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现为首都医科大学公共卫生学院营养与食品卫生学系教授,博/硕士研究生导师;兼任中国营养学会青年工作委员会委员兼秘书,中国营养学会基础营养分会委员,中国营养学会特殊营养分会委员,北京市营养学会理事,北京神经内科学会基础与转化医学专业委员会常务委员。主要从事衰老相关慢性疾病的营养预防和营养干预研究工作。作为第一负责人承担国家自然科学基金项目5项;其他来源科研项目10余项。作为主要参加人参与科技部重点研发计划项目1项,科技部863项目1项,国家自然科学基金重点项目1项,国家自然科学基金项目2项。发表科研论文70余篇,其中在国际期刊上发表第一及通讯作者SCI收录论文27篇;主参编教材10部,英文论著1部。2011年被评为首都医科大学中青年骨干教师;2012年入选北京市优秀人才;2013年入选北京市青年拔尖人才;2017年被中国营养学会评为中国营养科学十大青年科技之星;2022年入选北京市高层次公共卫生技术人才学科骨干。
[1] 北京市卫生健康委员会,北京高层次公共卫生技术人才培养计划项目,n-3 PUFAs 摄入及 ApoE 基因型影响老年人认知功能障碍发生过程中的作用及机制研究;执行时间:2022.4-2025.4;编号:2022-3-032;
[2] 国家自然科学基金面上项目;DHA及ApoE4通过调控脂筏脂质构成影响老年人认知功能的作用及机制研究;执行时间:2022.1-2025.12; 编号:82173508;
[3] 国家自然科学基金面上项目;基于RBP4/STRA6信号通路探讨维生素A在胰岛素抵抗促老年人认知功能障碍发生过程中的作用及机制研究; 执行时间:2020.1-2023.12; 编号:81973027;
[4] 国家自然科学基金面上项目;SR-B1/CD36基因多态性及膳食维生素E摄入对DHA干预改善老年人认知功能效果的影响及其机制研究; 执行时间:2017.1-2020.12; 编号:81673148;
[5] 国家自然科学基金面上项目;GSTM1、GSTT1基因多态性及富含黄酮类物质膳食摄入与阿尔茨海默氏病的相关性研究; 执行时间:2013.1-2016.12; 编号:81273071;
[6] 国家自然科学基金青年基金;GSTT1、GSTM1基因多态性对富含黄酮类物质膳食干预效果的影响;执行时间:2010.01-2012.12;编号:30901196;
[7] 北京市教育委员会科技发展计划面上项目;GST基因多态性、饮食与阿尔茨海默氏病的交互作用研究;执行时间:2013.1-2015.12;编号:KM201310025011;
[8] 北京市自然科学基金面上项目;GSTs基因多态性与黄酮类物质抗氧化功效相关性研究; 编号:7092008;
[9] 北京市优秀人才资助计划(北京市委组织部);GSTT1/GSTM1基因多态性及抗氧化维生素与阿尔茨海默病的相关性研究;执行时间:2011.1-2012.12;编号:2011D005018000011;
[10] 北京市青年拔尖人才培育计划项目(北京市教委);蔬菜水果摄入对DHA干预改善老年人认知功能的影响;执行时间:2013.1-2015.12;编号:CIT&TCD201304188;
[11] 内蒙古乳业技术研究院委托开发项目;平稳血糖功能慢消化碳水化合物与膳食纤维原料信息库建立,执行时间:2019.7-2019.9;
[12] 内蒙古乳业技术研究院委托开发项目;促进消化、吸收功能原料信息库建立,执行时间:2018.12-2019.3;
[13] 中国营养学会营养科研基金—帝斯曼专项科研基金;膳食维生素E摄入对DHA饮食干预改善老年人认知功能效果的影响及其机制研究;执行时间:2016.1-2017.12,编号:CNS2015070B;
[1] Li P,Xu J, Guo Y, Ma X, Zhou S, Zhang C, Yu H, Wang Y, Wang X, Yuan L*. Association of plasma vitamin A level with type 2 diabetesmellitus: a community aging population-based cross-sectional study. Food Science and Human Wellness.2023, Accepted
[2] Wang X, Wang Y, Ma X, Zhou S,Xu J, Guo Y, Liu L, Liu Y, Gao L, Yuan L*.Gender-specific association of SLC19A1 and MTHFR genetic polymorphism withoxidative stress biomarkers and plasma folate levels in older adults. Exp Gerontol. 2023, 178:112208.
[3] Xu J, Huang X, Guo Y, Ma X, Li P,Zhou S, Zhang C, Chen R, Van Halm-Lutterodt N, Yuan L*.Dietary Docosahexaenoic Acid Modulated Cerebral Lipids, Fatty AcidTransporter Expression and Soluble Beta-Amyloid Levels in ApoE-/- and C57BL/6Jmice. Neuropathology and AppliedNeurobiology. 2023, 49(1):e12855.
