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现任北京安贞医院心衰中心主任，北京市心血管疾病防治办公室副主任，首都医科大学心脏病学系系务委员会委员。

兼任中国医师协会心血管内科医师分会预防与康复专业委员，中华医学会心血管病学分会青年委员和预防学组委员，中华医学会心血管病学分会临床研究学组副组长，北京医学会心血管病学分会青年委员会委员，北京市“阳光长城”慢病防治科普专家，北京心联乔治心脏健康研究所共同所长、汝阳农村健康研究所所长。Circulation杂志、PACE杂志、英国医学杂志（BMJ）中文版、中华心血管病杂志编委等多种国内外学术期刊编委。

发表论文300余篇，其中作为第一作者/通讯作者发表Lancet（IF 88.5）1篇、Circulation（IF 37.8）3篇、European Heart Journal（IF 39.3）1篇、JACC（IF 24.0）2篇、European Journal of Heart Failure（IF 18.2）1篇，Hypertension（IF 8.3）3篇、 Stroke（IF 8.3）1篇。

研究方向Research Directions

心力衰竭、心房颤动相关的临床和基础研究

2. 机电结构优化与控制研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。整体布局设计。

团队展示

临床方面：团队成员近年来主持开展多项大规模临床研究。近年主导的接种流感疫苗以改善急性心力衰竭患者预后：中国的一项多地区、季节性、以医院为基础的整群随机对照试验(PANDA II)，核心成果发表于国际顶级医学期刊Lancet。作为主要研究者的AFFIRMING研究将探索基于平板电脑的认知训练任务是否能改善房颤合并认知功能下降患者的认知水平。作为主要研究者XTREME研究将探索血脂康和阿托伐他汀对血脂异常合并糖尿病前期患者糖代谢的影响。这两项研究都将在2024年完成，都是相关领域新的突破性研究。此外，尚有中国高血压前期人群药物干预减少心血管事件的临床研究，饮食管理 APP预防肥胖的心力衰竭患者急诊就诊，住院和死亡的随机对照研究(IDEAL- HF)，健康家庭建设对人群血压的影响(Healthy Family Program)和低钠代用盐对心力衰竭患者死亡，心衰住院，心衰急诊就诊和生活质量的影响(RESCUE- HF)等研究正在开展实施。

团队成员创办非盈利组织北京心联乔治心脏健康研究所（HHRC）和汝阳农村健康研究所（RRHI），致力于帮助临床医生以较低的成本开展高质量临床研究，在研究设计、实施、数据管理、统计分析等多方面对研究者发起的研究进行指导和支持。同时培养项目管理、数据管理等多方面的临床研究人才。

基础方面：团队在心衰和房颤发病的分子机制方面数次获得国家自然科学基金和北京市教委重点项目。“心房衰老相关miR-509-3-5p/THBS1促纤维化在房颤发生中的机制和干预研究”项目和“miR-23a调控TRPM1介导的钙信号通路在老年性房颤中的分子机制”项目均获得国家自然科学基金的支持，并均在研究中。“心房衰老相关miR-509-3-5p/KLF10促房颤发生的分子机制和干预研究”项目获得北京市教委的支持，研究结果拟发表。此外，尚有腺相关病毒（AAV）介导的基因治疗再PKP2突变相关的致心律失常性心肌病（ACM）中的临床研究和增加a-MHC对心力衰竭的防治研究及分子机制探索等研究正在开展实施。

科研论文：近年来，团队成员在Lancet、Circulation、JACC、Hypertension等心血管顶级期刊上均发表了高质量的研究成果。团队中的研究生在学习期间成果颇丰。22级博士研究生以共同第一作者于Lancet杂志（IF 88.5）发表论文1篇，以第一作者发表多篇SCI和中文核心论文；21级博士研究生以独立第一作者于Circulation杂志（IF 37.8）发表论文1篇，以共同第一作者于Hypertension（IF 8.3）杂志发表论文1篇，此外，还以第一作者发表多篇SCI和中文核心论文，并荣获2023年国家奖学金。21级硕士研究生以第一作者身份发表论文3篇，总的影响因子约12分，并成功就读专业型博士。

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项目情况

1. 2030国家重大科技专项——高血压前期人群社区干预模式研究（2025.02-2027.12）

2. 北京安贞医院高水平研究专项——腺相关病毒（AAV）介导的基因治疗在 PKP2 突变相关的致心律失常性心肌病（ACM）中的临床研究（2025.06-2028.05）

