2007-2009主持国家自然科学基金面上项目“EPO-TAT 对神经元缺血的保护作用”，项目批准号：30670725，30万

2008-2010主持国家自然科学基金面上项目“远隔缺血后处理神经保护的时间窗及机制”，项目批准号：30770743，30万

2011-2013主持国家自然科学基金面上项目“EPO 血管内注射对大鼠脑梗死tPA 溶栓时间窗的作用及机制”，项目批准号：81071058，32万

2013-2016 主持国家自然基金面上项目“缺血后适应对脑缺血再灌注神经细胞周期激活抑制的分子机制”，项目批准号：81271461，75万

2015-2018  主持国家自然基金面上项目“新型变构EPO延迟应用对老龄小鼠脑缺血神经修复作用及机制”，项目批准号：81471340，70万

2018-2021 主持国家自然基金面上项目“MicroRNA494介导脑缺血神经细胞周期进程阻滞的分子机制”，项目批准号：81771413，54万

2020-2023 主持国家自然基金面上项目“TOPK介导脑缺血中性粒细胞增殖和表型转化的机制研究”，项目批准号：81971222，55万

2020-2022 主持首都科技发展科研专项项目 “早期预测静脉tPA溶栓治疗反应的外周血特异性标志物研究30万”，项目批准号：2020-2-1032

2022-2025 主持国家自然基金面上项目“NcRNAs调控HGF/c-Met介导中性粒细胞迁移参与急性缺血性卒中rtPA溶栓治疗反应的分子机制研究”，项目批准号：82171301，54万

2022-2024 主持北京市自然科学基金面上项目“C/EBPs靶向抑制未成熟中性粒细胞分化参与急性缺血性卒中的神经修复机制研究”，项目批准号：7222083，20万

2024-2027 主持国家自然科学基金委员会面上项目“TBC1D17-Rab5-JFC1轴调控中性粒细胞脱颗粒形成NE外泌体加重缺血性卒中再灌注损伤的机制研究”，项目批准号：82371306，49万元

2024-2028 主持国家卫健委科技创新2030“癌症、心脑血管、呼吸和代谢性疾病防治研究”重大项目“中药干预脑而管病相关认知障碍的作用机制及干预靶点研究”，项目批准号：2023700505809，410万元

近5年发表的文章：

1.         Han Z, Wang T, Li L, Fan J, Wang R,Zheng Y, Yan F, Zhao H, Luo Y, Jiao L. Expression profiles and potentialclinical significance of circular RNAs in peripheral neutrophils of patientswith intracranial atherosclerotic stenosis. BrainCirc. 2025;11:200-211. doi: 10.4103/bc.bc_16_24

2.         Zhao F, Wang T, Luo J, Gao H, Zheng Y,Wang R, Fan J, Zhao H, Han Z, Luo Y, et al. Endothelial Glycocalyx in CerebralInfarction After Endovascular Treatment in Patients With Intracranial ArteryStenosis. CNS Neurosci Ther.2025;31:e70545. doi: 10.1111/cns.70545

3.         Fan J, Zhong L, Shen T, Wang Y, Han Z,Zhao H, Yan F, Wang R, Zheng Y, Tao Z, et al. Elevated Plasma m6A DemethylaseFTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke. Cell Mol Neurobiol. 2025;45:64. doi:10.1007/s10571-025-01591-9

4.         Zheng Y, Ma S, Sun W, Yan F, Luo Y.Voclosporin promotes neurological function recovery by inhibiting inflammationand maintaining blood-brain barrier integrity following rtPA reperfusion afterMCAO in mice. Inflammopharmacology.2025;33:3317-3328. doi: 10.1007/s10787-025-01757-3

5.         Li X, Geng X, Fan J, Yan F, Wang R,Yang Z, Li Y, Wang J, Luo Y, Zhao H. Molecular Mediators of Neutrophil PrimaryGranule Release Following Acute Ischemic Stroke and their Associated EpigeneticModulation by HDAC2. Mol Neurobiol.2025;62:6544-6561. doi: 10.1007/s12035-025-04699-7

