个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
李静,教授、主任医师、博士生导师,现任首都医科大学宣武医院老年医学科主任、首都医科大学老年医学系副主任;担任中国老年医学学会高血压分会会长、北京医学会老年医学分会副会长、北京医师协会全科医师分会副会长、北京高血压防治协会副会长、北京医师协会心血管医师分会常委、Fellow of European Society of Cardiology(FESC)等;长期从事老年高血压管理、老年综合征的智能化评估和数字化干预、心血管衰老、冠状动脉功能学及腔内影像、冠状动脉血运重建等方面的临床和科研工作;主持包括国家自然科学基金、北京市自然科学基金在内多项国家级、省部级课题;入选北京市百千万人才工程计划、北京市高层次创新创业人才支持计划、北京市科技新星;研究成果发表在心血管领域顶级期刊。
1. 国家自然科学基金委员会,面上项目,82170347,内皮祖细胞分泌骨钙素通过羧基化修饰在血管内皮修复中发挥双向作用的机制,2022/01-2025/12,55万元,在研,主持;
2. 教育部高等学校科学研究发展中心,中国高校产学研创新基金-感染与控制专项,2024GR008,幽门螺杆菌致亚临床动脉粥样硬化的临床评价新技术,2024/09-2026/12,60万元,在研,主持;
3. 北京市科学技术委员会,新星交叉项目,20230484418,基于多模态生理信息的高血压驾驶人行为决策机理研究,2023/10-2025/10,50万元,已结题,主持;
4. 北京市卫生健康委员会,北京市属医学科研院所公益发展改革试点项目,JYY2023-13,老年综合征的智能化评估和数字化干预,2023/12-2025/12,790万元,在研,主持;
5. 国家自然科学基金委员会,面上项目,81470491,内皮功能和成骨表型内皮祖细胞在血管钙化中的作用和调控机制,2015/01-2018/12,73万元,已结题,主持;
6. 北京市自然科学基金委员会,面上项目,7192078,骨钙素阳性内皮祖细胞在血管内皮损伤修复中诱导血管钙化的机制研究,2019/01-2021/12,22万元,已结题,主持。
1. 国家自然科学基金委员会,面上项目,82170347,内皮祖细胞分泌骨钙素通过羧基化修饰在血管内皮修复中发挥双向作用的机制,2022/01-2025/12,55万元,在研,主持;
2. 教育部高等学校科学研究发展中心,中国高校产学研创新基金-感染与控制专项,2024GR008,幽门螺杆菌致亚临床动脉粥样硬化的临床评价新技术,2024/09-2026/12,60万元,在研,主持;
3. 北京市科学技术委员会,新星交叉项目,20230484418,基于多模态生理信息的高血压驾驶人行为决策机理研究,2023/10-2025/10,50万元,已结题,主持;
4. 北京市卫生健康委员会,北京市属医学科研院所公益发展改革试点项目,JYY2023-13,老年综合征的智能化评估和数字化干预,2023/12-2025/12,790万元,在研,主持;
5. 国家自然科学基金委员会,面上项目,81470491,内皮功能和成骨表型内皮祖细胞在血管钙化中的作用和调控机制,2015/01-2018/12,73万元,已结题,主持;
6. 北京市自然科学基金委员会,面上项目,7192078,骨钙素阳性内皮祖细胞在血管内皮损伤修复中诱导血管钙化的机制研究,2019/01-2021/12,22万元,已结题,主持。
一、SCI论文
1. Li J, Elrashidi MY, Flammer AJ, Lennon RJ, Bell MR, Holmes DR, Bresnahan JF, Rihal CS, Lerman LO, Lerman A. Long-term outcomes of fractional flow reserve-guided vs. angiography-guided percutaneous coronary intervention in contemporary practice. Eur Heart J 2013;34:1375–1383. PMID: 23344979.IF: 37.6
2. Guo J, Chen J, Wang G, Liu Z, Niu D, Wu Y, Song J, Gao J, Fan Z, Zhang Y, Si J, Zuo X, Shi N, Miao Z, Bai Z, Zhang L, Liu B, Li J. Plaque characteristics in patients with ST-segment elevation myocardial infarction and early spontaneous reperfusion. EuroIntervention 2021;17:e664–e671. PMID: 33495143. IF: 7.6
3. Si J, Li X-W, Wang Y, Zhang Y-H, Wu Q-Q, Zhang L-M, Zuo X-B, Gao J, Li J. Relationship between serum homocysteine levels and long-term outcomes in patients with ST-segment elevation myocardial infarction. Chin Med J (Engl) 2019;132:1028–1036. PMID: 30829711. IF: 7.5
4. Li Y, Li X-W, Zhang Y-H, Zhang L-M, Wu Q-Q, Bai Z-R, Si J, Zuo X-B, Shi N, Li J, Chu X. Prognostic significance of the hemoglobin A1c level in non-diabetic patients undergoing percutaneous coronary intervention: a meta-analysis. Chin Med J (Engl) 2020;133:2229–2235. PMID: 32826614. IF: 7.5
5. Li J, Flammer AJ, Lennon RJ, Nelson RE, Gulati R, Friedman PA, Thomas RJ, Sandhu NP, Hua Q, Lerman LO, Lerman A. Comparison of the effect of the metabolic syndrome and multiple traditional cardiovascular risk factors on vascular function. Mayo Clin Proc 2012;87:968–975. PMID: 22980166. IF: 6.9
