1. 项目编号：U25A2047

国家自然科学基金区域联合重点项目

双阴性调节性T细胞脂代谢稳态失衡调控衰老及相关疾病演进的机制研究

支持时间：2026.1-2029.12

资助金额：258万

2. 项目编号：L256017

北京市自然科学基金-大兴创新联合基金（重点项目）

代谢相关脂肪性肝病中双阴性T 细胞特征性改变及免疫学调控机制研究

支持时间：2025.07-2028.06

资助金额：100万

3. 项目编号：82270606

国家自然科学基金面上项目

oxLDL通过CD36调控双阴T细胞铁死亡影响NASH发病的机制研究

支持时间：2023.1-2026.12

资助金额：52万

人才项目资助：

 1. 项目编号：035

青年北京学者

支持时间：2021.01-2025.12

资助金额：400万

2.项目编号：DFL20220103

北京市医管中心“登峰”人才团队资助项目

支持时间：2022.01-2025.12

资助金额：160万

3. 项目编号：2013-2-026

北京市卫生系统高层次卫生技术人才——学科带头人培养计划

支持时间：2014.01-2016.12

资助金额：90万

4. 项目编号：2011D003034000037

北京市优秀人才培育计划课题资助（重点资助）

资助单位：北京市委组织部

项目名称：CD4CD8双阴性T调节细胞的体外转化通路调控及对同种异体免疫反应的抑制作用

责任：项目负责人

支持时间：2012.01-2013.12

5. 北京市留学人员科技活动项目择优资助－优秀类

资助单位：北京市组织部

项目名称：双阴性T调节细胞的体外转化及诱导器官移植免疫耐受的应用研究

责任：项目负责人

支持时间：2012.1-2013.12

科研项目资助：

1. 项目编号：U25A2047

国家自然科学基金区域联合重点项目

双阴性调节性T细胞脂代谢稳态失衡调控衰老及相关疾病演进的机制研究

支持时间：2026.1-2029.12

资助金额：258万

2. 项目编号：L256017

北京市自然科学基金-大兴创新联合基金（重点项目）

代谢相关脂肪性肝病中双阴性T 细胞特征性改变及免疫学调控机制研究

支持时间：2025.07-2028.06

资助金额：100万

3. 项目编号：82270606

国家自然科学基金面上项目

oxLDL通过CD36调控双阴T细胞铁死亡影响NASH发病的机制研究

支持时间：2023.1-2026.12

资助金额：52万

4. 项目编号：KZ202210025036

北京市教委-北自然联合重点项目

非酒精性脂肪性肝病中双阴性T细胞的异质性改变及其机制研究

支持时间：2022.01-2024.12

资助金额：80万

5. 项目编号：81870399

国家自然科学基金面上项目

双阴性T细胞在非酒精性脂肪性肝炎中的保护作用及其机制研究

支持时间：2019.1-2022.12

资助金额：53万

6. 项目编号：7172060

北京市自然科学基金面上项目

双阴性T细胞在肥胖相关胰岛素抵抗中的作用及机制探讨。

支持时间：2017.1-2019.12

资助金额：20万

7.项目编号：81570510

国家自然科学基金面上项目

αβTCR+CD4-CD8-T淋巴细胞在ConA诱导的免疫性肝损伤中的免疫调节机制研究。

支持时间：2016.1-2019.12

资助金额：51万

8. 2014年度北京市科技创新基地培育与发展工程专项(Z141107004414029)

支持时间：2014.08-2015.07

资助金额：100万

9.项目编号：81273271

国家自然科学基金面上项目

项目名称：CD4 T 细胞转化为CD4CD8双阴性T调节细胞的调控机制研究。

责任：项目负责人

支持时间：2013.1-2016.12

资助金额：60万

10.项目编号：7121006

北京市自然科学基金重点项目

项目名称：CD4-CD8-T细胞对NOD小鼠I型糖尿病的免疫调节机制

责任：项目负责人

支持时间：2012.1-2014.12

资助金额：40万

11. 项目编号：81141107

国家自然科学基金主任基金项目

项目名称：CD4CD8双阴性T调节细胞的体外转化通路调控及对同种异体免疫反应的抑制作用

责任：项目负责人

支持时间：2012.1-2012.12

通讯或共同通讯作者文章：

1.    NanXu, Peiyang Fang, Longyang Zhou, Xiaotong Han, Yuan Jiang, Xiyu Wang, JingjingZhu, Buer Li, Zihan Zhang, Hua Jin, Xiaonan Du, Guangyong Sun*, DongZhang*. SLAMF7 promotes TCRαβ+ double negative T cellantitumor activity through enhancing glutamine metabolism. Journal ofExperimental & Clinical Cancer Research. 2025 Oct 30;44(1):297.