[4] Ma X, Guo Y, Xu J, Wang X, DongS, Gao Y, Van Halm-Lutterodt N, Yuan L*. Effects ofdistinct n-6 to n-3 polyunsaturated fatty acid ratios on insulin resistant andAD-like phenotypes in high-fat diets-fed APP/PS1 mice. Food Research International. 2022, 162(Pt B):112207.
[5] Li P, Gao Y, Ma X, Zhou S, Guo Y, Xu J, Wang X, Van Halm-LutterodtN, Yuan L*. Study on the Association of Dietary Fatty Acid Intake and SerumLipid Profiles With Cognition in Aged Subjects With Type 2 Diabetes Mellitus. Front Aging Neurosci. 2022, 14:846132.
[6] Xu J, Guo Y, Huang X, Ma X, Li P, Wang Y, Wang X, Yuan L*. Effects ofDHA dietary intervention on hepatic lipid metabolism in apolipoproteinE-deficient and C57BL/6J wild-type mice. Biomed Pharmacother. 2021, 144:112329.
[7] Ma X, Guo Y, Li P, Xu J, Gao Y, Ren X, Van Halm-Lutterodt N, Yuan L*. Associationbetween ApoE status, circulating vitamin A and vitamin E levels withdyslipidemia in aging Chinese adults. Arch Med Res. 2021, 52(7):703-712.
[8] Guo Y, Ma X, Li P, Dong S, Huang X, Ren X, Yuan L*. High fatdiet caused discrepant peripheral and central nervous system metabolic changesin APPswe/PS1dE9 and wild-type C57BL/6J mice. Aging. 2020, 13(1):1236-1250.
[9] Guo Y, Li P, Ma X, Huang X, Liu Z, Ren X, Yang Y, Halm-Lutterodt NV,Yuan L*. Association of Circulating Cholesterol Level with CognitiveFunction and Mild Cognitive Impairment in the Elderly: A Community-basedPopulation Study. Curr Alzheimer Res. 2020, 17(6):556-565.
[10] Huang X, Guo Y, Li P, Ma X, Dong S, Hu H, Li Y, Yuan L*. Association of Circulating Retinoland α-TOH Levels with Cognitive Function in Aging Subject with Type 2 DiabetesMellitus. J Nutr Health Aging.2020, 24(3):290-299.
[11]Huang X, Zhen J, Dong S, Zhang H, Van Halm-Lutterodt N, Yuan L*. DHA and vitaminE antagonized the Aβ(25-35)-mediated neuron oxidative damage through activationof Nrf2 signaling pathways and regulation of CD36, SRB1 and FABP5 expression inPC12 cells. Food Funct. 2019, 10(2):1049-1061.
[12] Huang X, Zhang H, Zhen J, Dong S, Guo Y, Van Halm-Lutterodt N, Yuan L*. DiminishedCirculating Retinol and Elevated α-TOH/retinol Ratio Predict an Increased Riskof Cognitive Decline in Aging Chinese Adults, Especially in Subjects with ApoE2or ApoE4 Genotype. Aging. 2018, 10(12):4066-4083.
[13] Dong S, Huang X, Zhen J, VanHalm-Lutterodt N, Wang J, Zhou C, Yuan L*. Dietary Vitamin E Status Dictates OxidativeStress Outcomes by Modulating Effects of Fish Oil Supplementation in AlzheimerDisease Model APPswe/PS1dE9 Mice. Molecular Neurobiology. 2018, 55(12):9204-9219.
[14] Zhen J, Lin T, Huang X, Zhang H, Dong S, Wu Y, Song L, Xiao R, Yuan L*. Associationof ApoE Genetic Polymorphism and Type 2 Diabetes with Cognition in Non-DementedAging Chinese Adults: A Community Based Cross-Sectional Study. Aging Dis. 2018, 9(3):346-357.
[15] Huang X, Dong S, Zhen J, ZhangH, Lin T, Zeng Y, Van Halm-Lutterodt N, YuanL*. The Role ofApoE Polymorphism in the Relationship between Serum Steroid Hormone Levels and Cognitionin Older Chinese Adults: A Cross-Sectional Study. Front Endocrinol. 2018, 9:71.doi:10.3389/fendo.2018.00071
[16] Zhen J, Huang X, Van Halm-Lutterodt N, Dong S, Ma W, Xiao R, Yuan L*. ApoErs429358 and rs7412 polymorphism and Gender Differences of Serum Lipid Profileand Cognition in Aging Chinese Population. Frontier in aging neuroscience, 2017,9: doi: 10.3389/fnagi.2017.00248
[17] Yuan L, Liu J, ZhenJ, Xu Y, Chen S, Halm-Lutterodt NV, Xiao R. Vegetable and fruit juice enhancesantioxidant capacity and regulates antioxidant gene expression in rat liver,brain and colon. Genet Mol Biol, 2017, 40(1):134-141.
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