6.         Li Y, Tang F, Luo Y. The cellulardistribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-inducedstatus epilepticus and literature review. BrainCirc. 2024;10:343-353. doi: 10.4103/bc.bc_27_24

7.         Shen T, Fan J, Zheng Y, Luo Y, Liu P.Potential Predictive Value of Platelet Distribution Width for FunctionalOutcome After Ischemic Stroke. MolNeurobiol. 2024;62:4292-4300. doi: 10.1007/s12035-024-04556-z

8.         Zhong L, Xie Z, Han Z, Fan J, Wang R,Tao Z, Ma Q, Luo Y. Long Non-Coding H19 in Lymphocytes: Prognostic Value inAcute Ischemic Stroke Patients. Pharmaceuticals(Basel). 2024;17. doi: 10.3390/ph17081008

9.         Zhong L, Fan J, Yan F, Yang Z, Hu Y, LiL, Wang R, Zheng Y, Luo Y, Liu P. Long noncoding RNA H19 knockdown promotesangiogenesis via IMP2 after ischemic stroke. CNS Neurosci Ther. 2024;30:e70000. doi: 10.1111/cns.70000

10.        Huang Y, Han Z, Shen T, Zheng Y, Yang Z,Fan J, Wang R, Yan F, Tao Z, Luo Y, et al. Neutrophil migration participates inthe side effect of recombinant human tissue plasminogen activator. CNS Neurosci Ther. 2024;30:e14825. doi:10.1111/cns.14825

11.        Gao Q, Ni P, Wang Y, Huo P, Zhang X,Wang S, Xiao F, Li Y, Feng W, Yuan J, et al. DDAH1 promotes neurogenesis andneural repair in cerebral ischemia. ActaPharm Sin B. 2024;14:2097-2118. doi: 10.1016/j.apsb.2024.02.001

12.        Wang R-L, Yang Z-H, Huang Y-Y, Hu Y,Wang Y-L, Yan F, Zheng Y-M, Han Z-P, Fan J-F, Tao Z, et al.Erythropoietin-derived peptide ARA290 mediates brain tissue protection throughthe β-common receptor in mice with cerebral ischemicstroke. CNS Neurosci Ther.2024;30:e14676. doi: 10.1111/cns.14676

13.        Wang Y, Yang Z, Wang R, Zheng Y, Han Z,Fan J, Yan F, Liu P, Luo Y. Annexin A6 mitigates neurological deficit inischemia/reperfusion injury by promoting synaptic plasticity. CNS Neurosci Ther. 2024;30:e14639. doi:10.1111/cns.14639

14.        Hu Y, Huang S, Shen T, Wang R, Geng M,Wang Y, Zheng Y, Luo Y, Li S. Prognostic Significance of Plasma VEGFA andVEGFR2 in Acute Ischemic Stroke-a Prospective Cohort Study. Mol Neurobiol. 2024;61:6341-6353. doi:10.1007/s12035-024-03973-4

15.        Wang Y, Wang T, Han Z, Wang R, Hu Y,Yang Z, Shen T, Zheng Y, Luo J, Ma Y, et al. Explore the role of long noncodingRNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspectiveof neutrophils. Brain Circ.2023;9:240-250. doi: 10.4103/bc.bc_63_23

16.        Tian T, Wang L, Xu J, Jia Y, Xue K,Huang S, Shen T, Luo Y, Li S, Min L. Prediction of early neurologicaldeterioration in acute ischemic stroke patients treated with intravenousthrombolysis. J Cereb Blood Flow Metab.2023;43:2049-2059. doi: 10.1177/0271678X231200117

