1.科技部重点研发计划子课题，2022YFA0806401，测绘成体菌群及代谢产物在不同生理/病理状态下的动态变化规律，2022-12至2027-12，783万元，在研，主持；

2.国家自然科学基金委员会，面上项目，82470889，肠菌源DPP4同工酶通过抑制GLP-1/十四烷酸/PPARα通路促进代谢相关脂肪性肝病的机制研究，2025-01至2028-12 , 48万元，在研，主持；

3.国家自然科学基金委员会，面上项目，81972137，有氧运动通过GLP-1及其下游核受体及氧化应激信号改善小鼠心梗模型心功能康复，2020-01至2023-12 , 55万元，结题，主持；

4.国家自然科学基金委员会，面上项目，81770792，GLP-1受体激动剂通过FGF21/FGFR1/β-Klotho途径调节肥胖小鼠脂肪组织神经酰胺代谢异常的机制研究，2018-01至 2021-12, 56万元，结题，主持；

5.  北京市医管局重点专科扬帆计划，ZYLX202106，2021-01至2023-12，100万元，主持。

1、  Sun L#, Xie C#, Wang G#, Wu Y#,Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X,Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J,Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C*. Gut microbiota andintestinal FXR mediate the clinical benefits of metformin. Nat Med.2018;24(12):1919-1929. (IF:50, Q1)

2、  Wang K#, Zhang Z#, Hang J#, Liu J#, Guo F, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Luo X, Zhong Q, Ye C, Yun C, Zhang Y, Wang J, Bao R, Pang Y, Wang G*, Gonzalez F*, Lei X*, Qiao J*, Jiang C*, Microbial-host-isozyme analyses reveal microbial DPP4 as a potentialantidiabetic target. Science, 2023; 381(6657):eadd5787. (IF:45.8, Q1)

3、 Zhang Y#, Wang X#, Liu J#, Liu J#, Wagn K, Nie Q, Ye C, Sun L, Ma Y, Qu R, Mao Y, Zhang X, Lu H, Xia P, Zhao D, Wang G*, Zhang Z*, Fu W*, Jiang C*, Pang Y*, A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH. Cell Metab. 2024; 36(8):1823-1838. (IF:30.9, Q1)

4、 Liu J, Xu Y, Hu Y, Wang G*. Therole of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fattyliver disease and implications for therapy. Metabolism. 2015;64(3):380-390. (IF:11.9, Q1)

5、  Yu J#, Jin N#, Wang G*, ZhangF, Mao J, Wang X. Peroxisome proliferator-activated receptor gamma agonistimproves arterial stiffness in patients with type 2 diabetes mellitus andcoronary artery disease. Metabolism. 2007;56(10):1396-1401. (IF:11.9, Q1)

6、  Wang G#, Wei J#, Guan Y, Jin N, Mao J, Wang X*. Peroxisomeproliferator-activated receptor-gamma agonist rosiglitazone reduces clinicalinflammatory responses in type 2 diabetes with coronary artery disease aftercoronary angioplasty. Metabolism. 2005;54(5):590-597. (IF: 11.9, Q1)

7、 Zhang H#, Huang Y#, Chen S, Tang C, Wang G*, Du J*, Jin H*.Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetesmellitus, a new promising target for diabetes mellitus treatment? A review. J Adv Res. 2021;27:19-30. (IF:13, Q1)

8、 Liu J, Wang Y, An H, Liu J, Wei J, Wang H, Wang G*.Correlation between arterial stiffness and coronary flow velocity reserve insubjects with pulse wave velocity >1400 cm/s. Clin Exp Hypertens.2016;38(1):89-94. (IF: 3.5, Q2)

9、 Yang M#, Wei Y, Liu J, Wang Y*, Wang G*, Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus. Diabetes Metab J. 2025;49(4):883-892. (IF:8.5, Q1)

10、 Sun H#, Wu Z#, Wang G*, Liu J*, Normalized Creatinine-to-Cystatin C Ratio and Risk of Cardiometabolic Multimorbidity in Middle-Aged and Older Adults: Insights from the China Health and Retirement Longitudinal Study, Diabetes Metab J. 2025;49(3):448-461. (IF:8.5, Q1) 

11、  Sun W#, Wang G#, Zhang ZM, ZengXK, Wang X*. Chemokine RANTES is upregulated in monocytes from patients withhyperhomocysteinemia. Acta Pharmacol Sin. 2005;26(11):1317-1321. (IF: 8.4, Q1)

12、  Liu J, Wang G*, Jia Y, Xu Y*.GLP-1 receptor agonists: effects on the progression of non-alcoholic fattyliver disease. Diabetes Metab Res Rev. 2015;31(4):329-335. (IF: 6.0, Q1)