6. Liu Z, Xu Y, Wan Y, Gao J, Chu Y, Li J. Exosomes from adipose-derived mesenchymal stem cells prevent cardiomyocyte apoptosis induced by oxidative stress. Cell Death Discov 2019;5:79. PMID: 30911413. IF: 6.1
7. Li J, Rihal CS, Matsuo Y, Elrashidi MY, Flammer AJ, Lee M-S, Cassar A, Lennon RJ, Herrmann J, Bell MR, Holmes DR, Bresnahan JF, Hua Q, Lerman LO, Lerman A. Sex-related differences in fractional flow reserve-guided treatment. Circ Cardiovasc Interv 2013;6:662–670. PMID: 24149976. IF: 6.1
8.Yi M, Wu Y, Long J, Liu F, Liu Z, Zhang Y-H, Sun X-P, Fan Z-X, Gao J, Si J, Zuo X-B, Zhang L-M, Shi N, Miao Z-P, Bai Z-R, Liu B-Y, Liu H-R, Li J. Exosomes secreted from osteocalcin-overexpressing endothelial progenitor cells promote endothelial cell angiogenesis. Am J Physiol Cell Physiol 2019;317:C932–C941. PMID: 31411920. IF: 5.0
9. Zhang H, Yang J, Zhang Y, Xiao K, Wang Y, Si J, Li Y, Sun L, Sun J, Yi M, Chu X, Li J. Age and sex differences in the effects of short- and long-term exposure to air pollution on endothelial dysfunction. Environ Health Glob Access Sci Source 2024;23:63. PMID: 38978038. IF: 4.9
10. Zhang H, Yi M, Wang Y, Zhang Y, Xiao K, Si J, Shi N, Sun L, Miao Z, Zhao T, Sun X, Liu Z, Gao J, Li J. Air pollution and recurrence of cardiovascular events after ST-segment elevation myocardial infarction. Atherosclerosis2022;342:1–8. PMID: 34974197. IF: 4.9
11. Sun L, Xiao K, Miao Z, Zhang Y, Si J, Shi N, Zhang H, Zhao T, Li J. Prognostic Value of Normal Thyroid Stimulating Hormone in Long-Term Mortality in Patients With STEMI. Front Endocrinol 2022;13:806997. PMID: 35273563. IF: 3.9
12. Liu D, Wu L, Wu Y, Wei X, Wang W, Zhang S, Yi M, Li J, Liu H, Ma X. Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. Aging 2019;11:8982–8997. PMID: 31627188. IF: 3.9
13. Kong Q, Shi L, Yu R, Long D, Zhang Y, Chen Y, Li J. Biatrial enlargement as a predictor for reablation of atrial fibrillation. Int J Med Sci 2020;17:3031–3038. PMID: 33173423. IF: 3.2
14. Sun L, Fan Z, Gao J, Zhao T, Si J, Zhang H, Li Y, Sun J, Wang X, Liu Z, Yi M, Hua Y, Xing Y, Liu Z, Li J. Association between patent foramen ovale morphology and clinical outcomes following transcatheter closure. Int J Cardiol 2024;412:132307. PMID: 38945369. IF: 3.2
15. Li J, Flammer AJ, Nelson RE, Gulati R, Friedman PA, Thomas RJ, Sandhu NP, Reriani MK, Lerman LO, Lerman A. Normal vascular function as a prerequisite for the absence of coronary calcification in patients free of cardiovascular disease and diabetes. Circ J Off J Jpn Circ Soc 2012;76:2705–2710. PMID: 22850339. IF: 3.1
16. Li J, Flammer AJ, Reriani MK, Matsuo Y, Gulati R, Friedman PA, Thomas RJ, Sandhu NP, Lerman LO, Lerman A. High leukocyte count is associated with peripheral vascular dysfunction in individuals with low cardiovascular risk. Circ J Off J Jpn Circ Soc 2013;77:780–785. PMID: 23220800. IF: 3.1
17. Li J, Lerman A. Is high leukocyte count synonymous with the presence of endothelial dysfunction or atherosclerosis? Circ J Off J Jpn Circ Soc 2014;78:1010. PMID: 24476803. IF: 3.1.
