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首都医科大学公共卫生学院教授，博士生导师，获批北京市“长城学者”、“青年拔尖人才”、“中青年骨干教师”、“优秀人才”等人才项目。主持国家自然科学基金6项以及省部级课题4项，参与国家科技部、教育部博士点基金、国家和北京市自然科学基金等10余项。主要从事新型污染物的健康损害效应、机制与干预策略研究，着重从表观遗传学、菌群、代谢和炎症免疫、跨器官轴向调控等角度研究新型环境化学物的致病机理、标志物及防控措施。在Advanced Science，Gut Microbes, Environmental Science & Technology, EBioMedicine, J Hazard Mater，Environ Int, Nano Res，Particle and Fibre Toxicology，JCI Insight，Cell Death Dis等发表SCI论文70余篇。获批软著1项、获得教学科研奖6项，参编学术著作6部。建设环境卫生学慕课和虚拟仿真项目各1项。担任中华医学科技奖评审委员会委员，教育部科技库专家，国家和省部级自然科学基金项目的评审专家，教育部学位论文评审专家，中国毒理学会第八届工业毒理学专业委员会委员，中华预防医学会职业心理健康学组委员、北京环境诱变剂学会理事等。
近年主持的科研项目情况
1、国家自然科学基金面上项目，ISG15介导的类泛素化修饰在苯暴露重塑骨髓微环境致髓系分化抑制中的作用机制（82574057，2026.01-2029.12）；
2、国家自然科学基金面上项目，YTHDF3通过识别m6A修饰调控泛素结合酶表达在苯造血毒性中的作用和机制（82073520，2021.01-2024.12）；
3、国家自然科学基金面上项目，TET2介导STAT3低甲基化在苯造血毒性中的作用和机制（81773397， 2018.01-2021.12）；
4、国家自然科学基金面上项目，长链非编码RNA-VNN3和OBFC2A在苯血液毒性中的功能及机制研究（81472957，2015/01-2018/12）；
5、国家自然科学基金面上项目，差异甲基化基因作为低剂量苯毒效应敏感标志物的研究（81172639，2012.01-2015.12）；
6、“十三五”时期北京市属高校高水平教师队伍建设支持计划，长城学者(CIT&TCD20170323，2018.01-2020.12)。
近年主持的科研项目情况
1、国家自然科学基金面上项目，ISG15介导的类泛素化修饰在苯暴露重塑骨髓微环境致髓系分化抑制中的作用机制（82574057，2026.01-2029.12）；
2、国家自然科学基金面上项目，YTHDF3通过识别m6A修饰调控泛素结合酶表达在苯造血毒性中的作用和机制（82073520，2021.01-2024.12）；
3、国家自然科学基金面上项目，TET2介导STAT3低甲基化在苯造血毒性中的作用和机制（81773397， 2018.01-2021.12）；
4、国家自然科学基金面上项目，长链非编码RNA-VNN3和OBFC2A在苯血液毒性中的功能及机制研究（81472957，2015/01-2018/12）；
5、国家自然科学基金面上项目，差异甲基化基因作为低剂量苯毒效应敏感标志物的研究（81172639，2012.01-2015.12）；
6、“十三五”时期北京市属高校高水平教师队伍建设支持计划，长城学者(CIT&TCD20170323，2018.01-2020.12)。
1．Zhang W, Duan L, Liang J, Liu Z, Jiang G, Wang Z, Kang H, Huang D, Gao A*. Mechanistic Insights into the Effects of Liquid Crystalline Monomers on Intestinal Stem Cell Differentiation Imbalance by Integrating Machine Learning and Adverse Outcome Pathway Framework Based on Organoids. Environ Sci Technol. 2025 Aug 29. doi: 10.1021/acs.est.5c07403.
2．Duan L, Liang J, Zhang W, Liu Z, Kang H, Huang D, Wang Z, Jiang G, Gao A*. The liquid crystal monomer EtCBN induced neurotoxicity by activating the NOD-like receptor signaling pathway through the Muribaculum-epigallocatechin axis. J Hazard Mater. 2025 Jul 11;496:139206.
3．Kang H, Huang D, Zhang W, Wang J, Liu Z, Wang Z, Jiang G, Gao A*. Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis. Part Fibre Toxicol. 2025 May 9;22(1):10.
4．Wang Z, Zhang W, Liu Z, Huang D, Kang H, Wang J, Jiang G, Gao A*. Gut microbiota dysbiosis involved in decabromodiphenyl ether-induced bone homeostasis disorder through inflammaging. Environ Pollut. 2025 Mar1;368:125710.
5． Huang D, Kang H, Liu Z, Zhang W, Wang J, Wang Z, Jiang G, Gao A*. Ferroptosis involved in inhaled polystyrene microplastics leaded myocardial fibrosis through HIF-ROS-SLC7A11/GPX4 Pathway. Journal of Environmental Sciences,2026, 159,391-402
6．Liu Z, Wang J, Zhang W, Kang H, Huang D, Wang Z, Jiang G, Gao A*. Irf4 participates in benzene-induced hematopoietic senescence through mitochondrial ROS-dependent BCAA catabolism. Toxicology. 2025 Aug 28:154271.
7．Jiang G, Zhang W, Kang H, Liu Z, Duan L, Wang Z, Huang D, Liang J, Gao A*. Joint and nonlinear associations of serum folate and physical activity with depressive symptoms. J Affect Disord. 2025 Jul 26;391:119974.
8．Zhang W, Jiang G, Kang H, Wang J, Liu Z, Wang Z, Huang D, Gao A*. Environmental Enrichment Exposure Alleviates Geriatric Depressive-Like Symptoms through Regulating Neurogenesis and Neuroinflammation. Environ Health (Wash). 2024 Nov 20;3(3):259-270.
9．Kang H, Huang D, Zhang W, Wang J, Liu Z, Wang Z, Jiang G, Gao A*. Pulmonary Flora-Derived Lipopolysaccharide Mediates Lung-Brain Axis through Activating Microglia Involved in Polystyrene Microplastic-Induced Cognitive Dysfunction. Adv Sci (Weinh). 2024 Dec;11(47):e2404966.
10．Zhang L, Liu Z, Zhang W, Wang J, Kang H, Jing J, Han L, Gao A*. Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity. Gut Microbes. 2024 Jan-Dec;16(1):2323227.
11．Kang H, Zhang W, Jing J, Huang D, Zhang L, Wang J, Han L, Liu Z, Wang Z, Gao A*. The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways. J Hazard Mater. 2023Sep 15;458:131949.
12．Jing J, Zhang L, Han L, Wang J, Zhang W, Liu Z, Gao A*. Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines. Environ Int. 2022 Mar;161:107131.
13． Zhang W, Wang J, Liu Z, Zhang L, Jing J, Han L, Gao A*. Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis. Free Radic Biol Med. 2022 Nov 20;193(Pt 1):122-133.
14．Zhang L, Jing J, Han L, Liu Z, Wang J, Zhang W, Gao A*. Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism. Nano Res. 2022 Nov 15;16(2):2885-2894.
15． Guo X, Zhong W, Chen Y, Zhang W, Ren J, Gao A*. Benzene metabolites trigger pyroptosis and contribute to haematotoxicity via TET2 directly regulating the Aim2/Casp1 pathway. EBioMedicine. 2019; 47: 578-589.
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