导师风采
刘良发
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个人信息

Personal Information

  • 教授
  • 导师类别:硕士,博士生导师
  • 性别: 男
  • 学位:博士

联系方式

Contact Information

  • 所属院系:附属北京友谊医院
  • 所属专业: 耳鼻咽喉科学
  • 邮箱 : liuliangfa301@163.com
  • 工作电话 : -

个人简介

Personal Profile

2013-11 至 今, 首都医科大学附属北京友谊医院, 耳鼻咽喉头颈外科, 教授

2008-10 至 2013-10, 解放军总医院, 耳鼻咽喉头颈外科, 教授

2009-02 至 2009-04, 香港大学玛丽医院, 头颈外科

2000-10 至 2008-10, 解放军总医院, 耳鼻咽喉头颈外科, 副教授

1997-07 至 2000-10, 解放军总医院, 耳鼻咽喉头颈外科, 主治医师

1992-10 至 1994-08, 成都军区第47医院, 耳鼻喉科, 主治医师

1990-08 至 1992-10, 成都军区第47医院, 耳鼻喉科, 医师 


  • 研究方向Research Directions
头颈肿瘤外科基础与临床研究
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
项目情况

1.α2δ1调控头颈鳞癌多重耐药:基于条件性重编程和肿瘤类器官模型的分子机制研究, 2021-01至2023-12

2.PPI与H2RA预防应激性溃疡的多中心随机对照临床研究, 2018-06 至 2022-06

3.中国医学科学院条件保障部, 中国科学院科研仪器设备研制项目, 智能微相机阵列内窥成像系统研制, 2019-01至2020-12

4.2018-1-2052, 分化型甲状腺癌的风险分层及个体化治疗策略, 2018-01至2020-12

5.喉鳞状细胞癌肿瘤干细胞标志物相关研究, 2015-01至2018-12

6.Rh oC对喉鳞状细胞癌ALDH1+肿瘤干细胞的作用及机制研究, 2014-01 至 2017-12

7.干扰RhoC对喉鳞状细胞癌侵袭与转移影响的实验研究, 2015-01至2017-12


译著

《头颈外科手术重建》主译 科学出版社 201812


研究成果

学术论文:

1. Yanbo Dong,Jian Wang,Wei Ji,Mengzhu Zheng,Peng Wang,Liangfa Liu,Shanhu Li. Establishment and Preclinical Application of Conditional Reprogramming Culture System for Laryngeal and Hypopharyngeal Carcinoma. 2021.sci

2. WanXin Li #, Yanbo Dong#, Aobo Zhang, Jun Tian , Cheng Lu, Mohammad Shahed Quraishi , Liangfa Liu*. Management of deep neck infections from cervical esophageal perforation caused by foreign body: A case series study[J]. American Journal of Otolaryngology, 2020:102870.

3. WanXin Li #, Yanbo Dong#, Aobo Zhang, Jun Tian , Cheng Lu, Mohammad Shahed Quraishi , Liangfa Liu*.Management of deep neck infections from cervical esophageal perforation caused by foreign body: A case series study. AMERICAN JOURNAL OF OTOLARYNGOLOGY. 2021,42(102870):1-6.SCI

4. Li WX, Bai JQ, Dong YB, Liu LF. Diagnosis and Management of Giant Esophageal Fibrovascular Polyp With Hypopharyngeal Pedicle. Ear Nose Throat J. 2022 Jul;101(6):374-378. doi: 10.1177/01455613211046461. Epub 2021 Nov 29.

5. Li WX, Zhu Y, Dong Y, Liu L. Diagnosis and Management of Occult Cervical Tuberculous Lymphadenopathy. Ear Nose Throat J. 2022 Jul;101(6):359-364. doi: 10.1177/01455613211043692. Epub 2021 Nov 29.