18. Tan J, Si J, Xiao K-L, Zhang Y-H, Hua Q, Li J. Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction. J Geriatr Cardiol JGC 2024;21:421–430. PMID: 38800549. IF: 3.1
19. Tan J, Zhang Y-H, Si J, Xiao K-L, Hua Q, Li J. Incidence, predictors and prognosis of acute kidney injury in acute ST-segment elevation myocardial infarction patients undergoing emergent coronary angiography/primary percutaneous coronary intervention. J Geriatr Cardiol JGC 2023;20:139–149. PMID: 36910244. IF: 3.1
20. Zhang Y-H, Li J, Flammer AJ, Matsuo Y, Lee M-S, Lennon RJ, Bell MR, Holmes DR, Bresnahan JF, Rihal CS, Lerman LO, Lerman A. Long-term outcomes after fractional flow reserve-guided percutaneous coronary intervention in patients with severe coronary stenosis. J Geriatr Cardiol JGC 2019;16:329–337. PMID: 31105753. IF: 3.1
21. Li Y, Yi M, Wang X, Zhang Y, Xiao K, Si J, Sun L, Zhang H, Sun J, Liu Z, Zhao J, Chu X, Li J. Association between triglyceride-glucose index and endothelial dysfunction. Endocrine 2024. PMID: 38514591. IF: 3.0
22. Li Y, Zhang Y, Xiao K, Si J, Zhang H, Sun L, Miao Z, Zhao T, Sun J, Sun X, Liu Z, Gao J, Zhao J, Chu X, Li J. The incidence of subclinical atherosclerosis in subjects with low and moderate cardiovascular risk. Clin Cardiol2023;46:1260–1267. PMID: 37522647. IF: 2.4
23. Yi M, Li Y, Sun J, Si J, Liu H, Li J. Osteocalcin deficiency attenuates neointima formation after vascular injury in rat. BMC Cardiovasc Disord. 2025 Jul 21;25(1):534. PMID: 40691534. IF: 2.3
24. Li J, Zhang Y, Wang F, Liu B, Li H, Tang G, Chang Z, Liu A, Fu C, Lv Y, Gao J, Li J. Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19). BMC Cardiovasc Disord 2020;20:479. PMID: 33167876. IF: 2.0
25. Li Y, Li X, Zhang Y, Zhang L, Wu Q, Bai Z, Si J, Zuo X, Shi N, Li J, Chu X. Impact of glycemic control status on patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. BMC Cardiovasc Disord 2020;20:36. PMID: 32000678. IF: 2.0
26. Li Y-P, Fan Z-X, Gao J, Sun X-P, Zhu G-H, Zhang Y-H, Si J, Zuo X-B, Liu Z, Hua Q, Li J. Influencing factors of vascular endothelial function in patients with non-obstructive coronary atherosclerosis: a 1-year observational study. BMC Cardiovasc Disord 2020;20:40. PMID: 32000667. IF: 2.0
27. Hua Q, Fan L, Li J, Joint Committee for Guideline Revision. 2019 Chinese guideline for the management of hypertension in the elderly. J Geriatr Cardiol JGC 2019;16:67–99. PMID: 30923539. IF: 1.8
28. Hua Q, Fan L, Wang Z-W, Li J. 2023 Guideline for the management of hypertension in the elderly population in China. J Geriatr Cardiol JGC 2024;21:589–630. PMID: 38973827. IF: 1.8