17.        Huang Y, Gu S, Han Z, Yang Z, Zhong L,Li L, Wang R, Yan F, Luo Y, Borlongan C, et al. Cold Case of Thrombolysis: ColdRecombinant Tissue Plasminogen Activator Confers Enhanced Neuroprotection inExperimental Stroke. J Am Heart Assoc.2023;12:e029817. doi: 10.1161/JAHA.123.029817

18.        Zhao F, Zhong L, Wang Y, Wang R, Yang Z,Luo Y, Zheng Y. Untargeted metabolomics uncovering neuroprotective effect ofDl-3-n-butylphthalide on improving cognitive impairment induced by chroniccerebral hypoperfusion in rats. IntImmunopharmacol. 2023;119:110271. doi: 10.1016/j.intimp.2023.110271

19.        Yang Z, Wang R, Zheng Y, Luo Y. Is the β Common Receptor the Key Molecule for the Protective Effect ofErythropoietin? Aging Dis.2023;14:287-289. doi: 10.14336/AD.2022.0823

20.        Li L, Han Z, Wang R, Fan J, Zheng Y,Huang Y, Yang Z, Yan F, Liu P, Zhao H, et al. Association of admissionneutrophil serine proteinases levels with the outcomes of acute ischemicstroke: a prospective cohort study. JNeuroinflammation. 2023;20:70. doi: 10.1186/s12974-023-02758-1

21.        Li L, Han Z, Yang Z, Ma Q, Zhao H, WangR, Fan J, Zhong L, Hu Y, Liu P, et al. Circulating Inflammatory BiomarkersLevel before Thrombolysis for Acute Ischemic Stroke Predicts SymptomaticIntracerebral Hemorrhage. Aging Dis.2023;14. doi: 10.14336/AD.2022.0608

22.        Zhao Y, Ding M, Yan F, Yin J, Shi W,Yang N, Zhao H, Fang Y, Huang Y, Zheng Y, et al. Inhibition of the JAK2/STAT3pathway and cell cycle re-entry contribute to the protective effect of remoteischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusioninjury. CNS Neurosci Ther.2022;29:866-877. doi: 10.1111/cns.14023

23.        Shen T, Zhao Q, Luo Y, Wang T.Investigating the Role of Zinc in Atherosclerosis: A Review. Biomolecules. 2022;12. doi:10.3390/biom12101358

24.        Han Z, Li L, Tao Z, Wang R, Zhao H,Zheng Y, Yang Z, Zhong L, Fan J, Luo Y. Neutrophilic noncoding RNAs predictoutcomes of acute ischemic stroke patients treated with recombinant tissueplasminogen activator. Front Pharmacol.2022;13:1003806. doi: 10.3389/fphar.2022.1003806

25.        Hu Y, Luo Y, Zheng Y. Nrf2 Pathway andAutophagy Crosstalk: New Insights into Therapeutic Strategies for IschemicCerebral Vascular Diseases. Antioxidants(Basel). 2022;11. doi: 10.3390/antiox11091747

26.        Wang Y, Wang T, Luo Y, Jiao L.Identification Markers of Carotid Vulnerable Plaques: An Update. Biomolecules. 2022;12. doi:10.3390/biom12091192

27.        Zheng Y, Hu Y, Han Z, Yan F, Zhang S,Yang Z, Zhao F, Li L, Fan J, Wang R, et al. Lomitapide ameliorates middlecerebral artery occlusion-induced cerebral ischemia/reperfusion injury bypromoting neuronal autophagy and inhibiting microglial migration. CNS Neurosci Ther. 2022;28:2183-2194.doi: 10.1111/cns.13961

28.        Zhao F, Wang R, Huang Y, Li L, Zhong L,Hu Y, Han Z, Fan J, Liu P, Zheng Y, et al. Elevated plasma syndecan-1 asglycocalyx injury marker predicts unfavorable outcomes after rt-PA intravenousthrombolysis in acute ischemic stroke. FrontPharmacol. 2022;13:949290. doi: 10.3389/fphar.2022.949290

