导师风采
施致雄
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个人信息

Personal Information

  • 教授
  • 导师类别:硕士,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:公共卫生学院
  • 所属专业: 卫生毒理学
  • 邮箱 : szx0127@ccmu.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

施致雄,首都医科大学公共卫生学院教授,博士生导师。2009年博士毕业于中国疾病预防控制中心。从事环境污染与人群健康研究,主要研究内容为新污染物的人群暴露、健康效应与毒作用机制,以及新污染物的检测技术研发与应用,主持国家自然科学基金3项,以及北京市自然科学基金重点项目、面上项目、首都卫生发展专项基金等多项省部级课题。2014年入选北京市青年拔尖人才及北京市优秀人才。已发表研究论文60余篇,其中SCI收录近50篇(第一或通讯作者)。研究成果获批省部级科技进步二等奖一项。参编专著7部,教材6部。兼任中国生态学会生态健康与人类生态专委会委员、中国毒理学会分析毒理专委会委员,北京市预防医学会理化检验分会委员等职务。


  • 研究方向Research Directions
环境污染与人类健康,环境污染物检测技术
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
团队展示

IMG_1058

2023年教师节师生合影


2021年教师节师生合影

2021年 教师节师生合影


项目情况

1)  有机磷阻燃剂及其降解产物的膳食暴露评估、健康指导值制定与暴露风险特征分析,北京市教委-北京市自然科学基金联合资助重点项目,北京市教育委员会科技计划重点项目, 2023.1-2025.12

2)食品中有机磷酸酯及其降解产物的检测技术研发及北京居民膳食暴露评估,首都卫生发展科研专项, 2022.01-2024.12

3)  基于北京市总膳食研究的四溴双酚A/S类阻燃剂的人群暴露评估与甲状腺干扰效应研究,北京市教委-北京市自然科学基金联合资助项目,北京市教育委员会科技计划重点项目, 2019.1-2021.12

4) 十溴二苯乙烷的人群暴露评估及长期暴露的肝脏毒性效应研究, 国家自然科学基金面上项目,21777107,2018.1-2021.12

5) 溴系阻燃剂的母婴暴露评估及母体孕期/哺乳期暴露对子代神经发育的影响,国家自然科学基金面上项目,2015.1-2018.12

6) 典型溴系阻燃剂的暴露评估及低剂量暴露的代谢组学研究,国家自然科学基金青年基金, 2011.01-2013.12

7) 北京市食品中溴系阻燃剂的污染状况及其健康效应探索,北京市自然科学基金面上项目,2012.01-2014.12


科研项目

1)  有机磷阻燃剂及其降解产物的膳食暴露评估、健康指导值制定与暴露风险特征分析,北京市教委-北京市自然科学基金联合资助重点项目,北京市教育委员会科技计划重点项目, 2023.1-2025.12

2)食品中有机磷酸酯及其降解产物的检测技术研发及北京居民膳食暴露评估,首都卫生发展科研专项, 2022.01-2024.12

3)  基于北京市总膳食研究的四溴双酚A/S类阻燃剂的人群暴露评估与甲状腺干扰效应研究,北京市教委-北京市自然科学基金联合资助项目,北京市教育委员会科技计划重点项目, 2019.1-2021.12

4) 十溴二苯乙烷的人群暴露评估及长期暴露的肝脏毒性效应研究, 国家自然科学基金面上项目,21777107,2018.1-2021.12

5) 溴系阻燃剂的母婴暴露评估及母体孕期/哺乳期暴露对子代神经发育的影响,国家自然科学基金面上项目,2015.1-2018.12

6) 典型溴系阻燃剂的暴露评估及低剂量暴露的代谢组学研究,国家自然科学基金青年基金, 2011.01-2013.12

7) 北京市食品中溴系阻燃剂的污染状况及其健康效应探索,北京市自然科学基金面上项目,2012.01-2014.12


研究成果

(一)第一或通讯作者研究论文

2023年

1.Jiaying Liu, Linlin Song, Jing Zhan, Yunxin Zhong, Zhixiong Shi*, Occurrence of legacy and alternative per- and polyfluoroalkyl substances in serum from high exposure population and their disrupting effects on serum lipids and thyroid function, Science of the Total Environment, 2023, 878, 162988 (IF=10.753, 10.237) 

