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首都医科大学，基础医学院医学遗传与发育生物学学系，副教授，清华大学生物学系博士，北京市生理学会理事，北京市科技新星、北京市优秀青年知识分子、北京市优秀人才。
主要研究方向为肿瘤遗传学，多年来致力于肿瘤细胞侵袭行为与药物敏感性的细胞遗传学研究，以发现和验证潜在的标志物或靶点分子并探索其作用机制。近期融合高通量测序技术，从事复杂性疾病的RNA剪接机制研究，探索基因组水平的疾病诊疗方法。
国家自然科学基金委员会，面上项目，82073215，骨桥蛋白剪接变异体通过肿瘤分泌环境的信号重塑影响结直肠癌化疗敏感性的机制研究。
(1) Huan Niu, Meng Zhao, Jing Huang, Jing Wang, YangSi, Shan Cheng*, Wei Ding. UHMK1-dependentphosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells. Cell Commun Signal, 2022, 20(1):18.
(2) Mengtian Cui,Qingfang Zhao, Jing Wang, Yang Si, ShanCheng*, Wei Ding*. ATF6-mediated unfolded protein response facilitatesAAV2 transduction by releasing the suppression of AAV receptor on ER stress. JVirol, 2022, 96(3): e0110321.
(3) Jing Huang, Mu Hu, Huan Niu, Jing Wang, Yang Si, Shan Cheng*, Wei Ding*. Osteopontin isoform c promotes the survivalof cisplatin-treated NSCLC cells involving NFATc2-mediated suppression oncalcium-induced ROS levels. BMC Cancer, 2021, 21(1):750.
(4) Jing Niu, Rui-Qi Gao, Meng-Tian Cui, Chen-Guang Zhang, Shen-TaoLi, Shan Cheng*, Wei Ding*.Suppression of TCAB1 expression induced cellular senescence by lesseningproteasomal degradation of p21 in cancer cells. Cancer Cell Int, 2021, 21(1): 26.
(5) Chang Siyuan, Huang Jing, Niu Huan, Wang Jing, Si Yang, BaiZhigang, Cheng Shan*, Ding Wei.Epigenetic regulation of osteopontin splicing isoform c defines its role as amicroenvironmental factor to promote the survival of colon cancer cells from 5‑FUtreatment. Cancer Cell Int, 2020,20:452.
(6) Yang Fenglian(#); Hu Mu(#); Chang Siyuan; Huang Jing; Si Yang;Wang Jinghui; Cheng Shan*; Jiang Wenguo;Alteration in the sensitivity to crizotinib by Na+/H+exchanger regulatory factor 1 is dependent to its subcellular localization inALK-positive lung cancers, BMC Cancer,2020, 20(1):202.
(7) Huang Jing; Chang Siyuan; Lu Yabin; Wang Jing; Si Yang; Zhang Lijian;Cheng Shan*; Jiang Wenguo; Enhanced osteopontinsplicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypesin NSCLC cells, Cancer Cell Int,2019, 9: 306.
(8) Cui Mengtian; Lu Yabin; Tang Can; Zhang Ran; Wang Jing; Si Yang;Cheng Shan*; Ding Wei; A GenericMethod for Fast and Sensitive Detection of Adeno-Associated Viruses UsingModified AAV Receptor Recombinant Proteins, Molecules,2019, 24(21), pii: E3973.
(9) Hao Chengcheng(#); Cui Yuxin(#); Chang Siyuan(#); Huang Jing;Birkin Emily; Hu Mu;ZhiXiuyi; Li Wenbin; Zhang Lijian; Cheng Shan*; Jiang Wenguo*; OPN promotes the aggressiveness ofnon-small-cell lung cancer cells through the activation of the RON tyrosinekinase, Sci Rep, 2019, 9(1):18101.
(10) Yang Fenglian; Gu Yanan; Zhao Zehang; Huang Jing; Jiang Wenguo; Cheng Shan*; NHERF1 Suppresses LungCancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition, Anticancer Res, 2017, 37(8):4405-4414.
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