29. Li J, Hu Y-X, Wang W, Fang N-Y, Lu X-Z, Pi L, Liu M-L, Li W-M, Li Y-F, Qu P, Hua Q, He Q, Wu H-Y, Zhang Y-M, Chen X-P, Chen L-Y, Fan L, Zhao X-S, Zhu Z-M, Jiang Y-N, Guo Y-F, Yuan H, Gao P-J, Xu X-J, Cai J, Xie L-D, Chinese Society of Geriatric Hypertension, Chinese Geriatrics Society. Chinese expert consensus on the management of hypertension in the very elderly. J Geriatr Cardiol JGC 2016;13:945–953. PMID: 28321236. IF: 1.8
30. Xiao K, Liu M, Sun X, Zhang Y, Si J, Shi N, Sun L, Miao Z, Zhang H, Zhao T, Liu Z, Fan Z, Gao J, Li J. Association of vascular endothelial function and quality of life in patients with ischemia and non-obstructive coronary artery disease. Heart Vessels 2023;38:617–625. PMID: 36598570. IF: 1.4
31. Yi M, Wang X, Li Y, Li X, Si J, Zhang Y, Xiao K, Sun L, Zhang H, Sun J, Liu Z, Lin J, Xie Y, Zhang B, Zhao J, Chu X, Li J. Association between Metabolic Syndrome Score and Subclinical Atherosclerosis. Rev Cardiovasc Med. 2025 Mar 12;26(3):26811. PMID: 40160566. IF: 1.3
32. Li J, Zhang Y, Ma Y, Sun J, Li X, Chen B, Chen H, Dong P, Guo J, Guo L, Hao H, Ji H, Li K, Liu H, Lv S, Shen L, Shen Z, Wang G, Wang L, Wang L, Yu M, Zhang F, Zhang H, Zhang J, Zhao X, Yang Y. Causes of In-Hospital Death in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention in Beijing Area. Am J Cardiol. 2026 Jan 15;259:29-37. doi: 10.1016/j.amjcard.2025.09.030. Epub 2025 Sep 27. PMID: 41022245. IF: 2.1
33. Wang X, Yi M, Zhang Y, Xiao K, Si J, Sun L, Zhang H, Sun J, Liu Z, Lin J, Xie Y, Zhang B, Zhao J, Chu X, Li J. Lean Mass Index, Not Body Mass Index, is Essentially Associated with Arterial Stiffness in Chinese Adults: A Cross-Sectional Study. Diabetes Metab Syndr Obes. 2025 Nov 11;18:4141-4151. doi: 10.2147/DMSO.S556617. PMID: 41245741; PMCID: PMC12619619. IF: 3.0
二、指南共识
(1) 中国老年医学学会高血压分会,国家老年疾病临床医学研究中心中国老年心血管病防治联盟. 中国老年高血压管理指南2019[J]. 中华高血压杂志,2019,27(2):111-135.(撰写组长)
(2) 中国老年医学学会高血压分会,北京高血压防治协会,国家老年疾病临床医学研究中心(中国人民解放军总医院,首都医科大学宣武医院). 中国老年高血压管理指南2023[J]. 中华高血压杂志,2023,31(6):508-538.(通讯作者)
(3) 北京高血压防治协会,北京糖尿病防治协会,北京慢性病防治与健康教育研究会,等. 基层心血管病综合管理实践指南2020[J]. 中国医学前沿杂志(电子版),2020,12(8):前插1,1-73. (编委)
(4) 中国老年医学学会高血压分会. 脉搏波传导速度检测用于早期血管衰老评价的中国专家共识[J]. 中华高血压杂志,2021,29(12):1168-1172.(主持)
(5) 赵连友,孙英贤,李悦,等. 经皮冠状动脉介入治疗术后血压管理中国专家共识[J]. 中华高血压杂志,2022,30(6):506-513. DOI:10.16439/j.issn.1673-7245.2022.06.003.(执笔)
(6) 中国老年医学学会高血压分会. 老年人异常血压波动临床诊疗中国专家共识[J]. 中华高血压杂志,2017,25(2):132-140.(执笔)
(7) 中国老年医学学会高血压分会. 高龄老年人血压管理中国专家共识[J]. 中华高血压杂志,2015,23(12):1127-1134.(执笔)
(8) 中国老年医学学会高血压分会,中华医学会心血管病学分会,中国医师协会高血压专业委员会,等. 复方利血平氨苯蝶啶片(O号?)临床应用中国专家共识2021版[J]. 中国心血管杂志,2021,26(5):428-431.(执笔)
(9) 中华医学会心血管病学分会老年学组,国家老年疾病临床医学研究中心(解放军总医院. 老年心血管疾病合并衰弱评估与管理中国专家共识[J]. 中华老年多器官疾病杂志,2023,22(7):481-491.(专家组成员)
三、会议论文
(1) Jincheng Guo, Jing Li, Non-ruptured plaque and platelet-rich thrombi in ST-segment elevation myocardial infarction: new insight into early spontaneous reperfusion, ESC Congress 2019, Paris, France, 2019.08.31-09.04.