2.Xiangyang Li#, Yue Zhang#, Leqiang Gao, Xiaodi Yang, Guiqing Zhou, Yujian Sang, Jinglong Xue, Zhixiong Shi*, Zhiwei Sun, Xianqing Zhou*, BDE-209 induced spermatogenesis disorder by inhibiting SETD8/H4K20me1 related histone methylation in mice, Science of the Total Environment, 2023, 864, 161162 (IF=10.753, 10.237) 

3.Li Jing, Dan Zheng, Xuejing Sun, Zhixiong Shi*, DBDPE upregulates NOD-like receptor signaling to induce NLRP3 inflammasome-mediated HAECs pyroptosis, Environmental Pollution, 2023, 318, 120882 (IF=9.988, 10.366)

4.Shunying Yao#, Zhixiong Shi#, Pei Cao, Lei Zhang, Yu Tang, Pingping Zhou*, Zhaoping Liu*, A global survey of organophosphate esters and their metabolites in milk: Occurrence and dietary intake via milk consumption. Journal of Hazardous Materials, 2023, 442, 130080. (IF=14.224, 12.984)

5.Xuezhen Zhao, Bing Lyu*, Lei Zhang, Jingguang Li, Yunfeng Zhao, Yongning Wu, Zhixiong Shi*, Legacy and novel brominated flame retardants in animal-derived foods from China Total Diet Study (CTDS): Temporal trends, evidence of substitution, and dietary exposure assessment. Journal of Hazardous Materials, 2023, 443, 130223. (IF=14.224, 12.984)


2022年

1.Xuelei Chen, Nan Zhang, Liping Li, Rong Zhao, Ning Chen, Sai Fan*, Zhixiong Shi*, A simple method for simultaneous determination of organophosphate esters and their diester metabolites in dairy products and human milk by using solid phase extraction coupled to liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 2022, 414, 4255-4265(IF=4.478, 4.29)

2.Ning Chen#, Sai Fan#, Nan Zhang, Yao Zhao, Shunying Yao, Xuelei Chen, Xiaofeng Liu*, Zhixiong Shi*, Organophosphate esters and their diester metabolites in infant formulas and baby supplementary foods collected in Beijing, China: Occurrence and the implications for infant exposure. Science of the Total Environment, 2022, 827: 154272 (IF=10.753, 10.237) 

3.Tian Chen#, Xueting Wang#, Jiaxin Jia, Dejun Wang, Yanxin Gao, Xin Yang, Shixuan Zhang, Piye Niu*, Zhixiong Shi*, Reduced mitochondrial DNA copy number in occupational workers from brominated flame retardants manufacturing plants, Science of the Total Environment, 2022, 809, 151086 (IF=10.753, 10.237)

4.Li Jing#, Yanmin Sun#, Ji Wang, Xianqing Zhou, Zhixiong Shi*, Oxidative stress and endoplasmic reticulum stress contributed to hepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells, Chemosphere, 2022, 286:131550 (IF= 8.943, 8.52)


2021年

1.     Xuelei Chen#, Sai Fan#, Bing Lyu, Lei Zhang,Shunying Yao, Jiaying Liu,* Zhixiong Shi,* Yongning Wu, Occurrence and DietaryIntake of Organophosphate Esters via Animal-Origin Food Consumption in China:Results of a Chinese Total Diet Study, Journal of Agricultural and FoodChemistry, 2021, 69, 13964−13973 (IF = 5.895, 6.048)

2.    Xuezhen Zhao, Zhixiong Shi*, Legacy brominated flame retardants inhuman milk from the general population in Beijing, China: Biomonitoring,temporal trends from 2011 to 2018, and nursing infant’s exposure assessment,Chemosphere, 2021, 285:131533 (IF= 8.943,8.52)

