近年作为项目负责人主持的科研课题

1.     国家自然科学基金面上项目：《褪黑素通过调节SIRT3介导的氧化应激/线粒体自噬在心肌缺血再灌注损伤中的作用及其机制研究》（81871592）科研经费，57万元，2019.1-2022.12项目负责人

2.     国家重点研发计划子课题：《老年围手术期心脏、肾损伤风险评估及防治技术研究》（2018YFC2001900-02）科研经费，30万元，2019.1-2022.12项目负责人

3.     北京市医院管理局临床医学发展专项-扬帆重点计划《心血管麻醉学》（Z Y L X 2 0 1 8 1 0）,科研经费200万元,2018.1-2020.12项目负责人

4.     国家自然科学基金面上项目：《盐酸戊乙奎醚预处理和后处理对心肌缺血再灌注损伤保护机制及其线粒体信号通路的研究》（81471902）科研经费,80万元，2015.1-2018.12项目负责人

5.     北京市卫生系统学科带头人（2013-2-004），科研经费90万元 2013-2016，项目负责人

6.     国家自然科学基金面上项目：《ICAM-1 基因多态性与糖尿病周围神经病变易感性的相关性研究》（30972851），2010.1-2012.12，项目负责人 ，32万

7.     北京市科学技术委员会   首都临床特色应用研究：《糖尿病周围神经病变微创介入治疗规范化研究》（Z121107001012159），2012.7-2015.9，项目负责人 ，22.5万

8.     首都医学发展科研基金：《腰交感神经节持续阻滞治疗糖尿病痛性神经病变的研究》（2009-3145），2010.8-2013.7，项目负责人 ，10万

一、首都医科大学自然科学奖三等奖，《急性心肌梗死中心肌缺血再灌注损伤的线粒体机制研究》，2021.7，马骏，林多茂，杨艳丽，王兆麒，吴金晶，崔博群，张亮

二、《伴发心血管疾病患者围麻醉期处理》，副主编马骏，人卫出版社，2021

三、近5年首位作者或责任作者发表论文

1.     Dongni Zhang , Chuan Ouyang, Xu Zhao, Boqun Cui, Feng Dai, Lingzhong Meng*, Jun Ma*. Renal tissue desaturation and acute kidney injuryin infant cardiac surgery: A prospective propensity score-matched cohort study.British Journal of Anaesthesia, 2021，127 (4): 620-628.  IF 11.719/Q1

2.     Jinjing Wu, Yang Bai, Yaguang Wang, Jun Ma*. Melatonin andregulation of autophagy: mechanisms and therapeutic implications.Pharmacological Research, 2021,163:105279. https://doi.org/10.1016/j.phrs.2020.105279. IF 7.658/Q1

3.     Yang Bai, Yanli Yang, Yafen Gao, Duomao Lin, Zhaoqi Wang, JunMa*. Melatonin postconditioning ameliorates anoxia/reoxygenation injury byregulating mitophagy and mitochondrial dynamics in a SIRT3-dependent manner. EuropeanJournal of Pharmacology, 2021, (904) 174157:1-12. IF 4.432/Q2

4.     Li Y, Ma J, Jin Y, Li N, Zheng R, Mu W, Wang J, Si J, Chen J,Shang H. Benzodiazepines for treatment of patients with delirium excludingthose who are cared for in an intensive care unit. Cochrane Database ofSystematic Reviews 2020, Issue 2. Art. No.: CD012670. DOI:10.1002/14651858.CD012670.pub2

5.     Zhaoqi Wang, Yan Li, Duomao Lin, Jun Ma.* Effect of Melatonin onPostoperative Pain and Perioperative Opioid Use: A Meta-analysis and TrialSequential Analysis. Pain Practice, 2021,21( 2):190–203.

6.     Yan Li, Zhi Dou, Liqiang Yang, Qi Wang, Jiaxiang Ni, Jun Ma*.Oxycodone versus other opioid analgesics after laparoscopic surgery: ameta-analysis. European journal of medical research. 2021 Jan 09;26(1):4doi:10.1186/s40001-020-00463-w.