6. Li WX, Dong YB, Lu C, Bradley PJ, Liu LF. Survival and swallowing function outcome impact factors analysis of surgery-oriented comprehensive treatment for hypopharyngeal cancer in a series of 122 patients. Ear Nose Throat J. 2021 Nov 18:1455613211058108. doi: 10.1177/01455613211058108. Epub ahead of print.

7. Yanbo Dong,Guangzhi Ma,Yukun Liu,Siyu Lu, Liangfa Liu*.Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis. Dis Markers. 2020,.SCI

8. Yanbo Dong, Siyu Lu, Zhenxiao Wang, Liangfa Liu*.CCTs as new biomarkers for the prognosis of head and neck squamous cancer. Open Medicine. 2020,15(1):672-688.SCI

9. WanXin Li, Yanbo Dong, Aobo Zhang, Jun Tian, Cheng Lu, Jean Pierre Jeannon* ,Liangfa Liu*. surgical treatment of fourth branchial apparatus anomalies: a case series study . Journal of Otolaryngology-Head & Neck Surgery. 2020,49(79):1-8.SCI

10. Chaoping Huang, Zhenxiao Wang, Kun Zhang, Yanbo Dong,Aobo Zhang, Cheng Lu*,Liangfa Liu*.MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro. ANTI-CANCER DRUGS. 2020,31(3):260-271.SCI

11. Wenting Pang , Aobo Zhang , Cheng Lu , Jun Tian , Wanxin Li , Zhenxiao Wang , Yanbo Dong , Shuoqing Yuan , Zihao Niu , Yiyuan Zhu , M. Shahed Quraishi* ,Liangfa Liu*.Design and application of submental island flap to reconstruct non-circumferential defect after hypopharyngeal carcinoma resection A prospective study of 27 cases. ACTA OTO-LARYNGOLOGICA. 2020,140(12):1036-1042.SCI

12. Zhenxiao Wang,Chaoping Huang,Aobo Zhang,Cheng Lu,Liangfa Liu*.Overexpression of circRNA_100290 promotes the progression of laryngeal squamous cell carcinoma through the miR-136-5p/RAP2C axis.. Biomedicine & Pharmacotherapy. 2020,May 125:10.1016/j.biopha.2020.109874[Epub ahead of print].SCI

13. Chaoping Huang,Zhenxiao Wang,Kun Zhang,Yanbo Dong,Aobo Zhang,Cheng Lu,Liangfa Liu*.MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro.. Anticancer Drugs. 2020,31(3):260-271.SCI

14. Chaoping Huanga#, Yan Li# , Wei Zhao, Aobo Zhang, Cheng Lu, Zhenxiao Wang and Liangfa Liu∗.α2δ1 may be a potential marker for cancer stem cell in laryngeal squamous cell carcinoma. Cancer Biomarkers. 2019,24(1):97-107.SCI

15. Patrick J. Bradley, Liangfa Liu.Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes. Curr Opin Otolaryngol Head Neck Surg. 2019,27(2):123-129.SCI

16. Li Y,Min D,Wang K,Yin S,Zheng H,Liu L*.MicroRNA‑152 inhibits cell proliferation, migration and invasion by directly targeting MAFB in nasopharyngeal carcinoma. Molecular medicine reports. 2017,15(02):948-956.SCI

17. Yueying Ma,Liangfa Liu*.Progress of head and neck surgery in China. ENT & Audiology News. 2017,26(1):62-64.

18. Junbo Zhang, Xue He, Huaiyin Shi, Weiwei Guo, Yueying Ma, Yanli Liu, Liangfa Liu*.Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma. Int J Clin Exp Pathol. 2015,8(1):244-251.SCI

19. Ma, Y.,Liu, L.*, Wang, W., Lu, C., Zhang, A., Song, Y.,Zhang, R., Oghagbon, E.K., Xiang, M..Reconstruction of hypopharyngeal non-circumferential defects with a submental island flap after hypopharyngeal carcinoma ablation, our experience of 13 cases. Clinical Otolaryngology. 2015,Aug 21. :doi: 10.1111/coa.12522. [Epub ahead of print].SCI


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