3.     Xuelei Chen, Wei Li, Jingguang Li, Sai Fan,Zhixiong Shi*, Rapid determination of 13 organophosphorus flame retardants inmilk by using modified quick, easy, cheap, effective, rugged, and safetechnique, solid-phase extraction, and HPLC-MS/MS, Journal of SeparationScience, 2021, 44(11): 2269-2278 (IF=3.614, 2.904)

4.     Xuelei Chen, Xuezhen Zhao, Zhixiong Shi*, Organophosphorus flame retardants in breast milk fromBeijing, China:Occurrence, nursing infant’s exposure and risk assessment, Scienceof the Total Environment, 2021, 771, 145404  (IF=10.753, 10.237)

5.     Xuezhen Zhao#, Xiaodi Yang#, Yinglin Du,Renbo Li, Tao Zhou, Yuwei Wang, Tian Chen, Dejun Wang*, Zhixiong Shi*,Polybrominated diphenyl ethers in serum from residents living in a brominatedflame retardant production area: Occurrence, influencing factors, andrelationships with thyroid and liver function, Environmental Pollution, 2021, 270,116046 (IF=9.988,10.366)

6. Xuezhen Zhao#, Tian Chen#, Bin Yang, Dejun Wang, Wen Sun, Yuwei Wang,Xiaodi Yang, Sheng Wen, Jingguang Li*, Zhixiong Shi*, Serum levels of novelbrominated flame retardants (NBFRs) in residents of a major BFR-producingregion: Occurrence, impact factors and the relationship to thyroid and liverfunction, Ecotoxicology and Environmental Safety, 2021, 208, 111467 (IF=7.129,7.284)

 

2020年

1.  Xuezhen Zhao#, Tian Chen#, Dejun Wang,Yinglin Du, Yan Wang, Wenwen Zhu, Melikedilnur Bekir,Dong Yu*, Zhixiong Shi*, Polybrominated diphenyl ethers and decabromodiphenylethane in paired hair/serum and nail/serum from corresponding chemicalmanufacturing workers and their correlations to thyroid hormones, liver andkidney injury markers, Science of the Total Environment, 2020, 729, 139049 (IF=10.753, 10.237)

2. Jiandi Wang, Jian Li, Zhixiong Shi*, Dietary exposure assessment ofa nursing mother-infant cohort to legacy and novel brominated flame retardants:Results of a 3-day duplicate diet study in Beijing, China, Chemosphere, 2020, 254:126843(IF= 8.943,8.52)

3.  Morong Huang#, Jian Li#, Zhongxin Xiao,Zhixiong Shi*, Tetrabromobisphenol A and hexabromocyclododecane isomers inbreast milk from the general population in Beijing, China: Contaminationlevels, temporal trends, nursing infant’s daily intake and risk assessment,Chemosphere, 2020, 244: 125524 (IF= 8.943, 8.52)

4. Yanmin Sun, Yuwei Wang, Baolu Liang, Tian Chen, Dan Zheng, XuezhenZhao, Li Jing*, Xianqing Zhou, Zhiwei Sun, Zhixiong Shi*, Hepatotoxicity ofdecabromodiphenyl ethane (DBDPE) and decabromodiphenyl ether (BDE-209) in28-day exposed Sprague-Dawley Rats, Science of the Total Environment, 2020, 705,135783 (IF=10.753,10.237)

 

2019年

1. Tian Chen, Morong Huang, Jian Li, Jingguang Li, Zhixiong Shi*, Polybrominated diphenyl ethers and novelbrominated flame retardants in human milk from the general population inBeijing, China: Occurrence, temporal trends, nursing infants’ exposure and riskassessment, Science of the Total Environment, 2019, 689:278-286 (IF=10.753, 10.237)

2.  Tian Chen, Dong Yu, Luping Yang, ShaofengSui, Shibo Lv, Yi Bai, Wen Sun, Yuwei Wang, Li Chen, Zhiwei Sun, Lin Tian,Dejun Wang*, Piye Niu*, Zhixiong Shi*, Thyroid function and decabromodiphenylethane (DBDPE) exposure in Chinese adults from a DBDPE manufacturing area,Environment International, 2019, 133:105179 (IF=13.352, 13.238)