7.     Cui B, Ou-Yang C, Xie S, Lin D, Ma J*. Effects of differentventilation on cerebral oxygen saturation and cerebral blood flow before andafter modified ultrafiltration in infants during ventricular septal defectrepair. Cardiol Young. 2021 Mar;31(3):371-376. doi: 10.1017/S1047951120003984.Epub 2021 Feb 5. PMID: 33541455.

8.     YANLI YANG  and  JUN MA*. Mild AKI is associated withmortality of patients  who underwentcardiopulmonary bypass surgery. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2020,20: 2969-2974.

9.     Sun H, He M, Pang J, Guo X, Huo Y, Ma J*. Continuous LumbarSympathetic Blockade Enhances the Effect of Lumbar Sympatholysis on RefractoryDiabetic Neuropathy: A Randomized Controlled Trial. Diabetes Ther. 2020Nov;11(11):2647-2655. doi: 10.1007/s13300-020-00918-7. Epub 2020 Sep 11. PMID:32915421; PMCID: PMC7547930.

10.  Cunlei Zhang, Jun Ma*. Chest X-ray Image Analysis andPenehyclidine Hydrochloride Postconditioning Influence of Lung IschemiaReperfusion Injury. J. Med. Imaging Health Inf, 2020, 10:2834–2841

11.  Cui B, Ou-Yang C, Xie S, Lin D, Ma J*. Age-relatedcerebrovascular carbon dioxide reactivity in children with ventricular septaldefect younger than 3 years. Pediatr Anesth. 2020;00:1–7.https://doi.org/10.1111/ pan.13967

12.  Congna Zi, Chunlei Zhang, Yanli Yang, Jun Ma*. Penehyclidinehydrochloride protects against anoxia/reoxygenation injury in cardiomyocytesthrough ATP‐sensitive potassiumchannels, and the Akt/GSK‐3β and Akt/mTOR signalingpathways. Cell Biol Int 44 (2020) 1353–1362

13.  Wenyu Yao, Mingyuan Yang, Qinghao Cheng, Shiqiang Shan, BoYang, Qian Han, Jun Ma*. Effect of Pressure-Controlled Ventilation-Volume Guaranteedon One-Lung Ventilation in Elderly Patients Undergoing Thoracotomy. Med Sci Monit, 2020; 26: e921417-1- e921417-7. DOI:10.12659/MSM.921417

14.  Jinjing Wu, Yanli Yang, Yafen Gao, Zhaoqi Wang, Jun Ma*. MelatoninAttenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive MitophagyThrough the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells. Drug Design,Development and Therapy, 2020:14 2047–2060.

15.  Li-yuan Wang, Jing Wu, Ya-fen Gao, Duo-mao Lin, Jun Ma*. Medium-and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme Acarboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells. Korean JPhysiol Pharmacol 2020;24(1):19-26.

16.  Lin D, Cui B, Ma J*, Ren J. MiR-183-5p protects rat heartsagainst myocardial ischemia/reperfusion injury through targeting VDAC1. BioFactors. 2019;1–11.https://doi.org/10.1002/biof.1571     

17.  JY Ren, DM Lin, CB Wang, YL Yang, ZQ Wang, BQ Cui, J Ma*. PostconditioningProtection Against Myocardiocyte Anoxia/Reoxygenation Injury From PenehyclidineHydrochloride. Drug Design, Development and Therapy, 2019, 13: 3977–3988.

18.  Li T, Qu W, Zhang X, Zhang Y, Ma J*. Puerarin alleviatescognitive dysfunction in rats after anesthesia with propofol. Int J Clin Exp Med2019, 12(3):2697-2703.

19.  Qinghao Cheng, Lei Li, Duomao Lin, Renjiao Li, Yun Yue, HuafengWei, Jun Ma. Effects of acute hypercapnia on cognitive function in patientsundergoing bronchoscope intervention. Journal of Thoracic Disease, 2019, 11(3):1065-1071.