29.        Han Z, Li L, Zhao H, Wang R, Yan F, TaoZ, Fan J, Zheng Y, Zhao F, Huang Y, et al. MicroRNA-193a-5p Rescues IschemicCerebral Injury by Restoring N2-Like Neutrophil Subsets. Transl Stroke Res. 2022;14:589-607. doi: 10.1007/s12975-022-01071-y

30.        Yang Z-H, Zhang S-J, Zhao H-P, Li F-F,Tao Z, Luo Y-M, Wang R-L. Erythropoietin promotes the differentiation of fetalneural stem cells into glial cells via the erythropoietin receptor-β common receptor/Syne-1/H3K9me3 pathway. CNS Neurosci Ther. 2022;28:1351-1364. doi: 10.1111/cns.13876

31.        Zhong L, Luo Y, Fan J. LncRNAs:Promising Therapeutic Targets and Biomarkers for Ischemic Stroke. Transl Stroke Res. 2022;14:803-805. doi:10.1007/s12975-022-01048-x

32.        Hu Y, Zheng Y, Wang T, Jiao L, Luo Y.VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral IschemicStroke. Aging Dis. 2022;13:647-654.doi: 10.14336/AD.2021.1121

33.        Chen S, Li L, Peng C, Bian C, Ocak PE,Zhang JH, Yang Y, Zhou D, Chen G, Luo Y. Targeting Oxidative Stress andInflammatory Response for Blood-Brain Barrier Protection in IntracerebralHemorrhage. Antioxid Redox Signal.2022;37:115-134. doi: 10.1089/ars.2021.0072

34.        Li G, Ma X, Zhao H, Fan J, Liu T, Luo Y,Guo Y. Long non-coding RNA H19 promotes leukocyte inflammation in ischemicstroke by targeting the miR-29b/C1QTNF6 axis. CNS Neurosci Ther. 2022;28:953-963. doi: 10.1111/cns.13829

35.        Wang Y, Wei P, Yan F, Luo Y, Zhao G.Animal Models of Epilepsy: A Phenotype-oriented Review. Aging Dis. 2022;13:215-231. doi: 10.14336/AD.2021.0723

36.        Yan F, Tian Y, Huang Y, Wang Q, Liu P,Wang N, Zhao F, Zhong L, Hui W, Luo Y. Xi-Xian-Tong-Shuan capsule alleviatesvascular cognitive impairment in chronic cerebral hypoperfusion rats bypromoting white matter repair, reducing neuronal loss, and inhibiting theexpression of pro-inflammatory factors. BiomedPharmacother. 2021;145:112453. doi: 10.1016/j.biopha.2021.112453

37.        Li F, Wang N, Zheng Y, Luo Y, Zhang Y.cGAS- Stimulator of Interferon Genes Signaling in Central Nervous SystemDisorders. Aging Dis.2021;12:1658-1674. doi: 10.14336/AD.2021.0304

38.        Zhang S, Zhan L, Li X, Yang Z, Luo Y,Zhao H. Preclinical and clinical progress for HDAC as a putative target forepigenetic remodeling and functionality of immune cells. Int J Biol Sci. 2021;17:3381-3400. doi: 10.7150/ijbs.62001

39.        Zhao F, Yang Z, Wang N, Jin K, Luo Y.Traditional Chinese Medicine and Western Medicine Share Similar PhilosophicalApproaches to Fight COVID-19. Aging Dis.2021;12:1162-1168. doi: 10.14336/AD.2021.0512

40.        Zhao F, Han Z, Wang R, Luo Y.Neurological Manifestations of COVID-19: Causality or Coincidence? Aging Dis. 2021;12:27-35. doi:10.14336/AD.2020.0917

41.        Wang R, Zhang S, Yang Z, Zheng Y, Yan F,Tao Z, Fan J, Zhao H, Han Z, Luo Y. Mutant erythropoietin enhances white matterrepair via the JAK2/STAT3 and C/EBPβ pathway inmiddle-aged mice following cerebral ischemia and reperfusion. Exp Neurol. 2020;337:113553. doi:10.1016/j.expneurol.2020.113553

