个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
张栋梁,首都医科大学附属北京口腔医院正畸科,教授、主任医师、硕士研究生导师。长期以来从事临床医疗及教学工作,带领专业团队致力于正畸专业的临床新技术改良、示教、培训及推广,以临床工作需要为出发点,发挥学科优势,主动与人工智能、数字化技术等其他学科联合,成功实现了模型数字化、正畸托槽精准定位技术等的临床转化。获得国家发明和实用新型专利共9项,发表核心期刊文章50余篇,SCI收录20篇。主编主译论著6本专业论著。主持参与国家级课题3项。
主持:
1. 北京市科学技术委员会,临床医学转化项目,SYGX202009,三维数字化错合畸形矫治系统的研发和 AR 实现,2020-11 至 2022-10,37.5 万元,在研;
2. 北京市卫生健康委员会,“一带一路”国际卫生合作项目,200705,中药骨碎补活性成份柚皮苷靶向纳米粒复合 3D 打印支架促成骨研究,2020-08 至2020-11,10 万元,已结题;
3. 首都医科大学,首医基础-临床科研合作基金重点课题,16JL07,CAD 高精度牙合畸形矫治技术的研发与临床应用,2016-01 至 2017-12,5 万元,已结题;
4. 北京市科学技术委员会,首都临床特色应用研究项目特色项目,Z141107002514149,牙颌畸形数字化精确隐形矫治技术的临床研究,2014-07至 2017-06,15 万元,已结题;
5. 国家自然科学基金委员会,科学部主任基金,81241035,计算机辅助设计制造个性化支架及模拟微重力培养组织工程骨修复腭裂骨缺损的实验研究,2013-01 至 2013-12,10 万元,已结题;
6. 北京市自然科学基金委员会,面上项目,3122018,基于个性化生物力学反应的正畸三维数字牙颌建模和仿真研究,2012-01 至 2014-12,11 万元,已结题;
7. 北京市科学技术委员会,北京科技新星计划 B 类,2008B68,计算机辅助口腔正畸微种植体支抗定位系统的研究及临床应用,2008-01 至 2011-01,27万元,已结题。
参加:
1. 北京市医院管理局,北京市医管局青年人才培养计划“青苗”计划,QML20181501,miRNA21 在正畸牙齿移动中的功能及机制研究,2019-01 至2020-12,6 万元,已结题;
2. 国家自然科学基金委员会,青年科学基金项目,81400476,氨基酸诱导纳米羟基磷灰石仿生修复软化釉质的显微分析研究,2015-01 至 2017-12,23 万元,已结题;
3. 北京市科学技术委员会,首都市民健康项目培育项目,Z141100002114020,个性化钛板种植体支抗矫治骨性上颌发育不足的三维疗效评价研究,2014-09至 2017-09,15 万元,已结题;
4. 北京口腔医院,院学科建设基金基础专项-重点项目,140903,氨基酸诱导纳米羟基磷灰石仿生修复软化釉质的显微分析研究,2014-04 至 2015-09,10万元,已结题;
5. 北京市卫生局,首都医学发展科研基金,2007-1032,北京地区青少年颅面生长发育监测及颅颌面畸形防治系统,2008-08 至 2011-07,55 万元,已结题;
6. 国家自然科学基金委员会,青年科学基金项目,30600718,Barx1 基因在牙齿形态发育中的作用研究,2007-01 至 2009-12,21 万元,已结题;
7. 北京市自然科学基金委员会,面上项目,7072028,Barx1 基因在牙齿形态发育中的作用研究,2007-01 至 2009-12,13 万元,已结题。
(1)Xin He, Zhan Yang, Xiao-yang Chu, Yun-xia Li, Biao Zhu, Yan-xia Huang, Wei Wang, Chun-yan Gao, Xu Chen, Chun-yan Zheng, Kai Yang*, Dong-liang Zhang*. ROR2 downregulation activates the MSX2/NSUN2/p21 regulatory axis and promotes dental pulp stem cell senescence. Stem Cells, 2022, 40, 290–302.
(2)Chen X, Gao C-Y, Chu X-Y, Zheng C-Y, Luan Y-Y, He X, Yang K*, Zhang D-L*. VEGF-Loaded Heparinised Gelatine-Hydroxyapatite-Tricalcium Phosphate Scaffold Accelerates Bone Regeneration via Enhancing Osteogenesis-Angiogenesis Coupling. Front. Bioeng. Biotechnol, 2022, 10:915181.
(3)Xing-yue Dong, Yan-xia Huang, Zhan Yang, Xiao-yang Chu, Jue Wu, Shan Wang, Xin He, Chun-Yan Gao, Xu Chen, Kai Yang*, Dong-liang Zhang*. Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4-FOXO1/SMS1 axis in sphingomyelin biosynthesis. Aging Cell, 2021, DOI: 10.1111/acel.13430.
(4)Zhe Dong, Qiang Ma, Chunyan Zheng, Yanxia Huang, Xingyue Dong, Kai Yang, Ya Tan, Huaying Hu, Zhuo Ren, Yousheng Yan, Dongliang Zhang*, and Li Lin*. Identification of novel heterozygous missense variant in the COL11A1 causing fetal craniofacial anomalies, All Life, 2022, 15:1, 240-246.
