022, 837: 155733.

[8]    Xueyan Li, Yan Li, Songqing Lv, Hailin Xu, Ru Ma, Zhiwei Sun, Yanbo Li*, Caixia Guo*. Long-term respiratory exposure to amorphous silica nanoparticles promoted systemic inflammation and progression of fibrosisin a susceptible mouse model. Chemosphere, 2022, 300: 134633.

[9]     Xinying Zhao, Hailin Xu, Xueyan Li, Yan Li, Songqing Lv, Yufan Liu, Caixia Guo*, Zhiwei Sun, Yanbo Li*. Myocardialtoxicity induced by silica nanoparticles in a transcriptome profile. Nanoscale,2022, 14(16): 6094-6108.

[10]  Alimire Abulikemu#, Xinying Zhao#,Yi Qi, Yufan Liu, Ji Wang, Wei Zhou, Huawei Duan, Yanbo Li, Zhiwei Sun, CaixiaGuo*. Lysosomal impairment-mediatedautophagy dysfunction responsible for the vascular endothelial apoptosis caused by silica nanoparticle via ROS/PARP1/AIF signaling pathway. Environ Pollut, 2022, 304: 119202.

[11]  Guo C#,Lv S#, Liu Y, Li Y*. Biomarkers for the adverse effects onrespiratory system health associated with atmospheric particulate matterexposure. J Hazard Mater, 2022, 421: 126760.

[12]  Xinying Zhao#, Alimire Abulikemu#,Songqing Lv, Yi Qi, Junchao Duan, Jie Zhang, Rui Chen, Caixia Guo*,Yanbo Li*, ZhiweiSun. Oxidative stress- and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomicperspective. Chemosphere, 2021, 275: 129969.

[13]  Guo C#,Liu Y#, Li Y*. Adverse effects of amorphous silica nanoparticles:Focus on human cardiovascular health. J Hazard Mater, 2021, 406: 124626.

[14]  Ma R, Qi Y, Zhao X,Li X, Sun X, Niu P, Li Y*, Guo C*, Chen R, Sun Z. Amorphous silicananoparticles accelerated atherosclerotic lesion progression in ApoE(-/-) mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage.Part Fibre Toxicol, 2020, 17(1): 50.

[15] Xiaoying Liu, Xinying Zhao, Xueyan Li, Songqing Lv, Ru Ma, Yi Qi, Alimire Abulikemu, Huawei Duan, Caixia Guo*, Yanbo Li*, Zhiwei Sun.PM2.5 triggered apoptosis in lung epithelial cells through the mitochondrial apoptotic way mediated by a ROS-DRP1-mitochondrial fission axis.J Hazard Mater, 2020, 397: 122608.

[16] Yi Qi#, Ru Ma#, XueyanLi, Songqing Lv, Xiaoying Liu, Alimire Abulikemu, XinyingZhao, Yanbo Li*, Caixia Guo*, Zhiwei Sun. Disturbed mitochondrialquality control involved in hepatocytotoxicity induced by silica nanoparticles.Nanoscale, 2020, 12(24): 13034-13045.

[17]  Yanbo Li, Ru Ma, Xiaoying Liu, Yi Qi, Alimire Abulikemu, Xinying Zhao, Huawei Duan, Xianqing Zhou, Caixia Guo*, Zhiwei Sun. Endoplasmic reticulum stress-dependent oxidative stress mediated vascular injury induced by silica nanoparticles in vivo and in vitro. NanoImpact, 2019, 14: 100169.

[18]  Caixia Guo, Ru Ma, Xiaoying Liu, Yinye Xia, Piye Niu, Junxiang Ma, Xianqing Zhou, Yanbo Li*, Zhiwei Sun.Silica nanoparticles induced endothelial apoptosis via endoplasmic reticulum stress-mitochondrial apoptotic signaling pathway. Chemosphere, 2018, 210:183-192.

[19] Guo C, Ma R, Liu X, Chen T, Li Y, Yu Y, Duan J, Zhou X, Li Y*, Sun Z*. Silica nanoparticles promote oxLDL-induced macrophage lipid accumulation and apoptosis via endoplasmic reticulum stress signaling. SciTotal Environ, 2018, 631-632: 570-579.

[20] Guo C, Wang J, Jing L, Ma R, Liu X, Gao L, Cao L, Duan J, Zhou X, Li Y*, Sun Z. Mitochondrial dysfunction, perturbations of mitochondrial dynamics and biogenesis involved in endothelial injury induced by silica nanoparticles. Environ Pollut, 2018, 236: 926-936.

[21]  Guo C, Wang J, Yang M, Li Y, Cui S, Zhou X, Li Y*, Sun Z*. Amorphous silica nanoparticles induce malignanttransformation and tumorigenesis of human lung epithelial cells via P53 signaling. Nanotoxicology, 2017,11(9-10): 1176-1194.

[22]  Guo C, Yang M, Jing L, Wang J, Yu Y, Li Y, Duan J, Zhou X, Li Y*, Sun Z*, Amorphous silica nanoparticles trigger vascular endothelialcell injury through apoptosis and autophagy via reactive oxygenspecies-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling. Int J Nanomedicine,2016, 11: 5257-5276.

[23]  Guo C, Xia Y, Niu P, Jiang L, DuanJ, Yu Y, Zhou X, Li Y*, Sun Z*. Silica nanoparticles induce oxidative stress,inflammation, and endothelial dysfunction in vitro via activation of theMAPK/Nrf2 pathway and nuclear factor-κB signaling. Int J Nanomedicine, 2015,10: 1463-1477.