3.  Dejun Wang#, Tian Chen#, Zhongjian Fu,Luping Yang, Renbo Li, Shaofeng Sui, Yuwei Wang, Zhixiong Shi*, Occupationalexposure to polybrominated diphenyl ethers or decabromodiphenyl ethane duringchemical manufacturing: Occurrence and health risk assessment, Chemosphere,2019, 231:385-392 (IF= 8.943, 8.52)

4. Yuwei Wang#, Tian Chen#, Yanmin Sun, Xuezhen Zhao, Dan Zheng, LiJing*, Xianqing Zhou, Zhiwei Sun, Zhixiong Shi*, A comparison of the thyroiddisruption induced by decabrominated diphenyl ethers (BDE-209) anddecabromodiphenyl ethane (DBDPE) in Rats, Ecotoxicology and EnvironmentalSafety, 2019, 174:224-235 (IF=7.129,7.284)

5.  Jiandi Wang, Xuezhen Zhao, Yifei Wang,Zhixiong Shi*, Tetrabromobisphenol A, hexabromocyclododecane isomers andpolybrominated diphenyl ethers in foodstuffs from Beijing, China: Contaminationlevels, dietary exposure and risk assessment, Science of the Total Environment,2019, 666:812-820 (IF=10.753, 10.237)

6.  Li Jing, Yanmin Sun, Yuwei Wang, BaoluLiang, Tian Chen, Dan Zheng, Xuezhen Zhao, Xianqing Zhou, Zhiwei Sun, ZhixiongShi*, Cardiovascular toxicity of decabrominated diphenyl ethers (BDE-209) anddecabromodiphenyl ethane (DBDPE) in rats, Chemosphere, 2019, 223:675-685 (IF= 8.943, 8.52)

 

2018年

1.  Yuwei Wang, Yanmin Sun, Tian Chen, ZhixiongShi*, Xianqing Zhou, Zhiwei Sun, Lei Zhang, Jingguang Li*, Determination ofpolybrominated diphenyl ethers and novel brominated flame retardants in humanserum by gas chromatography-atmospheric pressure chemical ionization-tandemmass spectrometry, Journal of Chromatography B, 2018, 1099: 64-72 (IF=3.318, 3.164 Q2)

2. Tian Chen#, Piye Niu#, Fanling Kong, Yuwei Wang, Yi Bai, Dong Yu,Jiaxin Jia, Luping Yang, Zhongjian Fu, Renbo Li, Jingguang Li, Lin Tian, ZhiweiSun, Dejun Wang*, Zhixiong Shi*, Disruption of thyroid hormone levels bydecabrominated diphenyl ethers (BDE-209) in occupational workers from adeca-BDE manufacturing plant, EnvironmentInternational, 2018, 120:505-515 (IF=13.352, 13.238)

3.  Zhixiong Shi, Lei Zhang, Jingguang Li,Yongning Wu*, Legacy and emerging brominated flame retardants in China: Areview on food and human milk contamination, human dietary exposure and riskassessment, Chemosphere, 2018, 198:522-536 (IF= 8.943, 8.52)

4. Jiandi Wang#, Yuwei Wang#, Zhixiong Shi*, Xianqing Zhou, Zhiwei Sun.Legacy and novel brominated flame retardants in indoor dust from Beijing,China: Occurrence, human exposure assessment and evidence for PBDEs replacement,Science of the Total Environment, 2018, 618:48-59 (IF=10.753, 10.237)

 

2017年及之前

1. Zhixiong Shi*, Lei Zhang, Yunfeng Zhao, Zhiwei Sun, Xianqing Zhou,Jingguang Li*, Yongning Wu. Dietary exposure assessment of Chinese populationto tetrabromobisphenol-A, hexabromocyclododecane and decabrominated diphenylether: Results of the 5th Chinese Total Diet Study, Environmental Pollution,2017, 229:539-547 (IF=8.071,8.35)

2. Zhixiong Shi*, Lei Zhang, Yunfeng Zhao, Zhiwei Sun, Xianqing Zhou,Jingguang Li*, Yongning Wu. A National Survey of Tetrabromobisphenol-A,Hexabromocyclododecane and Decabrominated Diphenyl Ether in Human Milk fromChina: Occurrence and Exposure assessment, Science of the Total Environment,2017, 599-600:237-245 (IF=7.963,7.842)