(5)Yan-xia Huang, Chun-yan Gao, Chun-yan Zheng, Xu Chen, You-sheng Yan, Yong-qing Sun, Xing-yue Dong, Kai Yang*, Dong-liang Zhang*. Investigation of a Novel LRP6 Variant Causing Autosomal-Dominant Tooth Agenesis. Front. Genet, 2021, DOI:10.3389/fgene.2021.688241.
(6)Xin He, Wei-hang Zhuang, Dong-liang Zhang*. A Three-Dimensional Finite Element Analysis: Maxillary Dentition Distalization with the Aid of Microimplant in Lingual Orthodontics. Int J Gen Med 2021:14 8455–8461.
(7) Shang Li#, Hua-ying Hu#, Jun-Jun Xu, Zhan-ke Feng, Yong-qing Sun, Xu Chen, Kai Yang, Ya-zhou Li*, Dong-liang Zhang*. Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis. Mol Genet Genom Med, 2021, DOI: 10.1002/mgg3.1839.
(8)Long Qin, Qiao Wang, Dongliang Zhang*, Xin He, and Binbin Wu. Optimized Attachment to Achieve Different Buccolingual Movement of Maxillary Molars in Clear Aligner Orthodontic System: Biomechanical Analysis. Nanoscience and Nanotechnology Letters. 2020, 12: 1249–1254.
(9)Kai Yang, Xing-yue Dong, Jue Wu, Jian-jiang Zhu, Ya Tan, You-sheng Yan, Li Lin, Dong-liang Zhang*. A clinical and multi‑ omics study of Van der Woude syndromein three generations of a Chinese family. Molecular medicine reports. 2020, 22: 2925-2931.
(10)Zhou Y, He X, Zhang D*. Study of bone remodeling in corticotomy-assisted orthodontic tooth movement in rats. J Cell Biochem. 2019, 120(9): 15952-15962.
(11)Qin Ling, Lu Chen, Hui Zhang, Dongliang Zhang*. Self-consistent field theory simulations of wormlike chains on cylindrical surface. Int J Numer Anal Mod. 2019, 16(2): 357–374.
(12)Yang K, Zhu J, Tan Y, et al., Whole-exome sequencing identified compound heterozygous variants in ROR2 gene in a fetus with Robinow syndrome. J Clin Lab Anal. 2019;e23074.
(13)Yingzhi Gu, Rui Zhuang, XianjuXie, Dongliang Zhang, Yuxing Bai.Optimization of clinically applied orthodontic archwire electrothermal treatment conditions by heat tint and mechanical properties: An experimental study. International Orthodontic. 2019, pii: S1761-7227(19)30109-3
(14)Gu Y, Bai Y, Zhang D*.Osteogenic stimulation of human dental pulp stem cells with a novel gelatin-hydroxyapatite-tricalcium phosphate scaffold. J Biomed Mater Res A. 2018 Jul;106(7):1851-1861.
(15)Zhang D, Goetz W, Braumann B, Bourauel C, Jaeger A.Effect of soluble receptors to interleukin-1 and tumor necrosis factor alpha onexperimentally induced root resorption in rats. J Periodontal Res. 2003,38(3):324-32.
(16)Zhou C, Zhang D, Bai Y, Li S. Casein phosphopeptide-amorphous calcium phosphate remineralization of primary teethearly enamel lesions. J Dent. 2014 ,42(1):21-9.
(17)Jäger A, Kunert D, Friesen T, Zhang D, Lossdörfer S, Götz W.Cellular and extracellular factors in early root resorption repair in the rat. Eur J Orthod. 2008 Aug;30(4):336-345.
(18)Götz W, Kunert D, Zhang D, Kawarizadeh A, Lossdörfer S, Jäger A.Insulin-like growth factor system components in the periodontium during tooth rootresorption and early repair processes in the rat. Eur J Oral Sci. 2006, 114(4):318-27.
(19)Jäger A, Zhang D, Kawarizadeh A, Tolba R, Braumann B, Lossdörfer S, Götz W.Soluble cytokine receptor treatment in experimental orthodontic tooth movement in therat. Eur J Orthod. 2005,27(1):1-11.
(20)Kawarizadeh A, Bourauel C, Zhang D, Götz W, Jäger A.Correlation of stress and strain profiles and the distribution of osteoclastic cells inducedby orthodontic loading in rat. Eur J Oral Sci. 2004,112(2):140-147.
北京市科技新星,北京市科学技术委员会
北京市卫生系统高层次卫生技术人才,北京市卫生局
北京市十百千卫生人才,北京市卫生局
德国国家学术交流中心奖学金获得者
获得临床技术专利 9 项
1. 现代口腔正畸技术与临床思维. 清华大学出版社, 2016.
2. 口腔正畸舌侧矫治技术. 辽宁科学技术出版社, 2018.
3. 正畸治疗技术基本原理. 北方联合出版社, 2018.
4. 口腔正畸临床高效矫治. 北京工业大学出版社, 2019.
5. 儿童错合畸形早期矫治, 辽宁科学技术出版社, 2019.
6. 成人口腔正畸临床高效矫治原理与技术, 中国协和医科大学出版社, 2021.
文件上传中...