3. 饮食管理APP预防肥胖的心力衰竭患者急诊就诊、住院和死亡的随机对照研究（202301-202512）

4. 老年疾病临床数据库与生物样本库建设（202007-202306）

5. 基于人脸和步态生物识别技术的心力衰竭患者远程监测研究（202301-202612）

6. 腺相关病毒（AAV）介导的基因治疗再PKP2突变相关的致心律失常性心肌病（ACM）中的临床研究

7. 中国高血压前期人群药物干预减少心血管事件的临床研究（202502-202712）

8. 增加a-MHC对心力衰竭的防治研究及分子机制探索

9. 心衰患者焦虑抑郁情绪管理数字疗法的可行性研究

10. 低钠代用盐对心力衰竭患者死亡、心衰住院、心衰急诊就诊和生活质量的影响：一项多中心、双盲、随机对照试验

科研项目

承担北京市优秀人才培养资助计划、教育部留学回国人员科研基金、国家自然科学基金、区域创新发展联合基金、首都发展基金、北京市自然科学基金、“十二五”国家科技支撑计划等多项科研项目、“十三五”国家重点攻关计划、2030国家科技重大专项等多项科研项目。

研究成果

五年重要论文：

1:Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China. Lancet. 2025;406(10507):1020-1031.

Craig S Anderson, Chang Hua, Zhiyan Wang, Chi Wang, Chao Jiang, Rong Liu, Rong Han, Qiang Li, Sana Shan, Laurent Billot,C Raina Macintyre, Anushka Patel, Hongjia Zhang, Changsheng Ma, Jianzeng Dong, Xin Du.SCI(IF=88.5)

2: Pulmonary Vein Isolation With Optimized Linear Ablation vs Pulmonary Vein Isolation Alone for Persistent AF: The PROMPT-AF Randomized Clinical Trial. JAMA. 2025 Feb 4;333(5):381-389. Caihua Sang, Qiang Liu, Yiwei Lai, Shijun Xia, Ruhong Jiang, Songnan Li, Qi Guo, Qifan Li, Mingyang Gao, Xueyuan Guo, Lihong Huang, Nian Liu, Chenxi Jiang, Song Zuo, Xiaoxia Liu, Mengmeng Li, Weili Ge, Shangming Song, Lianghua Chen, Shuanglun Xie, Jiangang Zou, Ke Chen, Xiangfei Liu, Hesheng Hu, Xinhua Wang, Jinlin Zhang, Zhaojun Wang, Chi Wang, Liu He, Chao Jiang, Ribo Tang, Ning Zhou, Yunlong Wang, Deyong Long, Xin Du, Chenyang Jiang, Laurent Macle, Jianzeng Dong, Changsheng Ma. SCI(IF=55)

3:The Effect of Frailty on the Efficacy and Safety of Intensive Blood Pressure Control: A Post Hoc Analysis of the SPRINT Trial. Circulation. 2023;148(7):565-574. Zhiyan Wang, Xin Du, Chang Hua, Wenjie Li, Hao Zhang, Xinru Liu, Yufeng Wang, Chao Jiang, Jiakun Guo, Qiang Lv, Craig S Anderson, Jianzeng Dong, Changsheng Ma.SCI(IF=38.6)

4：Identifying Risk Factors for Left Ventricular Thrombus in Patients with Ischemic Left Ventricular Aneurysm Using Cardiac MRI. Thromb Haemost. 2025 Mar 24. Yanfang Wu, Hui Wang, Zhiyan Wang, Chang Hua, Ran Xiong, Hao Fu, Qiang Lv, Lei Xu, Xin Du, Jianzeng Dong.SCI(IF=4.3)

5: Sex-specific trends in the global burden and risk factors of atrial fibrillation and flutter from 1990 to 2021. 2025 Mar 8;15(1):8092. Xiaodong Peng, Jue Wang, Chen Tang, Liu He, Jiangtao Li, Shijun Xia, Xiangyi Kong, Ning Zhou, Deyong Long, Caihua Sang, Xin Du, Jianzeng Dong, Changsheng Ma.SCI(IF=3.9)

6: Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device. iScience. 2025 Jan 7;28(2):111764. Yifan Lu, Shuanglei Zhao, Jie Han, Qiang Lv, Xin Du, Zhengdong Hua, Keli Huang, Zhenwei Ge, Xiaoning Sun, Dan Zhu, Yongfeng Shao, Hongjia Zhang, Ming Gong.SCI(IF=4.1)

