01  首都医科大学附属北京世纪坛医院院级课题(2012-C13,2012-2014):Cldn-7调控STAT3信号通路促进大肠癌肝转移分子机制研究
02  首都医科大学基础-临床科研合作基金(12JL15,2012-2014):Claudin-7在炎症相关性大肠癌中的作用机制研究
03  首都医科大学附属北京世纪坛医院国自然青年博士基金(2013-2015):Claudin-7基因条件性小鼠的敲除建立及临床应用
04  2013年留学回国人员科研启动基金(2013-2014):Cldn-7诱导“EMT”促进大肠癌侵袭、转移分子机制研究
05  北京市教育委员会科技计划面上项目(2014-2016):可诱导Cldn-7条件性基因敲出小鼠模型建立及临床价值初探
06  2013年度铁道部科技研究开发计划课题(2013-2014): 北京市铁路职工大肠癌早期自主筛查情况调查及干预
07  北京市中医药管理局课题(2014-2016): 西黄丸调控miRNA逆转大肠癌多药耐药的作用机制研究
08  北京市留学人员科技活动资助项目: 可诱导条件性Cldn-7基因敲除小鼠自发大肠癌的分子机制研究
09  北京世纪坛医院留学回国启动基金：Cldn-7基因敲除小鼠在消化道疾病中的应用
10  北京市卫生系统高层次卫生技术人才培养计划(编号:2014-3-048) (2014-2017): 42万
11  国家自然科学基金面上项目(项目批准号:81372585,2014-2017): Cldn-7调控Integrin/FAK信号通路参与大肠癌发生、侵袭转移的机制研究
12  首都医科大学附属北京世纪坛医院科研基金(2016.1-2017.12)：可诱导Cldn-7条件性基因敲除小鼠模型的建立及其在大肠癌发生发展中作用机制研究
13  国家自然科学基金面上项目(项目批准号:81772557 ,2018-2021): Cldn7和SOX9相互作用调控β-catenin信号通路维持大肠癌干样细胞特性的分子机制研究
14  北京自然科学基金面上项目（项目批准号:7192087，2019.01-2021.12：基于可诱导肠道条件性基因敲除小鼠模型探讨Cldn7对肠道肿瘤发生发展的分子机制
15  国家自然科学基金面上项目 （82170525，2022.1-2025.12：Cldn-7调控Lgr5+结肠干细胞参与溃疡性结肠炎发生发展的作用及分子机制研究

1       Hao M, Wang K, Ding Y, Li H, Liu Y, Ding L. Which patients are prone to suffer liver metastasis? A review of risk factors of metachronous liver metastasis of colorectal cancer. Eur J Med Res. 2022 Jul 25;27(1):130

2       Zhu Y, Ma L, Wei W, Li X, Chang Y, Pan Z, Gao H, Yang R, Bi Y, Ding L. Metagenomics analysis of cultured mucosal bacteria from colorectal cancer and adjacent normal mucosal tissues. J Med Microbiol. 2022 Apr;71(4).

3       Mengdi Hao, Huimin Li, Kun Wang, Yin Liu, Xiaoqing Liang and Lei Ding*.Predicting metachronous liver metastasis in patients with colorectal cancer: development and assessment of a new nomogram. World Journal of Surgical Oncology .(2022) 20:80

4       Yuhan Ding , Kun Wang , Chang Xu, Mengdi Hao, Huimin Li and Lei Ding*.Intestinal Claudin-7 defciency impacts the intestinal microbiota in mice with colitis. BMC Gastroenterology (2022) 22:24

5      Xu C, Ding YH, Wang K, Hao M, Li H, Ding L. Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling. J Transl Med. 2021 Jul 19;19(1):311.

6      Wang K, Ding Y, Xu C, Hao M, Li H, Ding L. Cldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrity. Oncoimmunology. 2021 May 11;10(1):1923910.

7       Yu H, Ma L, Zhu Y, Li W, Ding L, Gao H. Significant diagnostic value of circulating tumour cells in colorectal cancer. Oncol Lett. 2020 Jul;20(1):317-325

8     Xing T, Benderman LJ, Sabu S, Parker J, Yang J, Lu Q, Ding L, Chen YH. Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation. Cell Mol Gastroenterol Hepatol. 2020;9(4):641-659. 

9      Yuhan Ding, Wenxia Li, Kun Wang, Chang Xu, Mengdi Hao, Lei Ding*. Perspectives of the Application of Liquid Biopsy in Colorectal Cancer. BioMed Research International. 2020: 6843180. 

10    Chang Y, Hou F, Pan Z, Huang Z, Han N, Bin L, Deng H, Li Z, Ding L, Gao H, Zhi F, Yang R, Bi Y. Optimization of Culturomics Strategy in Human Fecal Samples. Front Microbiol. 2019 Dec 17;10:2891.

11    Hou F, Chang Y, Huang Z, Han N, Bin L, Deng H, Li Z, Pan Z, Ding L, Gao H, Yang R, Zhi F, Bi Y. Application of LpxC enzyme inhibitor to inhibit some fast-growing bacteria in human gut bacterial culturomics. BMC Microbiol. 2019 Dec 30;19(1):308.

12    Kun Wang, Tengyan Li, Chang Xu, Yuhan Ding, Wenjing Li, Lei Ding*. Claudin-7 downregulation induces metastasis and invasion in colorectal cancer via the promotion of epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2019; 508(3):797-804. 

13    Wenjing Li, Chang Xu, Kun Wang, Yuhan Ding, Lei Ding*. Non-tight junction-related function of Claudin-7 in interacting with Integrinβ1 to suppress colorectal cancer cell proliferation and migration. Cancer Management and Research. 2019;11: 1443–1451.

14    Xu Chang, Kun Wang, Yuhan Ding, Wenjing Li, and Lei Ding*. Claudin-7 gene knockout causes the destruction of intestinal structure and the death of mice. World Journal of Gastroenterology. 2019; 25(5): 521-643. 

15    Xu Chang, Xiaonan Wang, Wenjing Li, Kun Wang, and Lei Ding*. Expression and Clinical Significance of Claudin-7 in Patients With Colorectal Cancer. Technology in Cancer Research &Treatment. 2018,17:1-10.

16    Kun Wang, Chang Xu, Wenjing Li, Lei Ding*. Emerging clinical signifcance of claudin-7 in colorectal cancer: a review. Cancer Management and Research. 2018;10 :3741–3752.

17    Wen-Jing Li, Chang Xu, Kun Wang, Teng-Yan Li, Xiao-Nan Wang, Hui Yang, Tiaosi Xing, Wen-Xia Li, Yan-Hua Chen*, Hong Gao* and Lei Ding*. Severe intestinal inflammation in the small intestine of mice induced by controllable deletion of Claudin-7. Dig Dis Sci. 2018; 63(5):1200-1209.