(2) Jin Si, Chong Zheng, Jie Lu, Jing Li. Hypoperfused myocardium and systolic function in patients with AMI undergoing complete revascularization, ESC Congress 2024, London, UK, 2024.08.30-2024.09.02.
(3) Haoyu Zhang, Jing Li. Age and sex differences in the effects of short- and long-term exposure to air pollution on endothelial dysfunction, ESC Congress 2024, London, UK, 2024.08.30-2024.09.02.
(4) Lijie Sun, Zhenxing Fan, Jing Gao, Zhi Liu, Jing Li. Association between patent foramen ovale morphology and clinical outcomes following transcatheter closure, Transcatheter cardiovascular therapeutics(TCT)2024,Washington, D.C., US, 2024.10.27-2024.10.30.
(5) Haoyu Zhang, Jing Li. Prognostic significance of different body temperature trajectories and fever in patients with ST-segment elevation myocardial infarction, ESC Congress 2025, Madrid, Spain, 2025.08.29-2025.09.01.
(6) Jinghao Sun, Jing Li. Impact of admission time, mode of arrival, and hospital level on treatment delay among patients with ST elevation myocardial infarction, ESC Congress 2024, Madrid, Spain, 2025.08.29-2025.09.01.
(7) Baichuan Gu, Haoyu Zhang, Jing Li. Biological ageing mediates the associations between disrupted rest-activity circadian rhythms and all-cause and cardiovascular mortality in US adults: NHANES 2011-2014, ESC Congress 2025, Madrid, Spain, 2025.08.29-2025.09.01.
四、授权发明专利
(1) 李静; 张迎花; 司瑾; 吴晴晴; 左雪冰; 石宁 ; eNOS突变体在促进血管生成中的应用, 2020-02-18; 中国, CN201711013899.0
(2) 李静; 张迎花; 司瑾; 吴晴晴; 左雪冰; 石宁 ; 骨钙素在调节内皮祖细胞外泌体中的应用, 2020-02-18, 中国, CN201711218900.3
(3) 李静; 相前; 衣明; 司瑾; 肖克令; 孙丽杰; 张浩宇; 孙璟皓; 王心怡; 张冰堰 ; 微血管内皮功能检测方法、装置、电子设备及存储介质, 2024-12-17, 中国, ZL 2024 1 1290938.1
五、获得学术奖励
(1) 李静(1/1),老年医学奖“杰出贡献奖”,中国老年医学学会-北京医学奖励基金会,杰出贡献奖,其他,2017(李静)
(2) 李静(2/8),经灌注球囊冠状动脉注射维拉帕米处理介入术中慢血流与无复流的疗效,北京市通州区人民政府,自然科学,其他,2017(郭金成,李静,李东宝,王德昭,华琦,徐荣,王国忠,陈文明)
(3) 李静(8/8),生理性舒张功能减退与舒张性心力衰竭的鉴别诊断及临床意义,北京市人民政府,自然科学,省部二等奖,2004(华琦,张建,高敬,秦俭,沈祖培,陈海翎,皮林,李静)

文件上传中...