7: Radiosurgery versus observation for brainstem cavernous malformations: a 5-year multicentre cohort study. Brain. 2025 Apr 3;148(4):1134-1143. Da Li, Jian-Cong Weng, Shi-Bin Sun, Gui-Jun Zhang, Bo-Han Yao, Guo-Kai Wang, Jing Chen, Shou-Xin Feng, Hai-Tao Liu, Fu-Gui Zhou, Pan-Pan Liu, Lu Kong, Hui Zhou, Hao-Yu Zhang, Xiao-Jun Zeng, Ze-Yu Wu, Jiu-Luan Lin, Cong Ren, Wei Wang, Hong-Jun Zhang, Xiao-Ying Xu, Lai-Rong Song, Xin Du， Liang Wang. SCI(IF=11.7)

8: Association between the preprocedural serum potassium level and atrial fibrillation recurrence after catheter ablation. Heart Rhythm. 2024 Dec;21(12):2429-2436. Zejun Yang, Jue Wang, Chao Jiang, Hang Guo, Mingxiao Li, Zixu Zhao, Manlin Zhao, Sitong Li, Yiwei Lai, Liu He, Xueyuan Guo, Songnan Li, Nian Liu, Chenxi Jiang, Ribo Tang, Deyong Long, Xin Du, Caihua Sang, Jianzeng Dong, Changsheng Ma. SCI(IF=5.7)

9: Comparison of admission glycemic variability and glycosylated hemoglobin in predicting major adverse cardiac events among type 2 diabetes patients with heart failure following acute ST-segment elevation myocardial infarction. J Transl Int Med. 2024 May 21;12(2):188-196. Xiuxiu Yang, Gong Su, Tao Zhang, Hongxia Yang, Hong Tao, Xin Du, Jianzeng Dong. SCI(IF=7.4)

10: Small Left Ventricle in Patients With Atrial Fibrillation Is Associated With Increased Cardiovascular Risk. J Am Coll Cardiol. 2024 May 21;83(20):1957-1969. Mingxiao Li, Lan Ren, Liu He, Yiwei Lai, Jue Wang, Sitong Li, Xiaodong Peng, Manlin Zhao, Qifan Li, Zixu Zhao, Le Zhou, Chao Jiang, Song Zuo, Xueyuan Guo, Songnan Li, Nian Liu, Chenxi Jiang, Ribo Tang, Deyong Long, Xin Du, Caihua Sang, Jianzeng Dong, Changsheng Ma. SCI(IF=22.3)

11: Covert Cerebrovascular Changes in People With Heart Disease: A Systematic Review and Meta-Analysis. Neurology. 2024 Apr 23;102(8):e209204. Zien Zhou, Shoujiang You, Yuki Sakamoto, Ying Xu, Song Ding, Wenyi Xu, Wenjie Li, Jie Yu, Yanan Wang, Katie Harris, Candice Delcourt, Mathew J Reeves, Richard I Lindley, Mark W Parsons, Mark Woodward, Craig Anderson, Xin Du, Jun Pu, Joanna M Wardlaw, Cheryl Carcel. SCI(IF=8.5)

12: Efficiency and Durability of EIVOM on Acute Reconnection After Mitral Isthmus Bidirectional Block. JACC Clin Electrophysiol. 2024 Apr;10(4):685-694. Song Zuo, Caihua Sang, Deyong Long, Xiaowen Bo, Yiwei Lai, Qi Guo, Yufeng Wang, Mengmeng Li, Liu He, Xin Zhao, Xueyuan Guo, Nian Liu, Songnan Li, Wei Wang, Chenxi Jiang, Ribo Tang, Xin Du, Jianzeng Dong, Changsheng Ma.SCI(IF=7.7)

13: Factors associated with patients' healthcare-seeking behavior and related clinical outcomes under China's hierarchical healthcare delivery system. Front Public Health. 2024 Apr 12;12:1326272. Lizhu Guo, Xin Du, Huanqi Wu, Shijun Xia, Jing Du, Xiangrong Kong, Xiaohui Yang, Chi Wang, Jianzeng Dong, Changsheng Ma, Lilly Engineer.SCI(IF=3.4)