20.  Qinghao Cheng, Lei Li, Mingyuan Yang, Lei Sun, Renjiao Li,Rui Huang, Jun Ma. Moderate hypercapnia may not contribute to postoperative deliriumin patients undergoing bronchoscopic intervention. Medicine, 2019, 98:22:1-4.

21.  Liang Zhang, Cheng-Bin Wang, Bo Li, Duo-Mao Lin, Jun Ma*.RhoA/rho-kinase, nitric oxide and inflammatory response in LIMA during OPCABGwith isoflurane preconditioning. Journal of Cardiothoracic Surgery, 2019 Jan25;14(1):22.

22.  Mingwei He, Haiyan Sun, Jinlei Pang, Xiangfei Guo, YansongHuo, Xianhong Wu, Yaguang Liu, Jun Ma. Propofol alleviates hypoxia-inducednerve injury in PC-12 cells by up-regulation of microRNA-153. BMCAnesthesiology, 2018, 18:197:1-10.

24.  Yaguang Wang, Duomao Lin, Hongbao Tan, Yafen Gao, Jun Ma, Penehyclidinehydrochloride preconditioning provides pulmonary and systemic protection in arat model of lung ischaemia reperfusion injury. European Journal ofPharmacology, 2018, 839: 1-11.

25.  Xu F, Wang Q, Chen S, Ao H, Ma J*. The association between intraoperativedexmedetomidine and 1 year morbidity and mortality after cardiac surgery: Apropensity matched analysis of over 1400 patients. J Clin Anesth. 2018, 50(11):70-75.

26.  Yaguang Wang, Yafen Gao, Jun Ma. Pleiotropic effects andpharmacological properties of penehyclidine hydrochloride. Drug Design,Development and Therapy,2018, 12: 3289-3299.

27.  Lin D, Cui B, Ren J, Ma J*. Regulation of VDAC1 contributesto the cardioprotective effects of penehyclidine hydrochloride duringmyocardial ischemia/reperfusion. Exp Cell Res. 2018, 367(2):257-263.

28.  Wenjun Liu, Qian Huang, Duomao Lin, Liyun Zhao, Jun Ma*.Effect of lung protective ventilation on coronary heart disease patientsundergoing lung cancer resection. J Thorac Dis 2018;10(5):2760-2770.

29.  Yang Y, Ma J. High central venous pressure isassociated with acute kidney injury and mortality in patients underwent cardiopulmonarybypass surgery. Journal of Critical Care, 2018, 48(10): 211-215.

30.  Yang Y, Zhao L, Ma J. Penehyclidine hydrochloridepreconditioning provides cardiac protection in a rat model of myocardialischemia/reperfusion injury via the mechanism of mitochondrial dynamicsmechanism. Eur J Pharmacol. 2017 Oct 15;813:130-139. doi:10.1016/j.ejphar.2017.07.031. Epub 2017 Jul 26.

31.  Tan H, Lin D, Wang Z, Yang Y, Ma J. Cardioprotectivetime-window of Penehyclidine hydrochloride postconditioning: A rat study. Eur JPharmacol.  2017, 812 :48–56.

32.  Hongbao Tan, Li Chen, Jun Ma. Penehyclidine hydrochloridepost-conditioning reduces ischemia/reperfusion-induced cardiomyocyte apoptosisin rats. EXPERIMENTAL AND THERAPEUTIC MEDICINE. 2017, 14: 4272-4278.

33.  Wenjun Liu, Duomao Lin, Sajid Ali, Jun Ma. Comparisons of twoventilation modes with lung recruitment maneuver during one-lung ventilation inpatients undergoing thoracoscopic lobectomy. Biomedical Research, 2017, 28 (11):1-6.

34.  Zhaoqi Wang, Duomao Lin, Liang Zhang, Wenjun Liu, HongbaoTan, Jun Ma. Penehyclidine Hydrochloride Prevents Anoxia/Reoxygenation Injuryand Induces H9c2 Cardiomyocyte Apoptosis via A Mitochondrial Pathway. EUR JPHARMACOL, 2017, 797:115～123.