2.    ShaorongLi, Yaning Wang, Zihan Zhang, Haozhe Xu, Songyue Wu, Hua Jin, Xiaotong Han,Ying Liu, Xin Wen, Yi Wu, Zhongtao Zhang, Lei Hu, Liang Hu, Chunmei Zhang,Jinsong Wang, Renhong Yan, Mo Chen, Guozhi Xiao, Guangyong Sun*, DongZhang*, Songlin Wang*. Sodium nitrate protects against metabolicsyndrome by sialin-mediated macrophage rebalance. SignalTransduction and Targeted Therapy. 2025 Oct 2;10(1):323. 

3.    LinshaMa, Zongshan Shen, Shiyang Huang, Mingyang Li, Dan Tian, Dong Zhang*,Songlin Wang*. Therapeutic Potential of TCRαβ+CD4-CD8-T Cells in Periodontitis. Journalof Dental Research. 2025 Sep9:220345251362744. 

4.     Zeyu Wang, Yuan Jiang, Longyang Zhou, Xinjie Zhong, Jingjing Zhu, JieSun, Xiaotong Han, Hua Jin, Dong Zhang*, Guangyong Sun*. Fatty acidβ-oxidation enhances immune regulatory function of double-negative T cellsthrough pSTAT4–OX40 signaling pathway. Hepatol Commun. 2025 Aug 29;9(9): e0783. 

5.    ShiyangHuang, Lehan Pan, Mingyang Li, Shu Pang, Yue Tian, Wen Shi, Ye Zong, DongZhang*, Dan Tian*. CD8+ T Cell-DerivedPerforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-HydroxybutyrateSuppression in Mouse Colonic Epithelium. JInflamm Res. 2025 May 1:18:5895-5910. 

6.    MingyangLi, Lehan Pan, Yuxi Zhang, Shiyang Huang, YueTian, Dan Tian*, Dong Zhang*.Regulatory TCRαβ+ Double Negative T CellsSuppress γδ T Cells and Alleviate Colitis. Cell Mol GastroenterolHepatol. 2025 Jun 10:101553. 

7.     Shiyang Huang, Lehan Pan, Shu Pang, Hui Guo, Mingyang Li, YueTian, Wen Shi, Bihan Liu, Songlin Wang, Zusen Fan, Ye Zong*, DanTian*, Dong Zhang*. Perforin Generated by CD8+ TCells Exacerbates IBD-Induced Depression by Promoting CXCL9 Production inIntestinal Epithelial Cells. Gastroenterology. 2025 Aug;169(2):294-307.

8.    Chunpan Zhang, GuangyongSun, Hua Jin, Yunxiong Wei Shimeng Zheng XiyuWang Xinyan Zhao, Dong Zhang*, Jidong Jia*.Double-negativeT cells in combination with ursodeoxycholic acid ameliorates immune-mediatedcholangitis in mice. BMCMedicine. 2025 Apr 7;23(1):209. 

9.    Zeyu Wang Zixiao Yin GuangyongSun, Dong Zhang*, Jianguo Zhang*. Genetic evidence forthe liver-brain axis: lipid metabolism and neurodegenerative disease risk. Lipidsin Health and Disease. 2025 Feb 8;24(1):41. 

10.  Hua Jin, Mingyang Li, Xiyu Wang, Lu Yang, Xinjie Zhong, ZihanZhang, Xiaotong Han, Jingjing Zhu, Mengyi Li, Songlin Wang, Simon C. Robson*, Guangyong Sun*, DongZhang*. Purinergicsignaling by TCRαβ+ double-negative T cells ameliorates liverischemia-reperfusion injury. Science Bulletin. 2025 Jan 30;70(2):241-254. 