14: Orthostatic blood pressure changes do not influence cognitive outcomes following intensive blood pressure control. J Intern Med. 2024 Apr;295(4):557-568. Chao Jiang, Manlin Zhao, Mingxiao Li, Zhiyan Wang, Yu Bai, Hang Guo, Sitong Li, Yiwei Lai, Yufeng Wang, Mingyang Gao, Liu He, Xueyuan Guo, Songnan Li, Nian Liu, Chenxi Jiang, Ribo Tang, Deyong Long, Caihua Sang, Xin Du, Jianzeng Dong, Craig S Anderson, Changsheng Ma.SCI(IF=9.2)

15: Effect of Intensive Blood Pressure Control on Cardiovascular Outcomes in Cancer Survivors. Hypertension. 2024 Mar;81(3):620-628. Wenjie Li, Zhiyan Wang, Chao Jiang, Chang Hua, Yangyang Tang, Hao Zhang, Xinru Liu, Shiyue Zheng, Yufeng Wang, Mingyang Gao, Qiang Lv, Jianzeng Dong, Changsheng Ma, Xin Du.SCI(IF=8.2)

16: Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation. Chin Med J (Engl). 2024 Jan 20;137(2):172-180. Jing Lin, Deyong Long, Chenxi Jiang, Caihua Sang, Ribo Tang, Songnan Li, Wei Wang, Xueyuan Guo, Man Ning, Zhaoqing Sun, Na Yang, Yongchen Hao, Jun Liu, Jing Liu, Xin Du, Louise Morgan, Gregg C Fonarow, Sidney C Smith Jr, Gregory Y H Lip, Dong Zhao, Jianzeng Dong, Changsheng Ma.SCI(IF=7.3)

17: Impact of Sodium-Glucose Cotransporter 2 Inhibitor on Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With Diabetes: A Propensity-Score Matching Study and Meta-Analysis. J Am Heart Assoc. 2023 Dec 19;12(24):e031269. Zixu Zhao, Chao Jiang, Liu He, Shiyue Zheng, Yufeng Wang, Mingyang Gao, Yiwei Lai, Jingrui Zhang, Mingxiao Li, Wenli Dai, Song Zuo, Xueyuan Guo, Songnan Li, Chenxi Jiang, Nian Liu, Ribo Tang, Deyong Long, Xin Du, Caihua Sang, Jianzeng Dong, Changsheng Ma. SCI(IF=5.3)

18: Body mass index, frailty, and outcomes in heart failure with preserved ejection fraction. ESC Heart Fail. 2023 Dec 22. Wenjie Li, Zhiyan Wang, Chang Hua, Hao Zhang, Xinru Liu, Shiyue Zheng, Qiang Lv, Chao Jiang, Jianzeng Dong, Changsheng Ma, Xin Du. SCI(IF=3.7)

19: Systolic Blood Pressure Time in Target Range and Incident Atrial Fibrillation in Patients With Hypertension: Insights From the SPRINT Trial. Hypertension. 2023 Nov;80(11):2306-2314. Jue Wang, Chao Jiang, Sitong Li, Zhiyan Wang, Yufeng Wang, Yiwei Lai, Zhen Wang, Wenhe Lv, Yu Bai, Zejun Yang, Qi Guo, Lihong Huang, Liu He, Xueyuan Guo, Songnan Li, Nian Liu¹, Chenxi Jiang, Ribo Tang, Deyong Long, Xin Du, Caihua Sang, Jianzeng Dong, Changsheng Ma.SCI(IF=8.2)

20: Re-evaluating serum angiotensin-converting enzyme in sarcoidosis. Front Immunol. 2023 Oct 5;14:950095. Shi-Yue Zheng, Xin Du, Jian-Zeng Dong. SCI(IF=5.9)

21: Asymptomatic atrial fibrillation among hospitalized patients: clinical correlates and in-hospital outcomes in Improving Care for Cardiovascular Disease in China-Atrial Fibrillation. Europace. 2023 Oct 5;25(10):euad272. Jing Lin, Xue-Ying Wu, De-Yong Long, Chen-Xi Jiang, Cai-Hua Sang, Ri-Bo Tang, Song-Nan Li, Wei Wang, Xue-Yuan Guo, Man Ning, Zhao-Qing Sun, Na Yang, Yong-Chen Hao, Jun Liu, Jing Liu, Xin Du, Gregg C Fonarow, Sidney C Smith, Gregory Y H Lip, Dong Zhao, Jian-Zeng Dong, Chang-Sheng Ma.SCI(IF=7.4)