13、 Wang G#*, Liu J#, Yang N, Hu Y, Zhang H, Miao L, YaoZ, Xu Y. Levothyroxine treatment restored the decreased circulating fibroblastgrowth factor 21 levels in patients with hypothyroidism. Eur J Intern Med.2016;31:94-98. (IF: 6.1, Q1)

14、 Ding X, Tian J, Chang X, Liu J*, Wang G*. Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study. Eur J Prev Cardiol. 2025;32(13):1157-1165. (IF 7.5, Q1)

15、 Cui R#, Wei Y#, Liu J*, Wang G*, Hepatic insulin resistance affects the efficacy of metformin in patients with newly diagnosed type 2 diabetes: A Sub-Analysis of the MARCH trial. Diabetes Res Clin Pract. 2024, 214:111788 (IF:7.4, Q1)

16、 Liu S#, Sun H#, Liu J*, Wang G*, Accessing the relationship between six surrogate insulin resistance indexes and the incidence of rapid kidney function decline and the progression to chronic kidney disease among middle-aged and older adults in China: Results from the China health and retirement longitudinal study. Diabetes Res Clin Pract. 2024, 212:111705 (IF:7.4, Q1)

17、 Hu Y#, Liu J#, Zhang H, Xu Y, Hong T, Wang G*. Exenatide treatment decreases fasting fibroblast growth factor 21levels in patients with newly diagnosed type 2 diabetes mellitus. Diabetes Metab. 2016;42(5):358-363. (IF: 4.7, Q1)

18、 Wang G, Mao JM*, Wang X, Zhang FC. Effect of homocysteine on plaque formation and oxidative stress in patients with acutecoronary syndromes. Chin Med J (Engl). 2004;117(11):1650-1654. (IF: 7.3, Q1)

19、 Zhou L#, Wang Y#, Su J, An Y, Liu J, WangG*, Vitamin D Deficiency Is Associated with Impaired Sensitivity toThyroid Hormones in Euthyroid Adults, Nutrients, 2023, 15(17):3697 (IF:5,Q1)

20、 Sun H#, Zhu W#, Liu J, An Y, Wang Y, WangG*, Reduced sensitivity to thyroid hormones is associated with highremnant cholesterol levels in Chinese euthyroid adults, J Clin EndocrinolMetab. 2022. 108(1):166-174 (IF:5.1, Q1)

21、 Ding X, Wang Y, Liu J*, Wang G*,Impaired sensitivity to thyroid hormones is associated with elevated homocysteine levels in the euthyroid population. J Clin Endocrinol Metab. 2022.107(9):e3731-e3737 (IF: 5.1, Q1)

22、 Li X, Liu J, Zhou B, Li Y, Wu Z, Meng H*, WangG*. Sex Differences in the Effect of Testosterone on Adipose TissueInsulin Resistance from Overweight to Obese Adults. J Clin Endocrinol Metab.2021. 106(8): 2252-2263 (IF: 5.1, Q1)

23、 Fan H, Sun X, Zhang H, Liu J, Zhang P, Xu Y,Pan Q, Wang G*. Effect of Metformin on Fibroblast GrowthFactor-21 Levels in Patients with Newly Diagnosed Type 2 Diabetes. DiabetesTechnol Ther. 2016;18(3):120-126. (IF: 6.3, Q1)

24、 Wang G, Dai J, Mao J, Zeng X, Yang X, Wang X*.Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretionfrom monocytes in patients with hyperhomocysteinemia. Atherosclerosis.2005;179(2):395-402. (IF: 5.7, Q1)

25、 He L#, Zeng H#, Li F, Feng J, Liu S, Liu J,Yu J, Mao J, Hong T, Chen AF, Wang X, Wang G*. Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterinin patients with hyperhomocysteinemia. Am J Physiol Endocrinol Metab.2010;299(6):E1061-E1065. (IF: 3.1, Q1)

26、 Jiang L#, Zhou L#, Liu J, Wang Y, Wang G*, SexDifferences in the Association Between Thyroid Hormone Sensitivity andCardiovascular-Kidney-Metabolic Syndrome. J Clin Endocrinol Metab. 2025;110(10):e3303-e3312. (IF:5.1, Q1) 

27、 Wei Y#, Yang M#, Liu J, Wang Y*, Wang G*, Associations between Sensitivityto Thyroid Hormones and Visceral Adiposity in Euthyroid Adults. J Clin Endocrinol Metab. 2025;110(8):e2744-e2753.(IF:5.1, Q1) 

28、 Wen X#, Chang X#, He X, Cai Q, Wang G*, Liu J*, Increased Thyroid DPP4Expression is Associated with Inflammatory Process in Patients with Hashimoto'sThyroiditis. J Clin Endocrinol Metab. 2024, 109(6):1517-1525 (IF:5.1, Q1)