11. Yunxiong Wei, Yuan Jiang, Jingjing Zhu, Zihan Zhang, Mengyi Li,Shimeng Zheng, Xiyu Wang, Jie Sun, Changying Li, Wen Shi, Songlin Wang, XinjuanLiu， Minjie Lin, Zhongtao Zhang*, Dong Zhang*,Guangyong Sun*. CD36-mediated uptakeof oxidized LDL induces double-negative regulatory T cell ferroptosis inmetabolic dysfunction-associated steatotic liver disease. Metabolism.2025 Mar;164:156127. 

12.  Xiaohui Li, Shimeng Zheng, Haozhe Xu, ZihanZhang, Xiaotong Han, Yunxiong Wei, Hua Jin, Xiaonan Du, Hufeng Xu, Mengyi Li, Zhongtao Zhang, Songlin Wang, Guangyong Sun*,Dong Zhang*. The direct and indirect inhibition of adiposetissue macrophage proinflammation by acarbose in diet-induced obesity. Cell Reports Medicine. 2025 Jan 21;6(1):101883. 

13. Yongle Wu, Xiaotong Han, Longyang Zhou,Xinjuan Liu, Dong Zhang*, Guangyong Sun*. The T-box transcriptionfactor plays an important role in regulating the immunoregulatory function ofdouble-negative T cells. Biochem Biophys Res Commun. 2025Mar 8:752:151492. 

14. Xiaonan Du, XiaotongHan, Jingjing Zhu, Zihan Zhang, Hua Jin, Dong Zhang*, GuangyongSun*. Rapamycin ameliorates intrahepatic inflammation in MASLD by increasingmacrophage fatty acid oxidation levels. Int Immunopharmacol. 2025Oct 10:163:115288. 

15. Shiyang Huang, Kun Yang, Dongfang Sun,Lehan Pan, Lina Ma, Mingyang Li, Wen Shi, Ye Zong, Zhongtao Zhang, Chunbao Li,Yingchi Yang*, Dong Zhang*, Dan Tian*. Red Meat Diet ExacerbatesColitis by Promoting the Accumulation of Myeloid Cells and Disrupting GutMicrobiota. Mol Nutr Food Res. 2025 Aug19: e70203. 

16. Yingli Jing, Zihan Li, Fan Bai, YitongYan, Yan Li, Weijin Liu, Qiuying Wang, Lixi Zhao, Yanbing Zhu, Guangyong Sun, DongZhang*, Jianjun Li*, Yan Yu.* Neuroprotective role of DNTαβ Celltransplantation on modulating immune microenvironment in spinal cord injuredmice. Neurotherapeutics. 2025 Sep 22: e00743. 

17. Hua Jin, Mengmeng Chen, Xiyu Wang, Guangyong Sun, Hao Chen, DongZhang*. Estrogen deficiency impairsdouble-negative T cell function via NF-κB activation in postmenopausalosteoporosis. Biochem Biophys Res Commun. 2025 Aug 30:776:152212. 

18. Yunxiong Wei, Guangyong Sun, Yang Yang,Mingyang Li, Shimeng Zheng, Xiyu Wang, Xinjie Zhong, Zihan Zhang, Xiaotong Han,Haiyan Cheng, Dong Zhang*, Xueling Mei*. Double-negative Tcells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδlowT cells. Journalof Translational Medicine. 2024.Apr 2;22(1):328.

19.  Guangyong Sun, Yaning Wang, Lu Yang, Zihan Zhang, Yushang Zhao,Zongshan Shen, Xiaotong Han, Xiaonan Du, Hua Jin, Changying Li, Songlin Wang,Zhongtao Zhang, Dong Zhang*. Rebalancingliver-infiltrating CCR3+ and CD206+ monocytes improvesdiet induced NAFLD. Cell Reports. 2023 Jul 7;42(7):112753. 

20. Huan Wang, YushangZhao, Yuhualei Pan, Aiting Yang, Changying Li, SongWang, Zhao Dong, Mengyi Li, Songlin Wang, ZhongtaoZhang, Yanbing Zhu*, Dong Zhang*, Guangyong Sun*. Inhibition of phospholipase D1 ameliorates hepatocytesteatosis and non-alcoholic fatty liver disease. JHEP Reports. 2023 Mar 9;5(6):100726. 