42.        Fan J, Saft M, Sadanandan N,Gonzales-Portillo B, Park YJ, Sanberg PR, Borlongan CV, Luo Y. LncRNAs Stand asPotent Biomarkers and Therapeutic Targets for Stroke. Front Aging Neurosci. 2020;12:594571. doi:10.3389/fnagi.2020.594571

43.        Wang J, Cao B, Gao Y, Han D, Zhao H,Chen Y, Luo Y, Feng J, Guo Y. Long Non-Coding RNA H19 Positively AssociatesWith Aspirin Resistance in the Patients of Cerebral Ischemic Stroke. Front Pharmacol. 2020;11:580783. doi:10.3389/fphar.2020.580783

44.        Zhao H, Li F, Huang Y, Zhang S, Li L,Yang Z, Wang R, Tao Z, Han Z, Fan J, et al. Prognostic significance of plasmaIL-2 and sIL-2Rα in patients with first-ever ischaemicstroke. J Neuroinflammation.2020;17:237. doi: 10.1186/s12974-020-01920-3

45.        Huang Y, Chen S, Luo Y, Han Z. Crosstalkbetween Inflammation and the BBB in Stroke. CurrNeuropharmacol. 2020;18:1227-1236. doi: 10.2174/1570159X18666200620230321

46.        Li F, Zhao H, Li G, Zhang S, Wang R, TaoZ, Zheng Y, Han Z, Liu P, Ma Q, et al. Intravenous antagomiR-494 lessensbrain-infiltrating neutrophils by increasing HDAC2-mediated repression ofmultiple MMPs in experimental stroke. FASEBJ. 2020;34:6934-6949. doi: 10.1096/fj.201903127R

47.        Li L-Z, Huang Y-Y,Yang Z-H, Zhang S-J, Han Z-P, Luo Y-M. Potential microglia-based interventionsfor stroke. CNS Neurosci Ther.2020;26:288-296. doi: 10.1111/cns.13291

主编和副主编的专著：

1.     主译（Robert Zembroski），健康重建，（Rebuild），北京，人民卫生出版社，2021.01出版ISBN978-7-117-31000-0

3.     主编，TraditionalChinese Medicine in Aging and Disease Intervention，美国：ISOAD，2019年12月第一版 ISBN：978-1-54399-819-1

4.     主编，天然本草养出百岁人生，北京：中国医药科技出版社，2019年2月第1版，ISBN：978-7-5214-0662-7

5.     主编，神经系统疾病动物模型，北京：中国医药科技出版社，2017年6月第1版，ISBN：978-7-5067-9365-0

6.     主编，合理使用治疗神经系统疾病的中药注射剂，北京：中国医药科技出版社，2017年9月第1版，ISBN：978-7-5067-9509-8

7.     主编，养生密码---调元气 养太和，北京，中国医药科技出版社，2016年1月出版， ISBN：978-7-5067-8000-1

8.     主编，脑血管病实验方法学，北京，中国医药科技出版社，2014年4月第1版，ISBN：978-7-5067-6694-4

9.     副主编，亚低温神经保护与治疗，北京，人民卫生出版社，2022.01 ISBN：978-7-117-32568-4

10.   副主编，从探索走向成功-高利团队中西医结合学术思想成长记，北京，中国中医药出版社，2021年12月ISBN：978-7-5132-7153-0

11.   副主编，中西医结合望诊启迪，北京：人民卫生出版社，2018年1月第1版，ISBN：978-7-117-25815-9/R.25816

12.   副主编，神经系统（高等学校教材，器官-系统整合教材，供基础、临床、预防、口腔医学类等专业用）。人民卫生出版社， 2017年3月出版，ISBN：978-7-117-24023-9