3.  Jian Li#, Tian Chen#, Yuwei Wang, ZhixiongShi*, Xianqing Zhou, Zhiwei Sun, Dejun Wang*, Yongning Wu, Simple and fastanalysis of tetrabromobisphenol A, hexabromocyclododecane isomers, and polybrominateddiphenyl ethers in serum using solid-phase extraction or QuEChERS extractionfollowed by tandem mass spectrometry coupled to HPLC and GC, Journalof Separation Science, 2017, 40(3):709-716 (IF=3.645, 2.943, Q2)

4.  ZhixiongShi*, Lei Zhang, Jingguang Li, Yunfeng Zhao, Zhiwei Sun, Xianqing Zhou,Yongning Wu*, Novel brominated flame retardants in food composites and humanmilk from the Chinese Total Diet Study in 2011: Concentrations and a dietary exposureassessment, Environment International, 2016, 96: 82-90 (IF=9.621, 10.72)

5.  LeGao#, Jian Li#, Yandan Wu, Miaohao Yu, Tian Chen, Zhixiong Shi*, XianQing Zhou,Zhiwei Sun, Determinationof novel brominated flame retardants and polybrominated diphenyl ethers inserum using gas chromatography-mass spectrometrywith two simplified sample preparation procedures, Analytical and BioanalyticalChemistry, 2016, 408(27):7835–7844(“创之星”杯中国实验医学年度优秀论文评选,2017年 三等奖)(IF= 4.142,3.863, Q2)

6.  Zhixiong Shi, Yifei Wang, Piye Niu*, JiandiWang, Zhiwei Sun, Shuhua Zhang, Yongning Wu, Concurrent extraction, clean-up,and analysis of polybrominated diphenyl ethers, hexabromocyclododecane isomers,and tetrabromobisphenol A in human milk and serum, Journal of SeparationScience, 2013, 36(20):3402-3410. (IF=3.645,2.943, Q2)

71.  Zhixiong Shi*, Yang Jiao, Yue Hu, ZhiweiSun, Xianqing Zhou, Jinfang Feng, Jingguang Li, Yongning Wu*, Levels of tetrabromobisphenol A, hexabromocyclododecanes andpolybrominated iphenyl ethers in human milk from the general population inBeijing, China, Science of the Total Environment, 2013, 452-453:10-18 (IF=7.963, 7.842)

8.  ZhixiongShi, Yongning Wu*, Jingguang Li, Yunfeng Zhao, Jinfang Feng*. Dietary exposure assessmentof Chinese adults and nursing infants to tetrabromobisphenol-Aand hexabromocyclododecanes: occurrence measurements in foods and human milk.Environmental Science & Technology, 2009,43(12):4314-4319 (IF=11.357,12.154)

(二)参编专著

1.  吴永宁、李敬光 主编,施致雄等参编,持久性有机污染物的中国膳食暴露与人体负荷,科学出版社,2019年,ISBN:9787030623959

2.  吴永宁 主编,施致雄等参编,食品中有机污染物 检测方法标准操作程序,中国质检出版社/中国标准出版社,2018年,ISBN:978-7-5066-8750-8

3.  吴永宁、赵云峰、李敬光 主编,施致雄等参编,第五次全国总膳食研究,科学出版社,2018年,ISBN:9787030509635

4.  吴永宁、苗虹、李敬光 主译,施致雄等参译,食品污染物与残留分析,中国轻工业出版社,2017年,ISBN:978-7-5184-0766-8

5.  吴永宁、李筱薇主编,施致雄参编,第四次全国总膳食研究,化学工业出版社,2015年,ISBN:9787122227768

6. 吴永宁主编,施致雄等参编,食品污染监测及控制技术:理论与实践,ISBN: 9787122050618, 化学工业出版社,2011年

(三)科研获奖

1. 典型溴代阻燃剂的膳食和人体暴露评估技术,湖北省科学技术进步奖二等奖,  2018年



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