21. Yaning Wang, Xiaojing Sun, Xiaotong Han, Jie Sun, Li Li*, Dong Zhang*, Guangyong Sun*. Resveratrolimproves hepatic ischemia-reperfusion injury by inhibiting neutrophils via theERK signaling pathway. Biomedicine& Pharmacotherapy. 2023Feb 3;160:114358. 

22. Dan Tian, Yuhualei Pan, Yushang Zhao,Huan Wang, Yue Tian, Wen Shi, Chengjie Zhang, Lu Yang, Yanbing Zhu, YongboZhang*, Songlin Wang*, Dong Zhang*. TCRαβ+NK1.1-CD4-CD8- double-negative T cells inhibitcentral and peripheral inflammation and ameliorate ischemic stroke in mice.Theranostics. 2023 Jan 10;13(3):896-909. 

23.Sha Chen, Tingting Lv, Chunpan Zhang, HuaJin, Guangyong Sun, Dan Tian, Shuxiang Li, Weijia Duan, Shan Shan, Hong Ma,Xiaojuan Ou, Hong You, Dong Zhang*, Jidong Jia*. Reciprocalalterations in circulating and hepatic gamma-delta T cells in patients withprimary biliary cholangitis. Hepatol Int. 2022 Feb;16(1):195-206.

24.Mingyang Li, Haiyan Cheng, Dan Tian, LuYang, Xiaonan Du, Yuhualei Pan, Dong Zhang*, XuelingMei*. D-mannose suppresses γδ T cells and alleviates murinepsoriasis. Frontiers in Immunology. 2022 13:840755. 

25.Changying Li, Xiaonan Du, Zongshan Shen,Yunxiong Wei, Yaning Wang, Xiaotong Han, Hua Jin, Chunpan Zhang, Mengyi Li,Zhongtao Zhang, Songlin Wang, Dong Zhang*, Guangyong Sun *. Thecritical and diverse roles of CD4-CD8- double negative T cells in nonalcoholicfatty liver disease. Cellular and Molecular Gastroenterology and Hepatology.2022;13:1805–1827. 

26.Yu He, Yufeng Pei, Kai Liu, Ling Liu, YueTian, Hongyi Li, Min Cong, Tianhui Liu, Hong Ma, Hong You, Jidong Jia*, DongZhang*, Ping Wang*. GITR/GITRL reverse signalling modulates theproliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylateERK1/2 and Akt. Cell Death Dis. 2022 Apr 4;13(4):297. 

27.Longwei Xu, DanTian, Minsi Zhou, Jiuyue Ma, Guangyong Sun, Hua Jin, Mingyang Li, Dong Zhang*, Jing Wu*. OX40 expression ineosinophils aggravates OVA-induced eosinophilic gastroenteritis. Frontiersin Immunology. 2022; 13:841141. 

28.Lu Yang, Yanbing Zhu, DanTian, Song Wang, Jincheng Guo, Guangyong Sun, HuaJin, Chunpan Zhang, Wen Shi, M Eric Gershwin*, ZhongtaoZhang*, Yi Zhao*, Dong Zhang*. Transcriptomelandscape of double negative T cells by single-cell RNA sequencing. Journalof Autoimmunity. 2021 Jul; 121:102653.  

29.Shaorong Li, Hua Jin, Guangyong Sun,Chunmei Zhang, Jinsong Wang, Hufeng Xu, Dong Zhang*, SonglinWang*. Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion InjuryThrough NRF2-Mediated Antioxidative Stress. Frontiers inPharmacology. 2021 Jun 7;12:634115. 

30. Guangyong Sun, XinyanZhao, Mingyang Li, Chunpan Zhang, Hua Jin, ChangyingLi, Liwei Liu, Yaning Wang, Wen Shi, Dan Tian, HufengXu, Yue Tian, Yongle Wu, Kai Liu, Zhongtao Zhang*, DongZhang*. CD4 derived double negative T cells prevent thedevelopment and progression of nonalcoholic steatohepatitis. NatureCommunications. 2021Jan 28;12(1):650.